Detailed information for compound 1547487

Basic information

Technical information
  • TDR Targets ID: 1547487
  • Name: [3-[(3,4-dimethoxyphenyl)amino]piperidin-1-yl ]-quinoxalin-6-ylmethanone
  • MW: 392.451 | Formula: C22H24N4O3
  • H donors: 1 H acceptors: 3 LogP: 2.84 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1OC)NC1CCCN(C1)C(=O)c1ccc2c(c1)nccn2
  • InChi: 1S/C22H24N4O3/c1-28-20-8-6-16(13-21(20)29-2)25-17-4-3-11-26(14-17)22(27)15-5-7-18-19(12-15)24-10-9-23-18/h5-10,12-13,17,25H,3-4,11,14H2,1-2H3
  • InChiKey: KTVMVXPUAOAZRS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [3-[(3,4-dimethoxyphenyl)amino]-1-piperidyl]-quinoxalin-6-yl-methanone
  • [3-[(3,4-dimethoxyphenyl)amino]-1-piperidinyl]-(6-quinoxalinyl)methanone
  • [3-[(3,4-dimethoxyphenyl)amino]piperidin-1-yl]-quinoxalin-6-yl-methanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0763 0.5091 0.5091
Loa Loa (eye worm) hypothetical protein 0.0093 0.0538 0.0538
Schistosoma mansoni cathepsin F (C01 family) 0.0763 0.5091 0.5091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.5091 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0959 0.6423 0.6423
Giardia lamblia Cathepsin B precursor 0.0176 0.1104 0.1501
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0044 0.0206 0.0206
Echinococcus multilocularis geminin 0.009 0.0519 0.0519
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0763 0.5091 1
Schistosoma mansoni hypothetical protein 0.009 0.0519 0.0519
Schistosoma mansoni cathepsin S (C01 family) 0.0176 0.1104 0.1104
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0763 0.5091 0.5091
Giardia lamblia Hypothetical protein 0.0176 0.1104 0.1501
Giardia lamblia Cysteine protease 0.0176 0.1104 0.1501
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0036 0.0146 0.0146
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0176 0.1104 0.1104
Echinococcus multilocularis cathepsin b 0.1485 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0176 0.1104 0.1104
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0176 0.1104 0.1244
Loa Loa (eye worm) hypothetical protein 0.1485 1 1
Schistosoma mansoni cathepsin B (C01 family) 0.0176 0.1104 0.1104
Entamoeba histolytica cysteine proteinase, putative 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.5091 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0038 0.0165 0.0165
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0165 0.0165
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0176 0.1104 0.2159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0176 0.1104 0.1244
Giardia lamblia Cathepsin L precursor 0.0176 0.1104 0.1501
Echinococcus multilocularis cysteine protease 0.0763 0.5091 0.5091
Brugia malayi Cathepsin L-like precursor 0.0763 0.5091 0.5091
Plasmodium vivax vivapain-2 0.0763 0.5091 0.7496
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0038 0.0165 0.0165
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0038 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0763 0.5091 0.7496
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.5091 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1485 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0176 0.1104 0.1244
Loa Loa (eye worm) hypothetical protein 0.0244 0.1561 0.1561
Giardia lamblia Cathepsin L-like protease 0.0176 0.1104 0.1501
Plasmodium vivax unspecified product 0.0244 0.1561 0.0859
Onchocerca volvulus Cathepsin F homolog 0.0763 0.5091 1
Trypanosoma cruzi cysteine peptidase, putative 0.0763 0.5091 0.4812
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0015 0.0007 0.0007
Toxoplasma gondii cathepsin CPC2 0.0473 0.3123 0.4726
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0093 0.0538 0.0596
Giardia lamblia Cathepsin B precursor 0.0581 0.3856 0.5897
Toxoplasma gondii preprocathepsin c precursor, putative 0.0959 0.6423 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0763 0.5091 0.5091
Giardia lamblia Cysteine protease 0.0176 0.1104 0.1501
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0176 0.1104 0.1104
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0176 0.1104 0.1104
Schistosoma mansoni cathepsin C 0.0176 0.1104 0.1104
Loa Loa (eye worm) hypothetical protein 0.0176 0.1104 0.1104
Trypanosoma cruzi cysteine peptidase, putative 0.042 0.2761 0.2349
Brugia malayi Papain family cysteine protease containing protein 0.0176 0.1104 0.1104
Entamoeba histolytica cysteine protease, putative 0.0176 0.1104 0.2159
Brugia malayi Cathepsin L-like cysteine proteinase 0.0519 0.3435 0.3435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0176 0.1104 0.1244
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.1104 0.1104
Trypanosoma cruzi cysteine proteinase, putative 0.042 0.2761 0.2349
Loa Loa (eye worm) hypothetical protein 0.0176 0.1104 0.1104
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0176 0.1104 0.1244
Giardia lamblia Cathepsin B precursor 0.0176 0.1104 0.1501
