Detailed information for compound 1507556

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 319.437 | Formula: C16H33NO5
  • H donors: 4 H acceptors: 4 LogP: 0.83 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCOCCCCCN1C[C@H](O)[C@H]([C@@H]([C@@H]1CO)O)O
  • InChi: 1S/C16H33NO5/c1-2-3-6-9-22-10-7-4-5-8-17-11-14(19)16(21)15(20)13(17)12-18/h13-16,18-21H,2-12H2,1H3/t13-,14-,15+,16+/m0/s1
  • InChiKey: LLUQYJRYJAPGMA-CAOSSQGBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus UDP-glucose ceramide glucosyltransferase Starlite/ChEMBL References
Homo sapiens glucosidase, beta (bile acid) 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni ceramide glucosyltransferase Get druggable targets OG5_129848 All targets in OG5_129848
Echinococcus multilocularis ceramide glucosyltransferase Get druggable targets OG5_129848 All targets in OG5_129848
Loa Loa (eye worm) ceramide glucosyltransferase Get druggable targets OG5_129848 All targets in OG5_129848
Echinococcus multilocularis bile acid beta glucosidase Get druggable targets OG5_130651 All targets in OG5_130651
Schistosoma japonicum Ceramide glucosyltransferase, putative Get druggable targets OG5_129848 All targets in OG5_129848
Schistosoma mansoni bile acid beta-glucosidase-related Get druggable targets OG5_130651 All targets in OG5_130651
Candida albicans ceramide glucosyltransferase Get druggable targets OG5_129848 All targets in OG5_129848
Schistosoma japonicum Non-lysosomal glucosylceramidase, putative Get druggable targets OG5_130651 All targets in OG5_130651
Echinococcus granulosus ceramide glucosyltransferase Get druggable targets OG5_129848 All targets in OG5_129848
Schistosoma japonicum ko:K00720 ceramide glucosyltransferase [EC2.4.1.80], putative Get druggable targets OG5_129848 All targets in OG5_129848
Onchocerca volvulus Ceramide glucosyltransferase homolog Get druggable targets OG5_129848 All targets in OG5_129848
Echinococcus multilocularis non lysosomal glucosylceramidase Get druggable targets OG5_130651 All targets in OG5_130651
Schistosoma mansoni bile acid beta-glucosidase-related Get druggable targets OG5_130651 All targets in OG5_130651
Brugia malayi Ceramide glucosyltransferase Get druggable targets OG5_129848 All targets in OG5_129848
Candida albicans ceramide glucosyltransferase Get druggable targets OG5_129848 All targets in OG5_129848
Schistosoma japonicum Non-lysosomal glucosylceramidase, putative Get druggable targets OG5_130651 All targets in OG5_130651
Schistosoma japonicum Non-lysosomal glucosylceramidase, putative Get druggable targets OG5_130651 All targets in OG5_130651
Echinococcus granulosus non lysosomal glucosylceramidase Get druggable targets OG5_130651 All targets in OG5_130651
Echinococcus granulosus bile acid beta glucosidase Get druggable targets OG5_130651 All targets in OG5_130651
Schistosoma mansoni ceramide glucosyltransferase Get druggable targets OG5_129848 All targets in OG5_129848
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130651 All targets in OG5_130651
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0022 0.001 0.0019
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0147 0.0154
Leishmania major importin beta-1 subunit, putative 0.0024 0.0034 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.017 0.2068
Loa Loa (eye worm) hypothetical protein 0.0033 0.0138 0.0134
Schistosoma mansoni hypothetical protein 0.0033 0.0147 0.035
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0173 0.2108
Giardia lamblia GTOR 0.0044 0.0278 0.2077
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0173 0.0169
Toxoplasma gondii peptidylprolyl isomerase 0.007 0.0582 0.733
Echinococcus multilocularis bile acid beta glucosidase 0.0251 0.2748 0.296
Leishmania major hypothetical protein, conserved 0.0035 0.0173 0.2108
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0607 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.017 0.2068
Schistosoma mansoni alpha-glucosidase 0.0339 0.3789 0.9303
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0023 0.002 0.0158
Echinococcus granulosus muscleblind protein 0.0295 0.3262 0.7341
Echinococcus granulosus ceramide glucosyltransferase 0.0288 0.3185 0.7167
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0087 0.0792 1
Trypanosoma cruzi hypothetical protein, conserved 0.0087 0.0792 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0033 0.0138 0.1662
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0138 0.1662
Echinococcus granulosus importin subunit beta 1 0.0029 0.01 0.0216
Entamoeba histolytica hypothetical protein 0.0076 0.0655 0.8255
Schistosoma mansoni importin beta-1 0.0029 0.01 0.0236
Schistosoma mansoni hypothetical protein 0.0033 0.0147 0.035
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0278 0.0672
Trichomonas vaginalis alpha-glucosidase, putative 0.0087 0.0792 1
Schistosoma mansoni tsg101-related 0.0059 0.0453 0.1103
Echinococcus granulosus expressed protein 0.0071 0.0603 0.1347
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0246 0.2689 0.6597
Brugia malayi Glycosyl hydrolases family 31 protein 0.0033 0.0138 0.0134
Trichomonas vaginalis alpha-glucosidase, putative 0.0087 0.0792 1
Onchocerca volvulus Papilin homolog 0.0271 0.2986 0.332
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0023 0.002 0.0258
Loa Loa (eye worm) hypothetical protein 0.0116 0.1139 0.1135
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.007 0.0582 0.733
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0173 0.2189
Schistosoma mansoni hypothetical protein 0.0362 0.4073 1
