Detailed information for compound 1566143

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 321.348 | Formula: C19H16FN3O
  • H donors: 1 H acceptors: 3 LogP: 4.78 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cc(O)c2c(c1)n1c(nc(c1c(n2)C)C)c1ccccc1C
  • InChi: 1S/C19H16FN3O/c1-10-6-4-5-7-14(10)19-22-12(3)18-11(2)21-17-15(23(18)19)8-13(20)9-16(17)24/h4-9,24H,1-3H3
  • InChiKey: CUCTWVMJSNSTKF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 10A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_135363 All targets in OG5_135363
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative Get druggable targets OG5_135363 All targets in OG5_135363
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_135363 All targets in OG5_135363
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic Get druggable targets OG5_135363 All targets in OG5_135363
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic Get druggable targets OG5_135363 All targets in OG5_135363
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei cAMP-specific phosphodiesterase phosphodiesterase 10A 789 aa 666 aa 30.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lipoxygenase domain containing protein 0.0015 0.0013 0.0019
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0027 0.0047 0.0211
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0003 0.0004
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0023 0.0036 0.225
Loa Loa (eye worm) hypothetical protein 0.0029 0.0054 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0038 0.0187
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0068 0.0253
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0035 0.0854
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0047 0.0069
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0068 0.0253
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0022 0.0038
Echinococcus granulosus 7TM GPCR rhodopsin 0.0012 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0243
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.2561 0.7873 1
Chlamydia trachomatis DNA gyrase subunit B 0.0062 0.0157 0.6959
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0038 0.014
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0003 0.0004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0053 0.013 0.0219
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0003 0.0005
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0012 0.0003 0.0005
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0033 0.0066 0.1604
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0101 0.0171
Trypanosoma cruzi DNA polymerase eta, putative 0.0073 0.0191 0.4712
Echinococcus granulosus g protein coupled receptor 0.0012 0.0003 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0121 0.2973
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0.0003 0.0004
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0255 0.043
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0031 0.0061 0.0088
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0033 0.0066 0.161
Mycobacterium ulcerans acyl-CoA synthetase 0.0113 0.0313 0.1187
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0343 0.1025 0.1727
Giardia lamblia Protein tyrosine phosphatase 0.0027 0.0047 0.0692
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0033 0.0066 0.161
Brugia malayi A-kinase anchor protein 10, precursor 0.0018 0.0022 0.0021
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0012 0.0001 0.0001
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0012 0.0003 0.0004
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0083 0.014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0003 0.0005
Brugia malayi nuclear receptor RXR 0.0035 0.0073 0.0072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Schistosoma mansoni hypothetical protein 0.0038 0.0082 0.0138
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0191 0.4708
Toxoplasma gondii propionate-CoA ligase 0.0033 0.0068 0.1647
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0047 0.008
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0077 0.0291
Schistosoma mansoni ap endonuclease 0.0034 0.007 0.0118
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0066 0.0329
Schistosoma mansoni DNA polymerase eta 0.0073 0.0191 0.0322
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0012 0.0001 0.0002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0006 0.0025
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0003 0.0005
Echinococcus granulosus ecdysone induced protein 78C 0.0066 0.0168 0.0284
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0191 0.4712
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0003 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0066 0.0168 0.0167
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0024 0.004
Entamoeba histolytica hypothetical protein 0.0037 0.0078 0.0369
Entamoeba histolytica hypothetical protein, conserved 0.0051 0.0124 0.0601
Onchocerca volvulus 0.0024 0.0038 0.0246
Leishmania major cathepsin L-like protease 0.0013 0.0006 0.01
Trypanosoma brucei ISWI complex protein 0.0016 0.0013 0.0309
Loa Loa (eye worm) hypothetical protein 0.0084 0.0225 0.0286
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0007
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0035 0.0073 0.0122
Brugia malayi hypothetical protein 0.0027 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.1376 0.4214 0.5352
Onchocerca volvulus 0.0027 0.0047 0.031
Mycobacterium ulcerans hypothetical protein 0.0023 0.0035 0.0131
Loa Loa (eye worm) hypothetical protein 0.0035 0.0073 0.0092
Schistosoma mansoni hypothetical protein 0.0114 0.0318 0.0536
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0031 0.0061 0.0088
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0003 0.0004
Schistosoma mansoni amine GPCR 0.0012 0.0003 0.0005
Schistosoma mansoni loxhd1 0.0015 0.0013 0.0022
Onchocerca volvulus 0.0033 0.0068 0.0451
Giardia lamblia DNA damage repair protein 0.0023 0.0035 0.0515
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0073 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0022 0.0108
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0033 0.0068 0.0067
Leishmania major 4-coumarate:coa ligase-like protein 0.0113 0.0313 0.6059
Echinococcus multilocularis cysteine protease 0.0013 0.0006 0.0008
Echinococcus multilocularis dna polymerase eta 0.0073 0.0191 0.0277
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0101 0.0277 0.6816
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0003 0.0004
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0341 0.0433
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0033 0.0068 0.0253
Leishmania major phosphoinositide phosphatase 0.0179 0.0517 1
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0164 0.0238
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0006 0.0025
Loa Loa (eye worm) hypothetical protein 0.0035 0.0073 0.0092
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0012 0.0003 0.0002
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.003 0.0058 0.0215
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0023 0.0036 0.0524
Schistosoma mansoni hypothetical protein 0.0624 0.189 0.3187
Leishmania major mitochondrial DNA topoisomerase II 0.012 0.0335 0.6469
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0066 0.0168 0.0167
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0033 0.0068 0.1078
Echinococcus multilocularis somatostatin receptor 0.0012 0.0003 0.0004
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0077 0.1893
Echinococcus multilocularis allatostatin A receptor 0.0012 0.0003 0.0004
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.0047 0.008
Plasmodium vivax vivapain-2 0.0013 0.0006 0.012
Brugia malayi Latrophilin receptor protein 2 0.0056 0.0139 0.0138
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0062 0.0157 0.3863
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0003 0.0005
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0031 0.0061 0.006
Loa Loa (eye worm) glutathione reductase 0.0033 0.0068 0.0086
Onchocerca volvulus 0.0017 0.0017 0.0099
Echinococcus granulosus neuropeptide s receptor 0.0414 0.1245 0.2099
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0012 0.0003 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0022 0.0108
Brugia malayi hypothetical protein 0.0027 0.0047 0.0046
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0112 0.031 0.1176
Echinococcus granulosus survival motor neuron protein 1 0.0185 0.0537 0.0905
Brugia malayi hypothetical protein 0.0012 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Echinococcus granulosus sterol regulatory element binding protein 0.0119 0.0331 0.0559
Schistosoma mansoni hypothetical protein 0.0056 0.0139 0.0234
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0016
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0047 0.006
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0409 0.123 0.2073
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0164 0.0277
Echinococcus multilocularis sex peptide receptor 0.0012 0.0003 0.0004
Onchocerca volvulus 0.0017 0.0017 0.0099
Brugia malayi putative neuropeptide receptor NPR1 0.0012 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Leishmania major 4-coumarate:coa ligase-like protein 0.0113 0.0313 0.6059
Loa Loa (eye worm) hypothetical protein 0.0066 0.0168 0.0214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0229 0.0672 0.3404
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0152 0.0436 0.0435
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0077 0.0388
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0191 0.4708
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0035 0.0854
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.0061 0.0406
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0027 0.0047 0.008
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0031 0.0061 0.0103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0006 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0107 0.0294 0.0293
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0003 0.0005
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0004 0.0006
Echinococcus multilocularis FTZ F1 alpha 0.0066 0.0168 0.0244
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0113 0.0313 0.1187
Loa Loa (eye worm) hypothetical protein 0.0066 0.0168 0.0214
Schistosoma mansoni retinoic acid receptor RXR 0.0066 0.0168 0.0284
Toxoplasma gondii hypothetical protein 0.0023 0.0038 0.0912
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0001 0.0007
Toxoplasma gondii DNA topoisomerase I, putative 0.0142 0.0405 1
Trypanosoma brucei DNA polymerase eta, putative 0.0073 0.0191 0.4708
Entamoeba histolytica dual specificity protein phosphatase, putative 0.065 0.1972 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0012 0.0003 0.0005
Echinococcus granulosus thioredoxin glutathione reductase 0.0034 0.0069 0.0117
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0113 0.0313 1
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0035 0.0854
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0476 0.1435 1
Onchocerca volvulus 0.0027 0.0047 0.031
Brugia malayi glutathione reductase 0.0033 0.0068 0.0067
Onchocerca volvulus 0.0027 0.0047 0.031
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0054 0.0068
