Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.1047 | 0.1047 |
Mycobacterium ulcerans | Zn-dependent alcohol dehydrogenase, AdhX | 0.0153 | 0.0929 | 0.0865 |
Echinococcus multilocularis | synaptic vesicle membrane protein VAT 1 | 0.0056 | 0.007 | 0.0487 |
Mycobacterium tuberculosis | Probable alcohol dehydrogenase Adh | 0.0153 | 0.0929 | 0.0865 |
Leishmania major | nuclear receptor binding factor-like protein | 0.0098 | 0.0438 | 0.4594 |
Trypanosoma brucei | oxidoreductase, putative | 0.0153 | 0.0929 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0075 | 0.0242 | 0.2159 |
Mycobacterium tuberculosis | Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) | 0.0153 | 0.0929 | 0.0865 |
Toxoplasma gondii | quinone oxidoreductase, putative | 0.0153 | 0.0929 | 0.0911 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0153 | 0.0929 | 1 |
Mycobacterium tuberculosis | Probable NADP-dependent alcohol dehydrogenase AdhC | 0.0153 | 0.0929 | 0.0865 |
Schistosoma mansoni | alcohol dehydrogenase | 0.1184 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0929 | 0.0911 |
Leishmania major | oxidoreductase, putative | 0.0153 | 0.0929 | 1 |
Trypanosoma cruzi | quinone oxidoreductase, putative | 0.0056 | 0.007 | 0.055 |
Brugia malayi | jmjC domain containing protein | 0.0058 | 0.0088 | 0.0088 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0098 | 0.0438 | 0.0438 |
Mycobacterium tuberculosis | Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) | 0.0153 | 0.0929 | 0.0865 |
Loa Loa (eye worm) | carboxylesterase | 0.0075 | 0.0242 | 0.0222 |
Mycobacterium ulcerans | zinc-type alcohol dehydrogenase AdhD | 0.1184 | 1 | 1 |
Leishmania major | zinc binding dehydrogenase-like protein | 0.0153 | 0.0929 | 1 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0056 | 0.007 | 0.055 |
Trypanosoma brucei | oxidoreductase, putative | 0.0153 | 0.0929 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0153 | 0.0929 | 0.0865 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 | 0.103 | 0.865 | 0.864 |
Leishmania major | hypothetical protein, conserved | 0.0056 | 0.007 | 0.055 |
Mycobacterium ulcerans | oxidoreductase | 0.0098 | 0.0438 | 0.037 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0153 | 0.0929 | 0.0929 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0153 | 0.0929 | 0.0865 |
Mycobacterium ulcerans | dehydrogenase | 0.0153 | 0.0929 | 0.0865 |
Echinococcus multilocularis | acetylcholinesterase | 0.0075 | 0.0242 | 0.2159 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0075 | 0.0242 | 0.0222 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0153 | 0.0929 | 0.0865 |
Echinococcus multilocularis | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0153 | 0.0929 | 0.8854 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase AdhC | 0.0153 | 0.0929 | 0.0865 |
Mycobacterium tuberculosis | S-nitrosomycothiol reductase MscR | 0.0153 | 0.0929 | 0.0865 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0153 | 0.0929 | 1 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0153 | 0.0929 | 1 |
Echinococcus granulosus | geminin | 0.0167 | 0.1047 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0075 | 0.0242 | 0.0242 |
Mycobacterium tuberculosis | Possible oxidoreductase FadB5 | 0.0153 | 0.0929 | 0.0865 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0153 | 0.0929 | 0.0865 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0075 | 0.0242 | 0.0242 |
Schistosoma mansoni | zinc binding dehydrogenase | 0.0153 | 0.0929 | 0.0929 |
Mycobacterium ulcerans | NADP-dependent oxidoreductase | 0.0098 | 0.0438 | 0.037 |
Mycobacterium ulcerans | NADPH quinone oxidoreductase FadB4 | 0.0153 | 0.0929 | 0.0865 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0153 | 0.0929 | 0.0865 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0153 | 0.0929 | 0.0865 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase AdhE2 | 0.1184 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0058 | 0.0088 | 0.0068 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0153 | 0.0929 | 0.0865 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0438 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0242 | 0.0222 |
Mycobacterium ulcerans | polyketide synthase | 0.0153 | 0.0929 | 0.0865 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.0992 | 0.0974 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.1184 | 1 | 1 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD-dependent AdhB | 0.1184 | 1 | 1 |
