TDR Targets

Basic information

Technical information

TDR Targets ID: 1539053
Name: N-[1-(4-methoxyphenyl)-6,6-dimethyl-5,7-dihyd ro-4H-indazol-4-yl]-4-(1,2,4-triazol-1-yl)but anamide
MW: 408.497 | Formula: C22H28N6O2
H donors: 1 H acceptors: 4 LogP: 2.63 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)n1ncc2c1CC(C)(C)CC2NC(=O)CCCn1ncnc1
InChi: 1S/C22H28N6O2/c1-22(2)11-19(26-21(29)5-4-10-27-15-23-14-25-27)18-13-24-28(20(18)12-22)16-6-8-17(30-3)9-7-16/h6-9,13-15,19H,4-5,10-12H2,1-3H3,(H,26,29)
InChiKey: XSSACTFNCROFKV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[1-(4-methoxyphenyl)-6,6-dimethyl-5,7-dihydro-4H-indazol-4-yl]-4-(1,2,4-triazol-1-yl)butyramide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.007	0.2901	0.0812
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0068	0.2794	0.2794
Loa Loa (eye worm)	SH2 domain-containing protein	0.007	0.2901	0.2901
Echinococcus multilocularis	SH2 motif	0.007	0.2901	0.2901
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.007	0.2901	0.2901
Brugia malayi	Sex muscle abnormal protein 5	0.0138	0.7095	0.7095
Entamoeba histolytica	hypothetical protein	0.0068	0.2794	0.2794
Loa Loa (eye worm)	hypothetical protein	0.007	0.2901	0.2901
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2794	0.2794
Loa Loa (eye worm)	hypothetical protein	0.007	0.2901	0.2901
Schistosoma mansoni	dreadlocks/dock	0.0068	0.2794	0.2794
Brugia malayi	SH2 domain containing protein	0.007	0.2901	0.2901
Echinococcus granulosus	growth factor receptor bound protein 2	0.0138	0.7095	0.7095
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0157	0.8302	0.8302
Echinococcus granulosus	glycylpeptide N tetradecanoyltransferase	0.0185	1	1
Brugia malayi	SH2 domain containing protein	0.0089	0.4108	0.4108
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2794	0.2794
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.007	0.2901	0.2901
Plasmodium falciparum	glycylpeptide N-tetradecanoyltransferase	0.0185	1	1
Echinococcus multilocularis	NCK adaptor protein	0.0138	0.7095	0.7095
Entamoeba histolytica	hypothetical protein	0.0068	0.2794	0.2794
Loa Loa (eye worm)	hypothetical protein	0.007	0.2901	0.2901
Loa Loa (eye worm)	hypothetical protein	0.007	0.2901	0.2901
Echinococcus multilocularis	tyrosine protein kinase shark	0.0089	0.4108	0.4108
Schistosoma mansoni	tyrosine kinase	0.0157	0.8302	0.8302
Entamoeba histolytica	hypothetical protein, conserved	0.0068	0.2794	0.2794
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0068	0.2794	0.2794
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.4108	0.4108
Entamoeba histolytica	hypothetical protein	0.0068	0.2794	0.2794
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2794	0.2794
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0476	0.0476
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.007	0.2901	0.2901
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0157	0.8302	0.8302
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0157	0.8302	0.8302
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.2794	0.2794
Schistosoma mansoni	tensin	0.007	0.2901	0.2901
Brugia malayi	SH2 domain containing protein	0.007	0.2901	0.2901
Trypanosoma cruzi	hypothetical protein, conserved	0.0068	0.2794	0.2794
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.007	0.2901	0.2901
Brugia malayi	Variant SH3 domain containing protein	0.0138	0.7095	0.7095
Echinococcus multilocularis	SHC transforming protein 3	0.007	0.2901	0.2901
Entamoeba histolytica	protein kinase, putative	0.007	0.2901	0.2901
Schistosoma mansoni	growth factor receptor-bound protein	0.0138	0.7095	0.7095
Loa Loa (eye worm)	hypothetical protein	0.007	0.2901	0.2901
Echinococcus multilocularis	endophilin A3	0.0068	0.2794	0.2794
Trichomonas vaginalis	neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative	0.0068	0.2794	0.2794
Schistosoma mansoni	tensin-related	0.007	0.2901	0.2901
Trypanosoma cruzi	paraflagellar rod protein 5, putative	0.0068	0.2794	0.2794
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0138	0.7095	0.7095
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.007	0.2901	0.2901
Entamoeba histolytica	hypothetical protein	0.0068	0.2794	0.2794
Brugia malayi	SH2 domain containing protein	0.007	0.2901	0.2901
Entamoeba histolytica	protein kinase, putative	0.0068	0.2794	0.2794
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0157	0.8302	0.8302
Echinococcus granulosus	Spectrin alpha actinin	0.0068	0.2794	0.2794
