TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 465.54 | Formula: C30H27NO4
H donors: 1 H acceptors: 3 LogP: 6.59 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)C(=O)/C=C/c1cc2cc(C(=O)NC3CCCCC3)c(=O)oc2c2c1cccc2
InChi: 1S/C30H27NO4/c1-19-11-13-20(14-12-19)27(32)16-15-21-17-22-18-26(29(33)31-23-7-3-2-4-8-23)30(34)35-28(22)25-10-6-5-9-24(21)25/h5-6,9-18,23H,2-4,7-8H2,1H3,(H,31,33)/b16-15+
InChiKey: BLRURPUSHSYTDN-FOCLMDBBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	endonuclease G, mitochondrial precursor	0.0013	0.0936	0.2054
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.001	0.0676	0.1618
Loa Loa (eye worm)	CYP4Cod1	0.0004	0.001	0.0022
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0021	0.1864	0.5534
Leishmania major	ATP diphosphohydrolase	0.0042	0.4127	1
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0068	0.7022	0.8936
Schistosoma mansoni	guanosine-diphosphatase	0.0027	0.2563	0.2563
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.001	0.0676	1
Plasmodium vivax	glutathione reductase, putative	0.003	0.282	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0006	0.0244	0.0569
Trichomonas vaginalis	glutathione reductase, putative	0.001	0.0676	0.2638
Echinococcus granulosus	ectonucleotide	0.0018	0.1499	0.4448
Loa Loa (eye worm)	thrombospondin type 1 domain-containing protein	0.0046	0.4558	1
Brugia malayi	Nucleoside-diphosphatase mig-23	0.0027	0.2563	0.5624
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0012	0.0907	0.2693
Toxoplasma gondii	Nucleoside-diphosphatase	0.0027	0.2563	0.6202
Trichomonas vaginalis	adenosine diphosphatase, putative	0.0027	0.2563	1
Trypanosoma brucei	endonuclease G, putative	0.0013	0.0936	0.225
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.001	0.0676	0.1618
Trichomonas vaginalis	mercuric reductase, putative	0.001	0.0676	0.2638
Leishmania major	peptidyl-prolyl cis-trans isomerase, putative	0.0006	0.0244	0.0569
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0068	0.7022	0.8936
Echinococcus multilocularis	Polycystic kidney disease protein	0.0012	0.0907	0.2693
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0068	0.7022	0.8936
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.001	0.0676	0.5
Trypanosoma cruzi	endonuclease G, putative	0.0013	0.0936	0.225
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.1857	0.7243
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.001	0.0676	0.1618
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.001	0.0676	0.1618
Trichomonas vaginalis	rotamase, putative	0.0021	0.1857	0.7243
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0021	0.1864	0.409
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0021	0.1802	0.4353
Brugia malayi	Cytochrome P450 family protein	0.0015	0.1222	0.2682
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0021	0.1857	0.4073
Brugia malayi	cytochrome P450	0.0004	0.001	0.0022
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.001	0.0676	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0907	0.199
Schistosoma mansoni	ATP-diphosphohydrolase 1	0.0027	0.2563	0.2563
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.001	0.0676	0.1618
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.001	0.0676	0.2007
Trypanosoma brucei	endonuclease G, putative	0.0013	0.0936	0.225
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0008	0.0375	0.0822
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0035	0.3369	1
Toxoplasma gondii	GDA1/CD39 (nucleoside phosphatase) family protein	0.0042	0.4127	1
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0005	0.0099	0.0295
Brugia malayi	Bloom's syndrome protein homolog	0.0012	0.0895	0.1964
Trichomonas vaginalis	guanosine-diphosphatase, putative	0.0027	0.2563	1
Brugia malayi	Cytochrome P450 family protein	0.0004	0.001	0.0022
Loa Loa (eye worm)	cytochrome P450 family protein	0.0015	0.1222	0.2682
Schistosoma mansoni	loxhd1	0.0012	0.0907	0.0907
Echinococcus multilocularis	ectonucleoside triphosphate diphosphohydrolase	0.0027	0.2563	0.7608
Brugia malayi	Cytochrome P450 family protein	0.0004	0.001	0.0022
Loa Loa (eye worm)	hypothetical protein	0.001	0.0621	0.1362
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0013	0.0936	0.225
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0005	0.0099	0.0218
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0013	0.0936	0.225
Schistosoma mansoni	guanosine-diphosphatase	0.0027	0.2563	0.2563
