Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | UDP-glucose ceramide glucosyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.01 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0137 | 0.1571 | 0.1571 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0429 | 0.1215 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0096 | 0.104 | 0.2948 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0254 | 0.1641 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0314 | 0.089 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0254 | 0.072 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0288 | 0.3527 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0314 | 0.089 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0119 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.01 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0024 | 0.0069 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0097 | 0.1059 | 0.3002 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0333 | 0.5 |
Brugia malayi | CHE-14 protein | 0.0041 | 0.0333 | 0.0944 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0119 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.01 | 0.0283 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0288 | 0.3527 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0131 | 0.1491 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0137 | 0.1571 | 0.4454 |
Echinococcus multilocularis | expressed conserved protein | 0.009 | 0.0965 | 0.0965 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.023 | 0.0653 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0254 | 0.072 |
Echinococcus multilocularis | protein dispatched 1 | 0.0047 | 0.0408 | 0.0408 |
Echinococcus granulosus | expressed conserved protein | 0.009 | 0.0965 | 0.2735 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.01 | 0.0283 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0024 | 0.139 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.01 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0024 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0453 | 0.1283 |
Schistosoma mansoni | patched 1 | 0.0041 | 0.0333 | 0.0944 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.01 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.023 | 0.0653 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0041 | 0.0333 | 0.0333 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0119 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.01 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.01 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0254 | 0.1641 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0119 | 0.5 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0096 | 0.104 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.01 | 0.0283 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0119 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0288 | 0.3527 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0333 | 0.0944 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0119 | 0.5 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.3527 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0429 | 0.1215 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0024 | 0.0069 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0429 | 0.1215 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0006 | 0.0018 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0041 | 0.0333 | 0.0944 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0119 | 0.0336 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.3527 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.01 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0254 | 0.1641 |
Brugia malayi | Ceramide glucosyltransferase | 0.0288 | 0.3527 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.104 | 0.2948 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0024 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0429 | 0.1215 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0254 | 0.0254 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0254 | 0.072 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0119 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0041 | 0.0333 | 0.0944 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0041 | 0.0333 | 0.0944 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.01 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0254 | 0.1641 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0254 | 0.072 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0024 | 0.0069 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.01 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0096 | 0.104 | 0.104 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0288 | 0.3527 | 0.3527 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.01 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.01 | 0.0283 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0096 | 0.104 | 0.2948 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0119 | 0.0336 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.01 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0119 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.01 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.01 | 0.0283 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0314 | 0.089 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0024 | 0.0069 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0314 | 0.089 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.023 | 0.0653 |
Echinococcus multilocularis | protein patched | 0.0041 | 0.0333 | 0.0333 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.01 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1080 nM | Inhibition of GCS assessed as amount of UDP-glucose consumed during enzyme-catalyzed reaction | ChEMBL. | 21974949 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.