Detailed information for compound 153626

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 304.324 | Formula: C13H12N4O3S
  • H donors: 2 H acceptors: 2 LogP: 2.24 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N/C(=N\c1ccccc1Oc1cc(ccc1N)[N+](=O)[O-])/S
  • InChi: 1S/C13H12N4O3S/c14-9-6-5-8(17(18)19)7-12(9)20-11-4-2-1-3-10(11)16-13(15)21/h1-7H,14H2,(H3,15,16,21)
  • InChiKey: AJPPOGDYLGPNMT-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax spermidine synthase, putative 0.1138 0.5078 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.003
Loa Loa (eye worm) hypothetical protein 0.0355 0.148 0.1467
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0281 0.1137 0.2181
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.033 0.1363 0.2684
Echinococcus granulosus purine nucleoside phosphorylase 0.0193 0.0734 0.0734
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0156 0.0566 0.1648
Schistosoma mansoni SET domain protein 0.0121 0.0407 0.0407
Brugia malayi SET domain containing protein 0.0131 0.045 0.0444
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0193 0.0734 0.0728
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0193 0.0734 0.5
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0041 0.0037 0.0037
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0193 0.0734 0.095
Echinococcus granulosus uridine phosphorylase 1 0.0193 0.0734 0.0734
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.104 0.4628 0.9108
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.104 0.4628 0.9108
Schistosoma mansoni hypothetical protein 0.0041 0.0037 0.0037
Echinococcus granulosus purine nucleoside phosphorylase 0.0193 0.0734 0.0734
Echinococcus multilocularis hepatoma derived growth factor protein 0.0105 0.0329 0.0329
Echinococcus multilocularis purine nucleoside phosphorylase 0.0193 0.0734 0.0734
Echinococcus granulosus PWWP domain containing protein 2A 0.0105 0.0329 0.0329
Loa Loa (eye worm) CXXC zinc finger family protein 0.034 0.141 0.1397
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.104 0.4628 1
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0508 0.218 0.4294
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0064 0.0142 0.0206
Giardia lamblia UPL-1 0.0193 0.0734 0.5
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0193 0.0734 0.095
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0677 0.2958 0.2953
Trypanosoma brucei spermidine synthase 0.1138 0.5078 1
Leishmania major hypothetical protein, conserved 0.0105 0.0329 0.0648
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0049 0.0049
Echinococcus granulosus histone h3 methyltransferase 0.221 1 1
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.016 0.0582 0.1146
Echinococcus granulosus histone lysine n methyltransferase suv420h1 0.0147 0.0526 0.0526
Echinococcus multilocularis histone h3 methyltransferase 0.221 1 1
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0377 0.1581 0.4606
Plasmodium falciparum purine nucleoside phosphorylase 0.0193 0.0734 0.1445
Echinococcus granulosus PWWP domain containing protein 2A 0.0105 0.0329 0.0329
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0193 0.0734 0.2903
Schistosoma mansoni cpg binding protein 0.0342 0.1418 0.1418
Trypanosoma brucei transcription elongation factor s-II, putative 0.0105 0.0329 0.0577
Echinococcus multilocularis histone lysine n methyltransferase setb1 0.0036 0.0016 0.0016
Entamoeba histolytica Skb1 methyltransferase, putative 0.0064 0.0144 0.0012
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0193 0.0734 0.095
Schistosoma mansoni adenosylhomocysteinase 0.0233 0.0921 0.0921
Echinococcus granulosus cpg binding protein 0.0342 0.1418 0.1418
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0232 0.0913 0.0913
Toxoplasma gondii Purine nucleoside phosphorylase 0.0193 0.0734 0.2138
Brugia malayi Skb1 methyltransferase family protein 0.0064 0.0144 0.0139
