Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | glutamine synthetase, putative | 0.016 | 0.1764 | 0.5 |
Loa Loa (eye worm) | Gln-2 protein | 0.034 | 0.4739 | 1 |
Wolbachia endosymbiont of Brugia malayi | glutamine synthetase | 0.0478 | 0.7025 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0109 | 0.0927 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0383 | 0.0546 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0032 | 0.0045 |
Echinococcus granulosus | glutamine synthetase | 0.034 | 0.4739 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0092 | 0.0634 | 0.1278 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0092 | 0.0634 | 0.1278 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0383 | 0.0747 |
Schistosoma mansoni | glutamine synthetase bacteria | 0.0478 | 0.7025 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0135 | 0.1345 | 0.279 |
Schistosoma mansoni | glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) | 0.034 | 0.4739 | 0.6746 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0383 | 0.0747 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0032 | 0.0343 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0383 | 0.0546 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) | 0.0478 | 0.7025 | 0.4707 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.034 | 0.4739 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0383 | 0.0747 |
Mycobacterium ulcerans | hypothetical protein | 0.0318 | 0.438 | 0.3176 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0383 | 0.0546 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0032 | 0.0045 |
Brugia malayi | RNA binding protein | 0.0076 | 0.0383 | 0.4135 |
Trichomonas vaginalis | glutamine synthetase-bacteria, putative | 0.016 | 0.1764 | 0.5 |
Onchocerca volvulus | Glutamine synthetase homolog | 0.034 | 0.4739 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0092 | 0.0634 | 0.0902 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0383 | 0.4135 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0383 | 0.0546 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0114 | 0.0174 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0099 | 0.0757 | 0.8166 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0114 | 0.0174 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2502 | 0.3562 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0135 | 0.1345 | 0.279 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2502 | 0.3562 |
Trichomonas vaginalis | glutamine synthetase, putative | 0.016 | 0.1764 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0109 | 0.0927 | 0.1902 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0383 | 0.0747 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0124 | 0.1175 | 0.1673 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0114 | 0.1229 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.1345 | 0.279 |
Echinococcus multilocularis | geminin | 0.0205 | 0.2502 | 0.5248 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.034 | 0.4739 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0114 | 0.1229 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0383 | 0.4135 |
Entamoeba histolytica | glutamine synthetase, putative | 0.016 | 0.1764 | 0.5 |
Echinococcus multilocularis | glutamine synthetase | 0.034 | 0.4739 | 1 |
Schistosoma mansoni | glutamine synthetase bacteria | 0.0478 | 0.7025 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0032 | 0.0045 |
Echinococcus granulosus | geminin | 0.0205 | 0.2502 | 0.5248 |
Trypanosoma brucei | glutamine synthetase, putative | 0.034 | 0.4739 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0383 | 0.0546 |
Leishmania major | glutamine synthetase, putative | 0.034 | 0.4739 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.0383 | 0.0747 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.5929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.