Giardia lamblia Cathepsin L precursor 0.0176 0.1104 0.1501
Giardia lamblia Cathepsin B precursor 0.0176 0.1104 0.1501
Entamoeba histolytica cysteine proteinase, putative 0.042 0.2761 0.5416
Leishmania major cathepsin L-like protease 0.0763 0.5091 1
Loa Loa (eye worm) cathepsin B 0.0581 0.3856 0.3856
Trypanosoma cruzi major cysteine proteinase, putative 0.0176 0.1104 0.0599
Echinococcus multilocularis cathepsin b 0.1485 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0034 0.0133 0.0133
Giardia lamblia Cathepsin L precursor 0.0176 0.1104 0.1501
Trypanosoma cruzi cysteine peptidase, putative 0.0763 0.5091 0.4812
Giardia lamblia Cysteine protease 0.0176 0.1104 0.1501
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.042 0.2761 0.2349
Leishmania major cathepsin L-like protease 0.0763 0.5091 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0111 0.0111
Brugia malayi Papain family cysteine protease containing protein 0.0763 0.5091 0.5091
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1485 1 1
Echinococcus granulosus cathepsin L 0.0176 0.1104 0.1104
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0581 0.3856 0.3856
Brugia malayi cathepsin Z-like cysteine proteinase 0.0176 0.1104 0.1104
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Echinococcus granulosus cathepsin l cysteine peptidase 0.0763 0.5091 0.5091
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0176 0.1104 0.1244
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.042 0.2761 0.4882
Entamoeba histolytica cysteine protease, putative 0.0176 0.1104 0.2159
Onchocerca volvulus Cathepsin L homolog 0.0176 0.1104 0.1938
Toxoplasma gondii cathepsin B 0.0581 0.3856 0.5897
Loa Loa (eye worm) hypothetical protein 0.0044 0.0206 0.0206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0473 0.3123 0.4726
Trypanosoma cruzi cysteine peptidase, putative 0.0763 0.5091 0.4812
Brugia malayi cathepsin L precursor 0.0176 0.1104 0.1104
Plasmodium falciparum cysteine proteinase falcipain 1 0.042 0.2761 0.3114
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0176 0.1104 0.1244
Giardia lamblia Cathepsin B precursor 0.0581 0.3856 0.5897
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0146
Schistosoma mansoni transcription factor LCR-F1 0.0015 0.0007 0.0007
Brugia malayi cathepsin L-like precursor 0.0519 0.3435 0.3435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0473 0.3123 0.3794
Mycobacterium ulcerans hypothetical protein 0.0093 0.0538 0.5
Onchocerca volvulus 0.0763 0.5091 1
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Giardia lamblia Cathepsin B precursor 0.0176 0.1104 0.1501
Entamoeba histolytica cysteine protease, putative 0.0176 0.1104 0.2159
Schistosoma mansoni hypothetical protein 0.003 0.0111 0.0111
Plasmodium vivax unspecified product 0.042 0.2761 0.3114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Onchocerca volvulus 0.0519 0.3435 0.665
Echinococcus granulosus cathepsin L cysteine protease 0.042 0.2761 0.2761
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0093 0.0538 0.0538
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.1104 0.1104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.5091 1
Entamoeba histolytica cysteine proteinase, putative 0.0519 0.3435 0.6742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0176 0.1104 0.1244
Loa Loa (eye worm) hypothetical protein 0.0176 0.1104 0.1104
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0959 0.6423 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0176 0.1104 0.1244
Onchocerca volvulus 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Leishmania major cathepsin L-like protease 0.0763 0.5091 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0034 0.0133 0.0133
Echinococcus granulosus cathepsin b 0.1485 1 1
Echinococcus multilocularis cathepsin L 0.0176 0.1104 0.1104
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0959 0.6423 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0176 0.1104 0.1104
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0473 0.3123 0.3794
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1485 1 1
Onchocerca volvulus 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0176 0.1104 0.1244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.042 0.2761 0.4882
Entamoeba histolytica cysteine proteinase 1, putative 0.042 0.2761 0.5416
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0176 0.1104 0.1104
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0763 0.5091 0.5091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0176 0.1104 0.1244
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0244 0.1561 0.1561
Onchocerca volvulus Cathepsin L homolog 0.0763 0.5091 1
Entamoeba histolytica cysteine protease, putative 0.0763 0.5091 1
Echinococcus multilocularis cysteine protease 0.0763 0.5091 0.5091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.042 0.2761 0.2761
