Detailed information for compound 157082

Basic information

Technical information
  • TDR Targets ID: 157082
  • Name: 4-(2-cyclopropylethynyl)-6-(dimethylamino)-4- (trifluoromethyl)-1H-3,1-benzoxazin-2-one
  • MW: 324.298 | Formula: C16H15F3N2O2
  • H donors: 1 H acceptors: 1 LogP: 3.51 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1ccc2c(c1)C(C#CC1CC1)(OC(=O)N2)C(F)(F)F)C
  • InChi: 1S/C16H15F3N2O2/c1-21(2)11-5-6-13-12(9-11)15(16(17,18)19,23-14(22)20-13)8-7-10-3-4-10/h5-6,9-10H,3-4H2,1-2H3,(H,20,22)
  • InChiKey: SPVNTKYPTSKZGB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(2-cyclopropylethynyl)-6-dimethylamino-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
  • AIDS085867
  • (+/-)-4-Cyclopropylethynyl-6-dimethylamino-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one
  • AIDS-085867
  • Efavirenz deriv. 4d

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma congolense RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Schistosoma mansoni hypothetical protein Get druggable targets OG5_139608 All targets in OG5_139608
Plasmodium yoelii integrase-related Get druggable targets OG5_139608 All targets in OG5_139608
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0412 0.1536 1
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0361 0.0357
Brugia malayi Matrixin family protein 0.0057 0.0068 0.0066
Schistosoma mansoni glycogen phosphorylase 0.0048 0.003 0.0025
Trypanosoma brucei carbonic anhydrase-like protein 0.0236 0.0806 0.1392
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0495 0.1879 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0236 0.0806 0.0802
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.0139 0.0119
Onchocerca volvulus 0.0237 0.0812 0.453
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0811 0.3187 0.5106
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0064 0.0098 0.0113
Giardia lamblia GTOR 0.0107 0.0272 0.0371
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.0121 0.0151
Giardia lamblia CDC8 0.029 0.1031 0.1736
Echinococcus granulosus tar DNA binding protein 0.0128 0.0361 0.0342
Mycobacterium ulcerans thymidylate synthase 0.0163 0.0504 0.0848
Echinococcus granulosus serine protein kinase ATM 0.007 0.0121 0.0101
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0412 0.1536 0.1519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0148 0.0134
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0095 0.0222 0.0203
Entamoeba histolytica hypothetical protein 0.0108 0.0278 0.0402
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0274 0.0963 0.1459
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0148 0.0134
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0141 0.0413 0.0622
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0114 0.0302 0.0443
Echinococcus multilocularis serine protein kinase ATM 0.007 0.0121 0.0101
Schistosoma mansoni glycogen phosphorylase 0.0111 0.0291 0.0286
Schistosoma mansoni carbonic anhydrase-related 0.0141 0.0413 0.0408
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.033 0.0362
Onchocerca volvulus 0.0081 0.0167 0.0619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0272 0.0336
Leishmania major thymidylate kinase-like protein 0.029 0.1031 0.1792
Onchocerca volvulus 0.0135 0.0391 0.1976
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.2459 1 1
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0361 0.0357
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0095 0.0222 0.0282
Leishmania major cytidine deaminase-like protein 0.0057 0.0066 0.0068
Loa Loa (eye worm) hypothetical protein 0.0811 0.3187 0.3493
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0064 0.0098 0.0078
Trypanosoma cruzi thymidylate kinase, putative 0.029 0.1031 0.1621
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0274 0.0963 0.0945
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1401 0.5624 0.9044
Loa Loa (eye worm) thymidylate synthase 0.0163 0.0504 0.0553
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0057 0.0066 0.0068
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0026 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0152 0.014
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0252 0.04
Leishmania major phosphatidylinositol 3-kinase, putative 0.0274 0.0963 0.1671
Loa Loa (eye worm) hypothetical protein 0.007 0.0121 0.0133
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0486 0.1841 0.2887
Loa Loa (eye worm) hypothetical protein 0.0057 0.0068 0.0075
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0064 0.0098 0.0078
Trypanosoma brucei thymidylate kinase, putative 0.029 0.1031 0.1792
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0274 0.0963 0.1512
Brugia malayi Polyprenyl synthetase family protein 0.1401 0.5624 0.9044
