Detailed information for compound 1533134

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 269.325 | Formula: C13H11N5S
  • H donors: 1 H acceptors: 3 LogP: 3.16 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=NNc1nc2c(s1)cccc2)c1ccncn1
  • InChi: 1S/C13H11N5S/c1-9(10-6-7-14-8-15-10)17-18-13-16-11-4-2-3-5-12(11)19-13/h2-8H,1H3,(H,16,18)
  • InChiKey: ZMEIUSLAHMLILY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0189 0.0189
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0189 0.0189
Brugia malayi AKH receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0043 0.0658 0.0658
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Echinococcus granulosus zinc finger protein Ran binding 0.0138 0.3225 0.3225
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0307 0.0307
Schistosoma mansoni hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0205 0.5014 0.5014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0189 0.0189
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0189 0.0189
Schistosoma mansoni histamine h1 receptor 0.0026 0.0189 0.0189
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0307 0.0952
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis serotonin receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0189 0.0189
Echinococcus granulosus serotonin receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0189 0.0189
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0189 0.0189
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0389 1 1
Brugia malayi putative neuropeptide receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0189 0.0189
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0189 0.0189
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0138 0.3225 0.3225
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus granulosus hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi hypothetical protein 0.003 0.0307 0.0307
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0189 0.0189
Chlamydia trachomatis SWIB complex protein 0.0389 1 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Loa Loa (eye worm) brahma associated protein 0.0389 1 1
Brugia malayi Dopamine receptor protein 1 0.0026 0.0189 0.0189
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.338 0.338
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0138 0.3225 0.3225
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0189 0.0189
Entamoeba histolytica hypothetical protein 0.0043 0.0658 0.5
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi ORL1-like opioid receptor 0.0026 0.0189 0.0189
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0 0.5
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0189 0.0189
Brugia malayi GnHR receptor homolog 0.0026 0.0189 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.3225 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.0189 0.0189
Onchocerca volvulus 0.0138 0.3225 0.3095
Echinococcus granulosus neuropeptide receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0189 0.0189
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0138 0.3225 1
Brugia malayi YY1-associated factor 2 0.0138 0.3225 0.3225
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0138 0.3225 0.3225
Entamoeba histolytica hypothetical protein 0.0043 0.0658 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0389 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0189 0.0189
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0189 0.0189
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0189 0.0189
Echinococcus granulosus orexin receptor type 2 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Leishmania major hypothetical protein, conserved 0.0138 0.3225 1
Leishmania major hypothetical protein, conserved 0.0138 0.3225 1
Trichomonas vaginalis conserved hypothetical protein 0.0389 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi G-protein coupled receptor 0.0026 0.0189 0.0189
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0189 0.0189
Trypanosoma brucei hypothetical protein, conserved 0.0138 0.3225 1
Onchocerca volvulus 0.0389 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0189 0.0189
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0189 0.0189
Plasmodium vivax hypothetical protein, conserved 0.0389 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0138 0.3225 0.3225
Brugia malayi larval opioid receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0138 0.3225 0.3225
Echinococcus granulosus neuropeptide receptor A26 0.0026 0.0189 0.0189
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.003 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0138 0.3225 0.3225
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Echinococcus granulosus SWI:SNF matrix associated 0.0389 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0189 0.0189
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0189 0.0189
Brugia malayi Serotonin receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0189 0.0189
Schistosoma mansoni biogenic amine receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0189 0.0189
Brugia malayi hypothetical protein 0.0043 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi brahma associated protein 60 kDa 0.0389 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0189 0.0189
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0026 0.0189 0.0189
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0138 0.3225 1
Brugia malayi neuropeptide F receptor 0.0026 0.0189 0.0189
Schistosoma mansoni amine GPCR 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus granulosus g protein coupled receptor 0.0026 0.0189 0.0189
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0189 0.0189
Brugia malayi neuropeptide F receptor 0.0026 0.0189 0.0189
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0189 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0189 0.0189
Brugia malayi Dopamine receptor protein 2 0.0026 0.0189 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0189 0.0189
Brugia malayi SWIB/MDM2 domain containing protein 0.0389 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0658 0.0658
Echinococcus granulosus g protein coupled receptor 0.0026 0.0189 0.0189
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0189 0.0189
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0307 0.0307
Echinococcus multilocularis geminin 0.0205 0.5014 0.5014
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0189 0.0189
Echinococcus granulosus geminin 0.0205 0.5014 0.5014
Brugia malayi RE15519p 0.0026 0.0189 0.0189
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0138 0.3225 0.3225
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0189 0.0189
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0138 0.3225 0.3225
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0389 1 1
Brugia malayi sulfakinin receptor protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Chlamydia trachomatis DNA topoisomerase I 0.0389 1 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0189 0.0189
Schistosoma mansoni TRABID protein (C64 family) 0.0138 0.3225 0.3225
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0189 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0189 0.0189
Schistosoma mansoni biogenic amine receptor 0.0026 0.0189 0.0189
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0189 0.0189
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0138 0.3225 0.3225
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Leishmania major hypothetical protein, conserved 0.0138 0.3225 1
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.3225 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0658 0.0658
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0205 0.5014 0.5014
Schistosoma mansoni hypothetical protein 0.0389 1 1
Onchocerca volvulus 0.0138 0.3225 0.3095
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0189 0.0189
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi MH2 domain containing protein 0.0144 0.338 0.338
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0189 0.0189
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0138 0.3225 1
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis neuropeptide s receptor 0.0026 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0389 1 1
