Detailed information for compound 1516956

Basic information

Technical information
  • TDR Targets ID: 1516956
  • Name: 2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]-N-(ph enylmethyl)acetamide
  • MW: 278.393 | Formula: C13H14N2OS2
  • H donors: 1 H acceptors: 2 LogP: 3.04 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1ccccc1)CSc1scc(n1)C
  • InChi: 1S/C13H14N2OS2/c1-10-8-17-13(15-10)18-9-12(16)14-7-11-5-3-2-4-6-11/h2-6,8H,7,9H2,1H3,(H,14,16)
  • InChiKey: QAAHBMZEJMYEBW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-methylthiazol-2-yl)sulfanyl-N-(phenylmethyl)acetamide
  • 2-[(4-methyl-2-thiazolyl)thio]-N-(phenylmethyl)acetamide
  • N-(benzyl)-2-[(4-methylthiazol-2-yl)thio]acetamide
  • 2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]-N-(phenylmethyl)ethanamide
  • ZINC02645474
  • T5239269
  • MLS001033921
  • SMR000385789

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0066 0.1888 0.1888
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.011 0.3554 0.3518
Loa Loa (eye worm) hypothetical protein 0.0039 0.0889 0.0889
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.0057 0.0057
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.1457 0.1457
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.1457 0.4554
Loa Loa (eye worm) ctsf protein 0.0054 0.1457 0.1457
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0057
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.092 0.092
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.1457 0.4554
Echinococcus multilocularis lamin dm0 0.0026 0.0412 0.0358
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.004 0.092 0.1983
Onchocerca volvulus 0.0054 0.1457 0.7646
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.1457 0.1408
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0624 0.0624
Entamoeba histolytica cysteine protease, putative 0.0032 0.0624 0.4054
Trypanosoma cruzi cysteine proteinase, putative 0.0032 0.0624 0.0624
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.1457 0.4554
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0624 0.4054
Entamoeba histolytica cysteine protease, putative 0.0032 0.0624 0.4054
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0099 0.3132 1
Echinococcus granulosus cathepsin L cysteine protease 0.0032 0.0624 0.0571
Echinococcus multilocularis hypothetical protein 0.004 0.092 0.0868
Loa Loa (eye worm) hypothetical protein 0.0078 0.2335 0.2335
Entamoeba histolytica cysteine protease, putative 0.0032 0.0624 0.4054
Brugia malayi cathepsin L-like precursor 0.0039 0.0889 0.0889
Trypanosoma brucei calpain-like protein, putative 0.004 0.092 0.1983
Toxoplasma gondii cathepsin CPL 0.0054 0.1457 0.4554
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0099 0.3132 0.3132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1457 0.393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1457 0.4554
Entamoeba histolytica cysteine protease, putative 0.0032 0.0624 0.4054
Leishmania major cathepsin L-like protease 0.0054 0.1457 0.393
Plasmodium vivax vivapain-2 0.0054 0.1457 1
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0057 0.0057
Plasmodium falciparum cysteine proteinase falcipain 1 0.0032 0.0624 0.4054
Brugia malayi calpain 7 0.004 0.092 0.092
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.092 0.092
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0054 0.1457 0.1457
Loa Loa (eye worm) hypothetical protein 0.0039 0.0889 0.0889
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.1457 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0057
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.092 0.092
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0099 0.3132 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0099 0.3132 0.3132
Brugia malayi intermediate filament protein 0.0026 0.0412 0.0412
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0624 0.0912
Plasmodium vivax vivapain-1 0.0032 0.0624 0.4285
Leishmania major cathepsin L-like protease 0.0054 0.1457 0.393
Echinococcus granulosus cathepsin l1 0.0054 0.1457 0.1408
Schistosoma mansoni cathepsin C 0.0017 0.0057 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1457 0.393
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0017 0.0057 0.0389
Onchocerca volvulus Cathepsin L homolog 0.0054 0.1457 0.7646
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0057
Brugia malayi Cathepsin L-like cysteine proteinase 0.0039 0.0889 0.0889
Plasmodium vivax unspecified product 0.0017 0.0057 0.0389
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.092 0.092
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0624 0.0624
Schistosoma mansoni calpain C (C02 family) 0.004 0.092 0.092
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.004 0.092 0.1983
Loa Loa (eye worm) hypothetical protein 0.0039 0.0889 0.0889
