Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | 2-oxoisovalerate dehydrogenase subunit beta | 0.0035 | 0.6302 | 0.6302 |
Mycobacterium ulcerans | transketolase | 0.0035 | 0.6302 | 1 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0046 | 1 | 1 |
Schistosoma mansoni | transketolase | 0.0035 | 0.6302 | 0.6302 |
Trypanosoma brucei | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Mycobacterium ulcerans | pyruvate dehydrogenase E1 component subunit PdhB | 0.0035 | 0.6302 | 1 |
Chlamydia trachomatis | pyruvate dehydrogenase subunit beta | 0.0046 | 1 | 1 |
Plasmodium vivax | pyruvate dehydrogenase E1 component subunit beta, putative | 0.0046 | 1 | 1 |
Echinococcus granulosus | transketolase | 0.0035 | 0.6302 | 0.6302 |
Schistosoma mansoni | pyruvate dehydrogenase (lipoamide) | 0.0046 | 1 | 1 |
Schistosoma mansoni | transketolase | 0.0035 | 0.6302 | 0.6302 |
Mycobacterium leprae | Probable transketolase Tkt (TK) | 0.0035 | 0.6302 | 1 |
Toxoplasma gondii | transketolase | 0.0035 | 0.6302 | 0.6302 |
Chlamydia trachomatis | transketolase | 0.0035 | 0.6302 | 0.6302 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Brugia malayi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor | 0.0035 | 0.6302 | 0.6302 |
Treponema pallidum | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0035 | 0.6302 | 0.5 |
Mycobacterium tuberculosis | Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB | 0.0035 | 0.6302 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | pyruvate dehydrogenase subunit beta | 0.0046 | 1 | 1 |
Leishmania major | transketolase | 0.0035 | 0.6302 | 0.6302 |
Trypanosoma brucei | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Plasmodium vivax | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative | 0.0035 | 0.6302 | 0.6302 |
Echinococcus granulosus | pyruvate dehydrogenase | 0.0046 | 1 | 1 |
Chlamydia trachomatis | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0035 | 0.6302 | 0.6302 |
Plasmodium falciparum | pyruvate dehydrogenase E1 component subunit beta | 0.0046 | 1 | 1 |
Brugia malayi | transketolase | 0.0035 | 0.6302 | 0.6302 |
Brugia malayi | pyruvate dehydrogenase E1 component beta subunit, putative | 0.0046 | 1 | 1 |
Entamoeba histolytica | transketolase, putative | 0.0035 | 0.6302 | 0.5 |
Trypanosoma cruzi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Mycobacterium ulcerans | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0035 | 0.6302 | 1 |
Trypanosoma cruzi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Mycobacterium tuberculosis | Transketolase Tkt (TK) | 0.0035 | 0.6302 | 0.5 |
Trypanosoma cruzi | transketolase, putative | 0.0035 | 0.6302 | 0.6302 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.6302 | 0.6302 |
Onchocerca volvulus | 0.0034 | 0.5945 | 0.5 | |
Toxoplasma gondii | pyruvate dehydrogenase E1 component, beta subunit, putative | 0.0035 | 0.6302 | 0.6302 |
Entamoeba histolytica | transketolase, putative | 0.0035 | 0.6302 | 0.5 |
Echinococcus multilocularis | transketolase | 0.0035 | 0.6302 | 0.6302 |
Wolbachia endosymbiont of Brugia malayi | transketolase | 0.0035 | 0.6302 | 0.6302 |
Trypanosoma brucei | pyruvate dehydrogenase E1 beta subunit, putative | 0.0046 | 1 | 1 |
Entamoeba histolytica | transketolase, putative | 0.0035 | 0.6302 | 0.5 |
Trypanosoma brucei | chrX additional, unordered contigs | 0.0035 | 0.6302 | 0.6302 |
Mycobacterium leprae | PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS1 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS) | 0.0035 | 0.6302 | 1 |
Plasmodium falciparum | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative | 0.0035 | 0.6302 | 0.6302 |
Leishmania major | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PD-HE1Beta | 0.0046 | 1 | 1 |
Chlamydia trachomatis | oxoisovalerate dehydrogenase subunits alpha/beta | 0.0039 | 0.7735 | 0.7735 |
Plasmodium falciparum | 1-deoxy-D-xylulose 5-phosphate synthase | 0.0035 | 0.6302 | 0.6302 |
Trichomonas vaginalis | transketolase, putative | 0.0035 | 0.6302 | 0.5 |
Echinococcus multilocularis | transketolase | 0.0035 | 0.6302 | 0.6302 |
Trypanosoma brucei | transketolase, putative | 0.0035 | 0.6302 | 0.6302 |
Trypanosoma cruzi | transketolase, putative | 0.0035 | 0.6302 | 0.6302 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Mycobacterium tuberculosis | Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) | 0.0035 | 0.6302 | 0.5 |
Leishmania major | pyruvate dehydrogenase E1 beta subunit, putative | 0.0046 | 1 | 1 |
Echinococcus granulosus | transketolase | 0.0035 | 0.6302 | 0.6302 |
Toxoplasma gondii | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0035 | 0.6302 | 0.6302 |
Plasmodium vivax | 1-deoxy-D-xylulose 5-phosphate synthase, putative | 0.0035 | 0.6302 | 0.6302 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0046 | 1 | 1 |
Entamoeba histolytica | transketolase, chloroplast, putative | 0.0035 | 0.6302 | 0.5 |
Echinococcus multilocularis | pyruvate dehydrogenase | 0.0046 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 32.6427 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.