Echinococcus granulosus glycogen phosphorylase 0.0111 0.0291 0.0272
Entamoeba histolytica glycogen phosphorylase, putative 0.0111 0.0291 0.0422
Trichomonas vaginalis ap endonuclease, putative 0.0095 0.0222 0.0255
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0064 0.0098 0.0125
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0274 0.0963 0.1671
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0057 0.0066 0.0068
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0077 0.0148 0.0144
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0107 0.0272 0.0253
Brugia malayi hypothetical protein 0.0077 0.0152 0.02
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0486 0.1841 0.2928
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0163 0.0504 0.0852
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1401 0.5624 0.9044
Onchocerca volvulus 0.0195 0.0636 0.346
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0245 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0197 0.0214
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0361 0.0357
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0274 0.0963 0.1509
Echinococcus granulosus Na+ dependent nucleoside transporter 0.0363 0.1331 0.1314
Toxoplasma gondii LsmAD domain-containing protein 0.0102 0.0252 0.04
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0412 0.1536 0.2695
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0274 0.0963 0.1671
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0064 0.0098 0.0125
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0278 0.0274
Entamoeba histolytica cytidine deaminase, putative 0.0057 0.0066 0.0057
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1544 0.6215 1
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0412 0.1536 0.2695
Brugia malayi MH2 domain containing protein 0.0121 0.033 0.0488
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0274 0.0963 0.1671
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0095 0.0222 0.0348
Onchocerca volvulus 0.0455 0.1713 1
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0412 0.1536 0.1519
Giardia lamblia Thymidine kinase 0.1019 0.4044 0.7158
Echinococcus multilocularis thyroid hormone receptor alpha 0.0169 0.0531 0.0512
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0064 0.0098 0.0125
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1401 0.5624 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.1218 0.4869 0.7811
Echinococcus multilocularis musashi 0.0135 0.0391 0.0372
Brugia malayi Inositol-1 0.0074 0.0139 0.0179
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0693 0.076
Echinococcus multilocularis carbonic anhydrase 0.0141 0.0413 0.0394
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.029 0.1031 0.6564
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0412 0.1536 0.1519
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0106 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0421 0.1574 0.25
Plasmodium vivax hypothetical protein 0.0064 0.0098 0.0125
Brugia malayi hypothetical protein 0.0108 0.0278 0.0405
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0058 0.0039
Mycobacterium leprae conserved hypothetical protein 0.0064 0.0098 0.0219
Loa Loa (eye worm) carbonic anhydrase 3 0.0236 0.0806 0.0884
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0141 0.0413 0.0622
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.0121 0.0151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.04 0.0381
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0495 0.1879 0.3308
Schistosoma mansoni lozenge 0.0057 0.0067 0.0063
Trypanosoma brucei thymidine kinase 0.1019 0.4044 0.7177
Schistosoma mansoni lamin 0.0135 0.0391 0.0387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0234 0.0274
Loa Loa (eye worm) hypothetical protein 0.0057 0.0068 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0211 0.0236
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0148 0.0195
Brugia malayi thymidylate kinase 0.029 0.1031 0.1621
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0097 0.0234 0.0369
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0064 0.0098 0.0113
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0139 0.0119
Leishmania major phosphatidylinositol 3-kinase, putative 0.0077 0.0148 0.0215
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0163 0.0504 0.0852
Echinococcus multilocularis tar DNA binding protein 0.0128 0.0361 0.0342
Loa Loa (eye worm) polyprenyl synthetase 0.0412 0.1536 0.1684
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0107 0.0272 0.0391
Echinococcus multilocularis thymidine kinase 0.1223 0.4889 0.4879
Loa Loa (eye worm) matrix metalloproteinase 0.0057 0.0068 0.0075
Schistosoma mansoni hypothetical protein 0.0081 0.0167 0.0163
