Detailed information for compound 1506017

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 337.442 | Formula: C18H19N5S
  • H donors: 2 H acceptors: 2 LogP: 5.28 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCC(CC1)Nc1c(nc2n1ccs2)c1ccc2c(c1)cn[nH]2
  • InChi: 1S/C18H19N5S/c1-2-4-14(5-3-1)20-17-16(21-18-23(17)8-9-24-18)12-6-7-15-13(10-12)11-19-22-15/h6-11,14,20H,1-5H2,(H,19,22)
  • InChiKey: HENXDAXZQIPSPS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Rho-associated, coiled-coil containing protein kinase 2 Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Rho-associated protein kinase 1, putative Get druggable targets OG5_131020 All targets in OG5_131020
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus rho-associated protein kinase 1 Get druggable targets OG5_131020 All targets in OG5_131020
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma japonicum IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing Get druggable targets OG5_131020 All targets in OG5_131020
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis rho associated protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0167 0.0675 0.7137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0019 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0019 0.0086
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0024
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0225 0.1905
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0086
Brugia malayi Prion-like- 0.0007 0.0006 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0019 0.0086
Echinococcus granulosus Immunoglobulin 0.0011 0.0025 0.032
Schistosoma mansoni ferritin 0.0008 0.0013 0.0142
Brugia malayi Protein kinase domain containing protein 0.0547 0.2267 1
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0944 0.8367
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0059 0.0225 0.2856
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0019 0.0086
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.2363 0.9863 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0019 0.0086
Schistosoma mansoni neuroglian 0.0007 0.0006 0.0062
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0019 0.0216
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0019 0.0216
Echinococcus multilocularis neuroglian 0.0007 0.0006 0.0071
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0024
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0024
Brugia malayi Protein kinase domain containing protein 0.0193 0.0787 0.3472
Echinococcus granulosus neuroglian 0.0014 0.0037 0.0473
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.01 0.1109
Schistosoma mansoni vesicular amine transporter 0.0011 0.0025 0.028
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0008 0.0012 0.0052
Onchocerca volvulus 0.0231 0.0944 1
Schistosoma mansoni serine/threonine protein kinase 0.0193 0.0787 0.8736
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0007 0.0006 0.0071
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0006 0.0024
Plasmodium falciparum glycogen synthase kinase 3 0.0059 0.0225 0.5
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0007 0.0006 0.0071
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0019 0.0216
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0019 0.0086
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0025 0.0111
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0019 0.0216
Onchocerca volvulus Tyrosine kinase homolog 0.0171 0.0692 0.731
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0007 0.0006 0.0071
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0019 0.0216
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0111
Echinococcus multilocularis peroxidasin 0.0007 0.0006 0.0071
Echinococcus granulosus peroxidasin 0.0007 0.0006 0.0071
Brugia malayi nuclear receptor NHR-88 0.001 0.0019 0.0086
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0183 0.0742 0.3272
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0011 0.0025 0.028
Echinococcus granulosus roundabout 2 0.0007 0.0006 0.0071
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0193 0.0787 0.3472
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0019 0.0216
Schistosoma mansoni nephrin 0.0014 0.0037 0.0413
Onchocerca volvulus 0.0177 0.0718 0.7594
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0007 0.0006 0.0024
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0019 0.0086
Schistosoma mansoni titin 0.0007 0.0006 0.0062
Schistosoma mansoni ferritin 0.0008 0.0013 0.0142
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.2363 0.9863 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0086
Echinococcus granulosus tyrosine protein kinase otk 0.0007 0.0006 0.0071
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.16 0.6672 0.6761
Onchocerca volvulus 0.0029 0.01 0.1006
Schistosoma mansoni thyroid hormone receptor 0.001 0.0019 0.0216
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0024
Echinococcus multilocularis hemicentin 1 0.0007 0.0006 0.0071
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.01 0.127
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0019 0.0086
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0225 0.5
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0007 0.0006 0.0071
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0006 0.0024
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0274 0.1126 0.113
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0019 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0019 0.0086
