TDR Targets

Basic information

Technical information

TDR Targets ID: 153230
Name: (Z)-4-phenyl-5-(3-phenylmethoxyphenyl)pent-4- enoic acid
MW: 358.43 | Formula: C24H22O3
H donors: 1 H acceptors: 2 LogP: 5.67 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CC/C(=C/c1cccc(c1)OCc1ccccc1)/c1ccccc1
InChi: 1S/C24H22O3/c25-24(26)15-14-22(21-11-5-2-6-12-21)16-20-10-7-13-23(17-20)27-18-19-8-3-1-4-9-19/h1-13,16-17H,14-15,18H2,(H,25,26)/b22-16-
InChiKey: XKYSKEZOGQZDAD-JWGURIENSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(Z)-5-(3-benzyloxyphenyl)-4-phenyl-pent-4-enoic acid
(Z)-5-(3-benzyloxyphenyl)-4-phenyl-4-pentenoic acid
(Z)-5-(3-benzoxyphenyl)-4-phenyl-pent-4-enoic acid
(Z)-4-phenyl-5-[3-(phenylmethoxy)phenyl]pent-4-enoic acid
(Z)-5-[3-(benzyloxy)phenyl]-4-phenyl-pent-4-enoic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Endothelin receptor ET-A	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	Endothelin receptor ET-A	426 aa	412 aa	21.1 %
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	Endothelin receptor ET-A	426 aa	412 aa	20.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0037	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Onchocerca volvulus	4.1 G protein, putative homolog	0.0038	0.0042	0.0291
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0038	0.0042	0.0042
Onchocerca volvulus		0.0038	0.0042	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Mycobacterium tuberculosis	Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl)	0.0682	0.4388	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0038	0.0042	0.0042
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0077	0.0304	0.0304
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0024	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Echinococcus multilocularis	geminin	0.0135	0.0696	0.0696
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0038	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Onchocerca volvulus		0.0038	0.0042	0.0291
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0038	0.0042	0.0042
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0077	0.0304	0.0304
Mycobacterium tuberculosis	Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl)	0.0682	0.4388	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Onchocerca volvulus		0.0038	0.0042	0.0291
Mycobacterium leprae	Isocitrate lyase	0.032	0.1942	0.4425
Onchocerca volvulus		0.0038	0.0042	0.0291
Echinococcus granulosus	carbonic anhydrase	0.0077	0.0304	0.0304
Schistosoma mansoni	carbonic anhydrase	0.0077	0.0304	0.0304
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0134	0.0686	0.0686
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0134	0.0686	0.0686
Onchocerca volvulus		0.0038	0.0042	0.0291
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0077	0.0304	0.0304
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0038	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Brugia malayi	hypothetical protein	0.0245	0.1439	0.1439
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0038	0.0042	0.0042
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0037	0.0029	0.0029
Echinococcus granulosus	geminin	0.0135	0.0696	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Brugia malayi	hypothetical protein	0.0038	0.0042	0.0042
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0038	0.0042	0.0042
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0038	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0038	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0304	0.0304
Onchocerca volvulus		0.0038	0.0042	0.0291
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0038	0.0042	0.0042
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0038	0.0042	0.0042
Onchocerca volvulus		0.0038	0.0042	0.0291
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0038	0.0042	0.0042
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0038	0.0042	0.0042
Onchocerca volvulus		0.0038	0.0042	0.0291
Mycobacterium tuberculosis	Isocitrate lyase Icl (isocitrase) (isocitratase)	0.0682	0.4388	1
Onchocerca volvulus		0.0038	0.0042	0.0291
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0024	0.0406
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0024	0.0024
Schistosoma mansoni	pcd6 interacting protein-related	0.0038	0.0042	0.0042
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0037	0.0029	0.0029
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0038	0.0042	0.0718
Onchocerca volvulus		0.0038	0.0042	0.0291
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0038	0.0042	0.0042
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0119	0.0584	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0038	0.0042	0.0042
Onchocerca volvulus		0.0038	0.0042	0.0291
Trichomonas vaginalis	set domain proteins, putative	0.019	0.1065	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0038	0.0042	0.0042
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0038	0.0042	0.0042
Brugia malayi	Inositol-1	0.0036	0.0024	0.0024
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0038	0.0042	0.0042
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Brugia malayi	hypothetical protein	0.0038	0.0042	0.0042
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0038	0.0042	0.0042
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0038	0.0042	0.0042
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0038	0.0042	0.0042
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0038	0.0042	0.0042
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0038	0.0042	0.0042
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0038	0.0042	0.0042