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0148 0.0188
Echinococcus granulosus dna polymerase eta 0.0073 0.0191 0.0322
Plasmodium vivax acyl-CoA synthetase, putative 0.0084 0.0225 0.5552
Plasmodium falciparum GAF domain-related protein, putative 0.0023 0.0038 0.0912
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0026
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0033 0.0068 0.0253
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Brugia malayi Niemann-Pick C1 protein precursor 0.0276 0.0818 0.0817
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0068 0.0253
Trypanosoma cruzi trypanothione reductase, putative 0.0012 0.0001 0.0007
Schistosoma mansoni cpg binding protein 0.0025 0.0043 0.0072
Schistosoma mansoni biogenic amine receptor 0.0012 0.0003 0.0005
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0047 0.0069
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0033 0.0068 0.0253
Schistosoma mansoni opsin-like receptor 0.0012 0.0003 0.0005
Trypanosoma brucei unspecified product 0.0073 0.0191 0.4708
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0517 0.2617
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0035 0.0854
Leishmania major DNA damage repair protein, putative 0.0023 0.0035 0.0674
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0191 0.4708
Schistosoma mansoni axis inhibition protein axin 0.0018 0.0022 0.0038
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0113 0.0313 0.1187
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0076 0.02 0.0755
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0101 0.01
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0045 0.0104 0.0103
Loa Loa (eye worm) hypothetical protein 0.0113 0.0313 0.0398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0066 0.0168 0.0214
Schistosoma mansoni DNA topoisomerase type I 0.0142 0.0405 0.0683
Onchocerca volvulus 0.0027 0.0047 0.031
Brugia malayi Patched family protein 0.0017 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Loa Loa (eye worm) nuclear receptor NHR-67 0.0031 0.0061 0.0078
Schistosoma mansoni lipoxygenase 0.0065 0.0165 0.0278
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Echinococcus multilocularis G-protein coupled receptor, putative 0.0012 0.0003 0.0004
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0343 0.1025 0.1024
Echinococcus multilocularis Regulator of G protein signaling 20 0.0018 0.0022 0.0032
Loa Loa (eye worm) hypothetical protein 0.0118 0.033 0.0419
Echinococcus granulosus GPCR family 2 0.0056 0.0139 0.0234
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0006 0.0025
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0027 0.0047 0.008
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0077 0.1899
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0341 0.0433
Loa Loa (eye worm) RGS-3 protein 0.0018 0.0022 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0068 0.0253
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Mycobacterium ulcerans DNA gyrase subunit A 0.0023 0.0036 0.0134
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.008 0.0211 0.0799
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Brugia malayi nuclear receptor NHR-67 0.0031 0.0061 0.006
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0092 0.025 0.0362
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0033 0.0068 0.0253
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0003 0.0004
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0033 0.0068 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0038 0.0187
Onchocerca volvulus 0.0017 0.0017 0.0099
Toxoplasma gondii DNA topoisomerase 2, putative 0.0107 0.0294 0.7255
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0012 0.0001 0.0006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0056 0.0139 0.0138
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0047 0.008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0003 0.0004
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0003 0.0004
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0033 0.0068 0.0253
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0033 0.0068 0.0253
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpB 0.0179 0.0517 0.196
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0229 0.0672 0.3387
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0027 0.0047 0.008
Brugia malayi hypothetical protein 0.0015 0.0013 0.0012
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0018 0.0022 0.0108
Onchocerca volvulus 0.0031 0.0061 0.0406
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0191 0.4708
Echinococcus granulosus peregrin 0.0031 0.0061 0.0103
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0001 0.0007
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0013 0.0006 0.012
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Echinococcus granulosus g protein coupled receptor 0.0012 0.0003 0.0005
Loa Loa (eye worm) steroid hormone receptor 0.0066 0.0168 0.0214
Brugia malayi ImpB/MucB/SamB family protein 0.0073 0.0191 0.019
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0022 0.0108
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0012 0.0001 0.0006
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0061 0.0103
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.003 0.0058 0.0097
Trichomonas vaginalis antibiotic synthetase, putative 0.0033 0.0068 0.0338
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.0035 0.0854
Loa Loa (eye worm) hypothetical protein 0.0049 0.0117 0.0149
Brugia malayi Patched family protein 0.0017 0.0017 0.0016
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0152 0.0436 0.0631
Plasmodium vivax acetyl-CoA synthetase, putative 0.0033 0.0068 0.1647
Onchocerca volvulus 0.0027 0.0047 0.031
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.003 0.0058 0.1409
Brugia malayi hypothetical protein 0.0035 0.0073 0.0072
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0003 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0006 0.0025
Echinococcus multilocularis protein dispatched 1 0.0135 0.0383 0.0554
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0061 0.0103
Brugia malayi isocitrate dehydrogenase 0.003 0.0058 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0253 0.1277
Echinococcus multilocularis hypothetical protein 0.0027 0.0047 0.0069
Toxoplasma gondii hypothetical protein 0.0023 0.0038 0.0912
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.0047 0.008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0066 0.0168 0.0167
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0078
Brugia malayi Patched family protein 0.0017 0.0017 0.0016
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0077 0.1899
Plasmodium falciparum thioredoxin reductase 0.0033 0.0068 0.1661
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0013 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Brugia malayi Inositol-1 0.0036 0.0077 0.0077
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0077 0.1893
Brugia malayi Bromodomain containing protein 0.0078 0.0205 0.0205
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0013 0.0006 0.0025
Brugia malayi ImpB/MucB/SamB family protein 0.0073 0.0191 0.019
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0047 0.0069
Echinococcus granulosus Niemann Pick C1 protein 0.0395 0.1184 0.1996
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Echinococcus granulosus cathepsin L cysteine proteinase 0.0013 0.0006 0.001
Brugia malayi Regulator of G protein signaling domain containing protein 0.0018 0.0022 0.0021
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0022 0.0038
Brugia malayi Isocitrate dehydrogenase 0.003 0.0058 0.0057
Onchocerca volvulus 0.0027 0.0047 0.031
Echinococcus multilocularis expressed conserved protein 0.0259 0.0766 0.1109
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0084
Echinococcus granulosus lamin dm0 0.0024 0.0038 0.0064
Onchocerca volvulus 0.0027 0.0047 0.031
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0034 0.007 0.1028
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0019 0.0027
Echinococcus granulosus DNA topoisomerase 1 0.0142 0.0405 0.0683
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.0191 0.0723
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0253 0.1277
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0078
Onchocerca volvulus 0.0025 0.0043 0.0279
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0113 0.0313 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0113 0.0313 0.1187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0256 0.0757 0.0962
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0034 0.007 0.0262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0006 0.0025
Brugia malayi Thioredoxin reductase 0.0033 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0073 0.0191 0.0243
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0078 0.0132
Onchocerca volvulus 0.0017 0.0017 0.0099
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0003 0.0004
Onchocerca volvulus 0.0013 0.0006 0.002
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0027 0.0047 0.008
Giardia lamblia DINP protein human, muc B family 0.0073 0.0191 0.2837
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0056 0.0139 0.0234
Echinococcus granulosus geminin 0.0624 0.189 0.3187
Echinococcus granulosus nuclear factor of activated T cells 5 0.0057 0.0141 0.0238
Echinococcus multilocularis RUN 0.0015 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0066 0.0168 0.0244
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0013 0.0006 0.0007
Schistosoma mansoni hypothetical protein 0.0624 0.189 0.3187
Schistosoma mansoni microtubule-associated protein tau 0.1932 0.5931 1
Brugia malayi RE15519p 0.0012 0.0003 0.0002
Echinococcus multilocularis serotonin receptor 0.0012 0.0003 0.0004
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0864 0.2633 1
Schistosoma mansoni survival motor neuron protein 0.0038 0.0082 0.0138
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0027 0.0047 0.008
Echinococcus multilocularis neuropeptide FF receptor 2 0.0012 0.0003 0.0004
Schistosoma mansoni amine GPCR 0.0012 0.0003 0.0005
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0253 0.0426
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0034 0.007 0.0118
Brugia malayi AMP-binding enzyme family protein 0.0033 0.0068 0.0067
Schistosoma mansoni kinase 0.0047 0.0112 0.0188
Brugia malayi Cathepsin L-like precursor 0.0013 0.0006 0.0005
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0013 0.0006 0.0008
Plasmodium vivax multidomain scavenger receptor, putative 0.0015 0.0013 0.0298
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0027 0.0047 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0068 0.0253
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0047 0.008
Mycobacterium tuberculosis Probable dehydrogenase 0.0076 0.02 0.0755
Toxoplasma gondii hypothetical protein 0.0017 0.0017 0.0398
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0066 0.0168 0.0284
Onchocerca volvulus Huntingtin homolog 0.0118 0.033 0.2281
Plasmodium falciparum glutathione reductase 0.0033 0.0068 0.1661
Leishmania major cathepsin L-like protease 0.0013 0.0006 0.01
Brugia malayi TAR-binding protein 0.0064 0.0164 0.0164