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0095 0.0222 0.0315
Onchocerca volvulus Matrix metalloproteinase homolog 0.0127 0.0357 0.1769
Loa Loa (eye worm) hypothetical protein 0.0732 0.286 0.3135
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0064 0.0098 0.0078
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0486 0.1841 0.1837
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0252 0.0362
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0064 0.0098 0.0078
Trypanosoma brucei PAB1-binding protein , putative 0.0102 0.0252 0.04
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0139 0.0179
Echinococcus multilocularis glycogen phosphorylase 0.0111 0.0291 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0064 0.0098 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0148 0.0134
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0236 0.0806 0.1259
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0277 0.0976 0.1637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0915 0.3617 0.5801
Trypanosoma brucei thymidylate kinase, putative 0.029 0.1031 0.1792
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1544 0.6215 1
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1401 0.5624 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0026 0.0021
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0236 0.0806 0.0802
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0121 0.009
Trypanosoma brucei RNA helicase, putative 0.024 0.0822 0.142
Giardia lamblia Glycogen phosphorylase 0.0111 0.0291 0.0405
Loa Loa (eye worm) phosphatidylinositol 3 0.0077 0.0148 0.0162
Onchocerca volvulus Glycogen phosphorylase homolog 0.0111 0.0291 0.1367
Schistosoma mansoni thymidylate kinase 0.029 0.1031 0.1027
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0107 0.0272 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0272 0.0336
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0486 0.1841 0.293
Echinococcus multilocularis solute carrier family 28 0.0363 0.1331 0.1314
Toxoplasma gondii hypothetical protein 0.0141 0.0413 0.0688
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0048 0.003 0.0004
Giardia lamblia Deoxynucleoside kinase 0.0397 0.1474 0.2534
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0163 0.0504 0.05
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0495 0.1879 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.007 0.0121 0.0116
Trypanosoma brucei cytidine deaminase 0.0057 0.0066 0.0068
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0064 0.0098 0.0113
Schistosoma mansoni inositol monophosphatase 0.0074 0.0139 0.0134
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0274 0.0963 0.0945
Schistosoma mansoni hypothetical protein 0.0064 0.0098 0.0093
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.04 0.0381
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0064 0.0098 0.0093
Trichomonas vaginalis glycogen phosphorylase, putative 0.0111 0.0291 0.0366
Brugia malayi Matrixin family protein 0.0057 0.0068 0.0066
Schistosoma mansoni hypothetical protein 0.0046 0.002 0.0015
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0107 0.0272 0.0267
Echinococcus multilocularis isocitrate dehydrogenase 0.0047 0.0028 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0197 0.0214
Loa Loa (eye worm) hypothetical protein 0.0455 0.1713 0.1878
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0095 0.0222 0.0348
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0139 0.0119
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0412 0.1536 0.2437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0064 0.0098 0.0113
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0599 0.2309 0.3685
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0047 0.0028 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0196 0.0212
Schistosoma mansoni hypothetical protein 0.0141 0.0413 0.0408
Schistosoma mansoni ap endonuclease 0.0095 0.0222 0.0218
Schistosoma mansoni thyroid hormone receptor 0.0169 0.0531 0.0526
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.04 0.0381
Entamoeba histolytica hypothetical protein 0.0108 0.0278 0.0402
Echinococcus multilocularis lamin dm0 0.0135 0.0391 0.0372
Loa Loa (eye worm) matrixin family protein 0.0211 0.0706 0.0774
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.007 0.0121 0.0116
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1401 0.5624 0.5615
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0274 0.0963 0.0959
Loa Loa (eye worm) hypothetical protein 0.0043 0.0008 0.0009
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.007 0.0121 0.0147
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0095 0.0222 0.0348
Treponema pallidum thymidylate kinase (tmk) 0.029 0.1031 0.4083