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0111
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0086
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0059 0.0225 0.2495
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0193 0.0787 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0232
Brugia malayi Fibronectin type III domain containing protein 0.0011 0.0025 0.0111
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0019 0.0247
Echinococcus multilocularis lachesin 0.0007 0.0006 0.0071
Echinococcus granulosus rho-associated protein kinase 1 0.0177 0.0718 0.9125
Schistosoma mansoni serine/threonine protein kinase 0.0177 0.0718 0.7971
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0041 0.0515
Echinococcus multilocularis protein kinase shaggy 0.0059 0.0225 0.2856
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.01 0.1109
Echinococcus granulosus roundabout 2 0.0018 0.0053 0.0668
Schistosoma mansoni tyrosine kinase 0.0008 0.001 0.0109
Echinococcus multilocularis roundabout 2 0.0018 0.0053 0.0668
Brugia malayi hypothetical protein 0.0011 0.0025 0.0111
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0274 0.1126 0.113
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0007 0.0006 0.0024
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0007 0.0006 0.0024
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0225 0.5
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0225 0.0992
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0019 0.0247
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0007 0.0006 0.0071
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0274 0.1126 0.113
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0007 0.0006 0.0071
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0006 0.0024
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.01 0.1109
Echinococcus multilocularis roundabout 2 0.0007 0.0006 0.0071
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0006 0.0024
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0193 0.0787 0.8328
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.01 0.127
Schistosoma mansoni cell adhesion molecule 0.0007 0.0006 0.0062
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0019 0.0247
Schistosoma mansoni nuclear hormone receptor 0.001 0.0019 0.0216
Brugia malayi ecdysteroid receptor 0.001 0.0019 0.0086
Schistosoma mansoni cell adhesion molecule 0.0015 0.0041 0.045
Trypanosoma brucei RNA helicase, putative 0.0221 0.0901 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0019 0.0216
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0019 0.0247
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0019 0.0086
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0019 0.0247
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0019 0.0247
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.107 0.4454 0.4508
Echinococcus granulosus expressed protein 0.0008 0.0013 0.0163
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.0742 0.3272
Plasmodium vivax glycogen synthase kinase 3, putative 0.0059 0.0225 1
Echinococcus granulosus roundabout 2 0.0007 0.0006 0.0071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0111
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0019 0.0247
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0232
Schistosoma mansoni coup transcription factor 0.001 0.0019 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0019 0.0086
Echinococcus multilocularis ferritin 0.0008 0.0013 0.0163
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0024
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0019 0.0148
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0019 0.0086
Echinococcus granulosus ferritin 0.0008 0.0013 0.0163
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0547 0.2267 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0019 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0019 0.0086
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0011 0.0025 0.028
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0095 0.1213
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0019 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0019 0.0086
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0019 0.0247
Echinococcus multilocularis Immunoglobulin 0.0011 0.0025 0.032
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0019 0.0247
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0225 0.1905
Schistosoma mansoni apoferritin-2 0.0008 0.0013 0.0142
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0019 0.0247
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0019 0.0247
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.01 0.127
Schistosoma mansoni roundabout 0.0007 0.0006 0.0062
Schistosoma mansoni septate junction protein 0.0007 0.0006 0.0062
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0274 0.1126 0.113
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0193 0.0787 0.3472
Brugia malayi Peroxidasin 0.0007 0.0006 0.0024
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0019 0.0086
Schistosoma mansoni ferritin light chain 0.0008 0.0013 0.0142
Schistosoma mansoni nephrin 0.0007 0.0006 0.0062
Echinococcus multilocularis rho associated protein kinase 0.0177 0.0718 0.9125
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0274 0.1126 0.113
Treponema pallidum penicillin-binding protein (pbp-3) 0.107 0.4454 0.4446
Brugia malayi Pre-SET motif family protein 0.0203 0.0827 0.3647
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0007 0.0006 0.0062
