Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0127 | 0.0535 | 0.1894 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0138 | 0.0633 | 0.2283 |
Schistosoma mansoni | alpha-glucosidase | 0.1178 | 0.9534 | 1 |
Trypanosoma brucei | NAD+ synthase, putative | 0.008 | 0.0138 | 0.0673 |
Brugia malayi | dihydrofolate reductase family protein | 0.0168 | 0.089 | 0.0376 |
Toxoplasma gondii | Amylo-alpha-1,6-glucosidase | 0.0138 | 0.0633 | 0.6323 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0181 | 0.1001 | 0.374 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0181 | 0.1001 | 0.0493 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0127 | 0.0535 | 0.2614 |
Trichomonas vaginalis | nh(3)-dependent NAD(+) synthetase, putative | 0.008 | 0.0138 | 0.0321 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0303 | 0.2046 | 1 |
Trypanosoma cruzi | NAD+ synthase, putative | 0.008 | 0.0138 | 0.0673 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0168 | 0.089 | 0.1166 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0168 | 0.089 | 0.1632 |
Brugia malayi | hypothetical protein | 0.0237 | 0.1482 | 0.1001 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0168 | 0.089 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0181 | 0.1001 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0127 | 0.0535 | 0.1894 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0237 | 0.1482 | 0.0906 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0127 | 0.0535 | 0.1894 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1232 | 1 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0181 | 0.1001 | 0.4895 |
Trypanosoma cruzi | NAD+ synthase, putative | 0.008 | 0.0138 | 0.0673 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0181 | 0.1001 | 0.374 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0127 | 0.0535 | 0.2614 |
Treponema pallidum | NAD synthetase | 0.008 | 0.0138 | 0.5 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0366 | 0.2582 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.1482 | 0.146 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0834 | 0.6591 | 0.6583 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0366 | 0.2582 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0127 | 0.0535 | 0.1894 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.016 | 0.0817 | 0.1472 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0181 | 0.1001 | 1 |
Leishmania major | glycosyl hydrolase-like protein | 0.0127 | 0.0535 | 0.2614 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0181 | 0.1001 | 0.0978 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.0304 | 0.0177 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0834 | 0.6591 | 0.6361 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0144 | 0.0678 | 0.3313 |
Mycobacterium tuberculosis | Arylamine N-acetyltransferase Nat (arylamine acetylase) | 0.0619 | 0.4749 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1232 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0127 | 0.0535 | 0.1894 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0181 | 0.1001 | 0.4895 |
Schistosoma mansoni | alpha-glucosidase | 0.1178 | 0.9534 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0127 | 0.0535 | 0.4599 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0303 | 0.2046 | 1 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0127 | 0.0535 | 0.2614 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1232 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0168 | 0.089 | 0.0376 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0127 | 0.0535 | 0.1894 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0834 | 0.6591 | 0.6399 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0127 | 0.0535 | 0.1894 |
Onchocerca volvulus | 0.0888 | 0.7049 | 1 | |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0181 | 0.1001 | 0.0393 |
Plasmodium falciparum | glutamine-dependent NAD(+) synthetase, putative | 0.008 | 0.0138 | 1 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.0834 | 0.6591 | 0.6361 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0144 | 0.0678 | 0.3313 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0181 | 0.1001 | 1 |
Leishmania major | NAD synthase, putative | 0.008 | 0.0138 | 0.0673 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0127 | 0.0535 | 0.1894 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0168 | 0.089 | 0.0867 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.0971 | 0.0887 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0181 | 0.1001 | 0.4895 |
Plasmodium vivax | glutamine-dependent NAD(+) synthetase, putative | 0.008 | 0.0138 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0535 | 0.0511 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0181 | 0.1001 | 0.374 |
Schistosoma mansoni | dihydrofolate reductase | 0.0168 | 0.089 | 0.0801 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0138 | 0.0633 | 0.2283 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0181 | 0.1001 | 0.374 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0181 | 0.1001 | 0.0393 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0834 | 0.6591 | 1 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0834 | 0.6591 | 0.6868 |
Mycobacterium ulcerans | arylamine N-acetyltransferase Nat | 0.0619 | 0.4749 | 0.7146 |
Entamoeba histolytica | glycogen debranching enzyme, putative | 0.0138 | 0.0633 | 0.5737 |
Schistosoma mansoni | alpha glucosidase | 0.0181 | 0.1001 | 0.0919 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0633 | 0.0609 |
Mycobacterium ulcerans | hypothetical protein | 0.016 | 0.0817 | 0.1052 |
Brugia malayi | Amylo-alpha-1,6-glucosidase family protein | 0.0138 | 0.0633 | 0.0104 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0181 | 0.1001 | 0.374 |
Echinococcus granulosus | dihydrofolate reductase | 0.0168 | 0.089 | 0.0275 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.1232 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0181 | 0.1001 | 0.374 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0303 | 0.2046 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0168 | 0.089 | 1 |
Toxoplasma gondii | glutamine-dependent NAD(+) synthetase protein, putative | 0.008 | 0.0138 | 0.1375 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0181 | 0.1001 | 0.374 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0168 | 0.089 | 0.0275 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0237 | 0.1482 | 0.0906 |
Giardia lamblia | 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase | 0.0138 | 0.0633 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0303 | 0.2046 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0181 | 0.1001 | 0.374 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0181 | 0.1001 | 0.4895 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0144 | 0.0678 | 0.3313 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0181 | 0.1001 | 0.374 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.