Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | glutaminase | 0.0265 | 0.5451 | 0.5203 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.2632 | 0.4681 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.045 | 1 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0384 | 0.8386 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0151 | 0.2632 | 1 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.008 | 0.0875 | 0.0378 |
Loa Loa (eye worm) | glutaminase 2 | 0.0265 | 0.5451 | 0.9695 |
Treponema pallidum | pyruvate oxidoreductase | 0.0065 | 0.0517 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.0265 | 0.5451 | 1 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0258 | 0.5264 | 0.9363 |
Loa Loa (eye worm) | ILVBL protein | 0.0272 | 0.5622 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0257 | 0.5253 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0265 | 0.5451 | 0.5451 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0145 | 0.2489 | 0.5 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0145 | 0.2489 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.1762 | 0.3134 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0257 | 0.5253 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0225 | 0.446 | 0.7932 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.2632 | 0.4681 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0224 | 0.4422 | 0.4118 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0257 | 0.5253 | 0.4994 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.045 | 1 | 1 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.045 | 1 | 1 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0257 | 0.5253 | 1 |
Giardia lamblia | Pyruvate-flavodoxin oxidoreductase | 0.0065 | 0.0517 | 0.5 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0257 | 0.5253 | 0.4994 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.1762 | 0.3134 |
Mycobacterium ulcerans | hypothetical protein | 0.0145 | 0.2489 | 0.208 |
Schistosoma mansoni | glutaminase | 0.0265 | 0.5451 | 0.65 |
Brugia malayi | Muscleblind-like protein | 0.0151 | 0.2632 | 0.2632 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.045 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0151 | 0.2632 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.045 | 1 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0384 | 0.8386 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0151 | 0.2632 | 1 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.045 | 1 | 1 |
Entamoeba histolytica | pyruvate:ferredoxin oxidoreductase | 0.0065 | 0.0517 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.0265 | 0.5451 | 0.9695 |
Mycobacterium ulcerans | acetolactate synthase | 0.0257 | 0.5253 | 0.4994 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0145 | 0.2489 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.1762 | 0.1762 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0192 | 0.365 | 0.3304 |
Brugia malayi | follicle stimulating hormone receptor | 0.0225 | 0.446 | 0.446 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0145 | 0.2489 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.