Onchocerca volvulus | 0.0153 | 0.0929 | 0.0514 | |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0153 | 0.0929 | 0.0911 |
Mycobacterium tuberculosis | Possible dehydrogenase | 0.0153 | 0.0929 | 0.0865 |
Brugia malayi | hypothetical protein | 0.0161 | 0.0992 | 0.0992 |
Echinococcus granulosus | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0153 | 0.0929 | 0.8854 |
Mycobacterium tuberculosis | Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) | 0.0153 | 0.0929 | 0.0865 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0153 | 0.0929 | 0.0865 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0153 | 0.0929 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0148 | 0.0883 | 0.0883 |
Trypanosoma cruzi | quinone oxidoreductase, putative | 0.0056 | 0.007 | 0.055 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 0.002 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0056 | 0.007 | 0.055 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0153 | 0.0929 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0058 | 0.0088 | 0.0088 |
Brugia malayi | MAP kinase sur-1 | 0.005 | 0.002 | 0.002 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0058 | 0.0088 | 0.0663 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0056 | 0.007 | 0.055 |
Leishmania major | NADP-dependent alcohol dehydrogenase, putative | 0.0153 | 0.0929 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0058 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | acyl carrier protein | 0.0098 | 0.0438 | 0.0418 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.1184 | 1 | 1 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase Adh | 0.0153 | 0.0929 | 0.0865 |
Mycobacterium ulcerans | oxidoreductase FadB5 | 0.0153 | 0.0929 | 0.0865 |
Schistosoma mansoni | jumonji domain containing protein | 0.0058 | 0.0088 | 0.0088 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.1184 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0075 | 0.0242 | 0.2159 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0929 | 0.0911 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0929 | 0.0911 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0098 | 0.0438 | 0.4594 |
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.1184 | 1 | 1 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0153 | 0.0929 | 1 |
Echinococcus multilocularis | geminin | 0.0167 | 0.1047 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0153 | 0.0929 | 0.0929 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0153 | 0.0929 | 0.0865 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0153 | 0.0929 | 0.0865 |
Brugia malayi | Carboxylesterase family protein | 0.0075 | 0.0242 | 0.0242 |
Brugia malayi | jmjC domain containing protein | 0.0058 | 0.0088 | 0.0088 |
Mycobacterium ulcerans | oxidoreductase | 0.0153 | 0.0929 | 0.0865 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0153 | 0.0929 | 0.5 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0153 | 0.0929 | 0.5 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0153 | 0.0929 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0098 | 0.0438 | 0.0438 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0153 | 0.0929 | 0.0865 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0153 | 0.0929 | 1 |
Mycobacterium tuberculosis | Probable alcohol dehydrogenase AdhA | 0.0153 | 0.0929 | 0.0865 |
Echinococcus granulosus | acetylcholinesterase | 0.0075 | 0.0242 | 0.2159 |
Mycobacterium tuberculosis | Possible dehydrogenase | 0.0153 | 0.0929 | 0.0865 |
Trypanosoma brucei | Trans-2-enoyl-ACP reductase 1, putative | 0.0056 | 0.007 | 0.055 |
Loa Loa (eye worm) | oxidoreductase | 0.0056 | 0.007 | 0.005 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0153 | 0.0929 | 1 |
Toxoplasma gondii | type I fatty acid synthase | 0.0056 | 0.007 | 0.005 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0153 | 0.0929 | 0.0865 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0242 | 0.0222 |
Mycobacterium tuberculosis | Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.103 | 0.865 | 0.864 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0058 | 0.0088 | 0.0663 |
Trypanosoma brucei | Trans-2-enoyl-ACP reductase 2, putative | 0.0098 | 0.0438 | 0.4594 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase | 0.1184 | 1 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0153 | 0.0929 | 1 |
