Detailed information for compound 1567254

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 366.324 | Formula: C19H14N2O6
  • H donors: 4 H acceptors: 6 LogP: 3.7 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cc(ccc1NC(=O)c1cc(O)c(c(c1)O)O)c1ccccc1
  • InChi: 1S/C19H14N2O6/c22-16-9-13(10-17(23)18(16)24)19(25)20-14-7-6-12(8-15(14)21(26)27)11-4-2-1-3-5-11/h1-10,22-24H,(H,20,25)
  • InChiKey: XYJIXRKQRPDXOA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Muscleblind-like protein 0.0152 0.0938 0.1248
Trichomonas vaginalis aldo/keto reductase, putative 0.0415 0.2749 1
Brugia malayi Augmenter of liver regeneration 0.0034 0.0128 0.017
Toxoplasma gondii exonuclease III APE 0.0019 0.0021 0.0059
Toxoplasma gondii aldose reductase, putative 0.0415 0.2749 1
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0152 0.0536
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.002 0.0031 0.0026
Echinococcus granulosus bloom syndrome protein 0.002 0.0028 0.0037
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0031 0.0096
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0092 0.0123
Brugia malayi CHE-14 protein 0.0043 0.0187 0.0249
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0052 0.0048
Loa Loa (eye worm) hypothetical protein 0.0043 0.0187 0.0249
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.081 0.5477 0.7284
Loa Loa (eye worm) hypothetical protein 0.0034 0.0126 0.0168
Echinococcus multilocularis protoporphyrinogen oxidase 0.0103 0.0603 0.0802
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0021 0.0028
Brugia malayi hypothetical protein 0.0103 0.0603 0.0802
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0206 0.0275
Echinococcus granulosus flap endonuclease 1 0.0026 0.0071 0.0094
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0064 0.0216
Echinococcus granulosus aldo keto reductase 0.0415 0.2749 0.3656
Echinococcus granulosus voltage gated potassium channel subunit 0.012 0.0719 0.0956
Schistosoma mansoni serine/threonine protein kinase 0.1107 0.752 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0112 0.0663 0.2399
Toxoplasma gondii hypothetical protein 0.0049 0.0227 0.0809
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0133 0.0121
Leishmania major hypothetical protein, conserved 0.0025 0.0064 0.0216
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0876 0.3175
Trypanosoma brucei unspecified product 0.0037 0.0143 0.0505
Entamoeba histolytica hypothetical protein 0.0037 0.0144 0.045
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.014 0.0494
Onchocerca volvulus 0.0099 0.0572 0.0736
Echinococcus granulosus dna polymerase kappa 0.008 0.044 0.0585
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1467 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.0302 0.1084
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0028 0.0037
Mycobacterium ulcerans DNA polymerase IV 0.008 0.044 0.0436
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0082 0.0109
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.014 0.0494
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0233 0.0228
Trypanosoma brucei unspecified product 0.0073 0.0395 0.1421
Mycobacterium ulcerans monoamine oxidase 0.0103 0.0603 0.0599
Mycobacterium ulcerans dehydrogenase 0.0103 0.0603 0.0599
Mycobacterium ulcerans hypothetical protein 0.0107 0.0629 0.0625
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0021 0.0059
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0041
Loa Loa (eye worm) RNA binding protein 0.0064 0.0335 0.0446
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0052 0.0174
Echinococcus granulosus expressed conserved protein 0.0094 0.054 0.0718
Schistosoma mansoni hypothetical protein 0.0029 0.0092 0.0123
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.014 0.0187
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0128 0.017
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0335 0.0446
Mycobacterium ulcerans hypothetical protein 0.005 0.0233 0.0228
Loa Loa (eye worm) oxidoreductase 0.0415 0.2749 0.3656
Loa Loa (eye worm) hypothetical protein 0.0042 0.018 0.024
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0021 0.0225
Schistosoma mansoni inositol transporter 0.0038 0.0152 0.0202
Echinococcus granulosus peregrin 0.0039 0.0158 0.021
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0233 0.0831
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0041
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1107 0.752 1
Schistosoma mansoni hypothetical protein 0.0034 0.0126 0.0168
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0082 0.0109
Brugia malayi Common central domain of tyrosinase family protein 0.0099 0.0572 0.0761
Brugia malayi Pre-SET motif family protein 0.0209 0.1333 0.1772
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0082 0.0109
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0335 0.0446
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0415 0.2749 0.3656
Echinococcus granulosus aldo keto reductase family 1, member B4 0.012 0.0719 0.0956
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0112 0.0663 0.2399
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0082 0.0109
Echinococcus multilocularis dual specificity 0.037 0.2443 0.3249
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0112 0.0663 0.0882
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0112 0.0663 0.2399
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0415 0.2749 0.3656
Brugia malayi Serine/threonine-protein kinase Pim-3 0.1107 0.752 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.018 0.024
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0082 0.0109
Trichomonas vaginalis DNA polymerase eta, putative 0.008 0.044 0.1537
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0128 0.017
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0152 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0031 0.0037
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0064 0.0085
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0083 0.0462 0.0614
Loa Loa (eye worm) hypothetical protein 0.0343 0.2254 0.2997
Onchocerca volvulus 0.0296 0.193 0.2547
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0152 0.0202
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0082 0.0109
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0876 0.3175
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0052 0.0078
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0171 0.0227
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.0878 0.1167
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0031 0.0041
Loa Loa (eye worm) hypothetical protein 0.0037 0.0147 0.0195
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0082 0.0109
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0663 0.2355
