TDR Targets

Basic information

Technical information

TDR Targets ID: 1515219
Name: N-[2-[1-(2,5-dimethylphenyl)sulfonylpiperidin -2-yl]ethyl]-N'-(phenylmethyl)oxamide
MW: 457.586 | Formula: C24H31N3O4S
H donors: 2 H acceptors: 4 LogP: 3.59 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(c(c1)S(=O)(=O)N1CCCCC1CCNC(=O)C(=O)NCc1ccccc1)C
InChi: 1S/C24H31N3O4S/c1-18-11-12-19(2)22(16-18)32(30,31)27-15-7-6-10-21(27)13-14-25-23(28)24(29)26-17-20-8-4-3-5-9-20/h3-5,8-9,11-12,16,21H,6-7,10,13-15,17H2,1-2H3,(H,25,28)(H,26,29)
InChiKey: GQBFVJLQXZSJMY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-[1-(2,5-dimethylphenyl)sulfonyl-2-piperidyl]ethyl]-N'-(phenylmethyl)oxamide
N-[2-[1-(2,5-dimethylphenyl)sulfonyl-2-piperidinyl]ethyl]-N'-(phenylmethyl)oxamide
N'-(benzyl)-N-[2-[1-(2,5-dimethylphenyl)sulfonyl-2-piperidyl]ethyl]oxamide
N-[2-[1-(2,5-dimethylphenyl)sulfonylpiperidin-2-yl]ethyl]-N'-(phenylmethyl)ethanediamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0093	0.0115
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0267	0.148	0.458
Brugia malayi	MH2 domain containing protein	0.0144	0.0675	0.0833
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0095	0.0354	0.086
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0095	0.0354	0.0354
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-1	0.0517	0.3121	1
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0096	0.036	0.044
Schistosoma mansoni	hypothetical protein	0.0205	0.1072	0.1072
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.0095	0.0354	0.086
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0135	0.0136
Brugia malayi	translation initiation factor 4E	0.0517	0.3121	0.3848
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0072	0.0203	0.8726
Brugia malayi	hypothetical protein	0.0262	0.1451	0.1788
Trypanosoma brucei	RNA helicase, putative	0.0383	0.2244	0.7102
Schistosoma mansoni	hypothetical protein	0.0383	0.2244	0.2244
Plasmodium falciparum	telomerase reverse transcriptase	0.0089	0.0316	0.8559
Echinococcus multilocularis	ras gtpase	0.0155	0.0744	0.1075
Toxoplasma gondii	RNA-directed DNA polymerase	0.0089	0.0316	0.0736
Loa Loa (eye worm)	eukaryotic translation initiation factor 4E type 3	0.0062	0.0135	0.0166
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.0172	0.0172
Schistosoma mansoni	survival motor neuron protein	0.0054	0.0081	0.0081
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0062	0.0135	0.0136
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0675	0.0833
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0135	0.0136
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-2	0.0062	0.0135	0.0136
Schistosoma mansoni	P2X receptor subunit	0.0144	0.0672	0.0672
Mycobacterium leprae	Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho	0.0073	0.0208	1
Toxoplasma gondii	hypothetical protein	0.0062	0.0135	0.0136
Toxoplasma gondii	aldehyde dehydrogenase	0.0067	0.0172	0.026
Loa Loa (eye worm)	PDE1B protein	0.014	0.065	0.0802
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0067	0.0172	0.026
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0062	0.0135	0.0136
Plasmodium falciparum	eukaryotic translation initiation factor 4E	0.0062	0.0135	0.158
Trichomonas vaginalis	hypothetical protein	0.0062	0.0135	0.0136
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-4	0.0062	0.0135	0.0136
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0062	0.0135	0.0136
Loa Loa (eye worm)	hypothetical protein	0.1278	0.8112	1
Schistosoma mansoni	P2X receptor subunit	0.0144	0.0672	0.0672
Echinococcus multilocularis	expressed protein	0.0414	0.2446	0.3884
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0055	0.0093	0.0093
Giardia lamblia	Hypothetical protein	0.0062	0.0135	0.158
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.0095	0.0354	0.043
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-4	0.0062	0.0135	0.0136
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.0172	0.0172
Leishmania major	eukaryotic translation initiation factor eIF-4E, putative	0.0517	0.3121	1
Schistosoma mansoni	cell polarity protein	0.0155	0.0744	0.0744
Onchocerca volvulus		0.0095	0.0354	0.1472
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.615	1
Brugia malayi	Telomerase reverse transcriptase	0.0238	0.129	0.159
Trichomonas vaginalis	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0095	0.0354	0.086
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.0095	0.0354	0.086
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0055	0.0093	0.0093
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0055	0.0093	0.0115
Leishmania major	hypothetical protein, conserved	0.0062	0.0135	0.0136
Leishmania major	eukaryotic translation initiation factor 4e, putative	0.0062	0.0135	0.0136
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0517	0.3121	1
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.014	0.065	0.1839
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0089	0.0316	0.4002
Plasmodium falciparum	hypoxanthine-guanine phosphoribosyltransferase	0.0095	0.0354	1