Schistosoma mansoni	endonuclease related	0.0013	0.0936	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0907	0.199
Trichomonas vaginalis	DNA helicase recq, putative	0.0012	0.0895	0.3493
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.001	0.0676	0.1618
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0035	0.3369	1
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.001	0.0676	0.1484
Loa Loa (eye worm)	hypothetical protein	0.0021	0.1864	0.409
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.001	0.0676	0.0849
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0012	0.0907	0.2693
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0076	0.7857	1
Trichomonas vaginalis	guanosine-diphosphatase, putative	0.0027	0.2563	1
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0005	0.0099	0.0295
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.001	0.0676	0.1618
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0021	0.1802	0.4353
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0076	0.7857	1
Echinococcus granulosus	3'partial\|ectonucleoside triphosphate diphosphohydrolase	0.0027	0.2563	0.7608
Toxoplasma gondii	GDA1/CD39 (nucleoside phosphatase) family protein	0.0027	0.2563	0.6202
Leishmania major	DNA/RNA non-specific endonuclease-like protein	0.0013	0.0936	0.225
Mycobacterium tuberculosis	Probable dehydrogenase	0.0068	0.7022	0.8936
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0008	0.0375	0.0822
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0021	0.1864	0.5534
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.001	0.0676	0.1618
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0021	0.1802	0.4353
Trichomonas vaginalis	adenosine diphosphatase, putative	0.0027	0.2563	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0005	0.0099	0.0217
Echinococcus multilocularis	expressed protein	0.0021	0.1857	0.551
Loa Loa (eye worm)	cytochrome P450 family protein	0.0004	0.001	0.0022
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0007	0.0264	0.0617
Plasmodium falciparum	glutathione reductase	0.003	0.282	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.001	0.0676	0.2007
Leishmania major	nucleoside phosphatase, putative,guanosine diphosphatase, putative	0.0042	0.4127	1
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0021	0.1864	0.5534
Schistosoma mansoni	cytochrome P450	0.0004	0.001	0.001
Echinococcus multilocularis	RUN	0.0012	0.0907	0.2693
Trypanosoma brucei	nucleoside phosphatase, putative	0.0042	0.4127	1
Onchocerca volvulus		0.0021	0.1864	0.2622
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.001	0.0676	1
Echinococcus multilocularis	ectonucleoside triphosphate diphosphohydrolase	0.0027	0.2563	0.7608
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0021	0.1864	0.1864
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0018	0.1499	0.4448
Echinococcus multilocularis	Endonuclease G	0.0013	0.0936	0.2779
Trichomonas vaginalis	adenosine diphosphatase, putative	0.0027	0.2563	1
Trypanosoma cruzi	trypanothione reductase, putative	0.003	0.282	0.6824
Schistosoma mansoni	lipoxygenase	0.0035	0.3369	0.3369
Trichomonas vaginalis	adenosine/guanosine diphosphatase, putative	0.0027	0.2563	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.1499	0.3288
Loa Loa (eye worm)	doublecortin family protein	0.0012	0.0907	0.199
Leishmania major	endonuclease G, putative	0.0013	0.0936	0.225
Echinococcus granulosus	ectonucleoside triphosphate diphosphohydrolase	0.0027	0.2563	0.7608
Schistosoma mansoni	hypothetical protein	0.0004	0.001	0.001
Plasmodium vivax	multidomain scavenger receptor, putative	0.0012	0.0907	0.1908
Toxoplasma gondii	NADPH-glutathione reductase	0.001	0.0676	0.1618
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0005	0.0099	0.0218
Brugia malayi	hypothetical protein	0.0012	0.0907	0.199
Echinococcus granulosus	cytochrome P450 2K1	0.0004	0.001	0.0029
Echinococcus multilocularis		0.0004	0.001	0.0029
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0007	0.0264	0.0617
Echinococcus multilocularis	bloom syndrome protein	0.0012	0.0895	0.2658
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0099	0.0218
Trypanosoma brucei	trypanothione reductase	0.003	0.282	0.6824
Trichomonas vaginalis	rotamase, putative	0.0021	0.1802	0.703
Echinococcus granulosus	bloom syndrome protein	0.0012	0.0895	0.2658
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0006	0.0244	0.0569
Plasmodium falciparum	thioredoxin reductase	0.003	0.282	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0076	0.7857	1