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0021 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.044 0.1586
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0064 0.0085
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0581 0.0773
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0206 0.0275
Schistosoma mansoni eyes absent homolog 0.0088 0.0498 0.0663
Brugia malayi SWIRM domain containing protein 0.0103 0.0603 0.0802
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0265 0.0353
Schistosoma mansoni SET domain protein 0.0034 0.0125 0.0166
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.014 0.0438
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0415 0.2749 0.3656
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0042 0.018 0.2459
Brugia malayi AMP-binding enzyme family protein 0.005 0.0233 0.031
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0041
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0105 0.0363
Schistosoma mansoni hypothetical protein 0.0041 0.0177 0.0235
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0103 0.0603 0.8378
Plasmodium vivax JmjC domain containing protein 0.0025 0.0064 0.0832
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0233 0.0777
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0235 0.0312
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0233 0.0743
Schistosoma mansoni alpha-glucosidase 0.014 0.0857 0.114
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0021 0.0059
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0082 0.0109
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0581 0.0773
Loa Loa (eye worm) hypothetical protein 0.0152 0.0938 0.1248
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0346 0.046
Schistosoma mansoni DNA polymerase eta 0.0078 0.0432 0.0575
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.044 0.1586
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0078 0.1023
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.044 0.1586
Echinococcus granulosus aldo keto reductase 0.0415 0.2749 0.3656
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0335 0.0446
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0082 0.0109
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0052 0.0034
Trichomonas vaginalis set domain proteins, putative 0.0238 0.1531 0.5534
Brugia malayi ImpB/MucB/SamB family protein 0.0078 0.0432 0.0575
Toxoplasma gondii histone lysine-specific demethylase 0.0103 0.0603 0.2181
Brugia malayi polk-prov protein 0.0043 0.0188 0.025
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0099 0.0572 0.0761
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0415 0.2749 0.3656
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0415 0.2749 0.3656
Trichomonas vaginalis aldo-keto reductase, putative 0.0415 0.2749 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0082 0.0109
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0152 0.0202
Giardia lamblia Aldose reductase 0.0415 0.2749 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0041
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0082 0.0109
Entamoeba histolytica recQ family helicase, putative 0.002 0.0028 0.0026
Schistosoma mansoni jumonji domain containing protein 0.0135 0.0819 0.1089
Schistosoma mansoni topbp1 0.002 0.0031 0.0041
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0876 0.3175
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0152 0.0202
Plasmodium vivax hypothetical protein, conserved 0.0042 0.018 0.2459
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0053 0.0257 0.0342
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.037 0.2443 0.8885
Trichomonas vaginalis aldo/keto reductase, putative 0.0415 0.2749 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0254 0.0338
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0415 0.2749 0.3656
Schistosoma mansoni potassium channel beta 0.012 0.0719 0.0956
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.018 0.0639
Echinococcus granulosus phd:f box containing protein 0.0025 0.0064 0.0085
Loa Loa (eye worm) hypothetical protein 0.0362 0.2386 0.3173
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0083 0.0462 0.0614
Giardia lamblia PHD finger protein 15 0.0029 0.0092 0.0318
Brugia malayi jmjC domain containing protein 0.0025 0.0064 0.0085
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0696 0.4687 0.6233
Entamoeba histolytica protein kinase domain containing protein 0.037 0.2443 0.8878
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0028 0.0026
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0128 0.172
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.1107 0.752 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0265 0.0353
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0306 0.0407
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0041
Onchocerca volvulus 0.0042 0.018 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0082 0.0109
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0082 0.0109
Mycobacterium leprae Conserved hypothetical protein 0.0294 0.1921 0.6955
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0082 0.0109
Loa Loa (eye worm) hypothetical protein 0.0415 0.2749 0.3656
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0233 0.0777
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.014 0.0438
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0082 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0082 0.0109
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0028 0.0084
Trichomonas vaginalis aldo-keto reductase, putative 0.012 0.0719 0.2559
Loa Loa (eye worm) tyrosinase 1 0.0099 0.0572 0.0761
Echinococcus granulosus hypothetical protein 0.0415 0.2749 0.3656
Loa Loa (eye worm) hypothetical protein 0.0088 0.0498 0.0663
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0028 0.0037
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0581 0.2055
Leishmania major prostaglandin f synthase, putative 0.0415 0.2749 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0265 0.0353
Giardia lamblia Replication factor C, subunit 1 0.002 0.0031 0.0096
Brugia malayi hypothetical protein 0.002 0.0031 0.0041
Entamoeba histolytica deoxycytidyl transferase, putative 0.0053 0.0257 0.0865
Echinococcus granulosus mitogen activated protein kinase 3 0.0112 0.0663 0.0882
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0133 0.0121
Schistosoma mansoni aldo-keto reductase 0.0415 0.2749 0.3656
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.014 0.0438
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0415 0.2749 0.3656
Mycobacterium ulcerans hypothetical protein 0.0159 0.0987 0.0983
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0031 0.0368
Brugia malayi GH02984p 0.0343 0.2254 0.2997
Mycobacterium ulcerans hypothetical protein 0.012 0.0719 0.0715
