TDR Targets

Basic information

Technical information

TDR Targets ID: 1529920
Name: 6-butyl-N-(2,4-dimethoxyphenyl)-7,8-dihydro-5 H-pyrido[4,3-d]pyrimidin-2-amine
MW: 342.435 | Formula: C19H26N4O2
H donors: 1 H acceptors: 2 LogP: 3.18 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCCN1CCc2c(C1)cnc(n2)Nc1ccc(cc1OC)OC
InChi: 1S/C19H26N4O2/c1-4-5-9-23-10-8-16-14(13-23)12-20-19(21-16)22-17-7-6-15(24-2)11-18(17)25-3/h6-7,11-12H,4-5,8-10,13H2,1-3H3,(H,20,21,22)
InChiKey: LPYKOLZEMJKAMC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(6-butyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl)-(2,4-dimethoxyphenyl)amine
G421-0242
NCGC00131457-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	zinc finger protein Ran binding	0.0043	0.2685	0.2428
Schistosoma mansoni	hypothetical protein	0.0122	1	1
Schistosoma mansoni	TRABID protein (C64 family)	0.0043	0.2685	0.2428
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.1662	0.1662
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0043	0.2685	0.2428
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.1367	0.1367
Schistosoma mansoni	zinc finger protein	0.0043	0.2685	0.2428
Chlamydia trachomatis	SWIB complex protein	0.0122	1	0.5
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0122	1	1
Echinococcus granulosus	SWI:SNF matrix associated	0.0122	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.24	0.24
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0043	0.2685	0.6993
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.1632	0.1632
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0338	0.0338
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.1922	0.1922
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0054	0.3693	1
Schistosoma mansoni	hypothetical protein	0.0043	0.2685	0.2428
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0122	1	1
Chlamydia trachomatis	DNA topoisomerase I	0.0122	1	0.5
Leishmania major	hypothetical protein, conserved	0.0043	0.2685	0.6993
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0054	0.3693	0.3472
Onchocerca volvulus		0.0122	1	1
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0043	0.2685	0.6993
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0043	0.2685	0.2428
Toxoplasma gondii	ran binding protein	0.0043	0.2685	0.0375
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0043	0.2665	0.6934
Loa Loa (eye worm)	phosphatidylinositol 3	0.0054	0.3693	0.3472
Echinococcus multilocularis	zinc finger protein Ran binding	0.0043	0.2685	0.2428
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.2661	0.2661
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0338	0.0338
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.24	0.24
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0122	1	1
Brugia malayi	SWIB/MDM2 domain containing protein	0.0122	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.24	0.24
Loa Loa (eye worm)	brahma associated protein	0.0122	1	1
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0054	0.3693	0.3472
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0054	0.3693	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.1662	0.1662
Schistosoma mansoni	hypothetical protein	0.0122	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.2661	0.2661
Trypanosoma cruzi	target of rapamycin kinase 3	0.0043	0.2665	0.6934
Schistosoma mansoni	RNA binding protein	0.0043	0.2685	0.2428
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0054	0.3693	0.5
Brugia malayi	YY1-associated factor 2	0.0043	0.2685	0.2428
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0122	1	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0054	0.3693	0.5
Leishmania major	hypothetical protein, conserved	0.0043	0.2685	0.6993
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.1367	0.1367
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0054	0.3693	1
Echinococcus multilocularis	SWI:SNF matrix associated	0.0122	1	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0043	0.2685	0.2428
Brugia malayi	brahma associated protein 60 kDa	0.0122	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.2661	0.2661
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.2661	0.2661
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0043	0.2685	0.2428
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0054	0.3693	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.1662	0.1662
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.1371	0.1371
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.2955	0.2955
Schistosoma mansoni	fusion	0.0043	0.2685	0.2428
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0054	0.3693	0.3472
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.3693	0.3693
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0043	0.2685	0.6993
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0122	1	1
Schistosoma mansoni	hypothetical protein	0.0122	1	1
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0043	0.2685	0.6993
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.2661	0.2661
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.2685	0.6993
Loa Loa (eye worm)	hypothetical protein	0.0043	0.2685	0.2428
Echinococcus multilocularis	SWI:SNF matrix associated	0.0122	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.24	0.24
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0043	0.2685	0.6993
Trypanosoma cruzi	WLM domain containing protein, putative	0.0043	0.2685	0.6993
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0043	0.2685	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0043	0.2685	0.2428
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.1371	0.1371
Loa Loa (eye worm)	hypothetical protein	0.0043	0.2685	0.2428
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0338	0.0338
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0054	0.3693	0.3472
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0043	0.2685	0.6993
Giardia lamblia	GTOR	0.0054	0.3693	0.5
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0054	0.3693	1
Leishmania major	hypothetical protein, conserved	0.0043	0.2685	0.6993
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0043	0.2685	0.2428
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0043	0.2665	0.6934
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.1632	0.1632
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.24	0.24
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0338	0.0338
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.1371	0.1371
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.2685	0.6993
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.2685	0.6993
Leishmania major	hypothetical protein, conserved	0.0043	0.2685	0.6993
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0122	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0338	0.0338
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0043	0.2685	0.2428
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0054	0.3693	1
Trypanosoma cruzi	WLM domain containing protein, putative	0.0043	0.2685	0.6993
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0026	0.1033	0.207
Echinococcus granulosus	ring and YY1 binding protein	0.0043	0.2685	0.2428
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0043	0.2685	0.2428
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.1367	0.1367
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0122	1	1
Echinococcus granulosus	Zinc finger RanBP2 type	0.0043	0.2685	0.2428
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.3693	0.3693
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0122	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.2685	0.2428
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.1371	0.1371
Echinococcus multilocularis	SWI:SNF matrix associated	0.0122	1	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.2685	0.2428
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.2032	0.2032
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0043	0.2685	0.6993
Trichomonas vaginalis	conserved hypothetical protein	0.0122	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.2685	0.6993
Schistosoma mansoni	brg-1 associated factor	0.0122	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.24	0.24
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.2685	0.6993
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.24	0.24
Echinococcus multilocularis	ring and YY1 binding protein	0.0043	0.2685	0.2428
Leishmania major	hypothetical protein, conserved	0.0043	0.2685	0.6993
Plasmodium vivax	hypothetical protein, conserved	0.0122	1	0.5
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0023	0.0742	0.1204
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.3693	0.3693

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.1309 uM	PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465]	ChEMBL.	No reference
Potency (functional)	5.6234 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1706108

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1529920