Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0013 | 0.0356 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.2989 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.011 | 1 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.011 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0013 | 0.0356 | 0.0356 |
Loa Loa (eye worm) | brahma associated protein | 0.011 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.011 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0039 | 0.2989 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.2989 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.2989 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.2989 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0039 | 0.2989 | 1 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0039 | 0.2989 | 1 |
Schistosoma mansoni | hypothetical protein | 0.011 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.2989 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.011 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0356 | 0.0356 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0039 | 0.2989 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.011 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0039 | 0.2989 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.011 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.011 | 1 | 1 |
Schistosoma mansoni | brg-1 associated factor | 0.011 | 1 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0039 | 0.2989 | 0.273 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.2989 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.011 | 1 | 0.5 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.011 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0039 | 0.2989 | 0.273 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2989 | 0.2989 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.2989 | 1 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0039 | 0.2989 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.2989 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0356 | 0.0356 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.011 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.011 | 1 | 1 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.011 | 1 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0039 | 0.2989 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.2989 | 1 |
Schistosoma mansoni | hypothetical protein | 0.011 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.2989 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.011 | 1 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0039 | 0.2989 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2989 | 0.2989 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2989 | 0.2989 |
Schistosoma mansoni | hypothetical protein | 0.011 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2989 | 0.2989 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0039 | 0.2989 | 0.273 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.011 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.011 | 1 | 0.5 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.011 | 1 | 1 |
Onchocerca volvulus | 0.011 | 1 | 1 | |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0039 | 0.2989 | 0.273 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2989 | 0.2989 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.011 | 1 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0039 | 0.2989 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0039 | 0.2989 | 0.273 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.011 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.