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0064 0.0142 0.0206
Brugia malayi PWWP domain containing protein 0.0105 0.0329 0.0323
Brugia malayi polybromodomain protein 0.0041 0.0037 0.0031
Plasmodium vivax histone-lysine N-methyltransferase, putative 0.0091 0.0267 0.0525
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0193 0.0734 0.5
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0677 0.2958 0.2947
Brugia malayi Pre-SET motif family protein 0.0204 0.0786 0.0781
Mycobacterium ulcerans spermidine synthase 0.0897 0.397 0.831
Echinococcus granulosus hepatoma derived growth factor protein 0.0105 0.0329 0.0329
Schistosoma mansoni purine nucleoside phosphorylase 0.0193 0.0734 0.0734
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0189 0.0717 0.0717
Mycobacterium tuberculosis Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) 0.0848 0.3743 0.9299
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0193 0.0734 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0031 0.0031
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0168 0.062 0.062
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1561 0.702 0.7015
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0031 0.0031
Loa Loa (eye worm) spermidine synthase 0.1138 0.5078 0.507
Brugia malayi hypothetical protein 0.0064 0.0142 0.0136
Echinococcus multilocularis geminin 0.0182 0.0684 0.0684
Onchocerca volvulus 0.0283 0.1151 0.1112
Echinococcus multilocularis methylthioadenosine phosphorylase 0.104 0.4628 0.4628
Loa Loa (eye worm) adenosylhomocysteinase 0.0377 0.1581 0.1568
Echinococcus multilocularis peregrin 0.0136 0.0473 0.0473
Trypanosoma cruzi spermidine synthase, putative 0.1138 0.5078 1
Schistosoma mansoni bromo adjacent homology domain containing 0.0041 0.0037 0.0037
Schistosoma mansoni protein arginine n-methyltransferase 0.0129 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0116 0.038 0.0365
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0377 0.1581 0.2048
Loa Loa (eye worm) uridine phosphorylase 0.0193 0.0734 0.0719
Loa Loa (eye worm) hypothetical protein 0.0122 0.0407 0.0392
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0193 0.0734 0.0548
Trichomonas vaginalis set domain proteins, putative 0.1714 0.7721 1
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0377 0.1581 1
Schistosoma mansoni hepatoma derived growth factor 0.0105 0.0329 0.0329
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0377 0.1581 0.2176
Leishmania major hypothetical protein, conserved 0.0281 0.1137 0.224
Echinococcus multilocularis metastasis associated protein MTA1 0.0041 0.0037 0.0037
Brugia malayi hypothetical protein 0.0384 0.1613 0.1608
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0193 0.0734 0.5
Brugia malayi hypothetical protein 0.0384 0.1613 0.1608
Mycobacterium tuberculosis Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) 0.0897 0.397 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0193 0.0734 0.0734
Loa Loa (eye worm) hypothetical protein 0.0965 0.4279 0.4271
Leishmania major modification methylase-like protein 0.0508 0.218 0.4294
Leishmania major S-adenosylhomocysteine hydrolase 0.0377 0.1581 0.3114
Entamoeba histolytica hypothetical protein 0.0193 0.0734 0.2903
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0281 0.1137 0.2181
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0156 0.0566 0.0566
Loa Loa (eye worm) Carm1-pending protein 0.0156 0.0566 0.0551
Echinococcus multilocularis purine nucleoside phosphorylase 0.0193 0.0734 0.0734
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0193 0.0734 0.095
Schistosoma mansoni purine nucleoside phosphorylase 0.0193 0.0734 0.0734
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0677 0.2958 0.5793
Brugia malayi Protein arginine N-methyltransferase 0.016 0.0582 0.0577
Onchocerca volvulus 0.0384 0.1613 0.1737
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0313 0.1289 0.1289
Loa Loa (eye worm) hypothetical protein 0.0384 0.1613 0.16
