Detailed information for compound 1517057

Basic information

Technical information
  • TDR Targets ID: 1517057
  • Name: N-(3-methoxyphenyl)-1-(1,3,5-trimethylpyrazol -4-yl)sulfonylpiperidine-3-carboxamide
  • MW: 406.499 | Formula: C19H26N4O4S
  • H donors: 1 H acceptors: 4 LogP: 1.48 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)NC(=O)C1CCCN(C1)S(=O)(=O)c1c(C)nn(c1C)C
  • InChi: 1S/C19H26N4O4S/c1-13-18(14(2)22(3)21-13)28(25,26)23-10-6-7-15(12-23)19(24)20-16-8-5-9-17(11-16)27-4/h5,8-9,11,15H,6-7,10,12H2,1-4H3,(H,20,24)
  • InChiKey: ALAHDLJEJYSGJB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-methoxyphenyl)-1-(1,3,5-trimethylpyrazol-4-yl)sulfonyl-piperidine-3-carboxamide
  • N-(3-methoxyphenyl)-1-[(1,3,5-trimethyl-4-pyrazolyl)sulfonyl]-3-piperidinecarboxamide
  • N-(3-methoxyphenyl)-1-(1,3,5-trimethylpyrazol-4-yl)sulfonyl-nipecotamide
  • C436-1193
  • NCGC00108340-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, putative 0.0683 0.5163 0.6985
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0683 0.5163 1
Loa Loa (eye worm) ctsf protein 0.0683 0.5163 0.6985
Loa Loa (eye worm) hypothetical protein 0.0465 0.3235 0.4376
Entamoeba histolytica cysteine protease, putative 0.0364 0.2335 0.4522
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0146 0.0406 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0683 0.5163 1
Loa Loa (eye worm) hypothetical protein 0.0465 0.3235 0.4376
Entamoeba histolytica cysteine protease, putative 0.0364 0.2335 0.4522
Onchocerca volvulus 0.0683 0.5163 1
Echinococcus granulosus cathepsin l1 0.0465 0.3235 0.4071
Entamoeba histolytica cysteine proteinase, putative 0.0364 0.2335 0.4522
Entamoeba histolytica cysteine protease, putative 0.0364 0.2335 0.4522
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0874 0.6852 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0683 0.5163 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0683 0.5163 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0143 0.0381 0.0515
Brugia malayi Cathepsin L-like precursor 0.0683 0.5163 0.6985
Echinococcus granulosus cathepsin l1 0.0683 0.5163 0.6821
Echinococcus multilocularis calpain A 0.0418 0.2813 0.3469
Loa Loa (eye worm) calpain family protein 1 0.0279 0.1586 0.2146
Entamoeba histolytica cysteine protease, putative 0.0146 0.0406 0.0787
Loa Loa (eye worm) hypothetical protein 0.0465 0.3235 0.4376
Brugia malayi Papain family cysteine protease containing protein 0.0146 0.0406 0.055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0683 0.5163 1
Leishmania major cathepsin L-like protease 0.0683 0.5163 0.7535
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.039 0.2567 0.3473
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0146 0.0406 0.0027
Plasmodium vivax vivapain-3 0.0364 0.2335 0.4086
Echinococcus multilocularis cysteine protease 0.0683 0.5163 0.6821
Loa Loa (eye worm) hypothetical protein 0.0379 0.2473 0.3345
Echinococcus granulosus cathepsin L 0.0146 0.0406 0.0036
Onchocerca volvulus 0.0683 0.5163 1
Entamoeba histolytica cysteine proteinase, putative 0.0465 0.3235 0.6265
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0364 0.2335 0.2031
Brugia malayi cathepsin F-like cysteine proteinase 0.0218 0.1042 0.141
Leishmania major cathepsin L-like protease 0.0874 0.6852 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0683 0.5163 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0874 0.6852 1
Loa Loa (eye worm) hypothetical protein 0.0279 0.1586 0.2146
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0874 0.6852 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0465 0.3235 0.5946
Loa Loa (eye worm) hypothetical protein 0.0935 0.7391 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0146 0.0406 0.055
Trypanosoma brucei antigen, putative 0.0143 0.0381 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0683 0.5163 1
Loa Loa (eye worm) hypothetical protein 0.0336 0.2092 0.283
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0146 0.0406 0.0053
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0146 0.0406 0.0027
Schistosoma mansoni cathepsin s 0.0218 0.1042 0.0688
Entamoeba histolytica cysteine proteinase, putative 0.0683 0.5163 1
Brugia malayi Papain family cysteine protease containing protein 0.0364 0.2335 0.3159
Plasmodium vivax unspecified product 0.0146 0.0406 0.0053
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0146 0.0406 0.0027
Brugia malayi cathepsin L-like cysteine proteinase 0.0146 0.0406 0.055
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0364 0.2335 0.3159
Echinococcus multilocularis cathepsin b 0.0935 0.7391 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0146 0.0406 0.0787
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0416 0.28 0.2515
Entamoeba histolytica cysteine protease, putative 0.0146 0.0406 0.0787
