Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.047 | 0.5471 | 0.4994 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0821 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.097 | 0.097 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.097 | 0.1665 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0265 | 0.2834 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0265 | 0.2834 | 0.208 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0351 | 0.3941 | 0.3304 |
Schistosoma mansoni | acetolactate synthase | 0.0701 | 0.846 | 1 |
Giardia lamblia | Pyruvate-flavodoxin oxidoreductase | 0.0119 | 0.0951 | 0.5 |
Loa Loa (eye worm) | ILVBL protein | 0.0497 | 0.5823 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0158 | 0.1447 | 0.1447 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.047 | 0.5471 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.0277 | 0.298 | 0.5118 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0821 | 1 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0265 | 0.2834 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0231 | 0.2393 | 0.411 |
Echinococcus granulosus | muscleblind protein | 0.0158 | 0.1447 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0158 | 0.1447 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0277 | 0.298 | 0.298 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0265 | 0.2834 | 0.5 |
Loa Loa (eye worm) | glutaminase 2 | 0.0277 | 0.298 | 0.5118 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.047 | 0.5471 | 0.4994 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.047 | 0.5471 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.047 | 0.5471 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0158 | 0.1447 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.097 | 0.1665 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.0146 | 0.1293 | 0.0378 |
Mycobacterium ulcerans | acetolactate synthase | 0.047 | 0.5471 | 0.4994 |
Trichomonas vaginalis | glutaminase, putative | 0.0277 | 0.298 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0701 | 0.846 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0265 | 0.2834 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0821 | 1 | 1 |
Treponema pallidum | pyruvate oxidoreductase | 0.0119 | 0.0951 | 0.5 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0821 | 1 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.023 | 0.2373 | 0.1571 |
Brugia malayi | follicle stimulating hormone receptor | 0.0231 | 0.2393 | 0.2393 |
Mycobacterium ulcerans | glutaminase | 0.0277 | 0.298 | 0.2242 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.047 | 0.5481 | 0.9413 |
Schistosoma mansoni | glutaminase | 0.0277 | 0.298 | 0.3523 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1447 | 0.2486 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0821 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1447 | 0.2486 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0821 | 1 | 1 |
Entamoeba histolytica | pyruvate:ferredoxin oxidoreductase | 0.0119 | 0.0951 | 0.5 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0821 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.