TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 412.237 | Formula: C19H14BrN3O3
H donors: 1 H acceptors: 3 LogP: 3.36 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc(o1)C(=O)N1N=C(CC1c1ccccc1O)c1cccnc1
InChi: 1S/C19H14BrN3O3/c20-18-8-7-17(26-18)19(25)23-15(13-5-1-2-6-16(13)24)10-14(22-23)12-4-3-9-21-11-12/h1-9,11,15,24H,10H2
InChiKey: WNEROHGKDZHSKR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	fibroblast growth factor receptor 1	Starlite/ChEMBL	References
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References
Homo sapiens	v-akt murine thymoma viral oncogene homolog 2	Starlite/ChEMBL	References
Homo sapiens	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	Starlite/ChEMBL	References
Homo sapiens	fms-related tyrosine kinase 3	Starlite/ChEMBL	References
Homo sapiens	colony stimulating factor 1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium berghei	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	fibroblast growth factor receptor 4	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus granulosus	serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_128769	All targets in OG5_128769
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	fibroblast growth factor receptor 4	Get druggable targets OG5_128769	All targets in OG5_128769
Neospora caninum	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	Protein kinase B	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	p70 ribosomal S6 kinase beta	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	Fibroblast growth factor receptor precursor, putative	Get druggable targets OG5_128769	All targets in OG5_128769
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine threonine protein kinase nrc	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma japonicum	ko:K07390 monothiol glutaredoxin, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Giardia lamblia	Kinase, AGC PKA	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	rac serine:threonine kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei gambiense	rac serine-threonine kinase, putative,protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium knowlesi	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta-1, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	likely protein kinase similar to S. cerevisiae YPK2 (YMR104C)	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium yoelii	kinase Akt/PKB-related	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	Get druggable targets OG5_128769	All targets in OG5_128769
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_128769	All targets in OG5_128769
Loa Loa (eye worm)	AGC/AKT protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	IPR002048,Calcium-binding EF-hand;IPR001245,Tyrosine protein kinase;IPR000719,Protein kinase;IPR011009,Protein kinase-like,domai	Get druggable targets OG5_128769	All targets in OG5_128769
Candida albicans	protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase 2, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma japonicum	ko:K08792 serum/glucocorticoid regulated kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	Get druggable targets OG5_132967	All targets in OG5_132967
Schistosoma japonicum	ko:K04456 RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma congolense	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	Get druggable targets OG5_128769	All targets in OG5_128769
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	roundabout 2	0.0091	0.0645	0.5238
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0077	0.0518	0.0762
Plasmodium vivax	acyl-CoA synthetase, putative	0.0457	0.3807	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0167	0.1338
Schistosoma mansoni	tyrosine kinase	0.0126	0.0944	0.1635
Echinococcus multilocularis	muscleblind protein	0.0159	0.1229	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0126	0.0944	0.0941
Leishmania major	phosphonopyruvate decarboxylase-like protein	0.0258	0.2087	0.5274
Mycobacterium tuberculosis	Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS)	0.0799	0.6762	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0033	0.0143	0.1633
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0167	0.0407
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0252	0.0432
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.0003	0.0014
Brugia malayi	Fibronectin type III domain containing protein	0.0077	0.0518	0.0762
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0289	0.1275
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0085	0.0589	0.0586
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.0003	0.0014
Echinococcus granulosus	serine/threonine protein kinase	0.0033	0.0143	0.014
Trypanosoma brucei	rac serine-threonine kinase, putative	0.005	0.0289	0.0632
Echinococcus granulosus	roundabout 2	0.0091	0.0645	0.0642
Trypanosoma cruzi	phosphonopyruvate decarboxylase, putative	0.0258	0.2087	1
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.0003	0.0014
Mycobacterium ulcerans	glutaminase	0.0279	0.2263	0.3178
Schistosoma mansoni	nephrin	0.0083	0.0574	0.0992
Mycobacterium leprae	PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SH	0.0142	0.1082	0.1388