Onchocerca volvulus 0.0683 0.5163 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0146 0.0406 0.0027
Giardia lamblia Cathepsin B precursor 0.039 0.2567 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0146 0.0406 0.055
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0146 0.0406 0.0027
Brugia malayi Cathepsin L-like precursor 0.0683 0.5163 0.6985
Trypanosoma brucei calpain-like protein, putative 0.0143 0.0381 0.0556
Onchocerca volvulus 0.0683 0.5163 1
Entamoeba histolytica cysteine proteinase, putative 0.0364 0.2335 0.4522
Leishmania major cathepsin L-like protease 0.0683 0.5163 0.7535
Plasmodium vivax unspecified product 0.0218 0.1042 0.1383
Entamoeba histolytica cysteine protease, putative 0.0364 0.2335 0.4522
Brugia malayi Cathepsin L-like precursor 0.0683 0.5163 0.6985
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0364 0.2335 0.4054
Onchocerca volvulus 0.0236 0.1206 0.168
Loa Loa (eye worm) cathepsin B 0.039 0.2567 0.3473
Trypanosoma brucei cysteine peptidase C (CPC) 0.039 0.2567 0.3746
Loa Loa (eye worm) hypothetical protein 0.0146 0.0406 0.055
Schistosoma mansoni cathepsin F (C01 family) 0.0683 0.5163 0.4971
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.039 0.2567 0.2272
Leishmania major cysteine peptidase A (CPA) 0.0683 0.5163 0.7535
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0381 0.0515
Onchocerca volvulus 0.0683 0.5163 1
Loa Loa (eye worm) cysteine protease 0.0683 0.5163 0.6985
Entamoeba histolytica cysteine proteinase 1, putative 0.0364 0.2335 0.4522
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0143 0.0381 0.0515
Leishmania major cathepsin L-like protease 0.0683 0.5163 0.7535
Entamoeba histolytica cysteine protease, putative 0.0364 0.2335 0.4522
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0146 0.0406 0.0053
Leishmania major cathepsin L-like protease 0.0874 0.6852 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0874 0.6852 1
Loa Loa (eye worm) calpain family protein 1 0.0379 0.2473 0.3345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0683 0.5163 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0218 0.1042 0.141
Loa Loa (eye worm) hypothetical protein 0.0236 0.1206 0.1631
Brugia malayi fibroinase precursor 0.0146 0.0406 0.055
Brugia malayi Cathepsin L-like precursor 0.0683 0.5163 0.6985
Entamoeba histolytica cysteine proteinase, putative 0.0364 0.2335 0.4522
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0683 0.5163 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0381 0.0515
Trypanosoma cruzi cysteine proteinase, putative 0.0364 0.2335 0.3159
Brugia malayi Papain family cysteine protease containing protein 0.0364 0.2335 0.3159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0683 0.5163 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0146 0.0406 0.055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0874 0.6852 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0683 0.5163 0.6985
Trypanosoma cruzi cysteine peptidase, putative 0.0874 0.6852 0.927
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0683 0.5163 1
Toxoplasma gondii cathepsin B 0.039 0.2567 0.4542
Plasmodium vivax unspecified product 0.0364 0.2335 0.4086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0683 0.5163 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0683 0.5163 0.6821
Schistosoma mansoni cathepsin D (A01 family) 0.0147 0.042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0218 0.1042 0.141
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0364 0.2335 0.2031
Echinococcus multilocularis cysteine protease 0.0683 0.5163 0.6821
Trypanosoma cruzi cruzipain precursor, putative 0.0218 0.1042 0.141
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.039 0.2567 0.3746
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0146 0.0406 0.055
Trypanosoma cruzi cysteine peptidase, putative 0.0874 0.6852 0.927
Brugia malayi Papain family cysteine protease containing protein 0.0146 0.0406 0.055
Schistosoma mansoni cathepsin D (A01 family) 0.0147 0.042 0.0041
Plasmodium falciparum cysteine proteinase falcipain 3 0.0683 0.5163 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0683 0.5163 1
Schistosoma mansoni cathepsin F (C01 family) 0.0465 0.3235 0.2967
Entamoeba histolytica cysteine protease, putative 0.0364 0.2335 0.4522
Giardia lamblia Cathepsin B precursor 0.039 0.2567 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0146 0.0406 0.0053
Echinococcus granulosus cathepsin l cysteine peptidase 0.0683 0.5163 0.6821
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0683 0.5163 1
Brugia malayi Cathepsin L-like precursor 0.0683 0.5163 0.6985
Trypanosoma cruzi cysteine peptidase, putative 0.0218 0.1042 0.141
Brugia malayi cathepsin B-like cysteine proteinase 0.0935 0.7391 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0874 0.6852 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0146 0.0406 0.0053