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0624 0.0624
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1457 0.4554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1457 0.393
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.1457 0.4554
Entamoeba histolytica cysteine protease, putative 0.0032 0.0624 0.4054
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.004 0.092 0.1983
Leishmania major cathepsin L-like protease 0.0054 0.1457 0.393
Onchocerca volvulus 0.0026 0.0412 0.1941
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0017 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1457 0.4554
Plasmodium vivax serine-repeat antigen (SERA) 0.0017 0.0057 0.0389
Brugia malayi cathepsin Z-like cysteine proteinase 0.0017 0.0057 0.0057
Schistosoma mansoni calpain-7 (C02 family) 0.004 0.092 0.092
Leishmania major cathepsin L-like protease 0.0054 0.1457 0.393
Brugia malayi hypothetical protein 0.0025 0.0373 0.0373
Brugia malayi cathepsin L-like cysteine proteinase 0.0017 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0025 0.0373 0.0373
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.011 0.3554 0.3518
Entamoeba histolytica cysteine proteinase 1, putative 0.0032 0.0624 0.4054
Onchocerca volvulus 0.0054 0.1457 0.7646
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.004 0.092 0.1983
Loa Loa (eye worm) hypothetical protein 0.0026 0.0412 0.0412
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.092 0.092
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0373 0.2257
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.1457 0.4554
Trypanosoma cruzi major cysteine proteinase, putative 0.0017 0.0057 0.0057
Schistosoma mansoni cathepsin S (C01 family) 0.0017 0.0057 0.0057
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.011 0.3554 0.3554
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0624 0.0624
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0412 0.0412
Echinococcus granulosus intermediate filament protein 0.0026 0.0412 0.0358
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0032 0.0624 0.0624
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0412 0.0412
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0039 0.0889 0.0889
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1457 0.4554
Echinococcus multilocularis calpain family protein 1, d 0.0078 0.2335 0.2292
Loa Loa (eye worm) cysteine protease 0.0054 0.1457 0.1457
Loa Loa (eye worm) calpain family protein 1 0.0078 0.2335 0.2335
Plasmodium vivax unspecified product 0.0032 0.0624 0.4285
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.1457 0.1408
Echinococcus granulosus calpain 5 0.004 0.092 0.0868
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.1457 0.4554
Entamoeba histolytica cysteine protease, putative 0.0054 0.1457 1
Onchocerca volvulus 0.0039 0.0889 0.4546
Schistosoma mansoni lamin 0.0026 0.0412 0.0412
Leishmania major kinesin, putative 0.0028 0.0473 0.0362
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.092 0.092
Giardia lamblia Cathepsin B precursor 0.0099 0.3132 1
Echinococcus granulosus cathepsin l1 0.0039 0.0889 0.0837
Plasmodium vivax vivapain-3 0.0032 0.0624 0.4285
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0054 0.1457 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1457 0.4554
Schistosoma mansoni cathepsin B (C01 family) 0.0017 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0624 0.1846
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1457 0.393
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.1457 1
Leishmania major cathepsin L-like protease 0.0054 0.1457 0.393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1457 0.393
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0057 0.0057
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0373 0.2257
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.1457 0.4554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1457 0.393
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0017 0.0057 0.0389
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0889 0.5946
Leishmania major cathepsin L-like protease 0.0054 0.1457 0.393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1457 0.4554
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.092 0.092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1457 0.4554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1457 0.393
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.1457 0.4554
Onchocerca volvulus Cathepsin L homolog 0.0054 0.1457 0.7646
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1457 0.4554
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0057 0.0057
Echinococcus multilocularis calpain 5 0.004 0.092 0.0868
Trypanosoma cruzi cruzipain precursor, putative 0.0054 0.1457 0.1457