Leishmania major | quinone oxidoreductase, putative | 0.0153 | 0.0929 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0058 | 0.0088 | 0.0663 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.1184 | 1 | 1 |
Leishmania major | d-xylulose reductase, putative | 0.0153 | 0.0929 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0153 | 0.0929 | 1 |
Mycobacterium ulcerans | quinone reductase Qor | 0.0153 | 0.0929 | 0.0865 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0075 | 0.0242 | 0.2159 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.002 | 0.002 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0056 | 0.007 | 0.007 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.1184 | 1 | 1 |
Echinococcus granulosus | synaptic vesicle membrane protein VAT 1 | 0.0056 | 0.007 | 0.0487 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0148 | 0.0883 | 0.0865 |
Echinococcus multilocularis | acetylcholinesterase | 0.0075 | 0.0242 | 0.2159 |
Wolbachia endosymbiont of Brugia malayi | NADPH:quinone reductase | 0.0153 | 0.0929 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0058 | 0.0088 | 0.0663 |
Leishmania major | zinc-binding dehydrogenase-like protein | 0.0098 | 0.0438 | 0.4594 |
Leishmania major | quinone oxidoreductase-like protein,alcohol dehydrogenase, zinc-containing-like protein | 0.0056 | 0.007 | 0.055 |
Mycobacterium ulcerans | short-chain dehydrogenase | 0.0153 | 0.0929 | 0.0865 |
Leishmania major | oxidoreductase-like protein | 0.0153 | 0.0929 | 1 |
Schistosoma mansoni | quinone oxidoreductase | 0.0056 | 0.007 | 0.007 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase | 0.0153 | 0.0929 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.1047 | 0.1047 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 ratio (functional) | = 0.6 | Antagonist activity against Opioid receptor kappa 1 using ethylketazocine (EK) as agonist in guinea pig ileum measured as IC50 of agonist in presence of test compound/ agonist in absence of test compound | ChEMBL. | 3037078 |
IC50 ratio (functional) | = 0.8 | Antagonist activity against Opioid receptor mu 1 using morphine as agaonist in mouse vas deferens measured as IC50 of agonist in presence of test compound/ agonist in absence of test compound | ChEMBL. | 3037078 |
IC50 ratio (functional) | = 1.3 | Antagonist activity against Opioid receptor mu 1 using morphine agonist in guinea pig ileum measured as IC50 of agonist in presence of test compound/ agonist in absence of test compound | ChEMBL. | 3037078 |
IC50 ratio (functional) | = 3.3 | Antagonist activity against Opioid receptor delta 1 using [D-Ala2, D-Leu5] enkephalin (DADLE) as agonist in mouse vas deferens measured as IC50 of agonist in presence of test compound/ agonist in absence of test compound | ChEMBL. | 3037078 |
IC50 ratio (functional) | = 0.6 | Antagonist activity against Opioid receptor kappa 1 using ethylketazocine (EK) as agonist in guinea pig ileum measured as IC50 of agonist in presence of test compound/ agonist in absence of test compound | ChEMBL. | 3037078 |
IC50 ratio (functional) | = 0.8 | Antagonist activity against Opioid receptor mu 1 using morphine as agaonist in mouse vas deferens measured as IC50 of agonist in presence of test compound/ agonist in absence of test compound | ChEMBL. | 3037078 |
IC50 ratio (functional) | = 1.3 | Antagonist activity against Opioid receptor mu 1 using morphine agonist in guinea pig ileum measured as IC50 of agonist in presence of test compound/ agonist in absence of test compound | ChEMBL. | 3037078 |
IC50 ratio (functional) | = 3.3 | Antagonist activity against Opioid receptor delta 1 using [D-Ala2, D-Leu5] enkephalin (DADLE) as agonist in mouse vas deferens measured as IC50 of agonist in presence of test compound/ agonist in absence of test compound | ChEMBL. | 3037078 |
Inhibition (functional) | = 15.9 % | Agonistic activity was measured on the electrically stimulated longitudinal muscle of the guinea pig ileum (GPI) at 1 uM concentration | ChEMBL. | 3037078 |
Inhibition (functional) | = 20.4 % | Agonistic activity was measured on the electrically stimulated longitudinal muscle of the mouse vas deferens (MVD) at 1 uM concentration | ChEMBL. | 3037078 |
Inhibition (functional) | = 20.4 % | Agonistic activity was measured on the electrically stimulated longitudinal muscle of the mouse vas deferens (MVD) at 1 uM concentration | ChEMBL. | 3037078 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.