Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ATP synthase subunit epsilon | 0.0057 | 0.9303 | 0.9303 |
Toxoplasma gondii | ATP synthase, putative | 0.0024 | 0.1063 | 0.1143 |
Schistosoma mansoni | ATP synthase alpha subunit mitochondrial | 0.0044 | 0.6052 | 0.6505 |
Loa Loa (eye worm) | ATP synthase subunit delta | 0.0024 | 0.1063 | 0.1063 |
Toxoplasma gondii | atp synthase F1, epsilon subunit, putative | 0.0057 | 0.9303 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Mycobacterium tuberculosis | Probable ATP synthase alpha chain AtpA | 0.0044 | 0.6052 | 1 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA | 0.0044 | 0.6052 | 1 |
Plasmodium vivax | ATP synthase alpha chain, putative | 0.0044 | 0.6052 | 0.6505 |
Plasmodium vivax | ATP synthase epsilon chain, mitochondrial , putative | 0.0057 | 0.9303 | 1 |
Leishmania major | ATP synthase, epsilon chain, putative | 0.0024 | 0.1063 | 0.2587 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE EPSILON CHAIN ATPC | 0.0024 | 0.1063 | 0.1757 |
Onchocerca volvulus | ATP synthase subunit delta, mitochondrial homolog | 0.0024 | 0.1063 | 0.1757 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.528 | 0.5675 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.528 | 0.528 |
Trypanosoma cruzi | ATP synthase, epsilon chain, putative | 0.0024 | 0.1063 | 1 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit alpha | 0.0044 | 0.6052 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.528 | 0.528 |
Echinococcus multilocularis | ATP synthase subunit alpha, mitochondrial | 0.0044 | 0.6052 | 0.6505 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit alpha | 0.0044 | 0.6052 | 1 |
Mycobacterium tuberculosis | Probable ATP synthase beta chain AtpD | 0.0044 | 0.6052 | 1 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0036 | 0.4109 | 1 |
Leishmania major | ATPase alpha subunit | 0.0036 | 0.4109 | 1 |
Echinococcus multilocularis | ATP synthase subunit delta, mitochondrial | 0.0024 | 0.1063 | 0.1143 |
Brugia malayi | ATP synthase delta chain, mitochondrial precursor, putative | 0.0024 | 0.1063 | 0.1063 |
Echinococcus granulosus | mitochondrial F1F0 ATP synthase subunit epsilon | 0.0057 | 0.9303 | 1 |
Brugia malayi | ATP synthase alpha chain, mitochondrial precursor, putative | 0.0044 | 0.6052 | 0.6052 |
Schistosoma mansoni | ATP synthase delta chain mitochondrial | 0.0024 | 0.1063 | 0.1143 |
Mycobacterium tuberculosis | Probable ATP synthase epsilon chain AtpC | 0.0024 | 0.1063 | 0.1757 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE BETA CHAIN ATPD | 0.0044 | 0.6052 | 1 |
Echinococcus granulosus | 5'partial|ATP synthase subunit delta mitochondrial | 0.0024 | 0.1063 | 0.1143 |
Onchocerca volvulus | ATP synthase subunit alpha, mitochondrial homolog | 0.0044 | 0.6052 | 1 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit epsilon | 0.0024 | 0.1063 | 0.1757 |
Brugia malayi | ATP synthase epsilon chain, mitochondrial | 0.0057 | 0.9303 | 0.9303 |
Plasmodium falciparum | ATP synthase F1, alpha subunit | 0.0044 | 0.6052 | 0.6505 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 1 | 1 |
Plasmodium falciparum | ATP synthase subunit delta, mitochondrial, putative | 0.0024 | 0.1063 | 0.1143 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit epsilon | 0.0024 | 0.1063 | 0.1757 |
Plasmodium vivax | hypothetical protein, conserved | 0.0024 | 0.1063 | 0.1143 |
Leishmania major | ATPase alpha subunit | 0.0036 | 0.4109 | 1 |
Plasmodium falciparum | mitochondrial ATP synthase F1, epsilon subunit, putative | 0.0057 | 0.9303 | 1 |
Trypanosoma brucei | mitochondrial ATP synthase delta chain | 0.0024 | 0.1063 | 0.2587 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0036 | 0.4109 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.9303 | 1 |
Echinococcus granulosus | ATP synthase subunit alpha mitochondrial | 0.0044 | 0.6052 | 0.6505 |
Echinococcus multilocularis | mitochondrial F1F0 ATP synthase subunit epsilon | 0.0057 | 0.9303 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.