Mycobacterium tuberculosis	Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor	0.0073	0.0208	1
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0062	0.0135	0.0136
Leishmania major	hypoxanthine-guanine phosphoribosyltransferase	0.0095	0.0354	0.086
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0135	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0093	0.0115
Leishmania major	eukaryotic translation initiation factor, putative	0.0062	0.0135	0.0136
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0089	0.0316	0.0736
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.014	0.065	0.0802
Trypanosoma cruzi	eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative	0.0062	0.0135	0.0136
Loa Loa (eye worm)	hypothetical protein	0.006	0.0125	0.0154
Onchocerca volvulus	Putative eukaryotic translation initiation factor 4e	0.0062	0.0135	0.0288
Echinococcus granulosus	expressed protein	0.0414	0.2446	0.7769
Schistosoma mansoni	eukaryotic translation initiation factor 4e	0.0517	0.3121	0.3121
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0062	0.0135	0.0136
Brugia malayi	GTP-binding protein	0.0155	0.0744	0.0918
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.0095	0.0354	0.043
Leishmania major	eukaryotic translation initiation factor-like protein	0.0517	0.3121	1
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0517	0.3121	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0067	0.0172	0.026
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0062	0.0135	0.0136
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.014	0.065	0.065
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0055	0.0093	0.0093
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0055	0.0093	0.0093
Giardia lamblia	Telomerase catalytic subunit	0.0089	0.0316	0.8559
Echinococcus multilocularis	p2X purinoceptor 4	0.029	0.163	0.2536
Echinococcus granulosus	eukaryotic translation initiation factor 4E	0.0517	0.3121	1
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.014	0.065	0.1839
Toxoplasma gondii	eukaryotic initiation factor-4E, putative	0.0062	0.0135	0.0136
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0675	0.0833
Echinococcus multilocularis	geminin	0.0205	0.1072	0.1615
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0072	0.0203	0.8726
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0517	0.3121	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0093	0.0115
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0055	0.0093	0.0115
Plasmodium vivax	hypothetical protein, conserved	0.0062	0.0135	0.0739
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0055	0.0093	0.0115
Echinococcus granulosus	geminin	0.0205	0.1072	0.3231
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0125	0.0154
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.0517	0.3121	1
Giardia lamblia	hypothetical protein	0.0062	0.0135	0.158
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0062	0.0135	0.0136
Plasmodium vivax	translation initiation factor 4E, putative	0.0062	0.0135	0.0739
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0517	0.3121	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.014	0.065	0.1839
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.014	0.065	0.1839
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0055	0.0093	0.0093
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.014	0.065	0.1839
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0055	0.0093	0.0093
Echinococcus granulosus	L aminoadipate semialdehyde	0.0096	0.036	0.088
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.014	0.065	0.0919
Toxoplasma gondii	eukaryotic initiation factor-4E, putative	0.0517	0.3121	1
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0095	0.0354	0.086
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.014	0.065	0.1839
Schistosoma mansoni	cell polarity protein	0.0155	0.0744	0.0744
Toxoplasma gondii	hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT	0.0095	0.0354	0.086
Leishmania major	telomerase reverse transcriptase, putative	0.0089	0.0316	0.0736
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0062	0.0135	0.0136
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0096	0.036	0.0444
Mycobacterium ulcerans	hypoxanthine-guanine phosphoribosyltransferase Hpt	0.0095	0.0354	1
Echinococcus multilocularis	p2X purinoceptor 4	0.029	0.163	0.2536
Loa Loa (eye worm)	hypothetical protein	0.0096	0.036	0.0444
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0267	0.148	0.458
Schistosoma mansoni	P2X receptor subunit	0.029	0.163	0.163
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0055	0.0093	0.0093
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.014	0.065	0.1839
Leishmania major	xanthine phosphoribosyltransferase	0.0095	0.0354	0.086
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.0517	0.3121	1
Brugia malayi	GTP-binding protein, identical	0.0155	0.0744	0.0918
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0062	0.0135	0.0136
Echinococcus granulosus	survival motor neuron protein 1	0.0262	0.1451	0.4482