Echinococcus granulosus cysteine protease 0.0364 0.2335 0.2787
Entamoeba histolytica cysteine protease, putative 0.0364 0.2335 0.4522
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0683 0.5163 1
Brugia malayi Papain family cysteine protease containing protein 0.0146 0.0406 0.055
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0146 0.0406 0.0053
Echinococcus multilocularis cathepsin L cysteine protease 0.0683 0.5163 0.6821
Entamoeba histolytica cysteine protease, putative 0.0364 0.2335 0.4522
Leishmania major cathepsin L-like protease 0.0683 0.5163 0.7535
Schistosoma mansoni cathepsin F (C01 family) 0.0683 0.5163 0.4971
Brugia malayi Cathepsin L-like precursor 0.0218 0.1042 0.141
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0874 0.6852 1
Entamoeba histolytica cysteine protease, putative 0.0146 0.0406 0.0787
Loa Loa (eye worm) hypothetical protein 0.0146 0.0406 0.055
Plasmodium vivax vivapain-2 0.0683 0.5163 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0364 0.2335 0.3407
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0935 0.7391 0.7288
Loa Loa (eye worm) calpain 0.0143 0.0381 0.0515
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0146 0.0406 0.055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0364 0.2335 0.4054
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0416 0.28 0.3451
Entamoeba histolytica cysteine protease, putative 0.0364 0.2335 0.4522
Trypanosoma cruzi major cysteine proteinase, putative 0.0337 0.2095 0.2835
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0465 0.3235 0.5946
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0146 0.0406 0.0027
Entamoeba histolytica cysteine proteinase 2 0.0364 0.2335 0.4522
Brugia malayi Cathepsin L-like cysteine proteinase 0.0465 0.3235 0.4376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0683 0.5163 1
Brugia malayi cathepsin L-like precursor 0.0465 0.3235 0.4376
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0364 0.2335 0.2031
Brugia malayi calpain family protein 1 0.0379 0.2473 0.3345
Entamoeba histolytica cysteine protease, putative 0.0146 0.0406 0.0787
Brugia malayi cathepsin Z-like cysteine proteinase 0.0146 0.0406 0.055
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0143 0.0381 0.0515
Brugia malayi Cathepsin L-like precursor 0.0465 0.3235 0.4376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0683 0.5163 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.039 0.2567 0.4542
Entamoeba histolytica cysteine protease, putative 0.0683 0.5163 1
Plasmodium vivax vivapain-1 0.0364 0.2335 0.4086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0683 0.5163 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0379 0.2473 0.2175
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0146 0.0406 0.0027
Echinococcus granulosus cathepsin L cysteine proteinase 0.0683 0.5163 0.6821
Trypanosoma cruzi cysteine proteinase, putative 0.0364 0.2335 0.3159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0683 0.5163 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0935 0.7391 1
Leishmania major cathepsin L-like protease 0.0683 0.5163 0.7535
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0146 0.0406 0.0787
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0143 0.0381 0.0515
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0416 0.28 0.3451
Onchocerca volvulus 0.0465 0.3235 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0683 0.5163 1
Leishmania major cathepsin L-like protease 0.0874 0.6852 1
Echinococcus multilocularis cathepsin L 0.0146 0.0406 0.0036
Brugia malayi calpain 7 0.0143 0.0381 0.0515
Plasmodium vivax serine-repeat antigen (SERA) 0.0146 0.0406 0.0053
Trypanosoma cruzi cysteine protease, putative 0.0364 0.2335 0.3159
Onchocerca volvulus 0.0683 0.5163 1
Entamoeba histolytica cysteine protease, putative 0.0364 0.2335 0.4522
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0143 0.0381 0.0515
Loa Loa (eye worm) hypothetical protein 0.0218 0.1042 0.141
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0224 0.1093 0.0741
Plasmodium vivax vivapain-2 0.0683 0.5163 1
Onchocerca volvulus 0.0683 0.5163 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0146 0.0406 0.055
Trypanosoma cruzi cysteine peptidase, putative 0.0874 0.6852 0.927
Entamoeba histolytica cysteine protease, putative 0.0364 0.2335 0.4522
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0935 0.7391 0.7288
Brugia malayi cathepsin Z-like cysteine proteinase 0.0146 0.0406 0.055
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0146 0.0406 0.0053
Brugia malayi Papain family cysteine protease containing protein 0.0683 0.5163 0.6985
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0656 0.4924 0.6662
Entamoeba histolytica hypothetical protein 0.0146 0.0406 0.0787
