Detailed information for compound 1549701

Basic information

Technical information
  • TDR Targets ID: 1549701
  • Name: N-[(4-fluorophenyl)methyl]-1-(1,3,3-trimethyl -2-oxoindol-5-yl)sulfonylpiperidine-4-carboxa mide
  • MW: 473.56 | Formula: C24H28FN3O4S
  • H donors: 1 H acceptors: 4 LogP: 2.4 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCN(CC1)S(=O)(=O)c1ccc2c(c1)C(C)(C)C(=O)N2C)NCc1ccc(cc1)F
  • InChi: 1S/C24H28FN3O4S/c1-24(2)20-14-19(8-9-21(20)27(3)23(24)30)33(31,32)28-12-10-17(11-13-28)22(29)26-15-16-4-6-18(25)7-5-16/h4-9,14,17H,10-13,15H2,1-3H3,(H,26,29)
  • InChiKey: MSBKRQGIWZAZRY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(4-fluorophenyl)methyl]-1-(1,3,3-trimethyl-2-oxo-indolin-5-yl)sulfonyl-piperidine-4-carboxamide
  • N-[(4-fluorophenyl)methyl]-1-[(1,3,3-trimethyl-2-oxo-5-indolinyl)sulfonyl]-4-piperidinecarboxamide
  • N-(4-fluorobenzyl)-1-(2-keto-1,3,3-trimethyl-indolin-5-yl)sulfonyl-isonipecotamide
  • N-[(4-fluorophenyl)methyl]-1-(1,3,3-trimethyl-2-oxo-indol-5-yl)sulfonyl-piperidine-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0017 0.012 0.0244
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0419 0.701 1
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0045 0.0606 0.5862
Echinococcus multilocularis deoxyribonuclease 1 2 0.0014 0.0062 0.0077
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0068 0.099 0.1336
Mycobacterium ulcerans NADH dehydrogenase I subunit F 0.0028 0.0299 0.0199
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0205 0.3336 0.3295
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0205 0.3336 0.3267
Brugia malayi Pre-SET motif family protein 0.0043 0.0561 0.1136
Trichomonas vaginalis set domain proteins, putative 0.034 0.5649 0.8041
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0045 0.0606 0.5862
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.004 0.004
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.004 0.004
Schistosoma mansoni thyroid hormone receptor 0.0012 0.004 0.004
Echinococcus granulosus Polycystic kidney disease protein 0.0017 0.012 0.012
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0018 0.0132 0.01
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.004 0.008
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0018 0.0132 0.01
Schistosoma mansoni hypothetical protein 0.005 0.0691 0.0691
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.004 0.008
Echinococcus granulosus NADH dehydrogenase ubiquinone flavoprotein 1 0.0028 0.0299 0.0299
Echinococcus granulosus lipoxygenase domain containing protein 0.0017 0.012 0.012
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.004 0.004
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.004 0.008
Schistosoma mansoni microtubule-associated protein tau 0.0483 0.8102 0.8102
Echinococcus multilocularis transcription factor Dp 1 0.0027 0.0286 0.0353
Brugia malayi Cytochrome P450 family protein 0.0037 0.0455 0.092
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0045 0.0606 0.1227
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0014 0.0062 0.0126
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.004 0.004
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0014 0.0062 0.0126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.004 0.0077
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0077
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0.0028 0.0299 0.2549
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0241
Schistosoma mansoni thyroid hormone receptor 0.0012 0.004 0.004
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0018 0.0132 0.0132
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0419 0.701 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0014 0.0062 0.0123
Onchocerca volvulus NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog 0.0015 0.008 0.0072
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0046 0.0619 0.0801
Brugia malayi NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor 0.0028 0.0299 0.0605
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0043 0.0561 0.0561
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.004 0.0077
Trichomonas vaginalis ap endonuclease, putative 0.0068 0.099 0.1336
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0046 0.0619 0.0619
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0018 0.0132 0.01
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0205 0.3336 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.004 0.008
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) 0.0028 0.0299 0.0238
Echinococcus granulosus transcription factor Dp 1 0.0027 0.0286 0.0286
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0102 0.0204
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0419 0.701 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0052 0.0711 0.0711
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0014 0.0062 0.0123
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.004 0.004
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0028 0.0299 0.0341
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0419 0.701 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0046 0.0619 0.5999
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0068 0.099 0.0934
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0018 0.0132 0.01
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0014 0.0062 0.0126
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0419 0.701 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0018 0.0132 0.0132
Echinococcus granulosus histone lysine methyltransferase setb 0.0043 0.0561 0.0561
Trichomonas vaginalis ap endonuclease, putative 0.0068 0.099 0.1336
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0028 0.0299 0.2549
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0102 0.1579 0.1949
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0045 0.0606 0.5862
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0014 0.0062 0.0077
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.004 0.0077
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0046 0.0619 0.0619
Echinococcus multilocularis Ankyrin 0.001 0.0001 0.0002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0068 0.099 0.1336
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0014 0.0062 0.0126
Echinococcus multilocularis traf and tnf receptor associated protein 0.0014 0.0062 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0043 0.0561 0.0561
Schistosoma mansoni carbon catabolite repressor protein 0.0014 0.0062 0.0062
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0046 0.0619 0.5999