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0389 1 1
Echinococcus granulosus ring and YY1 binding protein 0.0138 0.3225 0.3225
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0189 0.0189
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0307 0.0307
Brugia malayi hypothetical protein 0.002 0.0015 0.0015
Echinococcus granulosus neuropeptide s receptor 0.0026 0.0189 0.0189
Brugia malayi G protein-coupled receptor 0.0026 0.0189 0.0189
Brugia malayi follicle stimulating hormone receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis ring and YY1 binding protein 0.0138 0.3225 0.3225
Brugia malayi Melatonin receptor type 1A 0.0026 0.0189 0.0189
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni fusion 0.0138 0.3225 0.3225
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0138 0.3225 1
Echinococcus multilocularis serotonin receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0189 0.0189
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0138 0.3225 0.3225
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0189 0.0189
Schistosoma mansoni myosin xvIII 0.0026 0.0189 0.0189
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0189 0.0189
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0189 0.0189
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0189 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0189 0.0189
Schistosoma mansoni opsin-like receptor 0.0026 0.0189 0.0189
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0138 0.3225 1
Schistosoma mansoni amine GPCR 0.0026 0.0189 0.0189
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0189 0.0189
Toxoplasma gondii ran binding protein 0.0138 0.3225 0.3225
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0189 0.0189
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0389 1 1
Echinococcus multilocularis zinc finger protein Ran binding 0.0138 0.3225 0.3225
Brugia malayi Serotonin receptor 0.0026 0.0189 0.0189
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0307 0.0952
Echinococcus granulosus somatostatin receptor 0.0026 0.0189 0.0189
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0389 1 1
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0189 0.0189
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0189 0.0189
Trypanosoma brucei hypothetical protein, conserved 0.0138 0.3225 1
Onchocerca volvulus 0.0138 0.3225 0.3095
Echinococcus multilocularis sex peptide receptor 0.0026 0.0189 0.0189
Schistosoma mansoni RNA binding protein 0.0138 0.3225 0.3225
Leishmania major hypothetical protein, conserved 0.003 0.0307 0.0952
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0189 0.0189
Echinococcus granulosus neuropeptide receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.338 0.338
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0138 0.3225 0.3225
Schistosoma mansoni neuropeptide receptor 0.0026 0.0189 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus granulosus Zinc finger RanBP2 type 0.0138 0.3225 0.3225
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0189 0.0189
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0189 0.0189
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0189 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.3225 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0189 0.0189
Schistosoma mansoni biogenic amine receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis somatostatin receptor 0.0026 0.0189 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0189 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Leishmania major hypothetical protein, conserved 0.0138 0.3225 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0389 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0189 0.0189
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0138 0.3225 0.3225
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0189 0.0189
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0189 0.0189
Echinococcus granulosus g protein coupled receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis SWI:SNF matrix associated 0.0389 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0307 0.0307
Schistosoma mansoni opsin-like receptor 0.0026 0.0189 0.0189
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0189 0.0189
Echinococcus granulosus fmrfamide receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis SWI:SNF matrix associated 0.0389 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0189 0.0189
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0138 0.3225 0.3225
Schistosoma mansoni amine GPCR 0.0026 0.0189 0.0189
Schistosoma mansoni amine GPCR 0.0026 0.0189 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0389 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0189 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi Dopamine receptor 0.0026 0.0189 0.0189
Schistosoma mansoni neuropeptide receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0189 0.0189
Echinococcus granulosus allatostatin A receptor 0.0026 0.0189 0.0189
Entamoeba histolytica hypothetical protein 0.0043 0.0658 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0189 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0189 0.0189
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0189 0.0189
Echinococcus multilocularis neuropeptide receptor A26 0.0026 0.0189 0.0189
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0189 0.0189
Echinococcus granulosus sex peptide receptor 0.0026 0.0189 0.0189
Schistosoma mansoni neuropeptide receptor 0.0026 0.0189 0.0189
Schistosoma mansoni adenoreceptor 0.0026 0.0189 0.0189
Schistosoma mansoni brg-1 associated factor 0.0389 1 1
Trypanosoma cruzi WLM domain containing protein, putative 0.0138 0.3225 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Entamoeba histolytica hypothetical protein 0.0043 0.0658 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0389 1 1
Brugia malayi G-protein coupled receptor 0.0026 0.0189 0.0189
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0189 0.0189
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0138 0.3225 0.3095
Schistosoma mansoni zinc finger protein 0.0138 0.3225 0.3225
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0307 0.0952
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0389 1 1
Schistosoma mansoni amine GPCR 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0189 0.0189
Leishmania major hypothetical protein, conserved 0.0138 0.3225 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0189 0.0189
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Brugia malayi hypothetical protein 0.0026 0.0189 0.0189
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.0189 0.0189
Schistosoma mansoni opsin-like receptor 0.0026 0.0189 0.0189
Onchocerca volvulus 0.0138 0.3225 0.3095
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0189 0.0189
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0138 0.3225 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0189
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0189 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0189 0.0189
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0189 0.0189
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0189 0.0189
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0138 0.3225 0.3225
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0189 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0189 0.0189
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0189 0.0189
Trypanosoma cruzi WLM domain containing protein, putative 0.0138 0.3225 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0189 0.0189
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0138 0.3225 0.3225
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0189 0.0189
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0138 0.3225 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0189 0.0189
Schistosoma mansoni neuropeptide receptor 0.0026 0.0189 0.0189

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1836 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.4467 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 1.4125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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