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0111
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0019 0.0247
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0019 0.0247
Echinococcus multilocularis expressed protein 0.0008 0.0013 0.0163
Schistosoma mansoni cell adhesion molecule 0.0007 0.0006 0.0062
Brugia malayi Pre-SET motif family protein 0.0029 0.01 0.0441
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0086
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0006 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0274 0.1126 1
Schistosoma mansoni apoferritin-2 0.0008 0.0013 0.0142
Schistosoma mansoni ferritin light chain 0.0008 0.0013 0.0142
Brugia malayi nuclear hormone receptor 0.001 0.0019 0.0086
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0059 0.0225 0.5
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.01 0.1109
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0225 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0179
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0006 0.0024
Echinococcus granulosus protein kinase shaggy 0.0059 0.0225 0.2856
Echinococcus granulosus twitchin 0.0016 0.0043 0.0552
Treponema pallidum penicillin-binding protein (pbp-2) 0.0274 0.1126 0.1114
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0019 0.0216
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0006 0.0024
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0193 0.0787 0.3472
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0193 0.0787 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0019 0.0247
Entamoeba histolytica protein kinase, putative 0.0059 0.0225 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0019 0.0148
Onchocerca volvulus 0.0175 0.0712 0.7528
Schistosoma mansoni ferritin 0.0008 0.0013 0.0142
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0006 0.0024
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0111
Schistosoma mansoni septate junction protein 0.0007 0.0006 0.0062
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0024
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0059 0.0225 0.2856
Schistosoma mansoni hypothetical protein 0.0221 0.0901 1
Echinococcus multilocularis neuroglian 0.0014 0.0037 0.0473
Schistosoma mansoni cell adhesion molecule 0.0007 0.0006 0.0062
Echinococcus granulosus lachesin 0.0007 0.0006 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0019 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0019 0.0086
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0086
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0059 0.0225 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0019 0.0086
Echinococcus granulosus contactin 0.0007 0.0006 0.0071
Echinococcus multilocularis tyrosine protein kinase otk 0.0007 0.0006 0.0071
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0019 0.0086
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0059 0.0225 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0086
Loa Loa (eye worm) hypothetical protein 0.0029 0.01 0.0441
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0086
Echinococcus granulosus FTZ F1 alpha 0.001 0.0019 0.0247
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0019 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0019 0.0086
Onchocerca volvulus 0.0059 0.0225 0.2336
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0019 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0019 0.0086
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0006 0.0024
Echinococcus granulosus neuroglian 0.0007 0.0006 0.0071
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0086
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0019 0.0086
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0007 0.0006 0.0062
Echinococcus multilocularis roundabout 2 0.0007 0.0006 0.0071
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0225 0.0992
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0019 0.0247
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.16 0.6672 0.6761
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0225 0.5
Mycobacterium ulcerans penicillin-binding protein PbpA 0.16 0.6672 0.6761
Echinococcus multilocularis Immunoglobulin 0.0011 0.0025 0.032
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0011 0.0025 0.032
Echinococcus multilocularis hemicentin 1 0.0007 0.0006 0.0071
Onchocerca volvulus 0.001 0.0019 0.0148
Brugia malayi intracellular kinase 0.0059 0.0225 0.0992
Mycobacterium ulcerans penicillin-binding lipoprotein 0.2363 0.9863 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0019 0.0216
Brugia malayi steroid hormone receptor 0.001 0.0019 0.0086
Echinococcus granulosus defective proboscis extension response 0.0011 0.0025 0.032
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0827 0.3647
Schistosoma mansoni ferritin 0.0008 0.0013 0.0142
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0019 0.0247
Echinococcus granulosus hemicentin 1 0.0007 0.0006 0.0071

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) Inhibition of JAK2 ChEMBL. 21288717
Ki (binding) Inhibition of Pak4 ChEMBL. 21288717
Ki (binding) = 0.622 uM Inhibition of Rock2 ChEMBL. 21288717
Ki (binding) = 0.642 uM Inhibition of GSK3-beta ChEMBL. 21288717
Ki (binding) = 1.292 uM Inhibition of Pim1 ChEMBL. 21288717
Ki (binding) = 5.339 uM Inhibition of KDR ChEMBL. 21288717
Ki (binding) = 1800 uM Inhibition of aurora 2 ChEMBL. 21288717

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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