Giardia lamblia Cathepsin L precursor 0.0176 0.1104 0.1501
Entamoeba histolytica cysteine protease, putative 0.0176 0.1104 0.2159
Entamoeba histolytica cysteine proteinase, putative 0.042 0.2761 0.5416
Brugia malayi Cathepsin L-like precursor 0.0763 0.5091 0.5091
Echinococcus multilocularis cathepsin L cysteine protease 0.0763 0.5091 0.5091
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0581 0.3856 0.3506
Loa Loa (eye worm) hypothetical protein 0.0176 0.1104 0.1104
Leishmania major cysteine peptidase A (CPA) 0.0763 0.5091 1
Trichomonas vaginalis conserved hypothetical protein 0.0176 0.1104 0.1244
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.5091 1
Loa Loa (eye worm) hypothetical protein 0.0519 0.3435 0.3435
Entamoeba histolytica cysteine proteinase, putative 0.042 0.2761 0.5416
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0176 0.1104 0.1244
Loa Loa (eye worm) hypothetical protein 0.0519 0.3435 0.3435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0519 0.3435 0.6362
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.5091 1
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Loa Loa (eye worm) hypothetical protein 0.0244 0.1561 0.1561
Onchocerca volvulus 0.0763 0.5091 1
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0093 0.0538 0.1044
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0157 0.0974 0.0974
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Brugia malayi Calcitonin receptor-like protein seb-1 0.0044 0.0206 0.0206
Trichomonas vaginalis conserved hypothetical protein 0.0176 0.1104 0.1244
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0763 0.5091 1
Onchocerca volvulus 0.0763 0.5091 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0959 0.6423 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0176 0.1104 0.1104
Toxoplasma gondii cathepsin CPC1 0.0959 0.6423 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0473 0.3123 0.4726
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0038 0.0165 0.0165
Entamoeba histolytica cysteine proteinase, putative 0.042 0.2761 0.5416
Trypanosoma cruzi cysteine peptidase, putative 0.0763 0.5091 0.4812
Trypanosoma cruzi cysteine peptidase, putative 0.0244 0.1561 0.1081
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.042 0.2761 0.2761
Echinococcus granulosus cathepsin L cysteine proteinase 0.0763 0.5091 0.5091
Giardia lamblia Encystation-specific protease 0.0473 0.3123 0.4726
Echinococcus granulosus tm gpcr rhodopsin 0.0157 0.0974 0.0974
Echinococcus granulosus cathepsin l1 0.0763 0.5091 0.5091
Entamoeba histolytica cysteine protease, putative 0.0176 0.1104 0.2159
Schistosoma mansoni cathepsin s 0.0244 0.1561 0.1561
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.5091 1
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0176 0.1104 0.1244
Leishmania major cathepsin L-like protease 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0015 0.0007 0.0007
Brugia malayi fibroinase precursor 0.0176 0.1104 0.1104
Echinococcus granulosus cathepsin L 0.042 0.2761 0.2761
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0763 0.5091 0.7496
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0959 0.6423 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0519 0.3435 0.6362
Loa Loa (eye worm) hypothetical protein 0.0244 0.1561 0.1561
Leishmania major cathepsin L-like protease 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0176 0.1104 0.1244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0176 0.1104 0.1244
Loa Loa (eye worm) hypothetical protein 0.0519 0.3435 0.3435
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0959 0.6423 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0176 0.1104 0.1244
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.1104 0.1104
Trypanosoma cruzi cysteine protease, putative 0.042 0.2761 0.2349
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0176 0.1104 0.1104
Brugia malayi Cathepsin L-like precursor 0.0519 0.3435 0.3435
Loa Loa (eye worm) cysteine protease 0.0763 0.5091 0.5091
Leishmania major cathepsin L-like protease 0.0763 0.5091 1
Giardia lamblia Cathepsin B precursor 0.0581 0.3856 0.5897
Schistosoma mansoni hypothetical protein 0.0015 0.0007 0.0007
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0763 0.5091 0.7496
Onchocerca volvulus Cathepsin L homolog 0.0763 0.5091 1
Echinococcus multilocularis cathepsin L 0.042 0.2761 0.2761
Loa Loa (eye worm) hypothetical protein 0.0077 0.0429 0.0429
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1485 1 1
Toxoplasma gondii cathepsin CPL 0.0763 0.5091 0.7872
Echinococcus granulosus cysteine protease 0.042 0.2761 0.2761
Entamoeba histolytica cysteine protease, putative 0.0176 0.1104 0.2159
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0244 0.1561 0.1561
Brugia malayi Cathepsin L-like precursor 0.0763 0.5091 0.5091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0034 0.0133 0.0133