Trypanosoma cruzi aldo/keto reductase, putative 0.0415 0.2749 1
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.014 0.0494
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0052 0.0174
Brugia malayi ShTK domain containing protein 0.0099 0.0572 0.0761
Leishmania major hypothetical protein, conserved 0.0034 0.0128 0.0448
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.044 0.1586
Brugia malayi NADH-dependent xylose reductase 0.012 0.0719 0.0956
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0083 0.0462 0.0614
Schistosoma mansoni hypothetical protein 0.0738 0.4976 0.6618
Echinococcus granulosus tar DNA binding protein 0.0064 0.0335 0.0446
Loa Loa (eye worm) hypothetical protein 0.0103 0.0603 0.0802
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0052 0.0048
Onchocerca volvulus 0.0415 0.2749 0.3639
Loa Loa (eye worm) hypothetical protein 0.0103 0.0603 0.0802
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.1014 0.1348
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0144 0.0191
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.0064 0.0085
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.0109
Loa Loa (eye worm) hypothetical protein 0.0031 0.0105 0.0139
Toxoplasma gondii aldo-keto reductase 0.012 0.0719 0.2603
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0105 0.0139
Loa Loa (eye worm) hypothetical protein 0.0038 0.0152 0.0202
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0184 0.0653
Brugia malayi steroid hormone receptor 0.0028 0.0082 0.0109
Loa Loa (eye worm) RecQ helicase 0.002 0.0028 0.0037
Mycobacterium tuberculosis Conserved protein 0.012 0.0719 0.0753
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0265 0.0353
Plasmodium vivax aldehyde reductase, putative 0.012 0.0719 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0082 0.0082
Leishmania major hypothetical protein, unknown function 0.0042 0.018 0.064
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.014 0.0438
Entamoeba histolytica protein kinase, putative 0.037 0.2443 0.8878
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0071 0.024
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0184 0.0653
Echinococcus multilocularis bloom syndrome protein 0.002 0.0028 0.0037
Echinococcus granulosus dual specificity 0.037 0.2443 0.3249
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0082 0.0109
Schistosoma mansoni DNA ligase IV 0.002 0.0031 0.0041
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.0109
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0128 0.0448
Schistosoma mansoni amine oxidase 0.0103 0.0603 0.0802
Onchocerca volvulus 0.0415 0.2749 0.3639
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0078 0.1023
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0415 0.2749 0.3656
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.014 0.0438
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0092 0.0123
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0112 0.0663 0.2399
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0028 0.0084
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0031 0.0041
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0089 0.0119
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0346 0.1244
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0071 0.024
Trichomonas vaginalis aldo-keto reductase, putative 0.0415 0.2749 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0415 0.2749 1
Giardia lamblia Aldose reductase 0.0415 0.2749 1
Echinococcus multilocularis aldo keto reductase 0.0415 0.2749 0.3656
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0105 0.0139
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0053 0.0257 0.0342
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.1972 0.7168
Loa Loa (eye worm) hypothetical protein 0.0103 0.0603 0.0802
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.044 0.1586
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.1972 0.7168
Schistosoma mansoni aldo-keto reductase 0.0415 0.2749 0.3656
Echinococcus granulosus muscleblind protein 0.0152 0.0938 0.1248
Echinococcus multilocularis voltage gated potassium channel subunit 0.012 0.0719 0.0956
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0415 0.2749 1
Schistosoma mansoni tyrosinase precursor 0.0099 0.0572 0.0761
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0206 0.0275
Trypanosoma cruzi UDP-galactopyranose mutase 0.0103 0.0603 0.2181
Brugia malayi jmjC domain containing protein 0.0154 0.0954 0.1269
Leishmania major aldo-keto reductase-like protein 0.0415 0.2749 1
Echinococcus multilocularis dna polymerase eta 0.0078 0.0432 0.0575
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.022 0.0292
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0064 0.0216
Brugia malayi MAP kinase sur-1 0.0112 0.0663 0.0882
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0099 0.0572 0.0761
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0155 0.0206
Brugia malayi RE40412p 0.0042 0.018 0.024
Leishmania major hypothetical protein, conserved 0.0027 0.0078 0.0266
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.037 0.2443 0.3249
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0021 0.0059
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.012 0.0719 1
Brugia malayi jmjC domain containing protein 0.0094 0.054 0.0718
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0071 0.024
Leishmania major DNA polymerase eta, putative 0.0078 0.0432 0.1558
Toxoplasma gondii zinc finger CDGSH-type domain-containing protein 0.0042 0.018 0.064
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.0109
Onchocerca volvulus 0.0042 0.018 0.0214
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.014 0.0494
Loa Loa (eye worm) hypothetical protein 0.005 0.0233 0.031
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0064 0.0085
Echinococcus multilocularis dnaJ subfamily C 6 0.0066 0.0345 0.0458
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0092 0.0318
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.022 0.0292
Loa Loa (eye worm) hypothetical protein 0.0078 0.0432 0.0575
Brugia malayi DKFZp564C0469 protein 0.002 0.0031 0.0041
Loa Loa (eye worm) oxidoreductase 0.0415 0.2749 0.3656
Schistosoma mansoni pol-related 0.0415 0.2749 0.3656
Onchocerca volvulus 0.0031 0.0105 0.0112
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0346 0.046
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0082 0.0109
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0296 0.193 0.2567
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0064 0.0085
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0028 0.0037
Mycobacterium tuberculosis Probable oxidoreductase 0.0415 0.2749 0.2944
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0028 0.0084
Trypanosoma brucei DNA polymerase eta, putative 0.0078 0.0432 0.1558