Trypanosoma cruzi	N-myristoyl transferase, putative	0.0185	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0157	0.8302	0.8302
Brugia malayi	SH3 domain containing protein	0.0068	0.2794	0.2794
Echinococcus multilocularis	tyrosine kinase	0.0089	0.4108	0.4108
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.2794	0.2794
Schistosoma mansoni	vav2	0.007	0.2901	0.2901
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0068	0.2794	0.2794
Schistosoma mansoni	GTPase activating protein	0.007	0.2901	0.2901
Brugia malayi	Variant SH3 domain containing protein	0.007	0.2901	0.2901
Echinococcus multilocularis	SH2 domain containing protein 7	0.007	0.2901	0.2901
Schistosoma mansoni	eps8-related protein	0.0068	0.2794	0.2794
Echinococcus granulosus	c src tyrosine kinase	0.0157	0.8302	0.8302
Echinococcus granulosus	SH2 domain containing adapter protein F	0.007	0.2901	0.2901
Brugia malayi	Peripheral plasma membrane protein CASK	0.0068	0.2794	0.2794
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.2794	0.2794
Loa Loa (eye worm)	protein-tyrosine kinase	0.0068	0.2794	0.2794
Entamoeba histolytica	hypothetical protein	0.0068	0.2794	0.2794
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.007	0.2901	0.0812
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0068	0.2794	0.2794
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0089	0.4108	0.4108
Brugia malayi	Protein kinase domain containing protein	0.0089	0.4108	0.4108
Brugia malayi	tRNA modification GTPase TrmE family protein	0.007	0.2901	0.2901
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.007	0.2901	0.2901
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2794	0.2794
Entamoeba histolytica	hypothetical protein, conserved	0.0068	0.2794	0.2794
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.007	0.2901	0.2901
Echinococcus multilocularis	signal transduction protein lnk realted	0.007	0.2901	0.2901
Brugia malayi	Variant SH3 domain containing protein	0.0068	0.2794	0.2794
Schistosoma mansoni	apoptosis stimulating of P53	0.0068	0.2794	0.2794
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0157	0.8302	0.8302
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.007	0.2901	0.2901
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0476	0.0476
Schistosoma mansoni	hypothetical protein	0.0068	0.2794	0.2794
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0157	0.8302	0.8302
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.0068	0.2794	0.2794
Loa Loa (eye worm)	hypothetical protein	0.007	0.2901	0.2901
Leishmania major	N-myristoyl transferase, putative	0.0185	1	1
Brugia malayi	Tensin	0.007	0.2901	0.2901
Echinococcus multilocularis	Spectrin alpha actinin	0.0068	0.2794	0.2794
Echinococcus granulosus	tyrosine protein kinase shark	0.0089	0.4108	0.4108
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0068	0.2794	0.2794
Trypanosoma cruzi	hypothetical protein, conserved	0.0068	0.2794	0.2794
Echinococcus multilocularis	expressed protein	0.0068	0.2794	0.2794
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.007	0.2901	0.2901
Onchocerca volvulus		0.0089	0.4108	1
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.2794	0.2794
Echinococcus granulosus	SH2 motif	0.007	0.2901	0.2901
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.4108	0.4108
Echinococcus granulosus	expressed conserved protein	0.007	0.2901	0.2901
Onchocerca volvulus		0.007	0.2901	0.0812
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.007	0.2901	0.2901
Echinococcus granulosus	NCK adaptor protein	0.0138	0.7095	0.7095
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.007	0.2901	0.2901
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0157	0.8302	0.8302
Brugia malayi	cytokine inducible SH2-containing protein 5	0.007	0.2901	0.2901
Schistosoma mansoni	run and tbc1 domain containing	0.0068	0.2794	0.2794
Loa Loa (eye worm)	hypothetical protein	0.007	0.2901	0.2901
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.4108	0.4108
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0476	0.0476
Echinococcus granulosus	suppressor of cytokine signaling 7	0.007	0.2901	0.2901
Echinococcus granulosus	expressed protein	0.0068	0.2794	0.2794
Brugia malayi	protein-tyrosine kinase	0.0068	0.2794	0.2794
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0068	0.2794	0.2794
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0068	0.2794	0.2794
Schistosoma mansoni	tyrosine kinase	0.0089	0.4108	0.4108
Brugia malayi	hypothetical protein	0.003	0.0476	0.0476
