Detailed information for compound 153459

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 797.891 | Formula: C47H47N3O9
  • H donors: 1 H acceptors: 6 LogP: 6.13 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#Cc1ccc(cc1)[C@H]1OC[C@H]([C@H](O1)c1cccnc1)C/C=C\CCC(=O)OCCOC(=O)CC/C=C\C[C@@H]1CO[C@@H](O[C@@H]1c1ccccc1O)c1ccc(cc1)C#N
  • InChi: 1S/C47H47N3O9/c48-28-33-17-21-35(22-18-33)46-56-31-38(44(58-46)37-12-9-25-50-30-37)10-3-1-5-15-42(52)54-26-27-55-43(53)16-6-2-4-11-39-32-57-47(36-23-19-34(29-49)20-24-36)59-45(39)40-13-7-8-14-41(40)51/h1-4,7-9,12-14,17-25,30,38-39,44-47,51H,5-6,10-11,15-16,26-27,31-32H2/b3-1-,4-2-/t38-,39-,44-,45+,46+,47+/m1/s1
  • InChiKey: TZTAYBMKFYSPIP-XSCIEUTISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thromboxane A2 receptor Starlite/ChEMBL No references
Homo sapiens thromboxane A synthase 1 (platelet) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei cytochrome P450, putative thromboxane A synthase 1 (platelet) 534 aa 498 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0018 0 0.5
Echinococcus granulosus peptide allatostatin:somatostatin 0.0112 0.252 1
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.0392 1 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0112 0.252 1
Echinococcus granulosus orexin receptor type 2 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni hypothetical protein 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0112 0.252 1
Brugia malayi AKH receptor 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Echinococcus granulosus g-protein coupled receptor 0.0112 0.252 1
Echinococcus multilocularis neuropeptide receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus sex peptide receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis neuropeptide receptor A26 0.0112 0.252 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni amine GPCR 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Giardia lamblia Aldose reductase 0.0018 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis G protein coupled receptor 139 0.0112 0.252 1
Entamoeba histolytica aldose reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0112 0.252 1
Brugia malayi GnHR receptor homolog 0.0112 0.252 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0112 0.252 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0112 0.252 1
Schistosoma mansoni adenoreceptor 0.0112 0.252 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0112 0.252 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0112 0.252 1
Leishmania major prostaglandin f synthase, putative 0.0018 0 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Schistosoma mansoni hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis serotonin receptor 0.0112 0.252 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0112 0.252 1
Brugia malayi Serotonin receptor 0.0112 0.252 1
Schistosoma mansoni biogenic amine receptor 0.0112 0.252 1
Echinococcus granulosus hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus fmrfamide receptor 0.0112 0.252 1
Echinococcus multilocularis somatostatin receptor 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Schistosoma mansoni biogenic amine receptor 0.0112 0.252 1
Echinococcus granulosus G protein coupled receptor 139 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Schistosoma mansoni neuropeptide receptor 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Mycobacterium ulcerans isocitrate lyase Icl 0.0392 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0112 0.252 1
Schistosoma mansoni opsin-like receptor 0.0112 0.252 1
Brugia malayi G-protein coupled receptor 0.0112 0.252 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) G-protein coupled receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis g-protein coupled receptor 0.0112 0.252 1
Echinococcus multilocularis neuropeptide s receptor 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus serotonin receptor 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Trypanosoma cruzi aldo-keto reductase 0.0018 0 0.5
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0112 0.252 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0112 0.252 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.252 1
Mycobacterium ulcerans isocitrate lyase AceAb 0.0392 1 1
Brugia malayi follicle stimulating hormone receptor 0.0112 0.252 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0112 0.252 1
Echinococcus multilocularis orexin receptor type 2 0.0112 0.252 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0112 0.252 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Entamoeba histolytica aldose reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Brugia malayi Dopamine receptor 0.0112 0.252 1
Echinococcus granulosus g protein coupled receptor 0.0112 0.252 1
Echinococcus granulosus dro:myosuppressin receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Echinococcus multilocularis g protein coupled receptor 0.0112 0.252 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0112 0.252 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0112 0.252 1
Echinococcus granulosus neuropeptides capa receptor 0.0112 0.252 1
Entamoeba histolytica aldose reductase, putative 0.0018 0 0.5
Brugia malayi hypothetical protein 0.0112 0.252 1
Echinococcus granulosus neuropeptide Y receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0112 0.252 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0112 0.252 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0112 0.252 1
Echinococcus multilocularis fmrfamide receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus g protein coupled receptor 0.0112 0.252 1
Echinococcus multilocularis neuropeptides capa receptor 0.0112 0.252 1
Echinococcus granulosus g protein coupled receptor 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Brugia malayi Dopamine receptor protein 1 0.0112 0.252 1
Echinococcus granulosus neuropeptide Y receptor 0.0112 0.252 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.0392 1 1