Trypanosoma cruzi	trypanothione reductase, putative	0.001	0.0676	0.1618
Brugia malayi	Cytochrome P450 family protein	0.0004	0.001	0.0022
Schistosoma mansoni	hypothetical protein	0.0012	0.0907	0.0907
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0005	0.0099	0.0295
Loa Loa (eye worm)	glutathione reductase	0.003	0.282	0.6186
Loa Loa (eye worm)	hypothetical protein	0.0021	0.1864	0.409
Echinococcus granulosus	thioredoxin glutathione reductase	0.003	0.282	0.8369
Onchocerca volvulus		0.0021	0.1864	0.2622
Trichomonas vaginalis	DNA helicase recq1, putative	0.0012	0.0895	0.3493
Trypanosoma cruzi	nucleoside phosphatase, putative	0.0042	0.4127	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0068	0.7022	0.8936
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.001	0.0676	0.2121
Mycobacterium tuberculosis	Probable oxidoreductase	0.0076	0.7857	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0012	0.0907	0.2693
Toxoplasma gondii	GDA1/CD39 (nucleoside phosphatase) family protein	0.0027	0.2563	0.6202
Trypanosoma cruzi	endonuclease G, putative	0.0013	0.0936	0.225
Schistosoma mansoni	rab6-interacting	0.0012	0.0907	0.0907
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.003	0.282	0.3581
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.001	0.0676	0.1618
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0021	0.1864	0.5534
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.001	0.0676	0.1618
Schistosoma mansoni	blooms syndrome DNA helicase	0.001	0.061	0.061
Trichomonas vaginalis	adenosine diphosphatase, putative	0.0027	0.2563	1
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0021	0.1857	0.4073
Trichomonas vaginalis	DNA helicase recq, putative	0.0007	0.0264	0.103
Plasmodium falciparum	nucleoside-diphosphatase, putative	0.0027	0.2563	0.9058
Schistosoma mansoni	adenosine diphosphatase	0.0042	0.4127	0.4127
Loa Loa (eye worm)	thioredoxin reductase	0.003	0.282	0.6186
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.001	0.0676	0.1618
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.001	0.0676	0.093
Plasmodium falciparum	glutathione reductase	0.001	0.0676	0.2121
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0021	0.1864	0.5534
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0021	0.1864	0.1864
Trichomonas vaginalis	guanosine-diphosphatase, putative	0.0027	0.2563	1
Plasmodium falciparum	LCCL domain-containing protein	0.0012	0.0907	0.297
Echinococcus granulosus	lipoxygenase domain containing protein	0.0012	0.0907	0.2693
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0021	0.1864	0.5534
Brugia malayi	Doublecortin family protein	0.0012	0.0907	0.199
Toxoplasma gondii	PPIC-type PPIASE domain-containing protein	0.0006	0.0244	0.0569
Toxoplasma gondii	thioredoxin reductase	0.003	0.282	0.6824
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0006	0.0244	0.0569
Schistosoma mansoni	rab6-interacting	0.0012	0.0907	0.0907
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.001	0.0676	0.093
Schistosoma mansoni	polycystin 1-related	0.0012	0.0907	0.0907
Plasmodium falciparum	thioredoxin reductase	0.001	0.0676	0.2121
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0021	0.1802	0.4353
Plasmodium vivax	nucleoside-diphosphatase mig-23, putative	0.0027	0.2563	0.8916
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0007	0.0264	0.0617
Loa Loa (eye worm)	cytochrome P450 family protein	0.0004	0.001	0.0022
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0008	0.0445	0.1058
Onchocerca volvulus		0.0046	0.4558	1
Echinococcus granulosus	ectonucleoside triphosphate diphosphohydrolase	0.0027	0.2563	0.7608
Brugia malayi	hypothetical protein	0.0012	0.0907	0.199
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.2563	1
Schistosoma mansoni	DNA helicase recq1	0.0005	0.0099	0.0099
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.001	0.0676	0.1618
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0005	0.0099	0.0218
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0068	0.7022	0.8936
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.001	0.0676	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.2563	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.001	0.0676	0.1618
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.001	0.0676	0.1618
Plasmodium vivax	thioredoxin reductase, putative	0.003	0.282	1
Loa Loa (eye worm)	RecQ helicase	0.0012	0.0895	0.1964
