Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.1186 | 1 | 1 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.1186 | 1 | 1 |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.0478 | 0.1022 | 0.1022 |
Brugia malayi | Polyprenyl synthetase family protein | 0.061 | 0.2693 | 0.1861 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.1186 | 1 | 1 |
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.0478 | 0.1022 | 0.1022 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.1186 | 1 | 1 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.061 | 0.2693 | 0.1861 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1186 | 1 | 0.5 |
Echinococcus granulosus | decaprenyl diphosphate synthase subunit 1 | 0.061 | 0.2693 | 0.2693 |
Leishmania major | solanesyl-diphosphate synthase, putative | 0.061 | 0.2693 | 0.262 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthetase, putative | 0.061 | 0.2693 | 1 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.1186 | 1 | 1 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthase, putative | 0.061 | 0.2693 | 1 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1186 | 1 | 0.5 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1186 | 1 | 1 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0405 | 0.0099 | 0.0099 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.1186 | 1 | 1 |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.0478 | 0.1022 | 0.1022 |
Chlamydia trachomatis | geranylgeranyl pyrophosphate synthase | 0.0397 | 0 | 0.5 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.1186 | 1 | 1 |
Leishmania major | farnesyl pyrophosphate synthase | 0.1186 | 1 | 1 |
Trypanosoma cruzi | solanesyl-diphosphate synthase | 0.061 | 0.2693 | 0.1861 |
Mycobacterium leprae | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) | 0.061 | 0.2693 | 0.5 |
Echinococcus multilocularis | decaprenyl diphosphate synthase subunit 1 | 0.061 | 0.2693 | 0.2693 |
Leishmania major | polyprenyl synthase, putative | 0.0478 | 0.1022 | 0.0932 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.0478 | 0.1022 | 0.5 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.061 | 0.2693 | 0.1861 |
Schistosoma mansoni | trans-prenyltransferase | 0.061 | 0.2693 | 0.2693 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.1186 | 1 | 1 |
Mycobacterium ulcerans | polyprenyl diphosphate synthetase, GrcC1 | 0.061 | 0.2693 | 0.2693 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.1186 | 1 | 1 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.1186 | 1 | 0.5 |
Echinococcus multilocularis | sodium channel protein | 0.0405 | 0.0099 | 0.0099 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.1186 | 1 | 1 |
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.1186 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.061 | 0.2693 | 1 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.061 | 0.2693 | 0.1861 |
Echinococcus granulosus | sodium channel protein | 0.0405 | 0.0099 | 0.0099 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.1186 | 1 | 0.5 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1186 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 9 uM | Inhibitory activity of the compound against Wt-MCF7 human breast cell line | ChEMBL. | 12825923 |
IC50 (functional) | = 9 uM | Inhibitory activity of the compound against Wt-MCF7 human breast cell line | ChEMBL. | 12825923 |
IC50 (functional) | = 18 uM | Inhibitory activity of the compound against MDA-MB-435 human breast cell line | ChEMBL. | 12825923 |
IC50 (functional) | = 18 uM | Inhibitory activity of the compound against MDA-MB-435 human breast cell line | ChEMBL. | 12825923 |
IC50 (functional) | = 38 uM | Inhibitory activity of the compound against MCF-12A human breast cell line | ChEMBL. | 12825923 |
IC50 (functional) | = 38 uM | Inhibitory activity of the compound against MCF-12A human breast cell line | ChEMBL. | 12825923 |
IC50 (functional) | = 44 uM | Inhibitory activity of the compound against MDA-MB-231 human breast cell line | ChEMBL. | 12825923 |
IC50 (functional) | = 44 uM | Inhibitory activity of the compound against MCF-10A human breast cell line | ChEMBL. | 12825923 |
IC50 (functional) | = 44 uM | Inhibitory activity of the compound against MDA-MB-231 human breast cell line | ChEMBL. | 12825923 |
IC50 (functional) | = 44 uM | Inhibitory activity of the compound against MCF-10A human breast cell line | ChEMBL. | 12825923 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12825923 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.