Treponema pallidum fructose-bisphosphate aldolase 0.0229 0.0672 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0072 0.0105
Brugia malayi Patched family protein 0.0017 0.0017 0.0016
Entamoeba histolytica hypothetical protein 0.0018 0.0022 0.0084
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0019 0.0032
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0033 0.0068 0.0086
Brugia malayi Papain family cysteine protease containing protein 0.0013 0.0006 0.0005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Schistosoma mansoni hypothetical protein 0.0021 0.003 0.0051
Brugia malayi Serotonin receptor 0.0012 0.0003 0.0002
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0253 0.1256
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0068 0.0253
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0084 0.0225 0.0853
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0112 0.031 0.1176
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0033 0.0066 0.0111
Schistosoma mansoni myosin xvIII 0.0012 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0084 0.0225 0.0286
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0033 0.0068 0.1653
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0006 0.001
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0033 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Leishmania major trypanothione reductase 0.0033 0.0068 0.1307
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0027 0.0047 0.1154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.012 0.2933
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0038 0.0912
Mycobacterium tuberculosis Conserved hypothetical protein 0.0073 0.0191 0.0723
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0035 0.0854
Schistosoma mansoni biogenic amine receptor 0.0012 0.0003 0.0005
Schistosoma mansoni thyroid hormone receptor 0.0066 0.0168 0.0284
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0066 0.0168 0.0167
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0083 0.014
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0003 0.0005
Schistosoma mansoni z-protein (S1r protein) 0.0018 0.0022 0.0038
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0011 0 0.0001
Echinococcus granulosus 7tm_1 domain containing protein 0.0012 0.0003 0.0005
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0047 0.008
Brugia malayi hypothetical protein 0.0017 0.0017 0.0016
Schistosoma mansoni lamin 0.0024 0.0038 0.0064
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.003 0.0058 0.1104
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0024 0.004
Onchocerca volvulus 0.0027 0.0047 0.031
Schistosoma mansoni biogenic amine receptor 0.0012 0.0003 0.0005
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0024 0.0023
Brugia malayi hypothetical protein 0.0012 0.0003 0.0002
Brugia malayi regulator of G-protein signaling egl-10 0.0018 0.0022 0.0021
Brugia malayi hypothetical protein 0.0027 0.0047 0.0046
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0191 0.4708
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0033 0.0068 0.1078
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Brugia malayi DNA topoisomerase I 0.0142 0.0405 0.0404
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0078 0.0113
Onchocerca volvulus 0.0027 0.0047 0.031
Brugia malayi Cathepsin L-like precursor 0.0013 0.0006 0.0005
Echinococcus granulosus neuropeptide FF receptor 2 0.0012 0.0003 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0003 0.0004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0056 0.0139 0.0201
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0033 0.0066 0.0111
Brugia malayi steroid hormone receptor 0.0066 0.0168 0.0167
Brugia malayi hypothetical protein 0.0037 0.0078 0.0077
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0021 0.0026
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0027 0.0047 0.0069
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0033 0.0068 0.1653
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0006 0.0025
Onchocerca volvulus 0.0027 0.0047 0.031
Onchocerca volvulus 0.0031 0.0061 0.0406
Brugia malayi ecdysteroid receptor 0.0066 0.0168 0.0167
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0078
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0253 0.1277
Echinococcus granulosus axis inhibition protein axin 0.0018 0.0022 0.0038
Plasmodium falciparum cysteine proteinase falcipain 3 0.0013 0.0006 0.012
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0078
Loa Loa (eye worm) hypothetical protein 0.0121 0.034 0.0432
Loa Loa (eye worm) DR-78 0.0031 0.0061 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0006 0.0025
Schistosoma mansoni ap endonuclease 0.0034 0.007 0.0118
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0034 0.007 0.4415
Schistosoma mansoni histamine h1 receptor 0.0012 0.0003 0.0005
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0028 0.0051 0.0471
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0006 0.0025
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0041 0.0068
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0045 0.0104 0.0392
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Plasmodium falciparum DNA topoisomerase 2 0.0107 0.0294 0.7255
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0047 0.006
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0276 0.0818 0.4132
Onchocerca volvulus 0.0027 0.0047 0.031
Loa Loa (eye worm) hypothetical protein 0.0343 0.1025 0.1301
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0084 0.0226 0.0855
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0046 0.0106 0.2607
Brugia malayi Probable DNA topoisomerase II 0.0107 0.0294 0.0293
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0061 0.006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0101 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0066 0.0168 0.0167
Entamoeba histolytica deoxycytidyl transferase, putative 0.0073 0.0191 0.0943
Brugia malayi Patched related family protein 12 0.0017 0.0017 0.0016
Echinococcus granulosus cathepsin l1 0.0013 0.0006 0.001
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0027 0.0047 0.006
Giardia lamblia PHD finger protein 15 0.0029 0.0054 0.0789
Plasmodium falciparum DNA gyrase subunit B 0.0062 0.0157 0.3863
Onchocerca volvulus Protein patched homolog 0.0017 0.0017 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0066 0.0168 0.0214
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0033 0.0068 0.0086
Brugia malayi AMP-binding enzyme family protein 0.0113 0.0313 0.0312
Echinococcus granulosus RUN 0.0015 0.0013 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0121 0.2973
Brugia malayi AMP-binding enzyme family protein 0.0113 0.0313 0.0312
Brugia malayi CHE-14 protein 0.0119 0.0331 0.033
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0077 0.0388
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0027 0.0047 0.1154
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0108 0.0542
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.012 0.2933
Echinococcus granulosus Regulator of G protein signaling 20 0.0018 0.0022 0.0038
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0078
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0024 0.003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0073 0.0092
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0003 0.0004
Echinococcus granulosus lipoxygenase domain containing protein 0.0015 0.0013 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0343 0.1025 0.1301
Schistosoma mansoni bromodomain containing protein 0.0066 0.0169 0.0284
Schistosoma mansoni opsin-like receptor 0.0012 0.0003 0.0005
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0253 0.0321
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0054 0.1309
Echinococcus granulosus expressed conserved protein 0.0259 0.0766 0.1292
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.065 0.1972 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Brugia malayi Regulator of G protein signaling domain containing protein 0.0018 0.0022 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0006 0.0025
Schistosoma mansoni niemann-pick C1 (NPC1) 0.028 0.0831 0.1402
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0033 0.0066 0.0329
Echinococcus granulosus alpha 1A adrenergic receptor 0.0012 0.0003 0.0005
Loa Loa (eye worm) nuclear hormone receptor 0.0031 0.0061 0.0078
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0101 0.0171
Trypanosoma brucei unspecified product 0.005 0.0121 0.2973
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0054 0.0091
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0012 0.0003 0.0005
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0027 0.0047 0.0069
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.003 0.0058 0.0083
Schistosoma mansoni polycystin 1-related 0.0015 0.0013 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0253 0.0426
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0066 0.0168 0.0244
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.003 0.0058 0.1409
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0023
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0076 0.02 0.0755
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0061 0.0088
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0113 0.0313 0.1187
Trypanosoma cruzi DNA topoisomerase II, putative 0.0101 0.0277 0.6818
Onchocerca volvulus 0.0027 0.0047 0.031
Echinococcus multilocularis geminin 0.0624 0.189 0.2736
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0003 0.0005
Loa Loa (eye worm) PXA domain-containing protein 0.0018 0.0022 0.0028
Mycobacterium ulcerans hypothetical protein 0.0113 0.0313 0.1187
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.012 0.2933
Brugia malayi photoreceptor-specific nuclear receptor 0.0066 0.0168 0.0167
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0047 0.006
Brugia malayi PHD-finger family protein 0.0013 0.0005 0.0004
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0033 0.0066 0.0329
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Schistosoma mansoni hypothetical protein 0.0121 0.034 0.0573
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0073 0.0191 0.0723
Entamoeba histolytica hypothetical protein 0.0037 0.0078 0.0369
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0019 0.0032
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0255 0.0369
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0078
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0024 0.0023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0001 0.0007
Echinococcus multilocularis cathepsin L cysteine protease 0.0013 0.0006 0.0008
Chlamydia trachomatis DNA gyrase subunit A 0.0023 0.0036 0.1566
Leishmania major cysteine peptidase A (CPA) 0.0013 0.0006 0.01
Onchocerca volvulus Cathepsin L homolog 0.0013 0.0006 0.002
Brugia malayi hypothetical protein 0.0017 0.0017 0.0016
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0021 0.0035
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0066 0.0329
Schistosoma mansoni neuropeptide receptor 0.0012 0.0003 0.0005
Schistosoma mansoni nuclear receptor nhr-48 0.0031 0.0061 0.0103
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0027 0.0047 0.1154
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0047 0.006
Brugia malayi latrophilin 2 splice variant baaae 0.0121 0.034 0.0339