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0281 0.0995 0.0977
Onchocerca volvulus 0.0064 0.0098 0.0196
Loa Loa (eye worm) hypothetical protein 0.007 0.012 0.0132
Entamoeba histolytica hypothetical protein 0.0064 0.0098 0.011
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.0237 0.0809 0.0791
Echinococcus granulosus lamin dm0 0.0135 0.0391 0.0372
Onchocerca volvulus Matrilysin homolog 0.02 0.0658 0.3598
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1331 0.5337 0.8581
Brugia malayi thymidylate synthase 0.0163 0.0504 0.077
Entamoeba histolytica hypothetical protein 0.1331 0.5337 0.8581
Echinococcus multilocularis transfer RNA-Ile 0.1223 0.4889 0.4879
Schistosoma mansoni hypothetical protein 0.0195 0.0636 0.0631
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.0139 0.0119
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1544 0.6215 1
Loa Loa (eye worm) runx1 0.0057 0.0067 0.0074
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.0139 0.0198
Trypanosoma cruzi polyprenyl synthase, putative 0.0573 0.2202 0.3514
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0412 0.1536 0.1519
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0064 0.0098 0.0125
Trichomonas vaginalis set domain proteins, putative 0.0237 0.0812 0.1214
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0064 0.0098 0.0125
Brugia malayi hypothetical protein 0.0455 0.1713 0.2725
Loa Loa (eye worm) RNA binding protein 0.0128 0.0361 0.0396
Echinococcus multilocularis glycogen phosphorylase 0.0111 0.0291 0.0272
Trypanosoma cruzi polyprenyl synthase, putative 0.0573 0.2202 0.3514
Loa Loa (eye worm) phosphatidylinositol 3 0.0064 0.0098 0.0107
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1401 0.5624 1
Plasmodium vivax hypothetical protein, conserved 0.0064 0.0098 0.0125
Loa Loa (eye worm) hypothetical protein 0.01 0.0245 0.0269
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.029 0.1031 0.5126
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0236 0.0806 0.1259
Loa Loa (eye worm) hypothetical protein 0.013 0.037 0.0405
Onchocerca volvulus Matrilysin homolog 0.0057 0.0068 0.0017
Plasmodium falciparum carbonic anhydrase 0.0141 0.0413 0.0688
Plasmodium falciparum thymidylate kinase 0.029 0.1031 0.1792
Schistosoma mansoni bromodomain containing protein 0.0063 0.0093 0.0089
Brugia malayi Matrixin family protein 0.0211 0.0706 0.1096
Echinococcus multilocularis lamin 0.0135 0.0391 0.0372
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0486 0.1841 0.2928
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0486 0.1841 0.324
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.1006 0.3991 0.7063
Mycobacterium ulcerans thymidylate kinase 0.029 0.1031 0.1789
Loa Loa (eye worm) hypothetical protein 0.0954 0.3775 0.4138
Echinococcus granulosus solute carrier family 28 0.0363 0.1331 0.1314
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0064 0.0098 0.0125
Leishmania major phosphatidylinositol 4-kinase, putative 0.0064 0.0098 0.0125
Brugia malayi Matrixin family protein 0.0057 0.0068 0.0066
Brugia malayi cytidine deaminase, identical 0.0057 0.0066 0.0061
Giardia lamblia Farnesyl diphosphate synthase 0.1401 0.5624 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0811 0.3187 0.3173
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0064 0.0098 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0196 0.0212
Loa Loa (eye worm) inositol-1 0.0074 0.0139 0.0152
Trichomonas vaginalis thymidylate kinase, putative 0.029 0.1031 0.1569
Onchocerca volvulus Putative thymidylate kinase 0.029 0.1031 0.5857
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0064 0.0098 0.0113
Loa Loa (eye worm) hypothetical protein 0.0102 0.0252 0.0276
Loa Loa (eye worm) hypothetical protein 0.0047 0.0026 0.0028
Echinococcus multilocularis survival motor neuron protein 1 0.0954 0.3775 0.3763
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0163 0.0504 0.0852
Schistosoma mansoni lamin 0.0135 0.0391 0.0387
Mycobacterium tuberculosis Hypothetical protein 0.0077 0.0152 0.0221
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0095 0.0222 0.0348
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0077 0.0148 0.0129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0026 0.0021
Loa Loa (eye worm) phosphatidylinositol 3 0.2247 0.9122 1
Plasmodium vivax ataxin-2 like protein, putative 0.0102 0.0252 0.04
Schistosoma mansoni lipoxygenase 0.0055 0.0058 0.0054
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.0381 0.0362
Loa Loa (eye worm) hypothetical protein 0.0141 0.0413 0.0452
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.007 0.0121 0.0101
Brugia malayi hypothetical protein 0.0954 0.3775 0.6057
Leishmania major phosphatidylinositol kinase related protein, putative 0.0064 0.0098 0.0125