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0416 0.28 0.2515
Echinococcus multilocularis cathepsin L 0.0364 0.2335 0.2787
Entamoeba histolytica cysteine protease, putative 0.0364 0.2335 0.4522
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0874 0.6852 1
Loa Loa (eye worm) hypothetical protein 0.0683 0.5163 0.6985
Onchocerca volvulus Cathepsin L homolog 0.0683 0.5163 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0381 0.0515
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0683 0.5163 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0364 0.2335 0.3407
Onchocerca volvulus Cathepsin F homolog 0.0683 0.5163 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0683 0.5163 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0146 0.0406 0.0027
Echinococcus multilocularis cathepsin b 0.0935 0.7391 1
Entamoeba histolytica cysteine proteinase, putative 0.0683 0.5163 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.1042 0.141
Echinococcus granulosus cathepsin b 0.0935 0.7391 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0146 0.0406 0.0053
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0381 0.0515
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0381 0.0556
Brugia malayi Cathepsin L-like precursor 0.0683 0.5163 0.6985
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0381 0.0556
Loa Loa (eye worm) hypothetical protein 0.0146 0.0406 0.055
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0935 0.7391 0.7288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0874 0.6852 1
Schistosoma mansoni cathepsin S (C01 family) 0.0146 0.0406 0.0027
Toxoplasma gondii cathepsin CPL 0.0683 0.5163 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0874 0.6852 1
Entamoeba histolytica cysteine protease, putative 0.0364 0.2335 0.4522
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0683 0.5163 1
Loa Loa (eye worm) fibroinase 0.0683 0.5163 0.6985
Echinococcus granulosus cathepsin b 0.0935 0.7391 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0683 0.5163 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0874 0.6852 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0683 0.5163 0.6985
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0381 0.0556
Plasmodium vivax serine-repeat antigen (SERA) 0.0146 0.0406 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0683 0.5163 1
Brugia malayi Cathepsin L-like precursor 0.0465 0.3235 0.4376
Plasmodium falciparum cysteine proteinase falcipain 1 0.0364 0.2335 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0364 0.2335 0.4522
Brugia malayi calpain family protein 1 0.0379 0.2473 0.3345
Trypanosoma cruzi cruzipain precursor, putative 0.0874 0.6852 0.927
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0218 0.1042 0.141
Echinococcus multilocularis calpain family protein 1, d 0.0279 0.1586 0.172
Trypanosoma brucei calpain-like protein, putative 0.0143 0.0381 0.0556
Loa Loa (eye worm) hypothetical protein 0.0146 0.0406 0.055
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0683 0.5163 0.6821
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0683 0.5163 1
Schistosoma mansoni cathepsin C 0.0146 0.0406 0.0027
Brugia malayi cathepsin L precursor 0.0146 0.0406 0.055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0683 0.5163 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.0406 0.055
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0146 0.0406 0.0053
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0146 0.0406 0.0053
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0143 0.0381 0.0515
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0143 0.0381 0.0556
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0146 0.0406 0.0027
Echinococcus granulosus cathepsin L cysteine protease 0.0364 0.2335 0.2787
Echinococcus granulosus cathepsin L 0.0364 0.2335 0.2787
Entamoeba histolytica cysteine protease, putative 0.0146 0.0406 0.0787
Giardia lamblia Cathepsin B precursor 0.039 0.2567 1
Entamoeba histolytica cysteine protease, putative 0.0146 0.0406 0.0787
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0143 0.0381 0.0556
Trypanosoma brucei calpain-like protein, putative 0.0143 0.0381 0.0556
Schistosoma mansoni cathepsin B (C01 family) 0.0146 0.0406 0.0027
Onchocerca volvulus Cathepsin L homolog 0.0683 0.5163 1
Trypanosoma cruzi cysteine peptidase, putative 0.0364 0.2335 0.3159
Trypanosoma brucei calpain-like protein, putative 0.0143 0.0381 0.0556
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0935 0.7391 0.7288
Loa Loa (eye worm) hypothetical protein 0.0146 0.0406 0.055
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0683 0.5163 0.6821
Echinococcus granulosus calpain A 0.0418 0.2813 0.3469

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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