Schistosoma mansoni ceramide glucosyltransferase 0.0288 0.3185 0.7819
Loa Loa (eye worm) hypothetical protein 0.0105 0.1004 0.1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0033 0.0138 0.1662
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.3487 0.3484
Echinococcus granulosus lysosomal alpha glucosidase 0.0393 0.4443 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0173 0.5
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0022 0.001 0.0019
Entamoeba histolytica hypothetical protein 0.0076 0.0655 0.8255
Schistosoma mansoni ran 0.0022 0.0008 0.0009
Onchocerca volvulus 0.0228 0.2464 0.2739
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0147 0.0154
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0173 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0087 0.0792 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0008 0.0008
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0147 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0035 0.0348
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0008 0.0003
Echinococcus multilocularis adam 0.0246 0.2689 0.2896
Schistosoma mansoni tsg101-related 0.0059 0.0453 0.1103
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.1004 0.1
Brugia malayi Muscleblind-like protein 0.0295 0.3262 0.3259
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0033 0.0138 0.1662
Schistosoma mansoni hypothetical protein 0.0072 0.0607 0.1481
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0278 0.3445
Loa Loa (eye worm) hypothetical protein 0.0029 0.01 0.0096
Brugia malayi Glycosyl hydrolases family 31 protein 0.0393 0.4443 0.444
Schistosoma mansoni tsg101-related 0.0048 0.0325 0.0787
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0171 0.2073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.017 0.2068
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0071 0.0603 0.0598
Echinococcus multilocularis neutral alpha glucosidase AB 0.0087 0.0792 0.0849
Schistosoma mansoni alpha glucosidase 0.0087 0.0792 0.1935
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0603 0.7586
Echinococcus granulosus geminin 0.0362 0.4073 0.9167
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0116 0.1139 0.2789
Loa Loa (eye worm) reprolysin 0.0116 0.1139 0.1135
Brugia malayi hypothetical protein 0.0071 0.0595 0.059
Loa Loa (eye worm) hypothetical protein 0.0035 0.0173 0.0169
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.007 0.0582 0.733
Echinococcus multilocularis lysosomal alpha glucosidase 0.0393 0.4443 0.4789
Mycobacterium leprae Probable lipase LipE 0.0035 0.0173 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.01 0.1269
Brugia malayi metalloprotease 0.0116 0.1139 0.1135
Brugia malayi Importin beta-1 subunit 0.0029 0.01 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0104 0.1229
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0278 0.3512
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0278 0.3445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0143 0.172
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0359 0.4032 0.9899
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0278 0.3512
Brugia malayi hypothetical protein 0.0246 0.2689 0.2685
Schistosoma mansoni hypothetical protein 0.0033 0.0147 0.035
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0087 0.0792 0.0787
Loa Loa (eye worm) hypothetical protein 0.0071 0.0595 0.059
Echinococcus multilocularis muscleblind protein 0.0295 0.3262 0.3515
Loa Loa (eye worm) hypothetical protein 0.0295 0.3262 0.3259
Brugia malayi RNA, U transporter 1 0.0083 0.0746 0.0741
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0022 0.001 0.0019
Trichomonas vaginalis alpha-glucosidase, putative 0.0087 0.0792 1
Echinococcus granulosus snurportin 1 0.0313 0.3487 0.7846
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0063 0.0696
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0056 0.5234
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.007 0.0582 0.7357
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0393 0.4443 0.444
Trichomonas vaginalis sucrase-isomaltase, putative 0.0087 0.0792 1
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0655 0.1599
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0171 0.2154
Loa Loa (eye worm) hypothetical protein 0.0035 0.0173 0.0169
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0022 0.001 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0063 0.0696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0066 0.0736
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.007 0.0582 0.733
Loa Loa (eye worm) metalloprotease 0.0116 0.1139 0.1135
Schistosoma mansoni rotamase 0.0071 0.0603 0.147
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0033 0.0138 0.1662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0278 0.3445
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.01 0.1269
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.01 0.1179
Leishmania major glycosyl hydrolase-like protein 0.0033 0.0138 0.1662
Loa Loa (eye worm) ceramide glucosyltransferase 0.0288 0.3185 0.3182
Loa Loa (eye worm) beta-lactamase 0.0035 0.0173 0.0169
Brugia malayi beta-lactamase family protein 0.0035 0.0173 0.0169
Echinococcus multilocularis snurportin 1 0.0313 0.3487 0.3757
Trichomonas vaginalis hypothetical protein 0.0034 0.0162 0.1959
Loa Loa (eye worm) hypothetical protein 0.0295 0.3262 0.3259
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0116 0.1139 0.2789