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0054 0.1457 1
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0624 0.4054
Onchocerca volvulus 0.0054 0.1457 0.7646
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0017 0.0057 0.0057
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.1457 0.1457
Entamoeba histolytica cysteine protease, putative 0.0032 0.0624 0.4054
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0017 0.0057 0.0389
Echinococcus granulosus lamin dm0 0.0026 0.0412 0.0358
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0017 0.0057 0.0389
Echinococcus multilocularis cysteine protease 0.0054 0.1457 0.1408
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.1457 0.1408
Entamoeba histolytica cysteine protease, putative 0.0032 0.0624 0.4054
Echinococcus granulosus calpain A 0.011 0.3554 0.3518
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0017 0.0057 0.0057
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0057 0.0057
Loa Loa (eye worm) calpain 5 0.0028 0.0473 0.0473
Entamoeba histolytica cysteine protease, putative 0.0032 0.0624 0.4054
Entamoeba histolytica cysteine protease, putative 0.0032 0.0624 0.4054
Trypanosoma cruzi major cysteine proteinase, putative 0.0017 0.0057 0.0057
Echinococcus granulosus calpain A 0.004 0.092 0.0868
Echinococcus multilocularis musashi 0.0026 0.0412 0.0358
Loa Loa (eye worm) hypothetical protein 0.0026 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0054 0.1457 0.1457
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0373 0.0373
Trypanosoma cruzi kinesin, putative 0.0028 0.0473 0.0473
Entamoeba histolytica protein kinase, putative 0.0028 0.0473 0.297
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0624 0.4054
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0017 0.0057 0.0389
Echinococcus multilocularis calpain 7 (C02 family) 0.004 0.092 0.0868
Trypanosoma brucei antigen, putative 0.004 0.092 0.1983
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0624 0.1846
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.1457 0.1457
Loa Loa (eye worm) cathepsin B 0.0099 0.3132 0.3132
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0057 0.0057
Entamoeba histolytica cysteine protease, putative 0.0032 0.0624 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0624 0.0624
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0624 0.4054
Leishmania major cysteine peptidase A (CPA) 0.0054 0.1457 0.393
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.1457 0.1457
Brugia malayi Cathepsin L-like precursor 0.0054 0.1457 0.1457
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.1457 0.1457
Brugia malayi calpain family protein 1 0.0105 0.3376 0.3376
Brugia malayi Cathepsin L-like precursor 0.0054 0.1457 0.1457
Brugia malayi Cathepsin L-like precursor 0.0054 0.1457 0.1457
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0017 0.0057 0.0057
Onchocerca volvulus 0.0054 0.1457 0.7646
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0373 0.1028
Giardia lamblia Cathepsin B precursor 0.0099 0.3132 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.2929 0.2929
Echinococcus granulosus lamin 0.0026 0.0412 0.0358
Onchocerca volvulus 0.0066 0.1888 1
Onchocerca volvulus 0.0054 0.1457 0.7646
Trypanosoma cruzi calpain cysteine peptidase, putative 0.004 0.092 0.092
Brugia malayi calpain 5 0.0028 0.0473 0.0473
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.011 0.3554 0.3554
Trypanosoma cruzi cysteine protease, putative 0.0032 0.0624 0.0624
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0017 0.0057 0.0057
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0017 0.0057 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1457 0.4554
Plasmodium vivax serine-repeat antigen (SERA) 0.0017 0.0057 0.0389
Echinococcus granulosus cathepsin L 0.0032 0.0624 0.0571
Brugia malayi calpain family protein 1 0.0105 0.3376 0.3376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1457 0.4554
Brugia malayi Cathepsin L-like precursor 0.0039 0.0889 0.0889
Brugia malayi hypothetical protein 0.0016 0.0039 0.0039
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0017 0.0057 0.0389
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0057
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0017 0.0057 0.0389
Brugia malayi Cathepsin L-like precursor 0.0054 0.1457 0.1457
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.1457 0.4554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1457 0.4554
Loa Loa (eye worm) hypothetical protein 0.0105 0.3376 0.3376
Onchocerca volvulus 0.0026 0.0412 0.1941
Brugia malayi cathepsin Z-like cysteine proteinase 0.0017 0.0057 0.0057
Brugia malayi cathepsin L precursor 0.0017 0.0057 0.0057
Echinococcus multilocularis calpain 0.004 0.092 0.0868
Echinococcus multilocularis lamin 0.0026 0.0412 0.0358
