Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0251 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0251 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0251 | 0.0798 |
Mycobacterium ulcerans | ornithine aminotransferase RocD1 and RocD2 | 0.0023 | 0.0058 | 0.0184 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0038 | 0.0251 | 0.0798 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0251 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0251 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0251 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0.0251 | 0.0798 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0251 | 1 |
Mycobacterium ulcerans | L-lysine aminotransferase | 0.0263 | 0.3151 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0251 | 0.0798 |
Schistosoma mansoni | ornithine--oxo-acid transaminase | 0.0023 | 0.0058 | 0.2304 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0023 | 0.0058 | 0.0058 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0038 | 0.0251 | 0.0798 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0038 | 0.0251 | 0.0798 |
Mycobacterium ulcerans | acetylornithine aminotransferase | 0.0023 | 0.0058 | 0.0184 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.0251 | 1 |
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | 0.0263 | 0.3151 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0251 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0.0251 | 0.0798 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0251 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0251 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0251 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0038 | 0.0251 | 0.0798 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0251 | 1 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0023 | 0.0058 | 0.5 |
Echinococcus granulosus | ornithine aminotransferase | 0.0023 | 0.0058 | 0.2304 |
Mycobacterium tuberculosis | Probable aminotransferase | 0.0023 | 0.0058 | 0.0184 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0251 | 0.0798 |
Onchocerca volvulus | 0.0038 | 0.0251 | 0.5 | |
Mycobacterium ulcerans | 4-aminobutyrate aminotransferase | 0.0023 | 0.0058 | 0.0184 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0251 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0251 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0251 | 1 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0023 | 0.0058 | 0.5 |
Mycobacterium tuberculosis | Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) | 0.0023 | 0.0058 | 0.0184 |
Onchocerca volvulus | 0.0038 | 0.0251 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0251 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0058 | 0.0184 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0251 | 0.0798 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0.0251 | 0.0798 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0245 | 0.2925 | 0.9284 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.0251 | 1 |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.0023 | 0.0058 | 0.0184 |
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | 0.0263 | 0.3151 | 1 |
Echinococcus multilocularis | Aminotransferase class III | 0.0023 | 0.0058 | 0.0058 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0251 | 0.0798 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0251 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0251 | 0.0798 |
Mycobacterium tuberculosis | Probable acetylornithine aminotransferase ArgD | 0.0023 | 0.0058 | 0.0184 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.0251 | 1 |
Plasmodium falciparum | ornithine aminotransferase | 0.0023 | 0.0058 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0038 | 0.0251 | 0.0798 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0251 | 0.0251 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0251 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0251 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0251 | 1 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0023 | 0.0058 | 0.2304 |
Onchocerca volvulus | 0.0038 | 0.0251 | 0.5 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0251 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0038 | 0.0251 | 0.0798 |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.0023 | 0.0058 | 0.0184 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0.0251 | 1 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0251 | 0.0798 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0251 | 0.0798 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0038 | 0.0251 | 0.0798 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0.0251 | 0.0798 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.0251 | 1 |
Mycobacterium ulcerans | 4-aminobutyrate aminotransferase | 0.0023 | 0.0058 | 0.0184 |
Mycobacterium tuberculosis | Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) | 0.0023 | 0.0058 | 0.0184 |
Mycobacterium ulcerans | glutamate-1-semialdehyde aminotransferase | 0.0023 | 0.0058 | 0.0184 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0023 | 0.0058 | 0.0058 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | Aminotransferase class III | 0.0023 | 0.0058 | 0.2304 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.