Loa Loa (eye worm)	carbonic anhydrase 3	0.0119	0.0584	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0134	0.0686	0.0686
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0038	0.0042	0.0042
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0038	0.0042	0.0042
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0038	0.0042	0.0042
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Onchocerca volvulus		0.0038	0.0042	0.0291
Echinococcus granulosus	tumor protein p63	0.0271	0.1612	0.1612
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0038	0.0042	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0119	0.0584	0.0584
Onchocerca volvulus		0.0038	0.0042	0.0291
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0077	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Onchocerca volvulus		0.0038	0.0042	0.0291
Echinococcus multilocularis	carbonic anhydrase	0.0077	0.0304	0.0304
Brugia malayi	hypothetical protein	0.0038	0.0042	0.0042
Schistosoma mansoni	hypothetical protein	0.0077	0.0304	0.0304
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0038	0.0042	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0038	0.0042	0.0042
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0167	0.0909	0.0909
Echinococcus multilocularis	carbonic anhydrase II	0.0119	0.0584	0.0584
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0038	0.0042	0.0042
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0038	0.0042	0.0042
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0038	0.0042	0.0042
Mycobacterium leprae	PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL)	0.0682	0.4388	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0038	0.0042	0.0042
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0024	0.078
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0038	0.0042	0.0042
Onchocerca volvulus		0.0038	0.0042	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Brugia malayi	Protein-tyrosine phosphatase	0.0038	0.0042	0.0042
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0038	0.0042	0.0042
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0024	0.0406
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0038	0.0042	0.0042
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0037	0.0029	0.0029
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Onchocerca volvulus		0.019	0.1065	0.7403
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0038	0.0042	0.0042
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0038	0.0042	0.0042
Echinococcus multilocularis	tumor protein p63	0.0271	0.1612	0.1612
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0038	0.0042	0.0718
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0038	0.0042	0.0042
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0119	0.0584	0.0584
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0024	0.0024
Schistosoma mansoni	hypothetical protein	0.0135	0.0696	0.0696
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0038	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0024	0.0222
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0038	0.0042	0.0042
Brugia malayi	Protein-tyrosine phosphatase 1	0.0038	0.0042	0.0042
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Schistosoma mansoni	carbonic anhydrase-related	0.0077	0.0304	0.0304
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Onchocerca volvulus		0.0038	0.0042	0.0291
Schistosoma mansoni	alpha-glucosidase	0.0115	0.056	0.056
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0024	0.0024
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0038	0.0042	0.0042
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0024	0.0222
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0119	0.0584	0.0584
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0038	0.0042	0.0042
Trichomonas vaginalis	pten, drome, putative	0.0038	0.0042	0.0393
Schistosoma mansoni	carbonic anhydrase-related	0.0077	0.0304	0.0304
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Giardia lamblia	Protein tyrosine phosphatase	0.0038	0.0042	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0304	0.0304
Echinococcus multilocularis	hypothetical protein	0.0038	0.0042	0.0042
Onchocerca volvulus		0.0038	0.0042	0.0291
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0024	0.0406
Onchocerca volvulus		0.0038	0.0042	0.0291
Echinococcus multilocularis	carbonic anhydrase	0.0077	0.0304	0.0304
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0024	0.5654
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0038	0.0042	0.0042
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0038	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Onchocerca volvulus		0.0038	0.0042	0.0291
Onchocerca volvulus		0.0038	0.0042	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Schistosoma mansoni	carbonic anhydrase-related	0.0077	0.0304	0.0304
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0024	0.5
Brugia malayi	hypothetical protein	0.0038	0.0042	0.0042
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0038	0.0042	0.0718
Echinococcus granulosus	carbonic anhydrase	0.0077	0.0304	0.0304
Schistosoma mansoni	alpha-glucosidase	0.0115	0.056	0.056
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1514	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0038	0.0042	0.0042
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0038	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0304	0.0304
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1514	1	1
Echinococcus multilocularis		0.0038	0.0042	0.0042