Giardia lamblia	CDC72	0.0185	1	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.2901	0.2901
Schistosoma mansoni	sorbin	0.0068	0.2794	0.2794
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0089	0.4108	0.4108
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0068	0.2794	0.2794
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.007	0.2901	0.2901
Schistosoma mansoni	nck2/grb4	0.0138	0.7095	0.7095
Brugia malayi	SH2 domain containing protein	0.007	0.2901	0.2901
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.007	0.2901	0.2901
Loa Loa (eye worm)	thyroid receptor interactor	0.0068	0.2794	0.2794
Echinococcus granulosus	SH2 motif	0.007	0.2901	0.2901
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.007	0.2901	0.2901
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.4108	0.4108
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0476	0.0476
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.2794	0.2794
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0157	0.8302	0.8302
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.4108	0.4108
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0068	0.2794	0.2794
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0157	0.8302	0.8302
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.4108	0.4108
Schistosoma mansoni	suppressor of cytokine signaling	0.007	0.2901	0.2901
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.4108	0.4108
Loa Loa (eye worm)	hypothetical protein	0.0089	0.4108	0.4108
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0068	0.2794	0.2794
Schistosoma mansoni	tyrosine kinase	0.0089	0.4108	0.4108
Brugia malayi	Tyrosine-protein kinase abl-1	0.0157	0.8302	0.8302
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0068	0.2794	0.2794
Brugia malayi	Src substrate cortactin	0.0068	0.2794	0.2794
Echinococcus granulosus	src region	0.0068	0.2794	0.2794
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0157	0.8302	0.8302
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0068	0.2794	0.2794
Loa Loa (eye worm)	hypothetical protein	0.007	0.2901	0.2901
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.2794	0.2794
Trypanosoma brucei	conserved protein	0.0068	0.2794	0.2794
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.007	0.2901	0.2901
Entamoeba histolytica	hypothetical protein	0.0068	0.2794	0.2794
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0157	0.8302	0.8302
Loa Loa (eye worm)	hypothetical protein	0.007	0.2901	0.2901
Trypanosoma cruzi	N-myristoyl transferase, putative	0.0185	1	1
Brugia malayi	Variant SH3 domain containing protein	0.007	0.2901	0.2901
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0476	1
Brugia malayi	Variant SH3 domain containing protein	0.0068	0.2794	0.2794
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0138	0.7095	0.7095
Schistosoma mansoni	tensin	0.007	0.2901	0.2901
Brugia malayi	Protein kinase domain containing protein	0.0089	0.4108	0.4108
Loa Loa (eye worm)	N-myristoyltransferase 2	0.0185	1	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.7095	0.7095
Echinococcus multilocularis	tensin	0.007	0.2901	0.2901
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.007	0.2901	0.2901
Entamoeba histolytica	glycylpeptide N-tetradecanoyltransferase, putative	0.0185	1	1
Echinococcus multilocularis	N chimaerin	0.007	0.2901	0.2901
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.007	0.2901	0.2901
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0068	0.2794	0.2794
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.007	0.2901	0.2901
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0157	0.8302	0.8302
Echinococcus granulosus	tyrosine kinase	0.0089	0.4108	0.4108
Loa Loa (eye worm)	TK protein kinase	0.0089	0.4108	0.4108
Onchocerca volvulus		0.0089	0.4108	1
Schistosoma mansoni	tyrosine kinase	0.0157	0.8302	0.8302
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0157	0.8302	0.8302
Schistosoma mansoni	suppressor of cytokine signaling	0.007	0.2901	0.2901
Trichomonas vaginalis	N-myristoyl transferase, putative	0.0122	0.609	0.609
Echinococcus granulosus	SH2 domain containing protein 7	0.007	0.2901	0.2901
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0089	0.4108	0.4108
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.007	0.2901	0.2901
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0089	0.4108	0.4108
Onchocerca volvulus		0.007	0.2901	0.0812
Echinococcus multilocularis	SH2 motif	0.007	0.2901	0.2901
Onchocerca volvulus		0.007	0.2901	0.0812