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0677 0.2958 0.5793
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0193 0.0734 0.2903
Echinococcus granulosus microtubule associated protein 2 0.0745 0.327 0.327
Loa Loa (eye worm) hypothetical protein 0.0054 0.0095 0.008
Schistosoma mansoni methylthioadenosine phosphorylase 0.0193 0.0734 0.0734
Echinococcus multilocularis cpg binding protein 0.0342 0.1418 0.1418
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0145 0.013
Echinococcus granulosus purine nucleoside phosphorylase 0.0193 0.0734 0.0734
Schistosoma mansoni polybromo-1 0.0041 0.0037 0.0037
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.0319 0.0319
Schistosoma mansoni cpg binding protein 0.034 0.141 0.141
Echinococcus multilocularis spermidine synthase 0.1138 0.5078 0.5078
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0377 0.1581 0.3062
Treponema pallidum pfs protein (pfs) 0.0193 0.0734 0.5
Toxoplasma gondii phosphorylase family protein 0.0193 0.0734 0.2138
Entamoeba histolytica hypothetical protein 0.0105 0.0329 0.0917
Echinococcus granulosus histone lysine n methyltransferase setb1 0.0036 0.0016 0.0016
Leishmania major spermidine synthase 0.1138 0.5078 1
Echinococcus granulosus methylthioadenosine phosphorylase 0.104 0.4628 0.4628
Trypanosoma brucei Histone methylation protein DOT1, putative 0.0281 0.1137 0.2181
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0377 0.1581 0.3114
Brugia malayi Adenosylhomocysteinase 0.0377 0.1581 0.1576
Loa Loa (eye worm) hypothetical protein 0.221 1 1
Trypanosoma brucei uridine phosphorylase 0.0193 0.0734 0.138
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0023 0.0023
Plasmodium falciparum protein arginine N-methyltransferase 5, putative 0.0064 0.0144 0.0284
Plasmodium vivax protein arginine N-methyltransferase 5, putative 0.0064 0.0144 0.0284
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0021
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0193 0.0734 0.095
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.104 0.4628 0.462
Plasmodium falciparum adenosylhomocysteinase 0.0377 0.1581 0.3114
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.033 0.1363 0.2684
Schistosoma mansoni methylthioadenosine phosphorylase 0.104 0.4628 0.4628
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0232 0.0913 0.0913
Echinococcus granulosus peregrin 0.0136 0.0473 0.0473
Onchocerca volvulus 0.1714 0.7721 1
Trichomonas vaginalis conserved hypothetical protein 0.0193 0.0734 0.095
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0377 0.1581 0.2618
Schistosoma mansoni adenosylhomocysteinase 0.0233 0.0921 0.0921
Loa Loa (eye worm) hypothetical protein 0.0105 0.0329 0.0314
Brugia malayi hypothetical protein 0.0105 0.0329 0.0323
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0508 0.218 0.6352
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0193 0.0734 0.2903
Brugia malayi Disco-interacting protein 2 homolog 0.0355 0.148 0.1475
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0508 0.218 0.218
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.104 0.4628 0.9108
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0021
Echinococcus multilocularis protein arginine N methyltransferase 5 0.0064 0.0144 0.0144
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.0281 0.1137 0.2181
Chlamydia trachomatis AMP nucleosidase 0.0193 0.0734 0.5
Schistosoma mansoni shk1 kinase-binding protein 0.0064 0.0144 0.0144
Trichomonas vaginalis shk1 kinase-binding protein, putative 0.0041 0.0038 0.0049
Echinococcus granulosus purine nucleoside phosphorylase 0.0193 0.0734 0.0734
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0041 0.0037 0.0037
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0508 0.218 0.218
Schistosoma mansoni suppressor of variegation 4-20-related 0.0147 0.0526 0.0526
Brugia malayi SET domain containing protein 0.0313 0.1289 0.1284