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.0381 0.0362
Schistosoma mansoni hypothetical protein 0.0862 0.3397 0.3394
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0274 0.0963 0.1056
Echinococcus multilocularis thymidine kinase 0.1223 0.4889 0.4879
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0064 0.0098 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0121 0.009
Trichomonas vaginalis thymidine kinase, putative 0.1019 0.4044 0.647
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0495 0.1879 0.3308
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0236 0.0806 0.1259
Echinococcus granulosus lamin 0.0135 0.0391 0.0372
Loa Loa (eye worm) thymidylate kinase 0.029 0.1031 0.113
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0274 0.0963 0.1509
Schistosoma mansoni hypothetical protein 0.029 0.1031 0.1027
Brugia malayi hypothetical protein 0.0102 0.0252 0.0362
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0274 0.0963 0.0959
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0079 0.0059
Leishmania major polyprenyl synthase, putative 0.0573 0.2202 0.3886
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.04 0.0396
Trichomonas vaginalis thymidine kinase, putative 0.1019 0.4044 0.647
Loa Loa (eye worm) hypothetical protein 0.0133 0.0381 0.0418
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0077 0.0148 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0272 0.0336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0234 0.0274
Loa Loa (eye worm) phosphatidylinositol 3 0.0064 0.0098 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0361 0.0357
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0274 0.0963 0.1671
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1544 0.6215 1
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0125 0.0097
Leishmania major hypothetical protein, unknown function 0.0064 0.0098 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0197 0.0214
Echinococcus multilocularis Glycosyl transferase, family 35 0.0111 0.0291 0.0272
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.0139 0.0176
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0079 0.0059
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0106 0.0278
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0163 0.0504 0.077
Entamoeba histolytica hypothetical protein 0.0108 0.0278 0.0402
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.0777 0.134
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0245 0.0291
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0163 0.0504 0.0852
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0207 0.0229
Loa Loa (eye worm) matrixin family protein 0.0127 0.0357 0.0391
Loa Loa (eye worm) hypothetical protein 0.0068 0.0114 0.0125
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0077 0.0148 0.0129
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0107 0.0272 0.0436
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0095 0.0222 0.0315
Toxoplasma gondii thymidylate kinase 0.029 0.1031 0.1792
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0811 0.3187 0.3173
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0028 0.0008
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.1479 0.5948 0.9569
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0412 0.1536 0.2435
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.007 0.0121 0.0151
Schistosoma mansoni inositol monophosphatase 0.0074 0.0139 0.0134
Trichomonas vaginalis thymidylate kinase, putative 0.029 0.1031 0.1569
Brugia malayi Intermediate filament tail domain containing protein 0.0135 0.0391 0.0587
Trichomonas vaginalis thymidine kinase, putative 0.1019 0.4044 0.647
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0065 0.0101 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Entamoeba histolytica hypothetical protein 0.0108 0.0278 0.0402
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0141 0.0413 0.0452
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.007 0.0121 0.0167
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0252 0.04
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0412 0.1536 0.2695
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0573 0.2202 0.3514
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0064 0.0098 0.0125
Echinococcus granulosus thymidylate kinase 0.029 0.1031 0.1013
Leishmania major thymidine kinase, putative 0.1019 0.4044 0.7177
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.007 0.0121 0.0151
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0057 0.0066 0.0061
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0107 0.0272 0.0436
Entamoeba histolytica thymidine kinase, putative 0.1019 0.4044 0.649
Schistosoma mansoni thymidine kinase 0.1223 0.4889 0.4887