Trypanosoma cruzi hypothetical protein, conserved 0.0087 0.0792 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.1139 0.1135
Brugia malayi Glycosyl hydrolases family 31 protein 0.0087 0.0792 0.0787
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0278 0.3445
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0087 0.0792 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0173 0.2108
Brugia malayi hypothetical protein 0.0076 0.0655 0.0651
Plasmodium falciparum importin beta, putative 0.0029 0.01 1
Echinococcus granulosus adam 0.0246 0.2689 0.6048
Mycobacterium ulcerans beta-lactamase 0.0035 0.0173 0.5
Schistosoma mansoni hypothetical protein 0.0362 0.4073 1
Loa Loa (eye worm) hypothetical protein 0.0775 0.8986 0.8986
Loa Loa (eye worm) hypothetical protein 0.0035 0.0173 0.0169
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2451 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0173 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0035 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0143 0.172
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0278 0.3445
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0008 0.0003
Loa Loa (eye worm) hypothetical protein 0.0271 0.2986 0.2983
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0173 0.2108
Onchocerca volvulus 0.0775 0.8986 1
Brugia malayi beta-lactamase 0.0035 0.0173 0.0169
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0033 0.0138 0.0149
Brugia malayi angiogenesis inhibito 0.0264 0.2894 0.2891
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0173 0.2108
Echinococcus granulosus neutral alpha glucosidase AB 0.0087 0.0792 0.1774
Brugia malayi Ceramide glucosyltransferase 0.0288 0.3185 0.3182
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0034 0.0334
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0655 0.0702
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0035 0.0348
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.0288 0.3185 0.3541
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0173 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0087 0.0792 1
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0116 0.1139 0.2557
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0138 0.1662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0066 0.0736
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0034 0.0334
Trichomonas vaginalis alpha-glucosidase, putative 0.0087 0.0792 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0655 0.1465
Plasmodium vivax importin-beta 2, putative 0.0029 0.01 0.5594
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0359 0.4032 0.9074
Echinococcus multilocularis lysosomal alpha glucosidase 0.0393 0.4443 0.4789
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0116 0.1139 0.1224
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0278 0.0274
Leishmania major hypothetical protein, conserved 0.0023 0.002 0.0158
Schistosoma mansoni ran 0.0022 0.0008 0.0009
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0138 0.1662
Brugia malayi hypothetical protein 0.0026 0.0056 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0143 0.172
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.1004 0.1
Schistosoma mansoni bile acid beta-glucosidase-related 0.0251 0.2748 0.6743
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0147 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.017 0.2068
Trichomonas vaginalis esterase, putative 0.0035 0.0173 0.2108
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0173 0.2108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0201 0.2461
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0008 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0035 0.0343
Entamoeba histolytica hypothetical protein 0.0076 0.0655 0.8255
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0173 0.0182
Mycobacterium ulcerans hypothetical protein 0.0035 0.0173 0.5
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0056 0.0617
Loa Loa (eye worm) hypothetical protein 0.0035 0.0173 0.0169
Trypanosoma brucei glucosidase, putative 0.0087 0.0792 1
Loa Loa (eye worm) hypothetical protein 0.017 0.1774 0.177
Onchocerca volvulus 0.0035 0.0173 0.0188
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0173 0.0415
Schistosoma mansoni ceramide glucosyltransferase 0.0288 0.3185 0.7819
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0138 0.1662
Trichomonas vaginalis rotamase, putative 0.0071 0.0603 0.7586
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0278 0.0295
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0173 0.2108
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0087 0.0792 1
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0071 0.0595 0.1329
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0278 0.3445
Echinococcus multilocularis non lysosomal glucosylceramidase 0.0251 0.2748 0.296
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0143 0.172
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0359 0.4032 0.4346
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0033 0.0138 0.1662
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.1004 0.1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0056 0.5234
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0056 0.0713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0143 0.172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0278 0.3445
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0034 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0093 0.1083
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0171 0.2073