Schistosoma mansoni sodium/solute symporter 0.0038 0.0152 0.0202
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0103 0.0603 0.2105
Brugia malayi nuclear hormone receptor 0.0028 0.0082 0.0109
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0187 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0082 0.0109
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0147 0.1985
Trichomonas vaginalis aldo-keto reductase, putative 0.0415 0.2749 1
Onchocerca volvulus 0.0415 0.2749 0.3639
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.014 0.0187
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0415 0.2749 0.3656
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.0064 0.0085
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0028 0.0037
Plasmodium falciparum protoporphyrinogen oxidase 0.0103 0.0603 0.8378
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.012 0.0719 0.2603
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0078 0.0266
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0031 0.0096
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0031 0.0096
Brugia malayi PHD-finger family protein 0.0029 0.0092 0.0123
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0105 0.0139
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0028 0.0037
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0031 0.0037
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0415 0.2749 1
Trypanosoma cruzi aldo/keto reductase, putative 0.012 0.0719 0.2603
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0154 0.0954 0.1269
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0082 0.0109
Loa Loa (eye worm) hypothetical protein 0.0037 0.0147 0.0195
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0034 0.0125 0.0166
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0064 0.0085
Trypanosoma cruzi DNA polymerase eta, putative 0.0078 0.0432 0.1558
Plasmodium vivax hypothetical protein, conserved 0.0042 0.018 0.2459
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0099 0.0572 0.0761
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.044 0.1586
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.1107 0.752 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.012 0.0719 0.2559
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0415 0.2749 0.3656
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0099 0.0572 0.0761
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0663 0.2355
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0187 0.0611
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.1014 0.1348
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0071 0.0183
Entamoeba histolytica hypothetical protein 0.0023 0.0052 0.0116
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0415 0.2749 1
Brugia malayi jmjC domain containing protein 0.0025 0.0064 0.0085
Trypanosoma brucei protein kinase, putative 0.0112 0.0663 0.2399
Entamoeba histolytica hypothetical protein 0.0037 0.0144 0.045
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0152 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0082 0.0109
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0415 0.2749 0.3656
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.014 0.0438
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0346 0.1244
Loa Loa (eye worm) hypothetical protein 0.0037 0.0147 0.0195
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0042 0.018 0.2459
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0103 0.0603 0.8378
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0021 0.0225
Leishmania major DNA polymerase eta, putative 0.0042 0.018 0.0639
Loa Loa (eye worm) MBCTL1 0.0054 0.0265 0.0353
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0415 0.2749 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.0592 0.0787
Echinococcus multilocularis conserved hypothetical protein 0.0042 0.018 0.024
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0415 0.2749 1
Entamoeba histolytica hypothetical protein 0.0037 0.0144 0.045
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0028 0.0026
Treponema pallidum DNA ligase (lig) 0.002 0.0031 0.3235
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0082 0.0109
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0031 0.0096
Schistosoma mansoni coup transcription factor 0.0028 0.0082 0.0109
Plasmodium falciparum aldo-keto reductase, putative 0.012 0.0719 1
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0082 0.0109
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.0878 0.1167
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0103 0.0603 0.0802
Entamoeba histolytica aldose reductase, putative 0.0415 0.2749 1
Echinococcus multilocularis mitogen activated protein kinase 0.0112 0.0663 0.0882
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0133 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0105 0.0139
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0082 0.0109
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0028 0.0037
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0235 0.0312
Schistosoma mansoni hypothetical protein 0.0041 0.0177 0.0235
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0128 0.172
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.008 0.044 0.1537
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0021 0.0028
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0335 0.0446
Schistosoma mansoni hypothetical protein 0.0037 0.0144 0.0191
Trichomonas vaginalis aldo-keto reductase, putative 0.0415 0.2749 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.193 0.2567
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0152 0.0202
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.014 0.0438
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0415 0.2749 0.3656
Mycobacterium ulcerans oxidoreductase 0.0415 0.2749 0.2745
Entamoeba histolytica hypothetical protein 0.002 0.0031 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0189 0.0671
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0082 0.0109
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.002 0.0031 0.3235
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0189 0.0671
Loa Loa (eye worm) hypothetical protein 0.0083 0.0462 0.0614
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0144 0.0191
Echinococcus granulosus dna polymerase eta 0.0078 0.0432 0.0575
Brugia malayi glutamate-cysteine ligase modifier subunit 0.012 0.0719 0.0956
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.022 0.0292
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0052 0.0174
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0126 0.0168
Echinococcus granulosus lysine specific demethylase 5A 0.0094 0.054 0.0718
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.022 0.0292
