Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | phospho-N-acetylmuramoyl-pentapeptide transferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Mycobacterium ulcerans | phospho-N-acetylmuramoyl-pentapeptide-transferase | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Treponema pallidum | phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Wolbachia endosymbiont of Brugia malayi | phospho-N-acetylmuramoyl-pentapeptide-transferase | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Mycobacterium leprae | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Chlamydia trachomatis | phospho-N-acetylmuramoyl-pentapeptide-transferase | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | 0.0896 | 1 | 1 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0687 | 0.6229 | 0.5 |
Echinococcus granulosus | thymidylate kinase | 0.0687 | 0.6229 | 0.5 |
Leishmania major | thymidylate kinase-like protein | 0.0687 | 0.6229 | 0.5 |
Schistosoma mansoni | thymidylate kinase | 0.0687 | 0.6229 | 0.5 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0687 | 0.6229 | 0.5 |
Plasmodium vivax | thymidylate kinase, putative | 0.0687 | 0.6229 | 0.5 |
Schistosoma mansoni | thymidylate kinase | 0.0687 | 0.6229 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0896 | 1 | 1 |
Toxoplasma gondii | thymidylate kinase | 0.0687 | 0.6229 | 0.5 |
Echinococcus multilocularis | thymidylate kinase | 0.0687 | 0.6229 | 0.5 |
Onchocerca volvulus | Putative thymidylate kinase | 0.0687 | 0.6229 | 0.5 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0687 | 0.6229 | 0.5 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0687 | 0.6229 | 0.5 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0687 | 0.6229 | 0.5 |
Plasmodium falciparum | thymidylate kinase | 0.0687 | 0.6229 | 0.5 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0687 | 0.6229 | 0.5 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0687 | 0.6229 | 0.5 |
Chlamydia trachomatis | thymidylate kinase | 0.0687 | 0.6229 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0687 | 0.6229 | 0.5 |
Mycobacterium ulcerans | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0896 | 1 | 1 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0687 | 0.6229 | 1 |
Loa Loa (eye worm) | thymidylate kinase | 0.0687 | 0.6229 | 0.5 |
Brugia malayi | thymidylate kinase | 0.0687 | 0.6229 | 0.5 |
Giardia lamblia | CDC8 | 0.0687 | 0.6229 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 280 ng ml-1 | Inhibitory activity against translocase I | ChEMBL. | 14611838 |
IC50 (binding) | = 280 ng ml-1 | Inhibitory activity against translocase I | ChEMBL. | 14611838 |
MIC (functional) | = 50 ug ml-1 | Antimycobacterial activity against Mycobacterium smegmatis (SANK 75075) | ChEMBL. | 14611838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.