Loa Loa (eye worm)	guanylate kinase	0.0068	0.2794	0.2794
Brugia malayi	Variant SH3 domain containing protein	0.0068	0.2794	0.2794
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.007	0.2901	0.0812
Plasmodium vivax	glycylpeptide N-tetradecanoyltransferase, putative	0.0185	1	1
Brugia malayi	Myosin tail family protein	0.0068	0.2794	0.2794
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0089	0.4108	0.4108
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2794	0.2794
Brugia malayi	hypothetical protein	0.0089	0.4108	0.4108
Schistosoma mansoni	tensin-related	0.007	0.2901	0.2901
Echinococcus granulosus	intersectin 2	0.0068	0.2794	0.2794
Echinococcus granulosus	SHC transforming protein 3	0.007	0.2901	0.2901
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0068	0.2794	0.2794
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0068	0.2794	0.2794
Schistosoma mansoni	adapter molecule crk	0.0138	0.7095	0.7095
Brugia malayi	hypothetical protein	0.007	0.2901	0.2901
Echinococcus granulosus	tyrosine protein kinase Srms	0.0089	0.4108	0.4108
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0157	0.8302	0.8302
Loa Loa (eye worm)	SH2 domain-containing protein	0.007	0.2901	0.2901
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0157	0.8302	0.8302
Schistosoma mansoni	hypothetical protein	0.0068	0.2794	0.2794
Loa Loa (eye worm)	SRC-1	0.0157	0.8302	0.8302
Brugia malayi	Protein kinase domain containing protein	0.0089	0.4108	0.4108
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0476	0.0476
Schistosoma mansoni	cell polarity protein	0.0068	0.2794	0.2794
Brugia malayi	protein-tyrosine kinase	0.0089	0.4108	0.4108
Echinococcus multilocularis	transfer RNA-Ala	0.0068	0.2794	0.2794
Brugia malayi	SRC-1	0.0157	0.8302	0.8302
Echinococcus granulosus	tyrosine protein kinase Blk	0.0089	0.4108	0.4108
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2794	0.2794
Echinococcus multilocularis	intersectin 2	0.0068	0.2794	0.2794
Schistosoma mansoni	dynamin-associated protein	0.0068	0.2794	0.2794
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0068	0.2794	0.2794
Loa Loa (eye worm)	STAT protein	0.007	0.2901	0.2901
Echinococcus multilocularis	nostrin	0.0068	0.2794	0.2794
Loa Loa (eye worm)	hypothetical protein	0.007	0.2901	0.2901
Leishmania major	hypothetical protein, conserved	0.003	0.0476	0.0476
Schistosoma mansoni	serine/threonine protein kinase	0.0088	0.4001	0.4001
Echinococcus multilocularis	glycylpeptide N tetradecanoyltransferase	0.0185	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.007	0.2901	0.2901
Echinococcus granulosus	suppressor of cytokine signaling 6	0.007	0.2901	0.2901
Echinococcus granulosus	tyrosine protein kinase Src42A	0.007	0.2901	0.2901
Brugia malayi	Variant SH3 domain containing protein	0.0068	0.2794	0.2794
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0089	0.4108	0.4108
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.007	0.2901	0.2901
Trichomonas vaginalis	N-myristoyl transferase, putative	0.0185	1	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0138	0.7095	0.7095
Loa Loa (eye worm)	TK/ABL protein kinase	0.0089	0.4108	0.4108
Loa Loa (eye worm)	hypothetical protein	0.007	0.2901	0.2901
Onchocerca volvulus		0.0089	0.4108	1
Brugia malayi	Spectrin alpha chain	0.0068	0.2794	0.2794
Echinococcus granulosus	signal transduction protein lnk realted	0.007	0.2901	0.2901
Trypanosoma brucei	N-myristoyl transferase, putative	0.0185	1	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0476	0.0476
Entamoeba histolytica	SH2 domain containing protein	0.007	0.2901	0.2901
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.007	0.2901	0.2901
Brugia malayi	SH2 domain containing protein	0.0089	0.4108	0.4108
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.4108	0.4108
Schistosoma mansoni	shc transforming protein	0.007	0.2901	0.2901
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0068	0.2794	0.2794
Brugia malayi	Variant SH3 domain containing protein	0.0138	0.7095	0.7095
Entamoeba histolytica	unconventional myosin IB	0.0068	0.2794	0.2794
Onchocerca volvulus		0.007	0.2901	0.0812
Echinococcus granulosus	tyrosine kinase	0.0089	0.4108	0.4108
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0068	0.2794	0.2794
Loa Loa (eye worm)	p53BP2	0.0068	0.2794	0.2794
Leishmania major	hypothetical protein, conserved	0.0068	0.2794	0.2794
Schistosoma mansoni	tyrosine kinase	0.0157	0.8302	0.8302
Schistosoma mansoni	growth factor receptor-bound protein	0.0138	0.7095	0.7095
