Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0436 | 0.5006 | 0.9051 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0246 | 0.208 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0.0176 | 0.5 |
Giardia lamblia | Pyruvate-flavodoxin oxidoreductase | 0.0111 | 0 | 0.5 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0761 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0132 | 0.0326 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0761 | 1 | 1 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0761 | 1 | 1 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0761 | 1 | 1 |
Entamoeba histolytica | pyruvate:ferredoxin oxidoreductase | 0.0111 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0761 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0246 | 0.208 | 0.208 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0435 | 0.4994 | 0.5 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0435 | 0.4994 | 0.4994 |
Schistosoma mansoni | acetolactate synthase | 0.065 | 0.8298 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0246 | 0.208 | 0.5 |
Treponema pallidum | pyruvate oxidoreductase | 0.0111 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.0326 | 0.0186 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0435 | 0.4994 | 0.5 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0435 | 0.4994 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 0.1831 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.0326 | 0.0186 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0246 | 0.208 | 0.5 |
Onchocerca volvulus | 0.023 | 0.1831 | 0.5 | |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.0135 | 0.0378 | 0.0378 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0435 | 0.4994 | 0.4994 |
Mycobacterium ulcerans | hypothetical protein | 0.0761 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0761 | 1 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0246 | 0.208 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase | 0.0435 | 0.4994 | 0.4994 |
Loa Loa (eye worm) | ILVBL protein | 0.0461 | 0.5384 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.065 | 0.8298 | 1 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0325 | 0.3304 | 0.3304 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 25.9185 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.