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0038 0.014
Loa Loa (eye worm) cysteine protease 0.0013 0.0006 0.0007
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Echinococcus multilocularis expressed protein 0.0359 0.1075 0.1556
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.012 0.2933
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Loa Loa (eye worm) hypothetical protein 0.0072 0.0188 0.0238
Echinococcus granulosus neuropeptide receptor A26 0.0414 0.1245 0.2099
Loa Loa (eye worm) hypothetical protein 0.0045 0.0104 0.0132
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0033 0.0066 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0013 0.0006 0.0025
Echinococcus multilocularis regulator of G protein signaling 0.0018 0.0022 0.0032
Onchocerca volvulus 0.0027 0.0047 0.031
Echinococcus multilocularis nuclear receptor nhr 48 0.0031 0.0061 0.0088
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0047 0.006
Loa Loa (eye worm) thioredoxin reductase 0.0033 0.0068 0.0086
Onchocerca volvulus 0.0027 0.0047 0.031
Schistosoma mansoni hypothetical protein 0.0114 0.0318 0.0536
Loa Loa (eye worm) hypothetical protein 0.0035 0.0073 0.0092
Brugia malayi Bromodomain containing protein 0.0031 0.0061 0.006
Schistosoma mansoni lamin 0.0024 0.0038 0.0064
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0056 0.0139 0.0201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.012 0.2933
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0003 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0006 0.0025
Trypanosoma brucei DNA topoisomerase ii 0.012 0.0335 0.8251
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0066 0.0168 0.0167
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0031 0.0061 0.0103
Brugia malayi AMP-binding enzyme family protein 0.0113 0.0313 0.0312
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0253 0.1744
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0035 0.086
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0003 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0028
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0142 0.0405 1
Brugia malayi Bromodomain containing protein 0.0039 0.0086 0.0085
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.0073 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0121 0.2973
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0066 0.0168 0.0284
Schistosoma mansoni neuropeptide receptor 0.0012 0.0003 0.0005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0047 0.006
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0012 0.0003 0.0004
Echinococcus granulosus regulator of G protein signaling 3 0.0018 0.0022 0.0038
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0029 0.0055 0.0205
Entamoeba histolytica acyl-CoA synthetase, putative 0.0113 0.0313 0.1565
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0072 0.0188 0.129
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0033 0.0066 0.0329
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0409 0.123 0.2073
Echinococcus granulosus cathepsin l cysteine peptidase 0.0013 0.0006 0.001
Brugia malayi Nuclear hormone receptor-like 1 0.0066 0.0168 0.0167
Loa Loa (eye worm) oxidoreductase 0.0033 0.0068 0.0086
Brugia malayi Patched family protein 0.0017 0.0017 0.0016
Entamoeba histolytica hypothetical protein 0.0018 0.0022 0.0084
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase) 0.0179 0.0517 0.196
Onchocerca volvulus 0.0027 0.0047 0.031
Toxoplasma gondii thioredoxin reductase 0.0033 0.0068 0.1661
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.012 0.2938
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0003 0.0004
Echinococcus granulosus neuropeptide receptor 0.0012 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0021 0.0035
Brugia malayi hypothetical protein 0.0031 0.0061 0.006
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0041 0.0059
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0027 0.0047 0.008
Schistosoma mansoni nuclear receptor 0.0031 0.0061 0.0103
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0078
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0013 0.0006 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0253 0.1277
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0027 0.0047 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0068 0.0253
Trichomonas vaginalis antibiotic synthetase, putative 0.0033 0.0068 0.0338
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0191 0.4708
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0034 0.007 0.1712
Schistosoma mansoni patched 1 0.0119 0.0331 0.0559
Brugia malayi intermediate filament protein 0.0024 0.0038 0.0037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0066 0.0168 0.0284
Echinococcus multilocularis axis inhibition protein axin 0.0018 0.0022 0.0032
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0028
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0012 0.0003 0.0004
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0004 0.0007
Brugia malayi GnHR receptor homolog 0.0012 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.0047 0.008
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0003 0.0005
Brugia malayi hypothetical protein 0.0012 0.0003 0.0002
Toxoplasma gondii hypothetical protein 0.0023 0.0038 0.0912
Plasmodium vivax thioredoxin reductase, putative 0.0033 0.0068 0.1661
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0191 0.4708
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0054 0.1309
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0066 0.0168 0.0284
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0012 0.0001 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0006 0.0025
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2249 0.691 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0006
Treponema pallidum exodeoxyribonuclease (exoA) 0.0034 0.007 0.1028
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0022 0.0038
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0089 0.0128
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0003 0.0005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0003 0.0004
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0012 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0229 0.0672 0.3404
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0073 0.0191 0.0277
Loa Loa (eye worm) hypothetical protein 0.0072 0.0188 0.0239
Brugia malayi RNA binding protein 0.0064 0.0164 0.0164
Echinococcus multilocularis musashi 0.0024 0.0038 0.0055
Brugia malayi hypothetical protein 0.0012 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0045
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0229 0.0672 0.3387
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0035 0.0854
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0012 0.0001 0.0002
Brugia malayi ORL1-like opioid receptor 0.0012 0.0003 0.0002
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0253 0.6229
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0047 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0035 0.0854
Trypanosoma brucei unspecified product 0.005 0.0121 0.2973
Schistosoma mansoni cpg binding protein 0.0028 0.0053 0.009
Schistosoma mansoni zinc finger protein 0.0031 0.0061 0.0103
Echinococcus granulosus sex peptide receptor 0.0012 0.0003 0.0005
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0018 0.0022 0.0038
Echinococcus granulosus expressed protein 0.0359 0.1075 0.1812
Toxoplasma gondii patched family protein 0.0017 0.0017 0.0398
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0066 0.0168 0.0284
Schistosoma mansoni hypothetical protein 0.0037 0.0078 0.0132
Mycobacterium tuberculosis Probable oxidoreductase 0.0084 0.0226 0.0855
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0047 0.008
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0003 0.0005
Loa Loa (eye worm) patched family protein 0.0017 0.0017 0.0022
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0022 0.0032
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0022 0.0038
Brugia malayi ecdysone receptor 0.0031 0.0061 0.006
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0027 0.0047 0.006
Toxoplasma gondii GAF domain-containing protein 0.0023 0.0038 0.0912
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Leishmania major DNA polymerase eta, putative 0.0073 0.0191 0.3693
Echinococcus multilocularis DNA topoisomerase 1 0.0142 0.0405 0.0586
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0077 0.1489
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0003 0.0004
Trypanosoma cruzi cysteine peptidase, putative 0.0013 0.0006 0.0127
Brugia malayi Protein-tyrosine phosphatase 1 0.0027 0.0047 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0191 0.4708
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0152 0.0436 0.0554
Onchocerca volvulus 0.0038 0.0082 0.0551
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0003 0.0005
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0033 0.0068 0.0253
Brugia malayi nuclear hormone receptor family member odr-7 0.0031 0.0061 0.006
Onchocerca volvulus Alhambra homolog 0.0029 0.0054 0.0355
Schistosoma mansoni hypothetical protein 0.0056 0.0139 0.0234
Brugia malayi Cathepsin L-like precursor 0.0013 0.0006 0.0005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0003 0.0005
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0027 0.0047 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0108 0.0542
Brugia malayi orphan nuclear receptor NR2E1 0.0031 0.0061 0.006
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0062 0.0157 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0086
Brugia malayi Cathepsin L-like precursor 0.0013 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0066 0.0168 0.0214
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0012 0.0003 0.0005
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0061 0.0088
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0107 0.0294 0.0426
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0003 0.0004
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0027 0.0047 0.0069
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0012 0.0003 0.0004
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0076 0.02 0.0755
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0152 0.0436 0.0735
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0077 0.0112
Echinococcus multilocularis cysteine protease 0.0013 0.0006 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0061 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0066 0.0168 0.0167
Loa Loa (eye worm) hypothetical protein 0.041 0.1232 0.1565
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0033 0.0066 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0022 0.0108
Mycobacterium tuberculosis Probable reductase 0.0076 0.02 0.0755
Leishmania major cathepsin L-like protease 0.005 0.012 0.2303
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Onchocerca volvulus Protein patched homolog 0.0017 0.0017 0.0099
Loa Loa (eye worm) hypothetical protein 0.0066 0.0168 0.0214
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0191 0.4712
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0027 0.0047 0.008
Loa Loa (eye worm) hypothetical protein 0.0084 0.0225 0.0286
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0191 0.4712
