Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.5358 | 0.6113 |
Schistosoma mansoni | lipoxygenase | 0.0083 | 0.4331 | 0.6387 |
Plasmodium falciparum | LCCL domain-containing protein | 0.002 | 0 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0167 | 1 | 0.5 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0095 | 0.5117 | 0.7547 |
Mycobacterium tuberculosis | Conserved protein | 0.0167 | 1 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0119 | 0.678 | 0.7954 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.7866 | 0.8973 |
Brugia malayi | hypothetical protein | 0.002 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0119 | 0.678 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0119 | 0.678 | 1 |
Brugia malayi | Doublecortin family protein | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.8766 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0167 | 1 | 0.5 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0167 | 1 | 0.5 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.002 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0167 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0145 | 0.8525 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.