Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0397 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0114 | 0.0114 |
Echinococcus granulosus | 6 phosphogluconate dehydrogenase | 0.0184 | 0.3846 | 0.3846 |
Schistosoma mansoni | peroxidasin | 0.0397 | 1 | 1 |
Toxoplasma gondii | 6-phosphogluconate dehydrogenase | 0.0184 | 0.3846 | 1 |
Echinococcus multilocularis | 6 phosphogluconate dehydrogenase | 0.0184 | 0.3846 | 0.3846 |
Giardia lamblia | 6-phosphogluconate dehydrogenase, decarboxylating | 0.0184 | 0.3846 | 1 |
Mycobacterium tuberculosis | Probable 6-phosphogluconate dehydrogenase, decarboxylating Gnd2 | 0.0184 | 0.3846 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0114 | 0.0114 |
Plasmodium falciparum | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0184 | 0.3846 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0114 | 0.0114 |
Trichomonas vaginalis | 3-hydroxyisobutyrate dehydrogenase, putative | 0.0184 | 0.3846 | 0.5 |
Trypanosoma cruzi | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0184 | 0.3846 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Treponema pallidum | 6-phosphogluconate dehydrogenase | 0.0184 | 0.3846 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0397 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0114 | 0.0114 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0114 | 0.0114 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0114 | 0.0114 |
Schistosoma mansoni | 6-phosphogluconate dehydrogenase | 0.0184 | 0.3846 | 0.3846 |
Onchocerca volvulus | Peroxidase homolog | 0.0397 | 1 | 1 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE GND1 | 0.0184 | 0.3846 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0114 | 0.0114 |
Mycobacterium tuberculosis | Probable 6-phosphogluconate dehydrogenase Gnd1 | 0.0184 | 0.3846 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0397 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Plasmodium vivax | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0184 | 0.3846 | 0.5 |
Onchocerca volvulus | 0.0397 | 1 | 1 | |
Schistosoma mansoni | transcription initiation factor iia (tfiia) gamma chain | 0.0074 | 0.0671 | 0.0671 |
Brugia malayi | Peroxidasin | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Trypanosoma cruzi | 6-phosphogluconate dehydrogenase, decarboxylating | 0.011 | 0.1691 | 0.3213 |
Brugia malayi | Animal haem peroxidase family protein | 0.0397 | 1 | 1 |
Trypanosoma brucei | 6-phosphogluconate dehydrogenase, decarboxylating | 0.0184 | 0.3846 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0397 | 1 | 1 |
Leishmania major | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0184 | 0.3846 | 0.5 |
Mycobacterium ulcerans | 6-phosphogluconate dehydrogenase | 0.0184 | 0.3846 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0397 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Trichomonas vaginalis | 6-phosphogluconate dehydrogenase, putative | 0.0184 | 0.3846 | 0.5 |
Onchocerca volvulus | 0.0397 | 1 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0397 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0397 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0114 | 0.0114 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0397 | 1 | 1 |
Onchocerca volvulus | 0.0397 | 1 | 1 | |
Brugia malayi | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0184 | 0.3846 | 0.3846 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0114 | 0.0114 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0397 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Toxoplasma gondii | 6-phosphogluconate dehydrogenase | 0.0184 | 0.3846 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0397 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0397 | 1 | 1 |
Chlamydia trachomatis | 6-phosphogluconate dehydrogenase | 0.0184 | 0.3846 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | pgd protein | 0.0184 | 0.3846 | 0.3846 |
Trichomonas vaginalis | 6-phosphogluconate dehydrogenase, putative | 0.0184 | 0.3846 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Mycobacterium ulcerans | 6-phosphogluconate dehydrogenase | 0.0184 | 0.3846 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.