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0265 0.0353
Mycobacterium tuberculosis Conserved hypothetical protein 0.0103 0.0603 0.0628
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0581 0.0773
Schistosoma mansoni topbp1 0.002 0.0031 0.0041
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0082 0.0082
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0415 0.2749 0.3656
Echinococcus granulosus replication factor c subunit 1 0.002 0.0031 0.0041
Loa Loa (eye worm) hypothetical protein 0.0099 0.0572 0.0761
Trichomonas vaginalis aldo-keto reductase, putative 0.0415 0.2749 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0053 0.0257 0.0342
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0265 0.0353
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0629 0.4229 0.4541
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0696 0.4687 0.6233
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1107 0.752 1
Schistosoma mansoni inositol transporter 0.0038 0.0152 0.0202
Loa Loa (eye worm) DnaJ domain-containing protein 0.0066 0.0345 0.0458
Brugia malayi Protein kinase domain containing protein 0.1107 0.752 1
Echinococcus multilocularis dna polymerase kappa 0.008 0.044 0.0585
Echinococcus granulosus conserved hypothetical protein 0.0042 0.018 0.024
Loa Loa (eye worm) hypothetical protein 0.0083 0.0464 0.0617
Plasmodium vivax hypothetical protein, conserved 0.0042 0.018 0.2459
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0105 0.0139
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0248 0.0886
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0028 0.0323
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0082 0.0109
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0128 0.017
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0112 0.0663 0.2399
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0031 0.0037
Brugia malayi jmjC domain containing protein 0.0025 0.0064 0.0085
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0464 0.0617
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0346 0.046
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0031 0.0037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0206 0.0275
Echinococcus multilocularis high affinity choline transporter 1 0.0343 0.2254 0.2997
Onchocerca volvulus 0.0415 0.2749 0.3639
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0064 0.0085
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0187 0.0249
Mycobacterium tuberculosis Possible oxidoreductase 0.0103 0.0603 0.0628
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0128 0.0448
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.0109
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0184 0.0653
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.005 0.0166
Entamoeba histolytica aldose reductase, putative 0.0415 0.2749 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0064 0.0085
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0031 0.0096
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0335 0.0446
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0021 0.0028
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0064 0.0085
Onchocerca volvulus 0.0103 0.0603 0.0777
Loa Loa (eye worm) hypothetical protein 0.005 0.0233 0.031
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.014 0.0438
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0028 0.0026
Loa Loa (eye worm) hypothetical protein 0.0099 0.0572 0.0761
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.044 0.1586
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0187 0.0249
Schistosoma mansoni hypothetical protein 0.0083 0.0462 0.0614
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0415 0.2749 1
Schistosoma mansoni apoptosis regulator bax 0.0083 0.0462 0.0614
Leishmania major UDP-galactopyranose mutase 0.0103 0.0603 0.2181
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.0085
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.022 0.0292
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0082 0.0109
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.012 0.0719 0.0956
Loa Loa (eye worm) ShTK domain-containing protein 0.0099 0.0572 0.0761
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0206 0.0275
Onchocerca volvulus 0.0099 0.0572 0.0736
Schistosoma mansoni jumonji/arid domain-containing protein 0.0094 0.054 0.0718
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0031 0.0037
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.1333 0.1772
Brugia malayi mbt repeat family protein 0.0048 0.022 0.0292
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0082 0.0109
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0037
Schistosoma mansoni hypothetical protein 0.0042 0.018 0.024
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0052 1
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0335 0.0446
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0395 0.1421
Mycobacterium leprae Possible oxidoreductase 0.012 0.0719 0.2531
Schistosoma mansoni alpha-glucosidase 0.014 0.0857 0.114
Echinococcus granulosus aldehyde reductase 0.0294 0.1921 0.2555
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.018 0.0639
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0206 0.0275
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0112 0.0663 0.2399
Schistosoma mansoni hypothetical protein 0.0041 0.0177 0.0235
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0335 0.0446
Loa Loa (eye worm) hypothetical protein 0.0048 0.022 0.0292
Loa Loa (eye worm) oxidoreductase 0.0415 0.2749 0.3656
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0128 0.0448
Echinococcus granulosus lysine specific histone demethylase 1A 0.0103 0.0603 0.0802
Trichomonas vaginalis aldo-keto reductase, putative 0.0415 0.2749 1
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0092 0.1223
Loa Loa (eye worm) hypothetical protein 0.0037 0.0147 0.0195
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0064 0.0085
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0147 0.1985
Brugia malayi TAR-binding protein 0.0064 0.0335 0.0446
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0028 0.0084
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0021 0.0016
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.014 0.0187
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.022 0.0292
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0415 0.2749 0.3656
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.012 0.0719 0.2559
Brugia malayi DnaJ domain containing protein 0.0066 0.0345 0.0458
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0235 0.0312
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0064 0.0085
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.0312
Entamoeba histolytica hypothetical protein 0.0037 0.0144 0.045