Echinococcus multilocularis cathepsin L cysteine protease 0.0763 0.5091 0.5091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Schistosoma mansoni cathepsin F (C01 family) 0.0763 0.5091 0.5091
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0038 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0581 0.3856 0.7286
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Giardia lamblia Hypothetical protein 0.0176 0.1104 0.1501
Loa Loa (eye worm) hypothetical protein 0.0763 0.5091 0.5091
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0763 0.5091 0.5091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.042 0.2761 0.4882
Loa Loa (eye worm) fibroinase 0.0763 0.5091 0.5091
Brugia malayi Cathepsin L-like precursor 0.0763 0.5091 0.5091
Schistosoma mansoni hypothetical protein 0.009 0.0519 0.0519
Brugia malayi Papain family cysteine protease containing protein 0.042 0.2761 0.2761
Trypanosoma brucei cysteine peptidase C (CPC) 0.0581 0.3856 0.7286
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0176 0.1104 0.2159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0176 0.1104 0.1501
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0176 0.1104 0.1104
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0581 0.3856 0.7286
Brugia malayi cathepsin F-like cysteine proteinase 0.0244 0.1561 0.1561
Leishmania major cathepsin L-like protease 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.5091 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0176 0.1104 0.1104
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0519 0.3435 0.3062
Entamoeba histolytica cysteine proteinase, putative 0.0763 0.5091 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Trypanosoma cruzi cruzipain precursor, putative 0.0244 0.1561 0.1081
Plasmodium vivax vivapain-3 0.042 0.2761 0.3114
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0662 0.4405 0.8493
Brugia malayi Cathepsin L-like precursor 0.0519 0.3435 0.3435
Onchocerca volvulus 0.0763 0.5091 1
Brugia malayi Papain family cysteine protease containing protein 0.042 0.2761 0.2761
Trypanosoma cruzi cruzipain precursor, putative 0.0763 0.5091 0.4812
Brugia malayi latrophilin 2 splice variant baaae 0.003 0.0111 0.0111
Onchocerca volvulus 0.0176 0.1104 0.1938
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Entamoeba histolytica cysteine proteinase 2 0.042 0.2761 0.5416
Brugia malayi Cathepsin L-like precursor 0.0763 0.5091 0.5091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Plasmodium vivax vivapain-2 0.0763 0.5091 0.7496
Loa Loa (eye worm) hypothetical protein 0.0033 0.013 0.013
Brugia malayi Cathepsin L-like precursor 0.0244 0.1561 0.1561
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0036 0.0146 0.0146
Plasmodium vivax vivapain-1 0.042 0.2761 0.3114
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0176 0.1104 0.1104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Onchocerca volvulus 0.0763 0.5091 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1485 1 1
Entamoeba histolytica hypothetical protein 0.0176 0.1104 0.2159
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.1104 0.1104
Trypanosoma cruzi major cysteine proteinase, putative 0.0176 0.1104 0.0599
Trypanosoma cruzi cysteine proteinase, putative 0.042 0.2761 0.2349
Brugia malayi Papain family cysteine protease containing protein 0.0176 0.1104 0.1104
Leishmania major cathepsin L-like protease 0.0763 0.5091 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.1104 0.1104
Echinococcus granulosus cathepsin l1 0.0519 0.3435 0.3435
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0146
Giardia lamblia Cathepsin B precursor 0.0176 0.1104 0.1501
Schistosoma mansoni cathepsin F (C01 family) 0.0519 0.3435 0.3435
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0034 0.0133 0.0133
Giardia lamblia Cathepsin L precursor 0.0176 0.1104 0.1501
Giardia lamblia Cathepsin L-like protease 0.0176 0.1104 0.1501
Echinococcus granulosus cathepsin b 0.1485 1 1
Giardia lamblia Cysteine protease 0.0176 0.1104 0.1501
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.042 0.2761 0.2761
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.042 0.2761 0.4882
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Giardia lamblia Cathepsin L precursor 0.0176 0.1104 0.1501
Loa Loa (eye worm) ctsf protein 0.0763 0.5091 0.5091
Loa Loa (eye worm) hypothetical protein 0.0176 0.1104 0.1104
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0044 0.0206 0.0206
Brugia malayi Cation transporter family protein 0.0036 0.0146 0.0146
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.1104 0.1104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Echinococcus granulosus geminin 0.009 0.0519 0.0519

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2512 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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