TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 239.289 | Formula: C10H6FNOS2
H donors: 1 H acceptors: 1 LogP: 2.9 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=C1NC(=S)SC1=Cc1ccc(cc1)F
InChi: 1S/C10H6FNOS2/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
InChiKey: BQOQSIQMDZUHKF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Rattus norvegicus	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania infantum	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania mexicana	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma congolense	serine/threonine-protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma brucei gambiense	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	Get druggable targets OG5_127901	All targets in OG5_127901
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania braziliensis	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Echinococcus granulosus	dual specificity	Get druggable targets OG5_127901	All targets in OG5_127901
Schistosoma japonicum	Serine/threonine-protein kinase minibrain, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma congolense	serine/threonine-protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127901	All targets in OG5_127901
Echinococcus multilocularis	dual specificity	Get druggable targets OG5_127901	All targets in OG5_127901
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania donovani	serine/threonine-protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127901	All targets in OG5_127901

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0307	0.0296
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0037	0.0093	0.0083
Brugia malayi	serine/threonine-protein kinase 6	0.1876	1	1
Entamoeba histolytica	protein kinase, putative	0.1876	1	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0046	0.0141	0.013
Echinococcus granulosus	tyrosine protein kinase HCK	0.003	0.0054	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0025	0.0014
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0046	0.0141	0.013
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0024	0.0025	0.0014
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0037	0.0093	0.0083
Brugia malayi	Nuclear hormone receptor-like 1	0.0046	0.0141	0.013
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0141	0.013
Schistosoma mansoni	nuclear hormone receptor	0.0046	0.0141	0.013
Schistosoma mansoni	thyroid hormone receptor	0.0046	0.0141	0.013
Brugia malayi	nuclear hormone receptor	0.0046	0.0141	0.013
Entamoeba histolytica	protein kinase, putative	0.003	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0141	0.013
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0024	0.0025	0.0014
Brugia malayi	nuclear receptor NHR-88	0.0046	0.0141	0.013
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0046	0.0141	0.013
Loa Loa (eye worm)	AUR protein kinase	0.1876	1	1
Trichomonas vaginalis	AGC family protein kinase	0.1876	1	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.0046	0.0141	0.013
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0307	0.0296
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0046	0.0141	0.013
Echinococcus granulosus	tyrosine kinase	0.0033	0.0074	0.0063
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0046	0.0141	0.013
Trichomonas vaginalis	AGC family protein kinase	0.1876	1	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0046	0.0141	0.013
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0123	0.0558	0.0547
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0046	0.0141	0.013
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.0025	0.0014
Schistosoma mansoni	retinoic acid receptor RXR	0.0046	0.0141	0.013
Trypanosoma cruzi	aurora B kinase, putative	0.1876	1	1
Loa Loa (eye worm)	AUR protein kinase	0.1876	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0046	0.0141	0.013
Echinococcus multilocularis	tyrosine protein kinase HCK	0.003	0.0054	0.0043
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0037	0.0093	0.0083
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0053	0.0179	0.0168
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0037	0.0093	0.0083
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0307	0.0296
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0046	0.0141	0.013
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0037	0.0093	0.0083
Echinococcus granulosus	ecdysone induced protein 78C	0.0046	0.0141	0.013
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0472	0.0462
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0046	0.0141	0.013
Entamoeba histolytica	protein kinase domain containing protein	0.1876	1	1
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.1876	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0046	0.0141	0.013
Loa Loa (eye worm)	steroid hormone receptor	0.0046	0.0141	0.013
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0046	0.0141	0.013
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0307	0.0296
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0037	0.0093	0.0083
Loa Loa (eye worm)	AUR protein kinase	0.1876	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0046	0.0141	0.013
Leishmania major	protein kinase, putative	0.1876	1	1
Entamoeba histolytica	protein kinase, putative	0.0123	0.0558	0.0558
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0307	0.0296
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0046	0.0141	0.013
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0046	0.0141	0.013
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0141	0.013
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0046	0.0141	0.013
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0307	0.0296
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.1876	1	1
Echinococcus granulosus	aurora kinase A	0.1876	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0046	0.0141	0.013
Brugia malayi	RNA binding protein	0.0076	0.0307	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0025	0.0014
Schistosoma mansoni	tyrosine kinase	0.0037	0.0093	0.0083
Schistosoma mansoni	protein kinase	0.1876	1	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0046	0.0141	0.013
Entamoeba histolytica	protein kinase , putative	0.1876	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0032	0.0068	0.0058
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0046	0.0141	0.013
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0037	0.0093	0.0083
Loa Loa (eye worm)	TK protein kinase	0.003	0.0054	0.0043
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0037	0.0093	0.0083
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0046	0.0141	0.013