Loa Loa (eye worm) phosphatidylinositol 3 0.0064 0.0098 0.0107
Echinococcus granulosus intermediate filament protein 0.0135 0.0391 0.0372
Loa Loa (eye worm) intermediate filament protein 0.0135 0.0391 0.0429
Mycobacterium ulcerans cytidine deaminase 0.0057 0.0066 0.0064
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0236 0.0806 0.1259
Onchocerca volvulus 0.0064 0.0098 0.0196
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0077 0.0148 0.0215
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1401 0.5624 0.9039
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1401 0.5624 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0064 0.0098 0.0078
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.007 0.012 0.0165
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0139 0.0198
Loa Loa (eye worm) hypothetical protein 0.0071 0.0124 0.0136
Brugia malayi intermediate filament protein 0.0135 0.0391 0.0587
Leishmania major hypothetical protein, conserved 0.0064 0.0098 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0136 0.0114
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0095 0.0222 0.0311
Schistosoma mansoni glycogen phosphorylase 0.0111 0.0291 0.0286
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0163 0.0504 0.0852
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0234 0.0274
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0252 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Loa Loa (eye worm) phosphatidylinositol 3 0.0107 0.0272 0.0298
Loa Loa (eye worm) phosphatidylinositol 3 0.0421 0.1574 0.1726
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0095 0.0222 0.0203
Echinococcus granulosus thymidine kinase 0.1223 0.4889 0.4879
Leishmania major solanesyl-diphosphate synthase, putative 0.0412 0.1536 0.2695
Schistosoma mansoni carbonic anhydrase 0.0141 0.0413 0.0408
Loa Loa (eye worm) phosphatidylinositol kinase 0.0064 0.0098 0.0107
Loa Loa (eye worm) hypothetical protein 0.0063 0.0091 0.01
Echinococcus granulosus thymidine kinase 0.1223 0.4889 0.4879
Echinococcus granulosus carbonic anhydrase 0.0141 0.0413 0.0394
Echinococcus multilocularis Zinc finger, PHD finger 0.0274 0.0963 0.0945
Chlamydia trachomatis thymidylate kinase 0.029 0.1031 0.4659
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0064 0.0098 0.0052
Loa Loa (eye worm) glycogen phosphorylase 0.0111 0.0291 0.0319
Loa Loa (eye worm) hypothetical protein 0.0141 0.0413 0.0452
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0195 0.0636 0.0983
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1401 0.5624 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0107 0.0272 0.0395
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0412 0.1536 0.2435
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0486 0.1841 0.2887
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0077 0.0148 0.0195
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.04 0.0602
Loa Loa (eye worm) hypothetical protein 0.0071 0.0125 0.0137
Brugia malayi follicle stimulating hormone receptor 0.024 0.0823 0.1285
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0114 0.0302 0.0443
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0095 0.0222 0.0244
Brugia malayi RNA binding protein 0.0128 0.0361 0.0539
Schistosoma mansoni hypothetical protein 0.0263 0.092 0.0915
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0486 0.1841 0.293
Echinococcus granulosus survival motor neuron protein 1 0.0954 0.3775 0.3763
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0495 0.1879 0.3305
Trypanosoma cruzi cytidine deaminase-like protein 0.0057 0.0066 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Echinococcus multilocularis Protein lozenge 0.0057 0.0067 0.0048
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1598 0.644 0.6432
Echinococcus multilocularis geminin 0.0862 0.3397 0.3384
Entamoeba histolytica hypothetical protein 0.0064 0.0098 0.011
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0141 0.0413 0.0622
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0083 0.0174 0.0261
Treponema pallidum octaprenyl-diphosphate synthase 0.0573 0.2202 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0065 0.0101 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0098 0.0052
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0095 0.0222 0.0482
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0278 0.0259
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0163 0.0504 0.2985
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.0363 0.1331 0.1314
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0274 0.0963 0.1459
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.04 0.0381
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.007 0.012 0.0149