Loa Loa (eye worm) jmjC domain-containing protein 0.0094 0.054 0.0718
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0415 0.2749 0.3656
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0346 0.1244
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.0987 0.1043
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0082 0.0109
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0071 0.0923
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0415 0.2749 0.3656
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0112 0.0663 0.2399
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0663 0.2355
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.037 0.2443 0.8885
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0071 0.024
Onchocerca volvulus 0.005 0.0233 0.0284
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0206 0.0275
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0052 0.0174
Loa Loa (eye worm) oxidoreductase 0.0415 0.2749 0.3656
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0152 0.0202
Schistosoma mansoni terminal deoxycytidyl transferase 0.0053 0.0257 0.0342
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0071 0.0094
Schistosoma mansoni ap endonuclease 0.0019 0.0021 0.0028
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0346 0.046
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.0085
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0064 0.0216
Trypanosoma brucei aldo/keto reductase, putative 0.012 0.0719 0.2603
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0154 0.0954 0.1269
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0738 0.4976 0.6618
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0031 0.0037
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0206 0.0275
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0464 0.0617
Trichomonas vaginalis aldo-keto reductase, putative 0.0415 0.2749 1
Echinococcus multilocularis 0.0103 0.0603 0.0802
Onchocerca volvulus 0.002 0.0031 0.0015
Echinococcus multilocularis mitogen activated protein kinase 3 0.0112 0.0663 0.0882
Plasmodium falciparum phd finger protein, putative 0.0029 0.0092 0.1223
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0071 0.0094
Schistosoma mansoni alpha glucosidase 0.0036 0.014 0.0187
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0064 0.0832
Onchocerca volvulus 0.0038 0.0152 0.0176
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0233 0.0228
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0147 0.2019
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.044 0.1586
Trichomonas vaginalis aldo-keto reductase, putative 0.0415 0.2749 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0415 0.2749 1
Echinococcus granulosus mitogen activated protein kinase 0.0112 0.0663 0.0882
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0052 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.1212 0.1612
Schistosoma mansoni high-affinity choline transporter 0.0343 0.2254 0.2997
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0233 0.0777
Schistosoma mansoni serine/threonine protein kinase 0.037 0.2443 0.3249
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.1014 0.1348
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0233 0.0228
Trichomonas vaginalis aldo-keto reductase, putative 0.0415 0.2749 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0498 0.0663
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.022 0.0266
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.022 0.0292
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0233 0.0228
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0171 0.0227
Brugia malayi hypothetical protein 0.002 0.0031 0.0041
Onchocerca volvulus 0.0094 0.054 0.0694
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0415 0.2749 0.3656
Entamoeba histolytica aldose reductase, putative 0.0415 0.2749 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0233 0.0228
Onchocerca volvulus Alhambra homolog 0.0029 0.0092 0.0096
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0082 0.0109
Onchocerca volvulus 0.0048 0.022 0.0266
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0128 0.0448
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.044 0.1586
Schistosoma mansoni patched 1 0.0043 0.0187 0.0249
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0415 0.2749 0.3656
Schistosoma mansoni ap endonuclease 0.0019 0.0021 0.0028
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0064 0.0085
Brugia malayi hypothetical protein 0.0017 0.0012 0.0016
Trichomonas vaginalis aldo/keto reductase, putative 0.0415 0.2749 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.0938 0.1248
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0071 0.0183
Chlamydia trachomatis protoporphyrinogen oxidase 0.0103 0.0603 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0082 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0105 0.0139
Echinococcus granulosus dnaJ subfamily C 6 0.0066 0.0345 0.0458
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0034 0.0125 0.0166
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0028 0.0084
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0021 0.0059
Entamoeba histolytica hypothetical protein 0.037 0.2443 0.8878
Brugia malayi jmjC domain containing protein 0.0025 0.0064 0.0085
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0031 0.0096
Schistosoma mansoni tyrosinase precursor 0.0099 0.0572 0.0761
Echinococcus multilocularis solute carrier family 5 0.0038 0.0152 0.0202
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0052 0.0373
Toxoplasma gondii zinc finger cdgsh type protein 0.0042 0.018 0.064
Plasmodium vivax hypothetical protein, conserved 0.0103 0.0603 0.8378
Trichomonas vaginalis aldo-keto reductase, putative 0.012 0.0719 0.2559
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0147 0.0136
Plasmodium falciparum flap endonuclease 1 0.0026 0.0071 0.0923
Echinococcus multilocularis nibrin 0.002 0.0031 0.0041
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0103 0.0603 0.8378
Trichomonas vaginalis protein kinase inhibitor, putative 0.0066 0.0345 0.1187
Echinococcus multilocularis muscleblind protein 1 0.0152 0.0938 0.1248
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0103 0.0603 0.0802
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0064 0.0216
Echinococcus granulosus high affinity choline transporter 1 0.0343 0.2254 0.2997
Entamoeba histolytica alcohol dehydrogenase, putative 0.012 0.0719 0.2559
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0335 0.0446
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0629 0.4229 0.4226
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0064 0.0085
Echinococcus multilocularis aldehyde reductase 0.0294 0.1921 0.2555
Schistosoma mansoni amine oxidase 0.0103 0.0603 0.0802