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0066 0.0168 0.0167
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0.0003 0.0004
Echinococcus multilocularis lipoxygenase domain containing protein 0.0015 0.0013 0.0019
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0012 0.0003 0.0005
Loa Loa (eye worm) TYRA-2 protein 0.0012 0.0003 0.0004
Loa Loa (eye worm) RNA binding protein 0.0064 0.0164 0.0209
Schistosoma mansoni rab6-interacting 0.0015 0.0013 0.0022
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0047 0.006
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0012 0.0003 0.0002
Schistosoma mansoni thyroid hormone receptor 0.0066 0.0168 0.0284
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0066 0.0168 0.0284
Trypanosoma cruzi ISWI complex protein 0.0016 0.0013 0.0316
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Schistosoma mansoni DNA topoisomerase type I 0.0142 0.0405 0.0683
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.0061 0.0406
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0078
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0864 0.2633 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0225 0.0286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0006 0.0025
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0034 0.007 0.0101
Toxoplasma gondii exonuclease III APE 0.0034 0.007 0.1706
Schistosoma mansoni hypothetical protein 0.0015 0.0013 0.0022
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0003 0.0005
Onchocerca volvulus 0.0113 0.0313 0.2168
Schistosoma mansoni neuropeptide receptor 0.0012 0.0003 0.0005
Brugia malayi sulfakinin receptor protein 0.0012 0.0003 0.0002
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0047 0.0069
Schistosoma mansoni protein tyrosine phosphatase 0.0027 0.0047 0.008
Echinococcus multilocularis lamin dm0 0.0024 0.0038 0.0055
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Brugia malayi protein C24B5.3 0.0017 0.0017 0.0016
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0003 0.0005
Schistosoma mansoni pcd6 interacting protein-related 0.0027 0.0047 0.008
Echinococcus granulosus dro:myosuppressin receptor 0.0012 0.0003 0.0005
Echinococcus multilocularis dnaJ subfamily B 0.0358 0.1069 0.1548
Onchocerca volvulus 0.0027 0.0047 0.031
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0029 0.0055 0.0205
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0673 0.2044 0.3446
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Echinococcus granulosus somatostatin receptor 0.0012 0.0003 0.0005
Schistosoma mansoni hypothetical protein 0.0029 0.0054 0.0091
Echinococcus granulosus fmrfamide receptor 0.0012 0.0003 0.0005
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0112 0.031 0.9892
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0053 0.0199
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0253 0.1277
Toxoplasma gondii isocitrate dehydrogenase 0.003 0.0058 0.1402
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0045 0.0104 0.015
Loa Loa (eye worm) intermediate filament protein 0.0024 0.0038 0.0048
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0057 0.0141 0.0205
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0018 0.0022 0.0032
Echinococcus multilocularis 0.0027 0.0047 0.0069
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0035 0.086
Brugia malayi Dopamine receptor protein 1 0.0012 0.0003 0.0002
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0003 0.0005
Leishmania major acetyl-CoA synthetase, putative 0.0033 0.0068 0.1296
Echinococcus multilocularis Niemann Pick C1 protein 0.0395 0.1184 0.1714
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0033 0.0068 0.0067
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0084 0.0225 0.0853
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0006 0.0025
Onchocerca volvulus 0.0033 0.0068 0.0451
Brugia malayi Patched family protein 0.0017 0.0017 0.0016
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0177 0.0513 0.0512
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0077 0.0365
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0033 0.0068 0.1647
Echinococcus granulosus FTZ F1 alpha 0.0066 0.0168 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0066 0.0168 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0331 0.1676
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0113 0.0313 0.1187
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0005
Brugia malayi Intermediate filament tail domain containing protein 0.0024 0.0038 0.0037
Onchocerca volvulus 0.0017 0.0017 0.0099
Schistosoma mansoni protein tyrosine phosphatase 0.0027 0.0047 0.008
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.012 0.2938
Echinococcus multilocularis microtubule associated protein 2 0.1932 0.5931 0.8583
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0047 0.006
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0033 0.0068 0.0253
Brugia malayi nuclear receptor RXR 0.0031 0.0061 0.006
Plasmodium falciparum acyl-CoA synthetase 0.0084 0.0225 0.5552
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0005
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0164 0.0209
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0023 0.0036 0.0869
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0033 0.0068 0.1653
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.012 0.2933
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0289 0.0857 0.0857
Trichomonas vaginalis pten, drome, putative 0.0027 0.0047 0.0235
Echinococcus granulosus regulator of G protein signaling 3 0.0018 0.0022 0.0038
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0078 0.0132
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0006 0.0025
Loa Loa (eye worm) doublecortin family protein 0.0015 0.0013 0.0016
Loa Loa (eye worm) hypothetical protein 0.0687 0.2086 0.265
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0018 0.0022 0.0038
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0003 0.0005
Echinococcus multilocularis g-protein coupled receptor 0.0012 0.0003 0.0004
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0035 0.0073 0.0105
Toxoplasma gondii patched family protein 0.0017 0.0017 0.0398
Entamoeba histolytica hypothetical protein 0.0037 0.0078 0.0369
Schistosoma mansoni hypothetical protein 0.0056 0.0139 0.0234
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0068 0.0253
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0027 0.0047 0.008
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0107 0.0294 0.0293
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0034 0.007 0.0262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0006 0.0025
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.012 0.0335 0.8252
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0012 0.0001 0.0007
Brugia malayi Patched family protein 0.0017 0.0017 0.0016
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0078 0.0132
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0101 0.0277 0.6816
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0003 0.0004
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.003 0.0058 0.0097
Leishmania major DNA topoisomerase IB, large subunit 0.0142 0.0405 0.7839
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0012 0.0001 0.0007
Plasmodium falciparum phd finger protein, putative 0.0029 0.0054 0.1309
Loa Loa (eye worm) hypothetical protein 0.0043 0.0099 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0191 0.4708
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0022 0.0108
Brugia malayi nuclear hormone receptor family member nhr-6 0.0031 0.0061 0.006
Loa Loa (eye worm) hypothetical protein 0.0145 0.0414 0.0525
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0073 0.0191 0.0322
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.012 0.2933
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.0035 0.0854
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0033 0.0066 0.0111
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0022 0.0038
Entamoeba histolytica phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative 0.0051 0.0124 0.0601
Toxoplasma gondii histone lysine methyltransferase SET1 0.005 0.012 0.2936
Brugia malayi Patched protein homolog 1 0.0017 0.0017 0.0016
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0013 0.0006 0.012
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0022 0.0032
Echinococcus granulosus dna polymerase kappa 0.0073 0.0191 0.0322
Schistosoma mansoni coup transcription factor 0.0066 0.0168 0.0284
Echinococcus granulosus thyroid hormone receptor alpha 0.0031 0.0061 0.0103
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0.0003 0.0004
Brugia malayi jmjC domain containing protein 0.0094 0.0255 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0066 0.0168 0.0167
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0024 0.0038 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0066 0.0168 0.0214
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0054 0.0078
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0164 0.0277
Leishmania major DNA polymerase kappa, putative 0.0073 0.0191 0.3693
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0068 0.0253
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0033 0.0068 0.0314
Echinococcus multilocularis isocitrate dehydrogenase 0.003 0.0058 0.0083
Echinococcus granulosus Protein patched homolog 1 0.0119 0.0331 0.0559
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0014 0.0023
Leishmania major tyrosine specific protein phosphatase, putative 0.0027 0.0047 0.0905
Trypanosoma brucei trypanothione reductase 0.0033 0.0068 0.1661
Giardia lamblia Kinase, PLK 0.0093 0.0253 0.3753
Leishmania major cathepsin L-like protease 0.0013 0.0006 0.01
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0012 0.0003 0.0004
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0006 0.001
Echinococcus granulosus lipoxygenase domain containing protein 0.0015 0.0013 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.0191 0.0723
Brugia malayi PHD-finger family protein 0.0027 0.0048 0.0047
Leishmania major cathepsin L-like protease 0.0013 0.0006 0.01
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0409 0.123 0.1779
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0033 0.0068 0.1653
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0152 0.0436 0.0735
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.0047 0.008
Loa Loa (eye worm) hypothetical protein 0.0056 0.0139 0.0176
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Entamoeba histolytica acyl-coA synthetase, putative 0.0113 0.0313 0.1565
Brugia malayi nuclear hormone receptor 0.0441 0.1328 0.1327
Echinococcus granulosus lamin 0.0024 0.0038 0.0064
Schistosoma mansoni hypothetical protein 0.0114 0.0318 0.0536
Brugia malayi nuclear receptor NHR-88 0.0031 0.0061 0.006
Schistosoma mansoni cpg binding protein 0.0028 0.0053 0.009
Trichomonas vaginalis DNA topoisomerase II, putative 0.0107 0.0294 0.1488
Brugia malayi Patched family protein 0.0017 0.0017 0.0016
Trypanosoma cruzi cruzipain precursor, putative 0.005 0.012 0.2938
Brugia malayi Patched family protein 0.0017 0.0017 0.0016
Onchocerca volvulus 0.0013 0.0006 0.002
Brugia malayi neuropeptide F receptor 0.0012 0.0003 0.0002
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0047 0.008
