Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | semaphorin 5B | 0.0077 | 0.2349 | 0.2348 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0043 | 0.0492 | 0.9062 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.2349 | 0.2874 |
Brugia malayi | Plexin repeat family protein | 0.0183 | 0.817 | 0.8169 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2349 | 0.2349 |
Echinococcus multilocularis | plexin a4 | 0.0217 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0542 | 0.054 |
Echinococcus multilocularis | hypothetical protein | 0.0077 | 0.2349 | 0.2348 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0039 | 0.0278 | 0.0276 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0042 | 0.0472 | 0.0575 |
Schistosoma mansoni | plexin | 0.0183 | 0.817 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0542 | 1 |
Brugia malayi | Sema domain containing protein | 0.0077 | 0.2349 | 0.2348 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2349 | 0.2349 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0036 | 0.014 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2349 | 0.2349 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0077 | 0.2349 | 0.2349 |
Schistosoma mansoni | plexin | 0.0107 | 0.3992 | 0.4885 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0542 | 0.0661 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0542 | 0.054 |
Brugia malayi | hypothetical protein | 0.0077 | 0.2349 | 0.2348 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.0183 | 0.817 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.3992 | 0.3992 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0542 | 0.054 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0542 | 1 |
Echinococcus granulosus | semaphorin 1A | 0.0077 | 0.2349 | 0.2348 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0039 | 0.0278 | 0.0276 |
Echinococcus multilocularis | semaphorin 5B | 0.0077 | 0.2349 | 0.2348 |
Schistosoma mansoni | hypothetical protein | 0.0107 | 0.3992 | 0.4885 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0036 | 0.014 | 1 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0077 | 0.2349 | 0.2349 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.817 | 0.817 |
Loa Loa (eye worm) | plexin A | 0.0217 | 1 | 1 |
Echinococcus granulosus | plexin a4 | 0.0217 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0002 | 0.0002 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.2349 | 0.2874 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0002 | 0.0002 |
Brugia malayi | Sema domain containing protein | 0.0077 | 0.2349 | 0.2348 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0002 | 0.0002 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0043 | 0.0492 | 0.9062 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2349 | 0.2349 |
Brugia malayi | hypothetical protein | 0.0077 | 0.2349 | 0.2348 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0542 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0542 | 0.0661 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0042 | 0.0472 | 0.0575 |
Schistosoma mansoni | semaphorin 5-related | 0.0077 | 0.2349 | 0.2874 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2349 | 0.2349 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2349 | 0.2349 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0542 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0039 | 0.0278 | 0.0278 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0039 | 0.0278 | 0.0276 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.