Trypanosoma brucei calpain-like protein, putative 0.004 0.092 0.1983
Brugia malayi Cathepsin L-like precursor 0.0054 0.1457 0.1457
Brugia malayi Cathepsin L-like precursor 0.0054 0.1457 0.1457
Leishmania major cathepsin L-like protease 0.0054 0.1457 0.393
Leishmania major cathepsin L-like protease 0.0054 0.1457 0.393
Giardia lamblia Cathepsin B precursor 0.0099 0.3132 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0889 0.2708
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.1457 0.1457
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.092 0.092
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0057 0.0057
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0412 0.0412
Trypanosoma brucei calpain-like protein, putative 0.004 0.092 0.1983
Onchocerca volvulus Cathepsin F homolog 0.0054 0.1457 0.7646
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.1457 0.4554
Echinococcus granulosus cysteine protease 0.0032 0.0624 0.0571
Trypanosoma cruzi cysteine proteinase, putative 0.0032 0.0624 0.0624
Toxoplasma gondii cathepsin B 0.0099 0.3132 1
Entamoeba histolytica cysteine proteinase 2 0.0032 0.0624 0.4054
Loa Loa (eye worm) calpain family protein 1 0.0105 0.3376 0.3376
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.092 0.092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1457 0.393
Echinococcus multilocularis calpain A 0.011 0.3554 0.3518
Trypanosoma brucei kinesin, putative 0.0028 0.0473 0.0362
Echinococcus granulosus calpain 7 C02 family 0.004 0.092 0.0868
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0017 0.0057 0.0057
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0057 0.0057
Trypanosoma cruzi kinesin, putative 0.0028 0.0473 0.0473
Trypanosoma brucei cysteine peptidase C (CPC) 0.0099 0.3132 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.1457 0.1457
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1457 0.393
Loa Loa (eye worm) calpain 0.004 0.092 0.092
Loa Loa (eye worm) fibroinase 0.0054 0.1457 0.1457
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0017 0.0057 0.0389
Echinococcus granulosus cathepsin L cysteine proteinase 0.0054 0.1457 0.1408
Brugia malayi Cathepsin L-like precursor 0.0039 0.0889 0.0889
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1457 0.4554
Schistosoma mansoni intermediate filament proteins 0.0026 0.0412 0.0412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0889 0.2708
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.1457 0.4554
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0057
Trypanosoma brucei calpain-like protein, putative 0.004 0.092 0.1983
Schistosoma mansoni cathepsin F (C01 family) 0.0039 0.0889 0.0889
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.1457 0.1408
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0373 0.0373
Brugia malayi fibroinase precursor 0.0017 0.0057 0.0057
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.0057 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1457 0.393
Echinococcus granulosus calpain 0.004 0.092 0.0868
Onchocerca volvulus 0.0054 0.1457 0.7646
Plasmodium vivax calpain, putative 0.004 0.092 0.6313
Schistosoma mansoni lamin 0.0026 0.0412 0.0412
Echinococcus multilocularis cathepsin L 0.0032 0.0624 0.0571
Plasmodium falciparum cysteine proteinase falcipain 3 0.0054 0.1457 1
Entamoeba histolytica cysteine protease, putative 0.0032 0.0624 0.4054
Echinococcus multilocularis cysteine protease 0.0054 0.1457 0.1408
Onchocerca volvulus 0.0054 0.1457 0.7646
Entamoeba histolytica cysteine protease, putative 0.0032 0.0624 0.4054
Plasmodium vivax vivapain-2 0.0054 0.1457 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0054 0.1457 0.1408
Schistosoma mansoni Mername-AA248 (C02 family) 0.004 0.092 0.092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1457 0.4554
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0017 0.0057 0.0389
Entamoeba histolytica calpain large subunit domain III containing protein 0.0028 0.0473 0.297
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0105 0.3376 0.3376
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0057 0.0057
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.004 0.092 0.1983
Schistosoma mansoni calpain (C02 family) 0.004 0.092 0.092
Entamoeba histolytica cysteine protease, putative 0.0032 0.0624 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.1457 0.1457
Schistosoma mansoni calpain-7 (C02 family) 0.004 0.092 0.092
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.1457 0.4554
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0373 0.2558
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.1457 0.393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0624 0.0912

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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