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0033	0.0143	0.1633
Mycobacterium ulcerans	pyruvate or indole-3-pyruvate decarboxylase Pdc	0.0457	0.3807	0.552
Trichomonas vaginalis	esterase, putative	0.0036	0.0167	0.0739
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0167	0.0407
Mycobacterium tuberculosis	Probable oxidoreductase (beta subunit)	0.0116	0.0859	0.1049
Mycobacterium leprae	PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE)	0.0799	0.6762	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0167	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0645	0.1592
Echinococcus multilocularis	neuroglian	0.0083	0.0574	0.4656
Mycobacterium ulcerans	2-oxoglutarate ferredoxin oxidoreductase subunit beta	0.0116	0.0859	0.1049
Giardia lamblia	Pyruvate-flavodoxin oxidoreductase	0.0116	0.0859	1
Mycobacterium ulcerans	acetolactate synthase	0.0457	0.3807	0.552
Schistosoma mansoni	cell adhesion molecule	0.0085	0.0589	0.1019
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.005	0.0289	0.0707
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0167	0.0739
Trypanosoma brucei	phosphonopyruvate decarboxylase-like protein, putative	0.0258	0.2087	1
Echinococcus granulosus	twitchin	0.0084	0.0577	0.0574
Echinococcus granulosus	defective proboscis extension response	0.0077	0.0518	0.0515
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0126	0.0944	0.7674
Entamoeba histolytica	protein kinase, putative	0.005	0.0289	0.3333
Entamoeba histolytica	protein kinase, putative	0.005	0.0289	0.3333
Onchocerca volvulus	Tyrosine kinase homolog	0.018	0.1411	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0518	0.1277
Brugia malayi	follicle stimulating hormone receptor	0.0233	0.1866	0.2757
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0167	0.0285
Echinococcus granulosus	muscleblind protein	0.0159	0.1229	0.1226
Loa Loa (eye worm)	AGC/AKT protein kinase	0.005	0.0289	0.0707
Echinococcus granulosus	nervana 2	0.0033	0.014	0.0137
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0231	0.1853	0.2556
Mycobacterium ulcerans	hypothetical protein	0.0799	0.6762	1
Echinococcus multilocularis	nervana 2	0.0033	0.014	0.1114
Trypanosoma cruzi	phosphonopyruvate decarboxylase, putative	0.0258	0.2087	1
Echinococcus granulosus	Immunoglobulin	0.0077	0.0518	0.0515
Trypanosoma brucei	phosphonopyruvate decarboxylase-like protein, putative	0.0258	0.2087	1
Schistosoma mansoni	vesicular amine transporter	0.0077	0.0518	0.0895
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0167	0.0407
Plasmodium falciparum	acyl-CoA synthetase	0.0457	0.3807	1
Schistosoma mansoni	acetolactate synthase	0.0683	0.5757	1
Mycobacterium ulcerans	acetolactate synthase 1 catalytic subunit	0.0799	0.6762	1
Echinococcus multilocularis	nervana 2	0.0033	0.014	0.1114
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0126	0.0944	0.0941
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0252	0.0249
Echinococcus granulosus	nervana 2	0.0033	0.014	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1229	0.3039
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0289	0.1275
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0033	0.0143	0.114
Toxoplasma gondii	AGC kinase	0.005	0.0289	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0132	0.1	0.1474
Trichomonas vaginalis	pyruvate-flavodoxin oxidoreductase, putative	0.0116	0.0859	0.3797
Mycobacterium tuberculosis	Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase)	0.0342	0.2809	0.4006
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0259	0.209	0.5174
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0518	0.1277
Treponema pallidum	pyruvate oxidoreductase	0.0116	0.0859	0.5
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0518	0.1277
Echinococcus granulosus	Glutaredoxin protein 5	0.0033	0.014	0.0137
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0077	0.0518	0.0895
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0167	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0167	0.0407
Mycobacterium ulcerans	hypothetical protein	0.0258	0.2087	0.2911
Echinococcus multilocularis	rac serine:threonine kinase	0.0033	0.0143	0.114
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0033	0.0143	0.014
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0289	0.1275
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0167	0.0125
Trichomonas vaginalis	pyruvate-flavodoxin oxidoreductase, putative	0.0116	0.0859	0.3797
Schistosoma mansoni	serine/threonine-protein kinase	0.0033	0.0143	0.0243
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0252	0.0432
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0167	0.0739
Trichomonas vaginalis	pyruvate-flavodoxin oxidoreductase, putative	0.0116	0.0859	0.3797
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0252	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0167	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0167	0.0407
Echinococcus multilocularis	Glutaredoxin protein 5	0.0033	0.014	0.1114
Loa Loa (eye worm)	glutaminase 2	0.0279	0.2263	0.5602
Schistosoma mansoni	serine/threonine-protein kinase	0.0033	0.0143	0.0243