Trypanosoma brucei	Eukaryotic translation initiation factor 4E type 5	0.0062	0.0135	0.0136
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.007	0.0189	0.0316
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0055	0.0093	0.0115
Echinococcus granulosus	p2X purinoceptor 4	0.029	0.163	0.5073
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0125	0.0154
Echinococcus granulosus	ras gtpase	0.0155	0.0744	0.215
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0062	0.0135	0.0136
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0517	0.3121	1
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0089	0.0316	0.0736
Plasmodium vivax	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0095	0.0354	0.4675
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0096	0.036	0.036
Giardia lamblia	Translation elongation factor	0.0062	0.0135	0.158
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.014	0.065	0.1839
Echinococcus granulosus	p2X purinoceptor 4	0.029	0.163	0.5073
Plasmodium falciparum	eukaryotic translation initiation factor 4E, putative	0.0062	0.0135	0.158
Brugia malayi	Phosphoribosyl transferase domain containing protein	0.0095	0.0354	0.0436
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-3	0.0062	0.0135	0.0136
Onchocerca volvulus		0.0096	0.036	0.1506
Giardia lamblia	Hypothetical protein	0.0062	0.0135	0.158
Echinococcus multilocularis	eukaryotic translation initiation factor 4E	0.0517	0.3121	0.4999
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0517	0.3121	1
Leishmania major	eukaryotic translation initiation factor-like	0.0517	0.3121	1
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E type 5, putative	0.0062	0.0135	0.0136
Loa Loa (eye worm)	GTP-binding protein	0.0155	0.0744	0.0918
Loa Loa (eye worm)	hypothetical protein	0.1223	0.7749	0.9552
Brugia malayi	Eukaryotic translation initiation factor 4E type 3, putative	0.0062	0.0135	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0262	0.1451	0.1788
Brugia malayi	eukaryotic translation initiation factor 4E-1	0.0062	0.0135	0.0166
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0067	0.0172	0.013
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0062	0.0135	0.0136
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0055	0.0093	0.0093
Trypanosoma brucei	telomerase reverse transcriptase	0.0089	0.0316	0.0736
Schistosoma mansoni	hypothetical protein	0.0205	0.1072	0.1072
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0125	0.0154
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0095	0.0354	0.086
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0095	0.0354	0.086
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0055	0.0093	0.0115
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.014	0.065	0.0919
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0095	0.0354	0.086
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.014	0.065	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0054	0.0081	0.01
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.0336	0.1933	1
Loa Loa (eye worm)	translation initiation factor 4E	0.0517	0.3121	0.3848
Schistosoma mansoni	hypothetical protein	0.0054	0.0081	0.0081
Loa Loa (eye worm)	eukaryotic translation initiation factor 4E-1	0.0062	0.0135	0.0166
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E type 5, putative	0.0062	0.0135	0.0136
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0095	0.0354	0.0354
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0062	0.0135	0.0136
Trypanosoma cruzi	eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative	0.0062	0.0135	0.0136
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0055	0.0093	0.0093
Echinococcus granulosus	eukaryotic translation initiation factor 4E type	0.0062	0.0135	0.0136
Schistosoma mansoni	P2X receptor subunit	0.029	0.163	0.163
Leishmania major	hypothetical protein, conserved	0.0062	0.0135	0.0136
Echinococcus multilocularis	survival motor neuron protein 1	0.0262	0.1451	0.2241
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-4	0.0062	0.0135	0.0136
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.0095	0.0354	0.086
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0267	0.148	0.458
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.1278	0.8112	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0055	0.0093	0.0093
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-3	0.0062	0.0135	0.0136
Giardia lamblia	Guanine phosphoribosyltransferase	0.0095	0.0354	1
Echinococcus granulosus	p2X purinoceptor 4	0.029	0.163	0.5073
Echinococcus multilocularis	p2X purinoceptor 4	0.029	0.163	0.2536
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.0095	0.0354	0.086
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0062	0.0135	0.0136

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.8184 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	4.1475 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.3489 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	20.5962 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1707986

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1515219