Echinococcus multilocularis metastasis associated protein 1 (mta1) 0.0041 0.0037 0.0037
Trypanosoma cruzi spermidine synthase, putative 0.1138 0.5078 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.0319 0.0319
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0508 0.218 0.425
Echinococcus granulosus bromo adjacent y domain containing 1 0.0041 0.0037 0.0037
Schistosoma mansoni adenosylhomocysteinase 0.0377 0.1581 0.1581
Echinococcus multilocularis adenosylhomocysteinase 0.0377 0.1581 0.1581
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0118 0.0393 0.0508
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0193 0.0734 0.095
Echinococcus multilocularis arginine glutamic acid dipeptide (RE) repeats 0.0041 0.0037 0.0037
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0965 0.4279 0.4271
Treponema pallidum uridine phosphorylase (udp) 0.0193 0.0734 0.5
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0193 0.0734 0.095
Brugia malayi NNMT/PNMT/TEMT family protein 0.0965 0.4279 0.4276
Echinococcus granulosus protein arginine N methyltransferase 5 0.0064 0.0144 0.0144
Brugia malayi ELM2 domain containing protein 0.0041 0.0037 0.0031
Leishmania major arginine N-methyltransferase, type II, putative;with=GeneDB:Tb927.10.640 0.0041 0.0038 0.0075
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0281 0.1137 0.2181
Onchocerca volvulus 0.0138 0.0481 0.0205
Loa Loa (eye worm) hypothetical protein 0.0965 0.4279 0.4271
Loa Loa (eye worm) Skb1 methyltransferase 0.0064 0.0144 0.0129
Echinococcus granulosus polybromo 1 0.0041 0.0037 0.0037
Echinococcus multilocularis microtubule associated protein 2 0.0745 0.327 0.327
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0193 0.0734 0.1445
Leishmania major hypothetical protein, conserved 0.0281 0.1137 0.224
Schistosoma mansoni hypothetical protein 0.0182 0.0684 0.0684
Schistosoma mansoni histone J3 methyltransferase 0.221 1 1
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.016 0.0582 0.1079
Trypanosoma cruzi transcription elongation factor s-II, putative 0.0105 0.0329 0.0577
Echinococcus granulosus metastasis associated protein MTA1 0.0041 0.0037 0.0037
Plasmodium falciparum histone-lysine N-methyltransferase, putative 0.0091 0.0267 0.0525
Trypanosoma cruzi arginine N-methyltransferase, type III 0.016 0.0582 0.1079
Echinococcus granulosus histone lysine methyltransferase setb 0.0232 0.0913 0.0913
Echinococcus multilocularis purine nucleoside phosphorylase 0.0193 0.0734 0.0734
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0031 0.0015
Echinococcus granulosus purine nucleoside phosphorylase 0.0193 0.0734 0.0734
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0377 0.1581 0.3062
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0193 0.0734 0.095
Toxoplasma gondii hypothetical protein 0.0105 0.0329 0.0958
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0021
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0677 0.2958 0.5793
Echinococcus granulosus protein arginine N methyltransferase 7 0.016 0.0582 0.0582
Echinococcus granulosus arginine glutamic acid dipeptide RE repeats 0.0041 0.0037 0.0037
Echinococcus multilocularis PWWP domain containing protein 2A 0.0105 0.0329 0.0329
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0677 0.2958 0.2958
Onchocerca volvulus 0.0355 0.148 0.1557
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0329 0.0577
Echinococcus granulosus DNA methyltransferase 2, putative 0.0508 0.218 0.218
Echinococcus multilocularis purine nucleoside phosphorylase 0.0193 0.0734 0.0734
Echinococcus granulosus disco interacting protein 2 0.0355 0.148 0.148
Echinococcus multilocularis PWWP domain containing protein 2A 0.0105 0.0329 0.0329
Trichomonas vaginalis CDC6, putative 0.0041 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0232 0.0913 0.0899
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0193 0.0734 0.138
Schistosoma mansoni cpg binding protein 0.0342 0.1418 0.1418
