Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholesteryl ester transfer protein, plasma | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0041 | 0.7701 | 1 | |
Brugia malayi | hypothetical protein | 0.0023 | 0.2713 | 0.3075 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0023 | 0.2713 | 0.3075 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.2713 | 0.3075 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1 | 0.1133 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0023 | 0.2713 | 0.3075 |
Brugia malayi | LBP/BPI | 0.0017 | 0.1 | 0.1133 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0041 | 0.7701 | 0.8728 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.798 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.7131 | 0.8083 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0041 | 0.7701 | 0.8728 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1 | 0.1133 |
Leishmania major | cytochrome p450-like protein | 0.004 | 0.7415 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.7701 | 0.8728 |
Onchocerca volvulus | 0.0041 | 0.7701 | 1 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.004 | 0.7415 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.2713 | 0.3075 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.8823 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.004 | 0.7415 | 0.8404 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0023 | 0.2713 | 0.3075 |
Loa Loa (eye worm) | CYP4Cod1 | 0.004 | 0.7415 | 0.8404 |
Trypanosoma cruzi | cytochrome P450, putative | 0.004 | 0.7415 | 1 |
Brugia malayi | hypothetical protein | 0.0017 | 0.1 | 0.1133 |
Onchocerca volvulus | 0.0023 | 0.2713 | 0.2556 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.2713 | 0.3075 |
Onchocerca volvulus | 0.0041 | 0.7701 | 1 | |
Brugia malayi | Cytochrome P450 family protein | 0.0032 | 0.5355 | 0.607 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.8823 | 1 |
Onchocerca volvulus | 0.0041 | 0.7701 | 1 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 0.5355 | 0.607 |
Onchocerca volvulus | 0.0041 | 0.7701 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0041 | 0.7701 | 0.8728 |
Onchocerca volvulus | 0.0041 | 0.7701 | 1 | |
Onchocerca volvulus | 0.0041 | 0.7701 | 1 | |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.004 | 0.7415 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.2713 | 0.3075 |
Onchocerca volvulus | 0.0041 | 0.7701 | 1 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0023 | 0.2713 | 0.3075 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.8823 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1 | 0.1133 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3426 | 0.3883 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.004 | 0.7415 | 0.8404 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.2713 | 0.3075 |
Brugia malayi | hypothetical protein | 0.0023 | 0.2713 | 0.3075 |
Onchocerca volvulus | 0.0023 | 0.2713 | 0.2556 | |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1 | 0.1133 |
Brugia malayi | Cytochrome P450 family protein | 0.004 | 0.7415 | 0.8404 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0041 | 0.7701 | 0.8728 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.8823 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.798 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0023 | 0.2713 | 0.3075 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.004 | 0.7415 | 0.8404 |
Trypanosoma brucei | cytochrome P450, putative | 0.004 | 0.7415 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.