Echinococcus multilocularis muscleblind protein 0.0152 0.0938 0.1248
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0233 0.0228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0082 0.0109
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0082 0.0109
Brugia malayi Protein kinase domain containing protein 0.037 0.2443 0.3249
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.0109
Brugia malayi hypothetical protein 0.0088 0.0498 0.0663
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.1972 0.7168
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0083 0.0462 0.0614
Schistosoma mansoni jumonji/arid domain-containing protein 0.0094 0.054 0.0718
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0052 0.0667
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.1014 0.1348
Brugia malayi nuclear receptor NHR-88 0.0028 0.0082 0.0109
Echinococcus multilocularis lysine specific demethylase 5A 0.0094 0.054 0.0718
Echinococcus multilocularis aldo keto reductase 0.0415 0.2749 0.3656
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0082 0.0109
Onchocerca volvulus 0.0415 0.2749 0.3639
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0302 0.1084
Onchocerca volvulus 0.0028 0.0082 0.0082
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0187 0.0249
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0128 0.0448
Schistosoma mansoni flap endonuclease-1 0.0024 0.0054 0.0071
Loa Loa (eye worm) hypothetical protein 0.0043 0.0188 0.025
Echinococcus multilocularis aldo keto reductase 0.0415 0.2749 0.3656
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0041
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0152 0.0202
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0092 0.0318
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0415 0.2749 0.3656
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0083 0.0462 0.0614
Brugia malayi AMP-binding enzyme family protein 0.005 0.0233 0.031
Loa Loa (eye worm) hypothetical protein 0.0103 0.0603 0.0802
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.044 0.1586
Plasmodium vivax hypothetical protein, conserved 0.0103 0.0603 0.8378
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0031 0.0037
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0078 0.1023
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0031 0.0041
Loa Loa (eye worm) apoptosis regulator protein 0.0083 0.0462 0.0614
Onchocerca volvulus 0.0083 0.0464 0.0592
Entamoeba histolytica protein kinase, putative 0.037 0.2443 0.8878
Loa Loa (eye worm) hypothetical protein 0.0027 0.0078 0.0104
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0082 0.0109
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0184 0.0653
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0103 0.0603 0.8378
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.1212 0.1612
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0082 0.0082
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0663 0.2355
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.044 0.1586
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0082 0.0109
Plasmodium vivax SET domain protein, putative 0.0031 0.0105 0.1396
Trypanosoma brucei glucosidase, putative 0.0036 0.014 0.0494
Schistosoma mansoni hypothetical protein 0.0294 0.1915 0.2547
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0155 0.0206
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.012 0.0719 0.2603
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0415 0.2749 0.3656
Leishmania major DNA polymerase kappa, putative 0.006 0.0302 0.1084
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.0109
Mycobacterium tuberculosis Conserved hypothetical protein 0.0053 0.0257 0.0255
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0233 0.0229
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.0109
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0092 0.0123
Echinococcus multilocularis expressed conserved protein 0.0094 0.054 0.0718
Brugia malayi Pre-SET motif family protein 0.0031 0.0105 0.0139
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.037 0.2443 0.8885
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0052 0.0667
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.044 0.1586
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.044 0.1586
Brugia malayi amine oxidase, flavin-containing family protein 0.0103 0.0603 0.0802
Onchocerca volvulus 0.0415 0.2749 0.3639
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0082 0.0109
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1363 0.9288 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.014 0.0438
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0144 0.0191
Loa Loa (eye worm) hypothetical protein 0.01 0.0581 0.0773
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0092 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0189 0.0671
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0233 0.0831
Entamoeba histolytica alcohol dehydrogenase, putative 0.012 0.0719 0.2559
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0082 0.0109
Echinococcus granulosus nibrin 0.002 0.0031 0.0041
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0028 0.0084
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0082 0.0109
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0064 0.0085
Brugia malayi RNA binding protein 0.0064 0.0335 0.0446
Echinococcus multilocularis peregrin 0.0039 0.0158 0.021
Loa Loa (eye worm) hypothetical protein 0.0103 0.0603 0.0802
Schistosoma mansoni hypothetical protein 0.0066 0.0345 0.0458
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.014 0.0187
Brugia malayi Bromodomain containing protein 0.0029 0.0092 0.0123
Brugia malayi Flap endonuclease-1 0.0026 0.0071 0.0094
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0082 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0082 0.0109
Trypanosoma brucei prostaglandin f synthase 0.0415 0.2749 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0112 0.0663 0.2399
Mycobacterium ulcerans DNA polymerase IV 0.008 0.044 0.0436
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0082 0.0109
Loa Loa (eye worm) hypothetical protein 0.0037 0.0147 0.0195
Loa Loa (eye worm) oxidoreductase 0.0415 0.2749 0.3656
Loa Loa (eye worm) hypothetical protein 0.0362 0.2386 0.3173
Trypanosoma cruzi UDP-galactopyranose mutase 0.0103 0.0603 0.2181
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0147 0.0142
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0064 0.0085
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0082 0.0109
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0233 0.0831
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0265 0.0353
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0021 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0082 0.0109