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.004 0.008
Brugia malayi NADH dehydrogenase subunit 1 0.016 0.2566 0.5192
Onchocerca volvulus 0.034 0.565 1
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0014 0.0062 0.0077
Echinococcus multilocularis microtubule associated protein 2 0.0483 0.8102 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0043 0.0561 0.0561
Schistosoma mansoni loxhd1 0.0017 0.012 0.012
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0018 0.0132 0.0163
Brugia malayi exodeoxyribonuclease III family protein 0.0068 0.099 0.2004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0062 0.0123
Schistosoma mansoni neutral sphingomyelinase 0.0014 0.0062 0.0062
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0028 0.0299 0.0299
Treponema pallidum fructose-bisphosphate aldolase 0.0419 0.701 1
Echinococcus granulosus Ankyrin 0.001 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.004 0.008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.004 0.008
Schistosoma mansoni rab6-interacting 0.0017 0.012 0.012
Echinococcus granulosus synaptojanin 1 0.0014 0.0062 0.0062
Onchocerca volvulus 0.0014 0.0062 0.004
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0014 0.0062 0.0126
Echinococcus multilocularis lipoxygenase domain containing protein 0.0017 0.012 0.0149
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0043 0.0561 0.0693
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.004 0.004
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0014 0.0062 0.0126
Onchocerca volvulus 0.0017 0.012 0.0144
Brugia malayi NADH dehydrogenase subunit 1, identical 0.016 0.2566 0.5192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.004 0.0077
Loa Loa (eye worm) hypothetical protein 0.0043 0.0561 0.1133
Loa Loa (eye worm) NADH dehydrogenase subunit 1 0.016 0.2566 0.519
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0045 0.0606 0.1227
Onchocerca volvulus 0.0014 0.0062 0.004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.004 0.0049
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.004 0.004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.004 0.008
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0045 0.0606 0.5862
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.004 0.008
Schistosoma mansoni ap endonuclease 0.0068 0.099 0.099
Leishmania major NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0028 0.0299 0.2549
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0068 0.099 0.1222
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.004 0.008
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.004 0.0049
Schistosoma mansoni synaptojanin 0.0014 0.0062 0.0062
Schistosoma mansoni lipoxygenase 0.0102 0.1579 0.1579
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0077
Loa Loa (eye worm) hypothetical protein 0.0014 0.0062 0.0123
Brugia malayi steroid hormone receptor 0.0012 0.004 0.008
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.004 0.004
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0028 0.0299 0.0341
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0068 0.099 1
Loa Loa (eye worm) doublecortin family protein 0.0017 0.012 0.0241
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0018 0.0132 0.0747
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0068 0.099 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.004 0.0049
Schistosoma mansoni synaptojanin 0.0014 0.0062 0.0062
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 51 kDa subunit 0.0028 0.0299 0.0602
Onchocerca volvulus 0.0017 0.012 0.0144
Echinococcus multilocularis lipoxygenase domain containing protein 0.0017 0.012 0.0149
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0102 0.0431
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0077
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0068 0.099 0.0713
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0102 0.0204
Brugia malayi Zinc finger, C2H2 type family protein 0.0018 0.0132 0.0266
Brugia malayi nuclear receptor NHR-88 0.0012 0.004 0.008
Mycobacterium ulcerans NADH dehydrogenase subunit H 0.0594 1 1
Plasmodium vivax SET domain protein, putative 0.0043 0.0561 0.5375
Schistosoma mansoni ap endonuclease 0.0068 0.099 0.099
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0068 0.099 0.2002
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0014 0.0062 0.0062
Echinococcus granulosus traf and tnf receptor associated protein 0.0014 0.0062 0.0062
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0299 0.4942 1
Brugia malayi Cytochrome P450 family protein 0.0016 0.0102 0.0207
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0043 0.0561 0.5375
Schistosoma mansoni hypothetical protein 0.0017 0.012 0.012
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0068 0.099 1
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) 0.0594 1 1
Brugia malayi nuclear hormone receptor 0.0012 0.004 0.008
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0077
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.004 0.004
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0014 0.0062 0.0077
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.001 0.0001 0.0001
Brugia malayi ecdysteroid receptor 0.0012 0.004 0.008
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.004 0.0077
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0018 0.0132 0.01
Leishmania major cytochrome p450-like protein 0.0016 0.0102 0.0431
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0045 0.0606 0.0509
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative 0.0028 0.0299 0.2549
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0018 0.0132 0.0163
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0077
Schistosoma mansoni nuclear hormone receptor 0.0012 0.004 0.004
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0102 0.0431
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0014 0.0062 0.0126
Onchocerca volvulus Putative neutral sphingomyelinase 0.0014 0.0062 0.004
Giardia lamblia Fructose-bisphosphate aldolase 0.0419 0.701 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.004 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.004 0.0077
Onchocerca volvulus 0.016 0.2566 0.4503
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0014 0.0062 0.0062
Echinococcus multilocularis neutral sphingomyelinase 0.0014 0.0062 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0419 0.701 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0077
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.004 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0561 0.0561