Schistosoma mansoni mixed-lineage leukemia protein mll 0.008 0.0217 0.0217
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.078 0.3432 0.676
Schistosoma mansoni adenosylhomocysteinase 0.0233 0.0921 0.0921
Echinococcus granulosus metastasis associated protein 1 mta1 0.0041 0.0037 0.0037
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0355 0.148 0.148
Trichomonas vaginalis conserved hypothetical protein 0.0193 0.0734 0.095
Leishmania major methylthioadenosine phosphorylase, putative 0.104 0.4628 0.9115
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0064 0.0142 0.0206
Schistosoma mansoni protein arginine n-methyltransferase 0.0156 0.0566 0.0566
Echinococcus granulosus purine nucleoside phosphorylase 0.0193 0.0734 0.0734
Brugia malayi jmjC domain containing protein 0.0102 0.0319 0.0314
Toxoplasma gondii phosphorylase family protein 0.0193 0.0734 0.2138
Loa Loa (eye worm) hypothetical protein 0.0064 0.0142 0.0127
Schistosoma mansoni hypothetical protein 0.0105 0.0329 0.0329
Echinococcus multilocularis uridine phosphorylase 1 0.0193 0.0734 0.0734
Schistosoma mansoni hypothetical protein 0.0182 0.0684 0.0684
Brugia malayi Spermidine synthase 0.1138 0.5078 0.5075
Loa Loa (eye worm) SET domain-containing protein 0.0147 0.0526 0.0511
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0677 0.2958 0.5793
Brugia malayi Pre-SET motif family protein 0.1561 0.702 0.7018
Trypanosoma cruzi spermidine synthase, putative 0.1138 0.5078 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0283 0.1151 0.1151
Echinococcus multilocularis SET and MYND domain containing protein 3 0.0076 0.0197 0.0197
Schistosoma mansoni phd finger protein 0.0105 0.0329 0.0329
Schistosoma mansoni uridine phosphorylase 0.0193 0.0734 0.0734
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0193 0.0734 0.138
Leishmania major S-adenosylmethionine decarboxylase 0.0677 0.2958 0.5824
Schistosoma mansoni methylthioadenosine phosphorylase 0.104 0.4628 0.4628
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.0105 0.0329 0.0577
Trypanosoma cruzi spermidine synthase, putative 0.1138 0.5078 1
Toxoplasma gondii hypothetical protein 0.0281 0.1137 0.3314
Schistosoma mansoni hypothetical protein 0.0105 0.0329 0.0329
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0508 0.218 1
Schistosoma mansoni adenosylhomocysteinase 0.0233 0.0921 0.0921
Echinococcus multilocularis polybromo 1 0.0041 0.0037 0.0037
Entamoeba histolytica adenosylhomocysteinase, putative 0.0377 0.1581 0.706
Trichomonas vaginalis shk1 kinase-binding protein, putative 0.0041 0.0038 0.0049
Onchocerca volvulus 0.034 0.141 0.1463
Brugia malayi SET domain containing protein 0.0147 0.0526 0.052
Brugia malayi CXXC zinc finger family protein 0.034 0.141 0.1405
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.0105 0.0329 0.0577
Echinococcus granulosus spermidine synthase 0.1138 0.5078 0.5078
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.012 0.0399 0.0399
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0193 0.0734 0.2903
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0677 0.2958 0.2958
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0677 0.2958 0.5793
Brugia malayi jmjC domain containing protein 0.004 0.0031 0.0025
Brugia malayi uridine phosphorylase family protein 0.0193 0.0734 0.0728
Leishmania major histone-lysine N-methyltransferase, putative 0.0281 0.1137 0.224
Schistosoma mansoni enhancer of zeste ezh 0.0313 0.1289 0.1289
Brugia malayi Carm1-pending protein 0.0156 0.0566 0.056
Echinococcus multilocularis protein arginine N methyltransferase 7 0.016 0.0582 0.0582
Loa Loa (eye worm) SET domain-containing protein 0.0313 0.1289 0.1275
Echinococcus multilocularis histone lysine n methyltransferase suv420h1 0.0147 0.0526 0.0526
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0508 0.218 0.4294
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0377 0.1581 0.2048
