Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0035 | 0.1213 | 0.7356 | |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Brugia malayi | methionyl-tRNA synthetase | 0.0022 | 0.0298 | 0.0444 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0057 | 0.269 | 1 |
Brugia malayi | methionyl-tRNA synthetase | 0.0057 | 0.269 | 0.4017 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0057 | 0.269 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0298 | 0.0444 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0971 | 0.0971 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0971 | 0.145 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0971 | 0.0971 |
Leishmania major | leucyl-tRNA synthetase, putative | 0.0022 | 0.0298 | 0.1106 |
Brugia malayi | protein ZK524.3 | 0.0022 | 0.0298 | 0.0444 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.3511 | 0.3511 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0971 | 0.0971 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.1449 | 0.8789 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0298 | 0.0444 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0298 | 0.0444 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.3511 | 0.3511 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0682 | 0.1942 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.6697 | 1 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0057 | 0.269 | 0.4017 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0057 | 0.269 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.1649 | 0.4697 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0022 | 0.0298 | 0.0298 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0057 | 0.269 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1449 | 0.2164 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0971 | 0.145 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.3467 | 0.3467 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0022 | 0.0298 | 0.0298 |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.3511 | 0.5242 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0057 | 0.269 | 1 |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.0035 | 0.1213 | 0.1811 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0022 | 0.0298 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.6697 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.1649 | 0.4697 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.6697 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0022 | 0.0298 | 0.0298 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.3511 | 0.3511 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0022 | 0.0298 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0971 | 0.0971 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.00000060783 | 0.00000090764 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.5618 | 0.839 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0971 | 0.0971 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0057 | 0.269 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.3467 | 0.5178 |
Schistosoma mansoni | transient receptor potential channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0022 | 0.0298 | 0.0298 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0971 | 0.0971 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0971 | 0.0971 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.1649 | 1 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.3511 | 0.3511 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.00000060783 | 0.00000090764 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0682 | 0.1942 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0971 | 0.0971 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.1449 | 0.2164 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0057 | 0.269 | 0.5 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0022 | 0.0298 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0881 | 0.1316 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0022 | 0.0298 | 0.0298 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0022 | 0.0298 | 0.5 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.3511 | 0.5242 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0057 | 0.269 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0971 | 0.0971 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0057 | 0.269 | 0.7663 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.3511 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0057 | 0.269 | 0.269 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.1449 | 0.4129 |
Schistosoma mansoni | transient receptor potential channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.5618 | 0.839 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.5618 | 0.839 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.3511 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0971 | 0.0971 |
Brugia malayi | olfactory channel protein osm-9 | 0.0017 | 0.00000060783 | 0.00000090764 |
Toxoplasma gondii | tRNA ligases class I (M) protein | 0.0022 | 0.0298 | 0.1106 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0057 | 0.269 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0057 | 0.269 | 0.269 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.3511 | 0.3511 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0022 | 0.0298 | 0.5 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0057 | 0.269 | 0.269 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0971 | 0.145 |
Onchocerca volvulus | 0.003 | 0.0881 | 0.5345 | |
Echinococcus multilocularis | geminin | 0.0164 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.1449 | 0.4129 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0057 | 0.269 | 1 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0057 | 0.269 | 1 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.3511 | 0.3511 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.5618 | 0.839 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.3467 | 0.5178 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.00000060783 | 0.00000090764 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0971 | 0.145 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.