Brugia malayi	hypothetical protein	0.0077	0.0518	0.0762
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0167	0.0739
Trichomonas vaginalis	pyruvate-flavodoxin oxidoreductase, putative	0.0116	0.0859	0.3797
Brugia malayi	Thiamine pyrophosphate enzyme, central domain containing protein	0.0799	0.6762	1
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.0003	0.0014
Mycobacterium leprae	Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS)	0.0799	0.6762	1
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0289	0.1275
Echinococcus multilocularis	muscleblind protein 1	0.0159	0.1229	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0126	0.0944	0.7674
Mycobacterium ulcerans	putative oxalyl-CoA decarboxylase	0.0799	0.6762	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0252	0.0616
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0289	0.1275
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0518	0.1277
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.0906	0.2239
Echinococcus multilocularis	Immunoglobulin	0.0077	0.0518	0.4201
Onchocerca volvulus		0.0167	0.1295	0.9067
Schistosoma mansoni	glutaminase	0.0279	0.2263	0.3927
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0518	0.1277
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0167	0.0407
Mycobacterium ulcerans	acetolactate synthase large subunit IlvB	0.0457	0.3807	0.552
Echinococcus granulosus	neuroglian	0.0083	0.0574	0.0571
Mycobacterium ulcerans	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	0.0142	0.1082	0.1388
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0077	0.0518	0.0895
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0289	0.1275
Brugia malayi	Muscleblind-like protein	0.0159	0.1229	0.1814
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0252	0.2028
Brugia malayi	glutaminase DH11.1	0.0279	0.2263	0.3343
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0259	0.209	0.3088
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0289	0.1275
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.0906	0.2239
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0167	0.0066
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0167	0.0739
Brugia malayi	MH2 domain containing protein	0.0122	0.0906	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0167	0.0407
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0167	0.0164
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0252	0.0432
Entamoeba histolytica	protein kinase 2, putative	0.0033	0.0143	0.1633
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0077	0.0518	0.4201
Loa Loa (eye worm)	glutaminase	0.0279	0.2263	0.5602
Mycobacterium tuberculosis	Probable oxalyl-CoA decarboxylase OxcA	0.0799	0.6762	1
Trichomonas vaginalis	pyruvate-flavodoxin oxidoreductase, putative	0.0116	0.0859	0.3797
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0233	0.1866	0.4619
Entamoeba histolytica	protein kinase, putative	0.005	0.0289	0.3333
Loa Loa (eye worm)	thiamine pyrophosphate enzyme	0.0458	0.3814	0.9447
Trichomonas vaginalis	pyruvate-flavodoxin oxidoreductase, putative	0.0116	0.0859	0.3797
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0033	0.014	0.0137
Entamoeba histolytica	pyruvate:ferredoxin oxidoreductase	0.0116	0.0859	1
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1229	0.3039
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0252	0.2028
Loa Loa (eye worm)	ILVBL protein	0.0484	0.4037	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0167	0.0243
Schistosoma mansoni	acetolactate synthase	0.0683	0.5757	1
Brugia malayi	beta-lactamase	0.0036	0.0167	0.0243
Echinococcus granulosus	serine threonine protein kinase nrc	0.0033	0.0143	0.014
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0518	0.1277
Schistosoma mansoni	tyrosine kinase	0.0022	0.0042	0.0067
Brugia malayi	p70 ribosomal S6 kinase beta	0.005	0.0289	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0589	0.1453
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0252	0.0249
Echinococcus multilocularis	Immunoglobulin	0.0077	0.0518	0.4201
Brugia malayi	Protein kinase domain containing protein	0.005	0.0289	0.0422
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0167	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0645	0.1592
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0033	0.014	0.1114
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0167	0.0739
Leishmania major	putative pyruvate/indole-pyruvate carboxylase, putative	0.0457	0.3807	1
Trichomonas vaginalis	glutaminase, putative	0.0279	0.2263	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0167	0.0125
Loa Loa (eye worm)	TK protein kinase	0.0132	0.1	0.247

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 10 uM	Inhibition of KIT2	ChEMBL.	20630752
IC50 (binding)	> 10 uM	Inhibition of KDR	ChEMBL.	20630752
IC50 (binding)	> 10 uM	Inhibition of FGFR1	ChEMBL.	20630752
IC50 (binding)	> 10 uM	Inhibition of AKT2	ChEMBL.	20630752
IC50 (binding)	> 10 uM	Inhibition of CSF1R	ChEMBL.	20630752
IC50 (binding)	> 10 uM	Inhibition of FLT3	ChEMBL.	20630752

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1782185

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1521429