Echinococcus granulosus	endophilin A3	0.0068	0.2794	0.2794
Brugia malayi	STAT protein, DNA binding domain containing protein	0.007	0.2901	0.2901
Brugia malayi	Protein kinase domain containing protein	0.0089	0.4108	0.4108
Schistosoma mansoni	hypothetical protein	0.007	0.2901	0.2901
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2794	0.2794
Brugia malayi	RhoGAP domain containing protein	0.007	0.2901	0.2901
Entamoeba histolytica	hypothetical protein	0.0068	0.2794	0.2794
Echinococcus multilocularis	c src tyrosine kinase	0.0157	0.8302	0.8302
Trypanosoma cruzi	hypothetical protein, conserved	0.0068	0.2794	0.2794
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.4108	0.4108
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0157	0.8302	0.8302
Schistosoma mansoni	C-fyn	0.0068	0.2794	0.2794
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2794	0.2794
Echinococcus granulosus	N chimaerin	0.007	0.2901	0.2901
Schistosoma mansoni	N-myristoyltransferase	0.0185	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.2794	0.2794
Brugia malayi	Protein kinase domain containing protein	0.0089	0.4108	0.4108
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.007	0.2901	0.2901
Schistosoma mansoni	sorting nexin	0.0068	0.2794	0.2794
Schistosoma mansoni	tensin	0.007	0.2901	0.2901
Schistosoma mansoni	Dab2-interacting protein-like	0.0068	0.2794	0.2794
Schistosoma mansoni	formin binding protein and related proteins	0.0068	0.2794	0.2794
Trypanosoma brucei	N-myristoyltransferase	0.0185	1	1
Echinococcus multilocularis		0.007	0.2901	0.2901
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0138	0.7095	0.7095
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0089	0.4108	0.4108
Onchocerca volvulus		0.007	0.2901	0.0812
Echinococcus granulosus	tensin	0.007	0.2901	0.2901
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0157	0.8302	0.8302
Loa Loa (eye worm)	TK/FER protein kinase	0.0089	0.4108	0.4108
Echinococcus granulosus	nostrin	0.0068	0.2794	0.2794
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0089	0.4108	0.4108
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2794	0.2794
Onchocerca volvulus		0.0089	0.4108	1
Echinococcus granulosus	hypothetical protein	0.007	0.2901	0.2901
Brugia malayi	Variant SH3 domain containing protein	0.0068	0.2794	0.2794
Loa Loa (eye worm)	SH2 domain-containing protein	0.007	0.2901	0.2901
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.0068	0.2794	0.2794
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0157	0.8302	0.8302
Onchocerca volvulus		0.0089	0.4108	1
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0068	0.2794	0.2794
Schistosoma mansoni	tyrosine kinase	0.0157	0.8302	0.8302
Onchocerca volvulus		0.0089	0.4108	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0476	0.0476
Brugia malayi	SH2 domain containing protein	0.007	0.2901	0.2901
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0068	0.2794	0.2794
Brugia malayi	Guanylate kinase family protein	0.0068	0.2794	0.2794
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0157	0.8302	0.8302
Loa Loa (eye worm)	hypothetical protein	0.007	0.2901	0.2901
Echinococcus multilocularis	SH2 motif	0.007	0.2901	0.2901
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0089	0.4108	0.4108
Schistosoma mansoni	signal transduction protein lnk-related	0.007	0.2901	0.2901
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.007	0.2901	0.2901
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0157	0.8302	0.8302
Brugia malayi	SH2 domain containing protein	0.007	0.2901	0.2901
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.0068	0.2794	0.2794
Trichomonas vaginalis	p67phox protein, putative	0.0068	0.2794	0.2794
Entamoeba histolytica	hypothetical protein	0.0068	0.2794	0.2794
Echinococcus multilocularis	tensin	0.007	0.2901	0.2901
Schistosoma mansoni	hypothetical protein	0.007	0.2901	0.2901
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0068	0.2794	0.2794
Schistosoma mansoni	SH2A	0.007	0.2901	0.2901
Brugia malayi	SH2 domain containing protein	0.007	0.2901	0.2901
Loa Loa (eye worm)	hypothetical protein	0.007	0.2901	0.2901

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.1122 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.1472 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	0.6702 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1.5849 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1901550

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1539053