Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | 0.0088 | 0.0965 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.003 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0208 | 1 |
Echinococcus granulosus | caspase 2 | 0.0068 | 0.0641 | 0.6221 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0208 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0208 | 0.0208 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0222 | 0.3231 | 0.3087 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0273 | 0.4088 | 0.4088 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.02 | 0.2856 | 0.2704 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0208 | 0.0447 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0064 | 0.0569 | 0.5521 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0043 | 0.0208 | 0.0208 |
Brugia malayi | hypothetical protein | 0.0048 | 0.0295 | 0.2861 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0208 | 1 |
Mycobacterium leprae | PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) | 0.042 | 0.6561 | 0.6488 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0043 | 0.0208 | 0.0208 |
Brugia malayi | Cell death protein 3 precursor | 0.0068 | 0.0641 | 0.6221 |
Plasmodium vivax | glutathione reductase, putative | 0.0088 | 0.0965 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0359 | 0.0851 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0208 | 0.216 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0048 | 0.0295 | 0.2861 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0043 | 0.0208 | 0.0208 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.02 | 0.2856 | 0.2856 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0092 | 0.1031 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0359 | 0.3481 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0092 | 0.1031 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.02 | 0.2856 | 0.2856 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0208 | 0.0447 |
Leishmania major | trypanothione reductase | 0.0088 | 0.0965 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0088 | 0.0965 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0222 | 0.3231 | 0.3231 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0208 | 0.0494 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.042 | 0.6561 | 0.6561 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0092 | 0.1031 | 0.2445 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0208 | 0.0208 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.017 | 0.1648 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0359 | 0.3481 |
Trypanosoma brucei | trypanothione reductase | 0.0088 | 0.0965 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0208 | 0.0447 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0208 | 0.0208 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0092 | 0.1031 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0222 | 0.3231 | 0.3231 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0043 | 0.0208 | 0.0208 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0088 | 0.0965 | 0.0965 |
Brugia malayi | Cytochrome P450 family protein | 0.0057 | 0.0443 | 0.43 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0359 | 0.0851 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0641 | 0.5476 |
Mycobacterium tuberculosis | Naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase) | 0.0624 | 1 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0068 | 0.0641 | 0.1521 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0208 | 0.0208 |
Treponema pallidum | NADH oxidase | 0.003 | 0 | 0.5 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0208 | 0.2021 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.042 | 0.6561 | 0.6561 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.02 | 0.2856 | 0.2856 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0359 | 0.3481 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0092 | 0.1031 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0092 | 0.1031 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0295 | 0.07 |
Plasmodium falciparum | thioredoxin reductase | 0.0088 | 0.0965 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0208 | 0.0494 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0208 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0088 | 0.0965 | 0.923 |
Echinococcus multilocularis | caspase 2 | 0.0068 | 0.0641 | 0.6221 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0208 | 0.216 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.0485 | 0.4707 |
Mycobacterium leprae | Isocitrate lyase | 0.0197 | 0.2804 | 0.265 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0222 | 0.3231 | 0.3231 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0208 | 0.2021 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0208 | 0.0447 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0208 | 0.216 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0068 | 0.0641 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0208 | 0.216 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0043 | 0.0208 | 0.0208 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0089 | 0.0984 | 0.9548 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0088 | 0.0965 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0208 | 0.2021 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0088 | 0.0965 | 0.923 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0359 | 0.3481 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0208 | 0.0447 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0485 | 0.3663 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0359 | 0.3481 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0295 | 0.1453 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0208 | 0.0447 |
Mycobacterium tuberculosis | Probable reductase | 0.02 | 0.2856 | 0.2856 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.0485 | 0.4707 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0208 | 0.2021 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0359 | 0.0851 |
Schistosoma mansoni | lipoxygenase | 0.0064 | 0.0569 | 0.135 |
Brugia malayi | glutathione reductase | 0.0088 | 0.0965 | 0.9357 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.02 | 0.2856 | 0.2856 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.003 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0208 | 0.0208 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0048 | 0.0295 | 0.2861 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0359 | 0.2195 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0208 | 0.216 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.003 | 0 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0089 | 0.0984 | 0.9548 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.017 | 0.0403 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0064 | 0.0569 | 0.5521 |
Onchocerca volvulus | 0.0048 | 0.0295 | 0.2 | |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.042 | 0.6561 | 0.6561 |
Brugia malayi | Thioredoxin reductase | 0.0088 | 0.0965 | 0.9357 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0208 | 1 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.042 | 0.6561 | 0.6561 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0208 | 0.0447 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0208 | 0.2021 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0043 | 0.0208 | 0.0208 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.02 | 0.2856 | 0.2856 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0208 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0208 | 0.0447 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0057 | 0.0443 | 0.3176 |
Mycobacterium ulcerans | naphthoate synthase | 0.0624 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.0485 | 0.3663 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.042 | 0.6561 | 0.6561 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0043 | 0.0208 | 0.0208 |
Plasmodium falciparum | glutathione reductase | 0.0088 | 0.0965 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0092 | 0.1031 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0208 | 0.2021 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0208 | 0.216 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0048 | 0.0292 | 0.0292 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.7 uM | Assayed against human skin fibroblast Collagenase using the spectrophotometric assay with the thiol ester substrate at pH 6.5. | ChEMBL. | 2153207 |
Ki (binding) | = 13 uM | Inihibition of human skin fibroblast Collagenase at pH 7.5 | ChEMBL. | 2153207 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.