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0046	0.0141	0.013
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0046	0.0141	0.013
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0032	0.0068	0.0058
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0046	0.0141	0.013
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0037	0.0093	0.0083
Echinococcus multilocularis	FTZ F1 alpha	0.0046	0.0141	0.013
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0046	0.0141	0.013
Echinococcus granulosus	tyrosine protein kinase Blk	0.0033	0.0074	0.0063
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0033	0.0074	0.0063
Mycobacterium tuberculosis	Arylamine N-acetyltransferase Nat (arylamine acetylase)	0.0763	0.4005	0.5
Brugia malayi	SRC-1	0.0037	0.0093	0.0083
Brugia malayi	protein-tyrosine kinase	0.0033	0.0074	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0141	0.013
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0037	0.0093	0.0083
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0046	0.0141	0.013
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0141	0.013
Onchocerca volvulus	Protein ultraspiracle homolog	0.0046	0.0141	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0046	0.0141	0.013
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.1876	1	1
Entamoeba histolytica	protein kinase, putative	0.1876	1	1
Brugia malayi	hypothetical protein	0.0024	0.0025	0.0014
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0307	0.0296
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0046	0.0141	0.013
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0024	0.0025	0.0014
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0046	0.0141	0.013
Brugia malayi	Protein kinase domain containing protein	0.0123	0.0558	0.0547
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0037	0.0093	0.0083
Brugia malayi	ecdysteroid receptor	0.0046	0.0141	0.013
Loa Loa (eye worm)	TK protein kinase	0.0033	0.0074	0.0063
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0307	0.0296
Brugia malayi	nuclear receptor RXR	0.0024	0.0025	0.0014
Plasmodium falciparum	serine/threonine protein kinase, putative	0.1876	1	0.5
Trichomonas vaginalis	AGC family protein kinase	0.1876	1	0.5
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.1876	1	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0141	0.013
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0037	0.0093	0.0083
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0046	0.0141	0.013
Echinococcus granulosus	dual specificity	0.0123	0.0558	0.0547
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.1876	1	1
Giardia lamblia	Aurora kinase	0.1876	1	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0037	0.0093	0.0083
Echinococcus multilocularis	dual specificity	0.0123	0.0558	0.0547
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0033	0.0074	0.0063
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0046	0.0141	0.013
Entamoeba histolytica	protein kinase domain containing protein	0.0123	0.0558	0.0558
Schistosoma mansoni	tyrosine kinase	0.0037	0.0093	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0141	0.013
Entamoeba histolytica	protein kinase, putative	0.0123	0.0558	0.0558
Schistosoma mansoni	serine/threonine protein kinase	0.0123	0.0558	0.0547
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0307	0.0296
Schistosoma mansoni	thyroid hormone receptor	0.0046	0.0141	0.013
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0046	0.0141	0.013
Echinococcus granulosus	FTZ F1 alpha	0.0046	0.0141	0.013
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0046	0.0141	0.013
Brugia malayi	steroid hormone receptor	0.0046	0.0141	0.013
Echinococcus multilocularis	aurora kinase A	0.1876	1	1
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.1876	1	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0046	0.0141	0.013
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0046	0.0141	0.013
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0046	0.0141	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0046	0.0141	0.013
Onchocerca volvulus	Bile acid receptor homolog	0.0046	0.0141	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0046	0.0141	0.013
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0046	0.0141	0.013
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0037	0.0093	0.0083
Trichomonas vaginalis	AGC family protein kinase	0.1876	1	0.5
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0046	0.0141	0.013
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0025	0.0014
Schistosoma mansoni	serine/threonine protein kinase	0.1876	1	1
Loa Loa (eye worm)	SRC-1	0.0037	0.0093	0.0083
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0033	0.0074	0.0063
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0307	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0141	0.013
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0024	0.0025	0.0014
Trypanosoma brucei	aurora B kinase	0.1876	1	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0046	0.0141	0.013
Mycobacterium ulcerans	arylamine N-acetyltransferase Nat	0.0763	0.4005	0.5
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0025	0.0014
Brugia malayi	Steroid receptor seven-up type 2	0.0046	0.0141	0.013
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0033	0.0074	0.0063
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0046	0.0141	0.013
Schistosoma mansoni	coup transcription factor	0.0046	0.0141	0.013
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0046	0.0141	0.013
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0025	0.0014
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0037	0.0093	0.0083
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0046	0.0141	0.013
Entamoeba histolytica	hypothetical protein	0.0123	0.0558	0.0558
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0307	0.0296
Brugia malayi	hypothetical protein	0.0024	0.0025	0.0014
Brugia malayi	serine/threonine kinase 12	0.1876	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.0025	0.0014
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0024	0.0025	0.0014
Toxoplasma gondii	aurora kinase	0.1876	1	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0037	0.0093	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0472	0.0462
Brugia malayi	TAR-binding protein	0.0076	0.0307	0.0296
Onchocerca volvulus		0.0046	0.0141	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0046	0.0141	0.013

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (binding)	= 0.622 uM	PUBCHEM_BIOASSAY: MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504442]	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1881824

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1542187