Brugia malayi ORL1-like opioid receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.0392 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Schistosoma mansoni amine GPCR 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Schistosoma mansoni amine GPCR 0.0112 0.252 1
Loa Loa (eye worm) TYRA-2 protein 0.0112 0.252 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0018 0 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0112 0.252 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0112 0.252 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Echinococcus granulosus neuropeptide receptor 0.0112 0.252 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0112 0.252 1
Echinococcus multilocularis neuropeptides capa receptor 0.0112 0.252 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Trypanosoma brucei aldo-keto reductase, putative 0.0018 0 0.5
Brugia malayi Serotonin receptor 0.0112 0.252 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0112 0.252 1
Schistosoma mansoni neuropeptide receptor 0.0112 0.252 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.252 1
Brugia malayi G protein-coupled receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Toxoplasma gondii aldose reductase, putative 0.0018 0 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Echinococcus granulosus neuropeptide s receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Echinococcus granulosus somatostatin receptor 0.0112 0.252 1
Trypanosoma brucei prostaglandin f synthase 0.0018 0 0.5
Brugia malayi larval opioid receptor 0.0112 0.252 1
Brugia malayi RE15519p 0.0112 0.252 1
Brugia malayi putative neuropeptide receptor 0.0112 0.252 1
Schistosoma mansoni myosin xvIII 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.252 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis neuropeptide Y receptor 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Echinococcus multilocularis g protein coupled receptor 0.0112 0.252 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis neuropeptide Y receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0018 0 0.5
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0018 0 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0112 0.252 1
Brugia malayi Melatonin receptor type 1A 0.0112 0.252 1
Brugia malayi G-protein coupled receptor 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0112 0.252 1
Echinococcus granulosus neuropeptide receptor 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0112 0.252 1
Schistosoma mansoni biogenic amine receptor 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Onchocerca volvulus 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Schistosoma mansoni neuropeptide receptor 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Brugia malayi sulfakinin receptor protein 0.0112 0.252 1
Schistosoma mansoni amine GPCR 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Leishmania major aldo-keto reductase-like protein 0.0018 0 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0112 0.252 1
Brugia malayi neuropeptide F receptor 0.0112 0.252 1
Brugia malayi putative neuropeptide receptor NPR1 0.0112 0.252 1
Brugia malayi neuropeptide F receptor 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Brugia malayi Dopamine receptor protein 2 0.0112 0.252 1
Schistosoma mansoni opsin-like receptor 0.0112 0.252 1
Schistosoma mansoni hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) G-protein coupled receptor 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Giardia lamblia Aldose reductase 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis sex peptide receptor 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Schistosoma mansoni histamine h1 receptor 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0112 0.252 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0018 0 0.5
Echinococcus multilocularis neuropeptide receptor 0.0112 0.252 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0018 0 0.5
Onchocerca volvulus 0.0112 0.252 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0112 0.252 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0112 0.252 1
Echinococcus granulosus allatostatin A receptor 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.252 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis serotonin receptor 0.0112 0.252 1
Echinococcus multilocularis g protein coupled receptor 0.0112 0.252 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.252 1
Echinococcus granulosus neuropeptides capa receptor 0.0112 0.252 1
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.252 1
Mycobacterium leprae Isocitrate lyase 0.0184 0.4429 0.4429
Echinococcus multilocularis allatostatin A receptor 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Onchocerca volvulus 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0112 0.252 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0112 0.252 1
Schistosoma mansoni amine GPCR 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0112 0.252 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0112 0.252 1
Schistosoma mansoni neuropeptide receptor 0.0112 0.252 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0018 0 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0112 0.252 1
Loa Loa (eye worm) neuropeptide F receptor 0.0112 0.252 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.252 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0112 0.252 1
Schistosoma mansoni opsin-like receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis fmrfamide receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Compound was tested for thromboxane TXA2 synthase inhibitory activity using human platelet ChEMBL. No reference
IC50 (binding) > 10 uM Compound was tested for thromboxane TXA2 synthase inhibitory activity using human platelet ChEMBL. No reference
Kd (functional) > 5 Thromboxane (TXA2) receptor antagonist activity using human platelet ChEMBL. No reference
pA2 (functional) < 5 Thromboxane (TXA2) receptor antagonist activity using human platelet ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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