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0038	0.0042	0.0042
Schistosoma mansoni	hypothetical protein	0.0135	0.0696	0.0696
Schistosoma mansoni	protein tyrosine phosphatase	0.0038	0.0042	0.0042
Toxoplasma gondii	hypothetical protein	0.0077	0.0304	1
Schistosoma mansoni	protein tyrosine phosphatase	0.0038	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Echinococcus multilocularis	carbonic anhydrase	0.0077	0.0304	0.0304
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0038	0.0042	0.0042
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0038	0.0042	0.0042
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1514	1	1
Mycobacterium ulcerans	isocitrate lyase Icl	0.0682	0.4388	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0038	0.0042	0.0042
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0038	0.0042	0.0718
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0038	0.0042	0.0042
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0038	0.0042	0.0042
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0119	0.0584	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0038	0.0042	0.0042
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0038	0.0042	0.0042
Plasmodium falciparum	carbonic anhydrase	0.0077	0.0304	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Brugia malayi	Pre-SET motif family protein	0.0167	0.0909	0.0909
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Echinococcus granulosus	lysosomal alpha glucosidase	0.0134	0.0686	0.0686
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0077	0.0304	0.0304
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0119	0.0584	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0038	0.0042	0.0042
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0038	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0038	0.0042	0.0042
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.1514	1	1
Brugia malayi	hypothetical protein	0.0038	0.0042	0.0042
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0119	0.0584	0.0584
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0038	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0037	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Mycobacterium ulcerans	isocitrate lyase AceAb	0.0682	0.4388	1
Schistosoma mansoni	cellular tumor antigen P53	0.004	0.0051	0.0051
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0038	0.0042	0.0042
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0038	0.0042	0.0042
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0038	0.0042	0.0042
Brugia malayi	Protein-tyrosine phosphatase	0.0038	0.0042	0.0042
Onchocerca volvulus		0.0077	0.0305	0.2123
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Leishmania major	tyrosine specific protein phosphatase, putative	0.0038	0.0042	0.0718
Echinococcus granulosus	carbonic anhydrase II	0.0119	0.0584	0.0584
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0038	0.0042	0.0042
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0024	0.0024
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0038	0.0042	0.0042
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0134	0.0686	0.0686
Loa Loa (eye worm)	inositol-1	0.0036	0.0024	0.0024
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0037	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0038	0.0042	0.0042
Onchocerca volvulus		0.0245	0.1439	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0037	0.0029	0.0029
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0038	0.0042	0.0042
Echinococcus granulosus	carbonic anhydrase	0.0077	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0038	0.0042	0.0718
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0038	0.0042	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0038	0.0042	0.0042
Trypanosoma brucei	carbonic anhydrase-like protein	0.0119	0.0584	1
Loa Loa (eye worm)	hypothetical protein	0.0245	0.1439	0.1439
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0038	0.0042	0.0042
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0038	0.0042	0.0042
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0037	0.0029	0.0029
Onchocerca volvulus		0.004	0.0051	0.0352
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0037	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0038	0.0042	0.0042
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0024	0.0406
Onchocerca volvulus		0.0038	0.0042	0.0291
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0038	0.0042	0.0042
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0024	0.0222
Schistosoma mansoni	protein tyrosine phosphatase	0.0038	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0042
Onchocerca volvulus		0.0038	0.0042	0.0291
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0038	0.0042	0.0042
Onchocerca volvulus		0.0038	0.0042	0.0291
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0038	0.0042	0.0042
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0077	0.0304	0.0304
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0038	0.0042	0.0042
Leishmania major	carbonic anhydrase-like protein	0.0119	0.0584	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0038	0.0042	0.0042
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0038	0.0042	0.0042

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.3 uM	Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.	ChEMBL.	9667965
IC50 (binding)	= 5.3 uM	Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.	ChEMBL.	9667965

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10546317

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 153230