Mycobacterium ulcerans lipase LipD 0.0035 0.0173 0.5
Schistosoma mansoni hypothetical protein 0.0033 0.0147 0.035
Schistosoma mansoni alpha-glucosidase 0.0339 0.3789 0.9303
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0056 0.0617
Echinococcus multilocularis importin subunit beta 1 0.0029 0.01 0.0103
Brugia malayi beta-lactamase family protein 0.0035 0.0173 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0035 0.0348
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0022 0.001 0.0121
Loa Loa (eye worm) hypothetical protein 0.0026 0.0056 0.0052
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0048 0.0325 0.4039
Trichomonas vaginalis maltase-glucoamylase, putative 0.0087 0.0792 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0173 0.5
Loa Loa (eye worm) hypothetical protein 0.0072 0.0607 0.0603
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0173 0.038
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0173 0.2108
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0147 0.0143
Onchocerca volvulus 0.0035 0.0173 0.0188
Echinococcus granulosus bile acid beta glucosidase 0.0251 0.2748 0.6181
Echinococcus granulosus GPCR family 2 0.0033 0.0147 0.0321
Leishmania major hypothetical protein, conserved 0.0026 0.0056 0.0617
Echinococcus multilocularis ceramide glucosyltransferase 0.0288 0.3185 0.3432
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0173 0.0415
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0008 0.0102
Echinococcus multilocularis geminin 0.0362 0.4073 0.439
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0034 0.0334
Schistosoma mansoni hypothetical protein 0.0313 0.3487 0.8559
Schistosoma mansoni hypothetical protein 0.0076 0.0655 0.1599
Echinococcus multilocularis GPCR, family 2 0.0033 0.0147 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0035 0.0348
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.007 0.0582 0.733
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0278 0.0616
Loa Loa (eye worm) angiogenesis inhibito 0.0134 0.1345 0.1341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0066 0.0736
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0071 0.0595 0.0637
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0138 0.1662
Loa Loa (eye worm) hypothetical protein 0.013 0.13 0.1296
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0147 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0143 0.172
Leishmania major alpha glucosidase II subunit, putative 0.0087 0.0792 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0056 0.0617
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0071 0.0603 0.0598
Echinococcus granulosus non lysosomal glucosylceramidase 0.0251 0.2748 0.6181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0143 0.172
Trypanosoma brucei glycosyl hydrolase-like protein 0.0033 0.0138 0.1747
Giardia lamblia Ceramide glucosyltransferase 0.0131 0.1308 1
Entamoeba histolytica hypothetical protein 0.0024 0.0034 0.0334
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0173 0.0169
Brugia malayi ADAMTS-like protease 0.0264 0.2894 0.2891
Loa Loa (eye worm) hypothetical protein 0.0033 0.0147 0.0143
Schistosoma mansoni bile acid beta-glucosidase-related 0.0251 0.2748 0.6743
Brugia malayi hypothetical protein 0.0775 0.8986 0.8986
Entamoeba histolytica hypothetical protein 0.0076 0.0655 0.8255
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0147 0.0143
Loa Loa (eye worm) hypothetical protein 0.0246 0.2689 0.2685
Toxoplasma gondii ABC1 family protein 0.0035 0.0173 0.2108
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0087 0.0792 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0173 0.0169
Echinococcus multilocularis muscleblind protein 1 0.0295 0.3262 0.3515
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0116 0.1139 0.2789
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0798 0.9272 1
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0022 0.001 0.5
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0278 0.3445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0035 0.0343
Trichomonas vaginalis maltase-glucoamylase, putative 0.0033 0.0138 0.1662
Echinococcus multilocularis expressed protein 0.0071 0.0603 0.0645
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0278 0.3445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.017 0.2068
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0278 0.0274
Brugia malayi Reprolysin 0.0116 0.1139 0.1135
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0056 0.2928
Trichomonas vaginalis rotamase, putative 0.007 0.0582 0.733
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0143 0.172
Onchocerca volvulus 0.0035 0.0173 0.0188

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.015 uM Inhibition of recombinant GBA2 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay ChEMBL. 24900289
IC50 (binding) = 0.15 uM Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay ChEMBL. 24900289
IC50 (binding) = 100 uM Inhibition of recombinant GBA1 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay ChEMBL. 24900289
IC50 (binding) = 200 uM Inhibition of lactase in mouse intestinal input by glucose release assay ChEMBL. 24900289
IC50 (binding) > 1000 uM Inhibition of maltase in mouse intestinal input by glucose release assay ChEMBL. 24900289
IC50 (binding) > 1000 uM Inhibition of sucrase in mouse intestinal input by glucose release assay ChEMBL. 24900289

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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