Brugia malayi nuclear receptor NHR-88 0.0066 0.0168 0.0167
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Brugia malayi hypothetical protein 0.0118 0.033 0.0329
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0027 0.0047 0.0069
Loa Loa (eye worm) hypothetical protein 0.0066 0.0168 0.0214
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0253 0.0252
Echinococcus granulosus hypothetical protein 0.0012 0.0003 0.0005
Loa Loa (eye worm) DNA topoisomerase I 0.0142 0.0405 0.0515
Plasmodium vivax topoisomerase I, putative 0.0142 0.0405 1
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0191 0.4708
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0006 0.0025
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0027 0.0047 0.008
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0024 0.003
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0066 0.0329
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0441 0.1328 0.1686
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0003 0.0005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0047 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0229 0.0672 0.3404
Onchocerca volvulus 4.1 G protein, putative homolog 0.0027 0.0047 0.031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Echinococcus multilocularis neuropeptide receptor A26 0.0414 0.1245 0.1801
Leishmania major cathepsin L-like protease 0.0013 0.0006 0.01
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0047 0.006
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0027 0.0047 0.0069
Brugia malayi Serotonin receptor 0.0012 0.0003 0.0002
Echinococcus granulosus nuclear receptor nhr 48 0.0031 0.0061 0.0103
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0033 0.0068 0.1078
Loa Loa (eye worm) hypothetical protein 0.0276 0.0818 0.1039
Loa Loa (eye worm) hypothetical protein 0.028 0.0829 0.1054
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0013
Echinococcus multilocularis cpg binding protein 0.0028 0.0053 0.0077
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0018 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0035 0.0073 0.0092
Schistosoma mansoni DNA topoisomerase II 0.0107 0.0294 0.0496
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0077 0.0388
Brugia malayi conserved hypotetical protein 0.0031 0.0061 0.006
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0253 0.6229
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.012 0.0335 0.8252
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0068 0.0253
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0078 0.0113
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0078
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0185 0.0537 0.0682
Echinococcus granulosus allatostatin A receptor 0.0012 0.0003 0.0005
Brugia malayi polk-prov protein 0.0023 0.0035 0.0035
Brugia malayi hypothetical protein 0.0012 0.0003 0.0002
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.0047 0.008
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Brugia malayi Protein-tyrosine phosphatase 0.0027 0.0047 0.0046
Plasmodium vivax DNA topoisomerase II, putative 0.0107 0.0294 0.7255
Echinococcus multilocularis lamin 0.0024 0.0038 0.0055
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0035 0.086
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0152 0.0436 0.0735
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0073 0.0072
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0042 0.0095 0.012
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0003 0.0004
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.0035 0.0854
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0003 0.0004
Loa Loa (eye worm) patched family protein 0.0017 0.0017 0.0022
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0034 0.007 0.0089
Trypanosoma cruzi tyrosine phosphatase, putative 0.0051 0.0124 0.3048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0066 0.0168 0.0244
Echinococcus granulosus protein tyrosine phosphatase n9 0.0027 0.0047 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0066 0.0168 0.0214
Echinococcus granulosus Niemann Pick C1 protein 0.0276 0.0818 0.1379
Onchocerca volvulus 0.0027 0.0047 0.031
Chlamydia trachomatis DNA gyrase subunit A 0.0023 0.0036 0.1566
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0066 0.0168 0.0244
Onchocerca volvulus Huntingtin homolog 0.0118 0.033 0.2281
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0066 0.0329
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0027 0.0047 0.008
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0083 0.0105
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0048
Echinococcus multilocularis dna polymerase kappa 0.0073 0.0191 0.0277
Leishmania major DNA polymerase eta, putative 0.0023 0.0035 0.0674
Brugia malayi hypothetical protein 0.0012 0.0003 0.0002
Trypanosoma cruzi DNA topoisomerase II, putative 0.0101 0.0277 0.6818
Loa Loa (eye worm) hypothetical protein 0.0066 0.0168 0.0214
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0083 0.014
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0066 0.1013
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0023 0.0036 0.0134
Mycobacterium ulcerans DNA gyrase subunit B 0.0062 0.0157 0.0594
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0012 0.0003 0.0004
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0041 0.0068
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0289 0.0857 0.1241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0006 0.0025
Onchocerca volvulus 0.0013 0.0006 0.002
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0012 0.0003 0.0005
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0027 0.0047 0.0211
Onchocerca volvulus 0.0027 0.0047 0.031
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0012 0.0003 0.0004
Brugia malayi CXXC zinc finger family protein 0.0025 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0047
Entamoeba histolytica hypothetical protein 0.0037 0.0078 0.0369
Brugia malayi exodeoxyribonuclease III family protein 0.0034 0.007 0.0069
Schistosoma mansoni protein tyrosine phosphatase 0.0027 0.0047 0.008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0084 0.0225 1
Onchocerca volvulus 0.0027 0.0047 0.031
Trichomonas vaginalis ap endonuclease, putative 0.0034 0.007 0.035
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0034 0.007 0.1706
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0033 0.0068 0.0255
Echinococcus granulosus dnaJ subfamily B 0.0358 0.1069 0.1803
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0018 0.0022 0.0038
Echinococcus multilocularis ecdysone induced protein 78C 0.0066 0.0168 0.0244
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0012 0.0003 0.0002
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.1185 0.3624 0.6111
Leishmania major DNA topoisomerase ii 0.0101 0.0277 0.5345
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0066 0.0168 0.0284
Loa Loa (eye worm) protein tyrosine phosphatase 0.0027 0.0047 0.006
Echinococcus granulosus jumonji domain containing protein 0.004 0.0089 0.0149
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0013
Brugia malayi larval opioid receptor 0.0012 0.0003 0.0002
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0054 0.0091
Brugia malayi hypothetical protein 0.0017 0.0017 0.0016
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0003 0.0005
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0066 0.0329
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0027 0.0047 0.0069
Brugia malayi hypothetical protein 0.0017 0.0017 0.0016
Brugia malayi protein C24B5.3 0.0017 0.0017 0.0016
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0253 0.4883
Plasmodium vivax DNA gyrase subunit A, putative 0.0023 0.0036 0.0869
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0027 0.0047 0.0046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0001 0.0007
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0033 0.0068 0.0253
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0047 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0006 0.0025
Brugia malayi hypothetical protein 0.0012 0.0003 0.0002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.003 0.0058 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0066 0.0168 0.0214
Plasmodium falciparum lipid/sterol:H+ symporter 0.0017 0.0017 0.0398
Loa Loa (eye worm) hypothetical protein 0.0302 0.0897 0.1139
Schistosoma mansoni growth hormone secretagogue receptor 0.0012 0.0003 0.0005
Echinococcus multilocularis neuropeptide s receptor 0.0414 0.1245 0.1801
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0034 0.007 0.1342
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0028
Onchocerca volvulus 0.0013 0.0006 0.002
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0012 0.0003 0.0004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0066 0.0168 0.0284
Schistosoma mansoni steroid hormone receptor ad4bp 0.0066 0.0168 0.0284
Brugia malayi hypothetical protein 0.0012 0.0003 0.0002
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0047 0.006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0066 0.0168 0.0214
Loa Loa (eye worm) hypothetical protein 0.0072 0.0188 0.0239
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0045 0.0104 0.2002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0054 0.1309
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0003 0.0005
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0157 0.0228
Schistosoma mansoni terminal deoxycytidyl transferase 0.0073 0.0191 0.0322
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0047 0.008
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0024 0.0034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0229 0.0672 0.3404
Schistosoma mansoni opsin-like receptor 0.0012 0.0003 0.0005
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0152 0.0436 0.0631
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0033 0.0068 0.1647
Echinococcus granulosus neuropeptide receptor 0.0012 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0041 0.0093 0.0119
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0068 0.0253
Echinococcus granulosus cpg binding protein 0.0028 0.0053 0.009
Onchocerca volvulus 0.0033 0.0068 0.0451
Schistosoma mansoni amine GPCR 0.0012 0.0003 0.0005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0409 0.123 0.1562
Leishmania major hypothetical protein, unknown function 0.0051 0.0124 0.2389
Onchocerca volvulus 0.0036 0.0077 0.0516
Brugia malayi hypothetical protein 0.0012 0.0003 0.0002
Brugia malayi tailless protein 0.0031 0.0061 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0006 0.0025
Brugia malayi Cathepsin L-like precursor 0.0013 0.0006 0.0005
Trypanosoma cruzi ISWI complex protein 0.0016 0.0013 0.0316
Brugia malayi Tachykinin-like peptides receptor 99D 0.0012 0.0003 0.0002
Giardia lamblia Fructose-bisphosphate aldolase 0.0229 0.0672 1
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0003 0.0005
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0084 0.0226 0.6824
Echinococcus multilocularis axis inhibition protein axin 0.0018 0.0022 0.0032
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.003 0.0058 0.1402
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0066 0.0168 0.0284
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0409 0.123 0.1229