Loa Loa (eye worm) hypothetical protein 0.0074 0.0188 0.0173
Schistosoma mansoni uridine phosphorylase 0.0193 0.0734 0.0734
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0031 0.0031
Plasmodium vivax SET domain protein, putative 0.0168 0.062 0.122
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0377 0.1581 0.3062
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0329 0.0577
Echinococcus multilocularis disco interacting protein 2 0.0355 0.148 0.148
Schistosoma mansoni hypothetical protein 0.0105 0.0329 0.0329
Toxoplasma gondii adenosylhomocysteinase, putative 0.0377 0.1581 0.4606
Echinococcus granulosus geminin 0.0182 0.0684 0.0684
Toxoplasma gondii histone arginine methyltransferase PRMT5 0.0064 0.0144 0.0421
Toxoplasma gondii DNA methyltransferase 2, putative 0.0508 0.218 0.6352
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0168 0.062 0.1805
Loa Loa (eye worm) hypothetical protein 0.0384 0.1613 0.16
Plasmodium falciparum spermidine synthase 0.1138 0.5078 1
Trypanosoma brucei protein arginine n-methyltransferase 7 0.016 0.0582 0.1079
Toxoplasma gondii histone lysine methyltransferase SET1 0.0073 0.0185 0.0539
Echinococcus granulosus purine nucleoside phosphorylase 0.0193 0.0734 0.0734
Trichomonas vaginalis origin recognition complex subunit, putative 0.0041 0.0037 0.0048
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0232 0.0913 0.0913
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0049 0.0049
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0041 0.0037 0.0037
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0193 0.0734 0.138
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0223 0.0223
Echinococcus granulosus adenosylhomocysteinase 0.0377 0.1581 0.1581
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0313 0.1289 0.1289
Schistosoma mansoni microtubule-associated protein tau 0.0745 0.327 0.327
Loa Loa (eye worm) PWWP domain-containing protein 0.0105 0.0329 0.0314
Schistosoma mansoni hepatoma derived growth factor 0.0105 0.0329 0.0329
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0193 0.0734 0.2903
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0041 0.0037 0.0037
Echinococcus granulosus SET and MYND domain containing protein 3 0.0076 0.0197 0.0197
Schistosoma mansoni hypothetical protein 0.0056 0.0105 0.0105
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0193 0.0734 0.2903
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0156 0.0566 0.0566
Echinococcus multilocularis bromo adjacent y domain containing 1 0.0041 0.0037 0.0037
Brugia malayi SET domain containing protein 0.0058 0.0115 0.0109
Trypanosoma brucei histone-lysine n-methyltransferase 0.0281 0.1137 0.2181
Loa Loa (eye worm) hypothetical protein 0.0384 0.1613 0.16
Brugia malayi MTAP 0.104 0.4628 0.4625
Echinococcus multilocularis purine nucleoside phosphorylase 0.0193 0.0734 0.0734
Brugia malayi GATA zinc finger family protein 0.0041 0.0037 0.0031
Brugia malayi hypothetical protein 0.0105 0.0329 0.0323
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0168 0.062 0.062
Toxoplasma gondii hypothetical protein 0.078 0.3432 1
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.012 0.0399 0.0399
Loa Loa (eye worm) protein arginine N-methyltransferase 0.016 0.0582 0.0567
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0281 0.1137 0.2181
Leishmania major nucleoside phosphorylase-like protein 0.0193 0.0734 0.1445
Echinococcus granulosus purine nucleoside phosphorylase 0.0193 0.0734 0.0734

Activities

Activity type Activity value Assay description Source Reference
ND (functional) 0 Logarithm of inhibitory concentration against HIV-induced cytopathogenicity in MT-4 cell cultures. ChEMBL. 12801239
ND (functional) 0 Logarithm of cytotoxic concentration that causes half of the cells to die in mock-infected MT-4 cell cultures. ChEMBL. 12801239

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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