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0335 0.0446
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.0031 0.0096
Echinococcus multilocularis protein patched 0.0043 0.0187 0.0249
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0082 0.0109
Brugia malayi hypothetical protein 0.0027 0.0078 0.0104
Schistosoma mansoni DNA helicase recq5 0.002 0.0028 0.0037
Schistosoma mansoni DNA polymerase IV / kappa 0.0016 0.0005 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0082 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0188 0.0668
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0031 0.0037
Echinococcus multilocularis protein dispatched 1 0.0049 0.0229 0.0305
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.037 0.2443 0.8885
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0103 0.0603 0.0802
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0042 0.018 0.2459
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.022 0.0292
Brugia malayi RE40412p 0.0042 0.018 0.024
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0128 0.0448
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.044 0.1586
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0663 0.0882
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.0109
Trypanosoma cruzi aldo-keto reductase 0.0415 0.2749 1
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0031 0.0041
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0233 0.0229
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0028 0.0037
Giardia lamblia Kinase, CMGC MAPK 0.0112 0.0663 0.2399
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.012 0.0719 0.2603
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0028 0.0037
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0206 0.0275
Brugia malayi AMP-binding enzyme family protein 0.005 0.0233 0.031
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0464 0.0617
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0078 0.0266
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0133 0.0121
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.1972 0.7168
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0082 0.0109
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0082 0.0109
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0415 0.2749 0.3656
Echinococcus multilocularis aldo keto reductase 0.0415 0.2749 0.3656
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0103 0.0603 0.0599
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0346 0.046
Onchocerca volvulus 0.0099 0.0572 0.0736
Brugia malayi hypothetical protein 0.0037 0.0144 0.0191
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0078 0.0266
Loa Loa (eye worm) ShTK domain-containing protein 0.0099 0.0572 0.0761
Mycobacterium ulcerans oxidoreductase 0.0103 0.0603 0.0599
Trypanosoma brucei aldo-keto reductase, putative 0.0415 0.2749 1
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0071 0.024
Loa Loa (eye worm) hypothetical protein 0.0066 0.0344 0.0457
Trichomonas vaginalis aldo-keto reductase, putative 0.0415 0.2749 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0346 0.1244
Echinococcus granulosus lysine specific histone demethylase 1A 0.0103 0.0603 0.0802
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0053 0.0257 0.0342
Schistosoma mansoni hypothetical protein 0.0083 0.0462 0.0614
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0105 0.0139
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0078 0.0266
Schistosoma mansoni hypothetical protein 0.0083 0.0462 0.0614
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0082 0.0109
Echinococcus granulosus aldo keto reductase 0.0415 0.2749 0.3656
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0464 0.0617
Schistosoma mansoni hypothetical protein 0.0041 0.0177 0.0235
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0103 0.0603 0.2181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0082 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0082 0.0109
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0233 0.0743
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.014 0.0438
Plasmodium falciparum aldehyde reductase, putative 0.012 0.0719 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.014 0.0438
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0064 0.0085
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0028 0.0323
Loa Loa (eye worm) hypothetical protein 0.0103 0.0603 0.0802
Trypanosoma brucei unspecified product 0.0037 0.0143 0.0505
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0064 0.0216
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0415 0.2749 0.3656
Onchocerca volvulus 0.012 0.0719 0.0932
Trichomonas vaginalis aldo-keto reductase, putative 0.012 0.0719 0.2559
Schistosoma mansoni DNA helicase recq1 0.002 0.0028 0.0037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0082 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0031 0.0037
Onchocerca volvulus 0.0238 0.1531 0.2014
Echinococcus granulosus solute carrier family 5 0.0038 0.0152 0.0202
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0082 0.0109
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.044 0.1586
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0188 0.0668
Brugia malayi topoisomerase 0.002 0.0031 0.0041
Loa Loa (eye worm) hypothetical protein 0.005 0.0233 0.031
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.0257 0.0342
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0415 0.2749 0.3656
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0082 0.0109
Brugia malayi mbt repeat family protein 0.0048 0.022 0.0292
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0083 0.0462 0.0614
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0346 0.1192
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.1107 0.752 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.1014 0.1348
Giardia lamblia DINP protein human, muc B family 0.006 0.0302 0.1084
Brugia malayi ecdysteroid receptor 0.0028 0.0082 0.0109
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.0302 0.0304
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.0031 0.0368
Onchocerca volvulus 0.0099 0.0572 0.0736
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0233 0.0228
Toxoplasma gondii PfMNL-2 CISD1 family iron-sulfur protein, putative 0.0042 0.018 0.064
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0415 0.2749 0.3656

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 45.8 uM Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation after 30 mins by fluorescence assay ChEMBL. 22112208
IC50 (binding) > 100 uM Inhibition of human MDR1 expressed in MDCK cells assessed as calcein AM accumulation after 30 mins by fluorescence assay ChEMBL. 22112208

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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