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.003 0.0038
Loa Loa (eye worm) isocitrate dehydrogenase 0.003 0.0058 0.0073
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0003 0.0004
Brugia malayi PHD-finger family protein 0.0029 0.0054 0.0053
Echinococcus multilocularis cathepsin L cysteine protease 0.0013 0.0006 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0164 0.0277
Brugia malayi AKH receptor 0.0012 0.0003 0.0002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Echinococcus multilocularis G protein coupled receptor 139 0.0012 0.0003 0.0004
Echinococcus granulosus G protein coupled receptor 139 0.0012 0.0003 0.0005
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.003 0.0058 0.1402
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0027 0.0047 0.0069
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Toxoplasma gondii patched family protein 0.0017 0.0017 0.0398
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0191 0.4708
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0066 0.0168 0.0167
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0253 0.1277
Trypanosoma brucei protein tyrosine phosphatase 1 0.0027 0.0047 0.1148
Toxoplasma gondii cathepsin CPL 0.0013 0.0006 0.012
Loa Loa (eye worm) hypothetical protein 0.0066 0.0168 0.0214
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0101 0.0129
Brugia malayi jmjC domain containing protein 0.0038 0.0083 0.0082
Loa Loa (eye worm) hypothetical protein 0.0119 0.0331 0.0421
Echinococcus multilocularis peregrin 0.0031 0.0061 0.0089
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0066 0.0246
Brugia malayi cytoplasmic intermediate filament protein 0.0013 0.0004 0.0003
Onchocerca volvulus 0.0013 0.0006 0.002
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0035 0.086
Brugia malayi Patched family protein 0.0017 0.0017 0.0016
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0077 0.0131
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0047 0.0069
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0027 0.0047 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Echinococcus multilocularis GPCR, family 2 0.0056 0.0139 0.0201
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Echinococcus multilocularis thioredoxin glutathione reductase 0.0034 0.0069 0.0101
Schistosoma mansoni DNA topoisomerase type I 0.0142 0.0405 0.0683
Brugia malayi Patched family protein 0.0017 0.0017 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.012 0.2933
Brugia malayi hypothetical protein 0.0031 0.0061 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0229 0.0672 0.3404
Onchocerca volvulus Bile acid receptor homolog 0.0066 0.0168 0.1155
Loa Loa (eye worm) hypothetical protein 0.0113 0.0313 0.0398
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0013 0.0006 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0022 0.0108
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0092 0.025 0.0422
Echinococcus granulosus intermediate filament protein 0.0024 0.0038 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0066 0.0329
Schistosoma mansoni zinc finger protein 0.0021 0.0031 0.0053
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0062 0.0157 0.0594
Brugia malayi Myosin head containing protein 0.0017 0.0017 0.0016
Onchocerca volvulus 0.0017 0.0017 0.0099
Plasmodium falciparum DNA gyrase subunit A 0.0023 0.0036 0.0869
Brugia malayi Calcitonin receptor-like protein seb-1 0.0177 0.0513 0.0512
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0003 0.0004
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0033 0.0068 0.1647
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0012 0.0003 0.0005
Schistosoma mansoni adenoreceptor 0.0012 0.0003 0.0005
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0033 0.0066 0.0329
Loa Loa (eye worm) TOPoisomerase family member 0.0107 0.0294 0.0374
Schistosoma mansoni hypothetical protein 0.0114 0.0318 0.0536
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Schistosoma mansoni lipoxygenase 0.0092 0.025 0.0422
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0012 0.0003 0.0005
Schistosoma mansoni inositol monophosphatase 0.0036 0.0077 0.0131
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0101 0.0171
Echinococcus granulosus tar DNA binding protein 0.0064 0.0164 0.0277
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0045 0.0104 0.0392
Loa Loa (eye worm) inositol-1 0.0036 0.0077 0.0098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0033 0.0068 0.0067
Trichomonas vaginalis DNA polymerase eta, putative 0.0073 0.0191 0.0966
Leishmania major 4-coumarate:coa ligase-like protein 0.0113 0.0313 0.6059
Brugia malayi hypothetical protein 0.0027 0.0047 0.0046
Echinococcus granulosus orexin receptor type 2 0.0012 0.0003 0.0005
Brugia malayi follicle stimulating hormone receptor 0.0012 0.0003 0.0002
Plasmodium vivax vivapain-2 0.0013 0.0006 0.012
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0045 0.0104 0.0175
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0107 0.0294 0.0496
Brugia malayi G-protein coupled receptor 0.0012 0.0003 0.0002
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0077 0.49
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0119 0.0331 0.0421
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0012 0.0003 0.0004
Brugia malayi hypothetical protein 0.0018 0.0022 0.0021
Leishmania major cathepsin L-like protease 0.005 0.012 0.2303
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0229 0.0672 0.3404
Onchocerca volvulus 0.0017 0.0017 0.0099
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Brugia malayi nuclear hormone receptor 0.0066 0.0168 0.0167
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0045 0.0104 0.0392
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0003 0.0005
Echinococcus granulosus g-protein coupled receptor 0.0012 0.0003 0.0005
Echinococcus multilocularis zinc finger protein 0.0021 0.0031 0.0045
Echinococcus multilocularis Polycystic kidney disease protein 0.0015 0.0013 0.0019
Onchocerca volvulus 0.0027 0.0047 0.031
Trichomonas vaginalis ap endonuclease, putative 0.0034 0.007 0.035
Plasmodium vivax patched family protein, putative 0.0017 0.0017 0.0398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.012 0.2933
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0027 0.0047 0.0069
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0035 0.086
Brugia malayi PXA domain containing protein 0.0018 0.0022 0.0021
Brugia malayi G-protein coupled receptor 0.0012 0.0003 0.0002
Brugia malayi Cathepsin L-like precursor 0.0013 0.0006 0.0005
Loa Loa (eye worm) patched family protein 0.0017 0.0017 0.0022
Schistosoma mansoni neuropeptide receptor 0.0012 0.0003 0.0005
Brugia malayi Steroid receptor seven-up type 2 0.0066 0.0168 0.0167
Onchocerca volvulus 0.0024 0.0038 0.0246
Echinococcus granulosus peptide allatostatin:somatostatin 0.0012 0.0003 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0101 0.0171
Entamoeba histolytica hypothetical protein 0.0018 0.0022 0.0084
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.008 0.0211 0.0799
Toxoplasma gondii patched family protein 0.0017 0.0017 0.0398
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0033 0.0068 0.1296
Loa Loa (eye worm) hypothetical protein 0.0084 0.0225 0.0286
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0012 0.0001 0.0006
Schistosoma mansoni neuropeptide f receptor 76f 0.0012 0.0003 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0229 0.0672 0.3404
Loa Loa (eye worm) latrophilin receptor protein 2 0.0056 0.0139 0.0176
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0035 0.0073 0.0122
Brugia malayi Doublecortin family protein 0.0015 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0078
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0003 0.0005
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0027 0.0047 0.0211
Loa Loa (eye worm) fibroinase 0.0013 0.0006 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0003 0.0005
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Loa Loa (eye worm) hypothetical protein 0.0113 0.0313 0.0398
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0061 0.0088
Echinococcus multilocularis sterol regulatory element binding protein 0.0119 0.0331 0.0479
Brugia malayi hypothetical protein 0.0018 0.0022 0.0021
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0164 0.0209
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0076 0.02 0.0755
Onchocerca volvulus 0.0027 0.0047 0.031
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0047 0.0069
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0033 0.0068 0.0253
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0029 0.0055 0.0205
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0034 0.007 0.1712
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0066 0.0168 0.0244
Mycobacterium ulcerans acyl-CoA synthetase 0.0113 0.0313 0.1187
Echinococcus granulosus Polycystic kidney disease protein 0.0015 0.0013 0.0022
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0003 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.008 0.0211 0.0799
Brugia malayi Protein-tyrosine phosphatase 0.0027 0.0047 0.0046
Brugia malayi regulator of G-protein signaling rgs-7 0.0018 0.0022 0.0021
Brugia malayi hypothetical protein 0.0012 0.0003 0.0002
Brugia malayi G protein-coupled receptor 0.0012 0.0003 0.0002
Echinococcus granulosus serotonin receptor 0.0012 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0078
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0113 0.0313 0.1187
Schistosoma mansoni rab6-interacting 0.0015 0.0013 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0191 0.4708
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0229 0.0672 0.3404
Echinococcus multilocularis thyroid hormone receptor alpha 0.0066 0.0168 0.0244
Onchocerca volvulus Cathepsin L homolog 0.0013 0.0006 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0033 0.0068 0.0067
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0035 0.0073 0.0092
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0027 0.0047 0.0069
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.003 0.0058 0.0083
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0073 0.0191 0.0966
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0066 0.0329
Brugia malayi Patched related family protein 4 0.0017 0.0017 0.0016
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0066 0.0168 0.0284
Brugia malayi hypothetical protein 0.0015 0.0013 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0109
Loa Loa (eye worm) hypothetical protein 0.0177 0.0513 0.0652
Brugia malayi Patched family protein 0.0017 0.0017 0.0016
Entamoeba histolytica DNA topoisomerase II, putative 0.0107 0.0294 0.1467
Schistosoma mansoni alpha-1 adrenergic receptor 0.0012 0.0003 0.0005
Brugia malayi hypothetical protein 0.0185 0.0537 0.0536
Plasmodium vivax glutathione reductase, putative 0.0033 0.0068 0.1661
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0033 0.0068 0.0253
Leishmania major DNA polymerase kappa, putative 0.0023 0.0035 0.0674
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0006 0.0025
Plasmodium vivax DNA gyrase subunit B, putative 0.0062 0.0157 0.3863
Echinococcus granulosus zinc finger protein 0.0021 0.0031 0.0053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0024 0.004
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0035 0.0854
