Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Rattus norvegicus | Cannabinoid CB1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | phospholipase D, putative | 0.0086 | 1 | 1 |
Trypanosoma cruzi | transketolase, putative | 0.0061 | 0.6314 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.2482 | 0.3092 |
Echinococcus multilocularis | phospholipase D | 0.0076 | 0.8562 | 0.8562 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PD-HE1Beta | 0.0034 | 0.2482 | 0.1172 |
Brugia malayi | transketolase | 0.0061 | 0.6314 | 0.6314 |
Trypanosoma brucei | transketolase, putative | 0.0061 | 0.6314 | 1 |
Mycobacterium ulcerans | transketolase | 0.0061 | 0.6314 | 1 |
Entamoeba histolytica | transketolase, putative | 0.0061 | 0.6314 | 0.5096 |
Echinococcus multilocularis | transketolase | 0.0061 | 0.6314 | 0.6314 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.5702 | 0.7103 |
Echinococcus granulosus | phospholipase D | 0.0076 | 0.8562 | 0.8562 |
Trypanosoma cruzi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0034 | 0.2482 | 0.1172 |
Loa Loa (eye worm) | 2-oxoisovalerate dehydrogenase subunit beta | 0.0034 | 0.2482 | 0.3092 |
Plasmodium vivax | transketolase, putative | 0.0038 | 0.316 | 1 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0034 | 0.2482 | 0.1172 |
Schistosoma mansoni | phospholipase D | 0.0086 | 1 | 1 |
Leishmania major | pyruvate dehydrogenase E1 beta subunit, putative | 0.0034 | 0.2482 | 0.3932 |
Echinococcus multilocularis | phospholipase D1 | 0.0086 | 1 | 1 |
Schistosoma mansoni | transketolase | 0.0061 | 0.6314 | 0.5096 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.5702 | 0.7103 |
Toxoplasma gondii | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0034 | 0.2482 | 0.1172 |
Brugia malayi | pyruvate dehydrogenase E1 component beta subunit, putative | 0.0034 | 0.2482 | 0.2482 |
Entamoeba histolytica | transketolase, putative | 0.0038 | 0.316 | 0.0901 |
Echinococcus granulosus | transketolase | 0.0061 | 0.6314 | 0.6314 |
Entamoeba histolytica | phospholipase D active site domain-containing protein | 0.0073 | 0.8027 | 0.7375 |
Echinococcus multilocularis | transketolase | 0.0061 | 0.6314 | 0.6314 |
Brugia malayi | pyruvate dehydrogenase E1 component beta subunit, mitochondrial | 0.0034 | 0.2482 | 0.2482 |
Onchocerca volvulus | 0.0022 | 0.0829 | 1 | |
Mycobacterium leprae | Probable transketolase Tkt (TK) | 0.0061 | 0.6314 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.2482 | 0.3092 |
Wolbachia endosymbiont of Brugia malayi | transketolase | 0.0061 | 0.6314 | 1 |
Plasmodium falciparum | transketolase | 0.0038 | 0.316 | 1 |
Giardia lamblia | Transketolase | 0.0038 | 0.316 | 0.5 |
Echinococcus multilocularis | pyruvate dehydrogenase | 0.0034 | 0.2482 | 0.2482 |
Trypanosoma brucei | pyruvate dehydrogenase E1 beta subunit, putative | 0.0034 | 0.2482 | 0.1172 |
Chlamydia trachomatis | transketolase | 0.0061 | 0.6314 | 1 |
Trypanosoma cruzi | transketolase, putative | 0.0061 | 0.6314 | 1 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0034 | 0.2482 | 0.1172 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.003 | 0.1973 | 0.1973 |
Brugia malayi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor | 0.0034 | 0.2482 | 0.2482 |
Entamoeba histolytica | transketolase, putative | 0.0061 | 0.6314 | 0.5096 |
Schistosoma mansoni | transketolase | 0.0061 | 0.6314 | 0.5096 |
Mycobacterium tuberculosis | Transketolase Tkt (TK) | 0.0061 | 0.6314 | 1 |
Entamoeba histolytica | transketolase, putative | 0.0061 | 0.6314 | 0.5096 |
Echinococcus granulosus | phospholipase D1 | 0.0086 | 1 | 1 |
Trypanosoma brucei | chrX additional, unordered contigs | 0.0034 | 0.2482 | 0.1172 |
Toxoplasma gondii | pyruvate dehydrogenase E1 component, beta subunit, putative | 0.0034 | 0.2482 | 0.1172 |
Leishmania major | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0034 | 0.2482 | 0.3932 |
Leishmania major | transketolase | 0.0061 | 0.6314 | 1 |
Trypanosoma brucei | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0034 | 0.2482 | 0.1172 |
Toxoplasma gondii | transketolase | 0.0061 | 0.6314 | 1 |
Trichomonas vaginalis | transketolase, putative | 0.0061 | 0.6314 | 1 |
Trypanosoma cruzi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0034 | 0.2482 | 0.1172 |
Trypanosoma brucei | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0034 | 0.2482 | 0.1172 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.8027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.8027 | 1 |
Treponema pallidum | transketolase | 0.0038 | 0.316 | 1 |
Echinococcus granulosus | transketolase | 0.0061 | 0.6314 | 0.6314 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.6314 | 0.7866 |
Entamoeba histolytica | phospholipase D, putative | 0.0086 | 1 | 1 |
Echinococcus granulosus | pyruvate dehydrogenase | 0.0034 | 0.2482 | 0.2482 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 560 nM | Binding affinity towards rat forebrain cannabinoid receptor 1 using [3H]CP-55,940 | ChEMBL. | 16190764 |
Ki (binding) | = 580 nM | Binding affinity towards mouse spleen cannabinoid receptor 2 using [3H]CP-55,940 | ChEMBL. | 16190764 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.