Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | NADPH oxidoreductase, putative | 0.1012 | 1 | 0.5 |
Brugia malayi | Hyaluronidase family protein | 0.0884 | 0.8316 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Entamoeba histolytica | modulator of drug activity B homolog, putative | 0.0253 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.0884 | 0.8316 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Schistosoma mansoni | Hyaluronidase | 0.0884 | 0.8316 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Loa Loa (eye worm) | hyaluronidase | 0.0884 | 0.8316 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0253 | 0 | 0.5 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.1012 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0759 | 0.6669 | 0.6669 |
Entamoeba histolytica | iron-sulfur flavoprotein, putative | 0.0253 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.1012 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.0884 | 0.8316 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.1012 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0884 | 0.8316 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.1012 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 20.4 % | Inhibition of equine BChE at 10 uM after 20 mins using butyrylthiocholine iodide as a substrate by Ellman's assay | ChEMBL. | 21417225 |
Inhibition (binding) | = 52 % | Inhibition of bovine AChE at 10 uM after 20 mins using acetylthiocholine iodide as a substrate by Ellman's assay | ChEMBL. | 21417225 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.