Brugia malayi Pre-SET motif family protein 0.0299 0.4942 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0014 0.0062 0.0123
Echinococcus multilocularis synaptojanin 1 0.0014 0.0062 0.0077
Schistosoma mansoni hypothetical protein 0.0014 0.0062 0.0062
Echinococcus granulosus lipoxygenase domain containing protein 0.0017 0.012 0.012
Toxoplasma gondii exonuclease III APE 0.0068 0.099 1
Brugia malayi hypothetical protein 0.0017 0.012 0.0244
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0046 0.0619 0.125
Echinococcus granulosus microtubule associated protein 2 0.0483 0.8102 0.8102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.004 0.0077
Echinococcus granulosus FTZ F1 alpha 0.0012 0.004 0.004
Schistosoma mansoni coup transcription factor 0.0012 0.004 0.004
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0046 0.0619 0.5999
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.004 0.008
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0014 0.0062 0.0062
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0014 0.0062 0.0062
Treponema pallidum exodeoxyribonuclease (exoA) 0.0068 0.099 0.1336
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0102 0.0431
Schistosoma mansoni rab6-interacting 0.0017 0.012 0.012
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0014 0.0062 0.0126
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.004 0.008
Schistosoma mansoni NADH dehydrogenase subunit 1 0.016 0.2566 0.2566
Plasmodium falciparum dihydroorotate dehydrogenase 0.0045 0.0606 0.5862
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0077
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0041 0.0534 0.0534
Onchocerca volvulus 0.016 0.2566 0.4503
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0045 0.0606 0.0547
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0014 0.0062 0.0126
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0052 0.0711 0.0877
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0077
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.004 0.004
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.004 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0419 0.701 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0043 0.0561 0.0693
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.004 0.004
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0046 0.0619 0.0764
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0419 0.701 1
Echinococcus granulosus neutral sphingomyelinase 0.0014 0.0062 0.0062
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0018 0.0132 0.01
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0068 0.099 0.099
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.004 0.008
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.004 0.004
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.004 0.004
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0046 0.0619 0.1253
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.004 0.0049
Loa Loa (eye worm) hypothetical protein 0.0014 0.0062 0.0123
Brugia malayi Doublecortin family protein 0.0017 0.012 0.0244
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0455 0.0918
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.004 0.008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.004 0.004
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0014 0.0062 0.0123
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0045 0.0606 0.5862
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.004 0.0049
Mycobacterium tuberculosis Possible formate hydrogenlyase HycD (FHL) 0.016 0.2566 0.2519
Brugia malayi Cytochrome P450 family protein 0.0016 0.0102 0.0207
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0068 0.099 1
Brugia malayi CCR4 0.0014 0.0062 0.0126
Echinococcus multilocularis RUN 0.0017 0.012 0.0149
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0028 0.0299 0.2549
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0014 0.0062 0.0123
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) flavoprotein 1 0.0028 0.0299 0.0369
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0045 0.0606 0.0317
Onchocerca volvulus 0.0043 0.0561 0.093
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0102 0.0204
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.004 0.004
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0068 0.099 0.0897
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0419 0.701 1
Schistosoma mansoni hypothetical protein 0.0594 1 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0014 0.0062 0.0123
Echinococcus granulosus RUN 0.0017 0.012 0.012
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0068 0.099 1
Brugia malayi hypothetical protein 0.016 0.2566 0.5192
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.004 0.008
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.004 0.004
Schistosoma mansoni nocturnin 0.0014 0.0062 0.0062
Plasmodium vivax multidomain scavenger receptor, putative 0.0017 0.012 0.0625
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0068 0.099 1
Mycobacterium ulcerans formate hydrogenlyase HycD 0.016 0.2566 0.2489
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0419 0.701 1
Schistosoma mansoni cript-related 0.0014 0.0062 0.0062
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0045 0.0606 0.5862
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0046 0.0619 0.5999
Schistosoma mansoni dihydroorotate dehydrogenase 0.0045 0.0606 0.0606
Echinococcus multilocularis Polycystic kidney disease protein 0.0017 0.012 0.0149
Leishmania major dihydroorotate dehydrogenase 0.0045 0.0606 0.5862
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0018 0.0132 0.01
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.004 0.0049
Schistosoma mansoni lipoxygenase 0.0071 0.1052 0.1052
Plasmodium falciparum LCCL domain-containing protein 0.0017 0.012 0.0625
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.004 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.004 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.004 0.008
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0241
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0102 0.1579 0.1579
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase subunit H 0.0594 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0062 0.0123
Schistosoma mansoni polycystin 1-related 0.0017 0.012 0.012

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1042 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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