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0019 0.0032
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0061 0.006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0027 0.0047 0.0069
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.0047 0.008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0066 0.0168 0.0167
Schistosoma mansoni amine GPCR 0.0012 0.0003 0.0005
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0084 0.0226 0.0855
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Schistosoma mansoni inositol monophosphatase 0.0036 0.0077 0.0131
Mycobacterium ulcerans acetyl-CoA synthetase 0.0033 0.0068 0.0253
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Loa Loa (eye worm) hypothetical protein 0.0066 0.0168 0.0214
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0033 0.0068 0.0253
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0177 0.0513 0.0652
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Onchocerca volvulus 0.0013 0.0006 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.0047 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0191 0.4708
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0027 0.0047 0.0046
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0066 0.0168 0.0214
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0076 0.02 0.5875
Brugia malayi Patched related family protein 10 0.0017 0.0017 0.0016
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0031 0.0061 0.0103
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0072 0.0188 0.129
Loa Loa (eye worm) hypothetical protein 0.0118 0.033 0.0419
Schistosoma mansoni intermediate filament proteins 0.0024 0.0038 0.0064
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.0035 0.0854
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0157 0.0265
Schistosoma mansoni nuclear receptor 0.0031 0.0061 0.0103
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0101 0.0147
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0.0003 0.0004
Schistosoma mansoni axis inhibition protein axin 0.0018 0.0022 0.0038
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.003 0.0058 0.0083
Echinococcus multilocularis regulator of G protein signaling 3 0.0018 0.0022 0.0032
Schistosoma mansoni hypothetical protein 0.0056 0.0139 0.0234
Brugia malayi neuropeptide F receptor 0.0012 0.0003 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0024 0.004
Leishmania major hypothetical protein, conserved 0.0016 0.0013 0.0247
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.0047 0.008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0038 0.0187
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0038 0.0082 0.0081
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0164 0.0277
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0078
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Echinococcus granulosus axis inhibition protein axin 0.0018 0.0022 0.0038
Leishmania major acetyl-CoA synthetase, putative 0.0033 0.0068 0.1296
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0012 0.0003 0.0005
Echinococcus multilocularis survival motor neuron protein 1 0.0185 0.0537 0.0777
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Echinococcus multilocularis Niemann Pick C1 protein 0.0276 0.0818 0.1184
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0021 0.0035
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0033 0.0066 0.0329
Brugia malayi Melatonin receptor type 1A 0.0012 0.0003 0.0002
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0033 0.0068 0.1647
Trypanosoma brucei isocitrate dehydrogenase, putative 0.003 0.0058 0.1402
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Onchocerca volvulus 0.0027 0.0047 0.031
Giardia lamblia DNA topoisomerase II 0.0101 0.0277 0.4117
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0033 0.0068 0.0098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0027 0.0047 0.006
Brugia malayi Dopamine receptor 0.0012 0.0003 0.0002
Brugia malayi hypothetical protein 0.0035 0.0073 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0164 0.0277
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0196 0.033
Toxoplasma gondii isocitrate dehydrogenase 0.003 0.0058 0.1402
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Echinococcus multilocularis regulator of G protein signaling 3 0.0018 0.0022 0.0032
Echinococcus granulosus g protein coupled receptor 0.0012 0.0003 0.0005
Onchocerca volvulus Protein ultraspiracle homolog 0.0066 0.0168 0.1155
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Brugia malayi MH2 domain containing protein 0.0122 0.0341 0.034
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0072 0.0188 0.129
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0066 0.0168 0.0284
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0068 0.0253
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0033 0.0068 0.0253
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0033 0.0066 0.0329
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0073 0.0191 0.0322
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0142 0.0405 1
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.012 0.2938
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0034 0.007 0.1706
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0061 0.0103
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.008 0.0211 0.0799
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0078
Onchocerca volvulus Cathepsin F homolog 0.0013 0.0006 0.002
Onchocerca volvulus 0.0013 0.0006 0.002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.0191 0.4712
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0253 0.0366
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Brugia malayi Patched family protein 0.0017 0.0017 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0066 0.0168 0.0167
Leishmania major cathepsin L-like protease 0.005 0.012 0.2303
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0101 0.0147
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0003 0.0005
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0068 0.1667
Echinococcus multilocularis protein patched 0.0119 0.0331 0.0479
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0033 0.0068 0.0253
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Onchocerca volvulus 0.0015 0.0013 0.007
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0003 0.0005
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0066 0.0329
Loa Loa (eye worm) ctsf protein 0.0013 0.0006 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0038 0.0187
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0045 0.0104 0.0175
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0003 0.0005
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0033 0.0068 0.1647
Onchocerca volvulus 0.0027 0.0047 0.031
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Schistosoma mansoni hypothetical protein 0.0358 0.1069 0.1803
Brugia malayi Patched family protein 0.0017 0.0017 0.0016
Trypanosoma cruzi major cysteine proteinase, putative 0.0039 0.0087 0.2122
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Chlamydia trachomatis DNA gyrase subunit B 0.0049 0.0117 0.5165
Brugia malayi hypothetical protein 0.0027 0.0047 0.0046
Loa Loa (eye worm) patched family protein 0.0017 0.0017 0.0022
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0021 0.003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0047 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0006 0.0025
Plasmodium falciparum LCCL domain-containing protein 0.0015 0.0013 0.0298
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0062 0.0157 0.2329
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0022 0.0038
Echinococcus multilocularis orexin receptor type 2 0.0012 0.0003 0.0004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0022 0.0038
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0018 0.0022 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.012 0.2933
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0113 0.0313 0.1187
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0034 0.007 0.1706
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0027 0.0047 0.0905
Brugia malayi PXA domain containing protein 0.0018 0.0022 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.012 0.2933
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0289 0.0857 0.1446
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0066 0.0168 0.0284
Loa Loa (eye worm) hypothetical protein 0.0043 0.0099 0.0126
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0066 0.0168 0.0284
Entamoeba histolytica acyl-CoA synthetase, putative 0.0113 0.0313 0.1565
Echinococcus granulosus microtubule associated protein 2 0.1932 0.5931 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0033 0.0066 0.161
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.003 0.0058 0.1402
Trypanosoma brucei polo-like protein kinase 0.0093 0.0253 0.6227
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0073 0.0191 0.3693
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0003 0.0004
Onchocerca volvulus 0.0015 0.0013 0.007
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0003 0.0005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0047 0.0046
Brugia malayi Dopamine receptor protein 2 0.0012 0.0003 0.0002
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0034 0.007 0.0326
Loa Loa (eye worm) patched family protein 0.0017 0.0017 0.0022
Brugia malayi putative neuropeptide receptor 0.0012 0.0003 0.0002
Brugia malayi Patched family protein 0.0017 0.0017 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0253 0.1277
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0012 0.0003 0.0002
Brugia malayi G protein-coupled receptor F59B2.13 0.0012 0.0003 0.0002
Echinococcus multilocularis serotonin receptor 0.0012 0.0003 0.0004
Plasmodium falciparum topoisomerase I 0.0142 0.0405 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0056 0.0139 0.0234
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.006
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0011 0 0.0001
Schistosoma mansoni nuclear hormone receptor 0.0066 0.0168 0.0284
Schistosoma mansoni acetyl-CoA synthetase 0.0033 0.0068 0.0114
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0066 0.0168 0.0244
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.0035 0.006
Onchocerca volvulus 0.0066 0.0168 0.1155
Echinococcus multilocularis dro:myosuppressin receptor 0.0012 0.0003 0.0004
Schistosoma mansoni zinc finger protein 0.0016 0.0013 0.0023
Loa Loa (eye worm) CXXC zinc finger family protein 0.0025 0.0043 0.0054
Schistosoma mansoni RAR-like nuclear receptor 0.0066 0.0168 0.0284
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0033 0.0068 0.0253
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0006 0.0025
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0027 0.0047 0.0069
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0033 0.0066 0.1604
Schistosoma mansoni amine GPCR 0.0012 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0022
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0061 0.0103

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 63.9 nM Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay ChEMBL. 21988093

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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