Echinococcus granulosus	Endonuclease G	0.0013	0.0936	0.2779
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.001	0.0676	0.1618
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0021	0.1864	0.5534
Echinococcus multilocularis	ectonucleotide	0.0018	0.1499	0.4448
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0021	0.1864	0.1864
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.001	0.0676	0.2121
Echinococcus granulosus	RUN	0.0012	0.0907	0.2693
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0021	0.1802	1
Loa Loa (eye worm)	cytochrome P450	0.0004	0.001	0.0022
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0021	0.1864	0.1864
Brugia malayi	Thioredoxin reductase	0.003	0.282	0.6186
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.001	0.0676	0.1618
Trypanosoma brucei	nucleoside diphosphatase, putative	0.0042	0.4127	1
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0021	0.1864	0.5534
Giardia lamblia	NADH oxidase lateral transfer candidate	0.001	0.0676	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.001	0.0676	0.0676
Plasmodium falciparum	apyrase, putative	0.0027	0.2563	0.9058
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0011	0.0731	0.2321
Echinococcus granulosus	Polycystic kidney disease protein	0.0012	0.0907	0.2693
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.001	0.0676	0.1618
Brugia malayi	Thrombospondin type 1 domain containing protein	0.0046	0.4558	1
Schistosoma mansoni	lipoxygenase	0.0012	0.0907	0.0907
Trypanosoma cruzi	nucleoside phosphatase, putative	0.0027	0.2563	0.6202
Mycobacterium tuberculosis	Probable reductase	0.0068	0.7022	0.8936
Toxoplasma gondii	DNA/RNA non-specific endonuclease	0.0013	0.0936	0.225
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0005	0.0099	0.0217
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.001	0.0676	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.2563	0.5624
Schistosoma mansoni	DNA helicase recq5	0.0005	0.0099	0.0099
Toxoplasma gondii	peptidylprolyl isomerase	0.0021	0.1802	0.4353
Treponema pallidum	NADH oxidase	0.001	0.0676	0.5
Echinococcus multilocularis	ectonucleoside triphosphate diphosphohydrolase	0.0027	0.2563	0.7608
Echinococcus multilocularis	ectonucleoside triphosphate diphosphohydrolase	0.0027	0.2563	0.7608
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0005	0.0099	0.0295
Schistosoma mansoni	hypothetical protein	0.0046	0.4558	0.4558
Echinococcus granulosus	expressed protein	0.0021	0.1857	0.551
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0021	0.1864	0.5534
Trypanosoma brucei	endonuclease G, putative	0.0013	0.0936	0.225
Loa Loa (eye worm)	hypothetical protein	0.0021	0.1864	0.409
Brugia malayi	glutathione reductase	0.003	0.282	0.6186
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0021	0.1864	0.5534
Toxoplasma gondii	NTPase II	0.0027	0.2563	0.6202
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0021	0.1864	0.5534
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0018	0.1499	0.4448
Schistosoma mansoni	rotamase	0.0021	0.1857	0.1857
Leishmania major	trypanothione reductase	0.003	0.282	0.6824
Echinococcus multilocularis	thioredoxin glutathione reductase	0.003	0.282	0.8369
Entamoeba histolytica	recQ family helicase, putative	0.0007	0.0264	0.1465

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 40 %	Ex vivo antithrombotic activity in mouse assessed as protection against collagen and adrenaline-induced hind limb paralysis or death at 30 uM/kg, po administered 60 mins prior to thrombotic challenge after 1 hr	ChEMBL.	22004722
Activity (functional)	= 44 %	Ex vivo antithrombotic activity in mouse assessed as protection against collagen and adrenaline-induced hind limb paralysis or death at 30 uM/kg, po administered 60 mins prior to thrombotic challenge after 3 days	ChEMBL.	22004722
Activity (ADMET)	= 84 %	Toxicity in mouse assessed as increase in bleeding time at 30 uM/kg, po administered 60 mins prior to tail incision after 1 hr relative to aspirin	ChEMBL.	22004722
Activity (ADMET)	= 109 %	Toxicity in mouse assessed as increase in bleeding time at 30 uM/kg, po administered 60 mins prior to tail incision after 3 days relative to aspirin	ChEMBL.	22004722
Time (functional)	= 10.6 min	Ex vivo anticoagulant activity in mouse assessed as prothrombin time in plasma at 30 uM/kg, po after for 3 days	ChEMBL.	22004722

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1923407

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1569156