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0141 0.0413 0.0622
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0135 0.0391 0.0429
Leishmania major hypothetical protein, conserved 0.0114 0.0302 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Brugia malayi TAR-binding protein 0.0128 0.0361 0.0539
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.0361 0.0396
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0573 0.2202 0.2187
Toxoplasma gondii target of rapamycin (TOR), putative 0.0095 0.0224 0.0351
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0107 0.0272 0.0436
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0412 0.1536 0.2692
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0047 0.0028 0.0023
Echinococcus multilocularis 0.0064 0.0098 0.0078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.04 0.0396
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0573 0.2202 0.2187
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0412 0.1536 0.2695
Echinococcus multilocularis thymidylate synthase 0.0163 0.0504 0.0486
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0361 0.0357
Echinococcus granulosus serine:threonine protein kinase SMG1 0.007 0.0121 0.0101
Leishmania major farnesyl pyrophosphate synthase 0.1401 0.5624 1
Trypanosoma cruzi thymidylate kinase, putative 0.029 0.1031 0.1621
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0095 0.0222 0.0344
Schistosoma mansoni survival motor neuron protein 0.0195 0.0636 0.0631
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0412 0.1536 0.2695
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.1218 0.4869 0.7811
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1401 0.5624 0.9039
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0573 0.2202 0.2199
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0274 0.0963 0.1512
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0278 0.0259
Schistosoma mansoni glutathione synthetase 0.0412 0.1536 0.1532
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0274 0.0963 0.1671
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.0098 0.0125
Echinococcus multilocularis carbonic anhydrase 0.0141 0.0413 0.0394
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0245 0.0351
Plasmodium vivax thymidylate kinase, putative 0.029 0.1031 0.1792
Leishmania major phosphatidylinositol kinase, putative 0.0064 0.0098 0.0125
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1401 0.5624 1
Giardia lamblia Phosphatidylinositol 4-kinase 0.0064 0.0098 0.0058
Toxoplasma gondii FATC domain-containing protein 0.007 0.0121 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Echinococcus multilocularis thymidylate kinase 0.029 0.1031 0.1013
Echinococcus granulosus thymidylate synthase 0.0163 0.0504 0.0486
Entamoeba histolytica glycogen phosphorylase, putative 0.0111 0.0291 0.0422
Trypanosoma cruzi thymidine kinase, putative 0.1019 0.4044 0.6491
Echinococcus granulosus carbonic anhydrase II 0.0236 0.0806 0.0788
Trypanosoma cruzi thymidine kinase, putative 0.1019 0.4044 0.6491
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0486 0.1841 0.2887
Echinococcus granulosus geminin 0.0862 0.3397 0.3384
Brugia malayi Matrixin family protein 0.0057 0.0068 0.0066
Schistosoma mansoni hypothetical protein 0.0108 0.0278 0.0274
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0026 0.0006
Brugia malayi Polyprenyl synthetase family protein 0.0412 0.1536 0.2437
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1401 0.5624 0.5622
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0139 0.0179
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0095 0.0222 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0148 0.0134
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0073 0.0131 0.0144
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0107 0.0272 0.0395
Loa Loa (eye worm) TAR-binding protein 0.0128 0.0361 0.0396
Echinococcus granulosus carbonic anhydrase 0.0141 0.0413 0.0394
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0028 0.0008
Entamoeba histolytica protein kinase rad3, putative 0.007 0.0121 0.0147
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.013 0.037 0.0365
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0047 0.0028 0.0008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.04 0.0439
Echinococcus multilocularis cytidine deaminase 0.0057 0.0066 0.0046
Entamoeba histolytica hypothetical protein 0.007 0.0121 0.0147
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0274 0.0963 0.0945
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0573 0.2202 0.2414
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.008 0.0163 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Schistosoma mansoni carbonic anhydrase-related 0.0141 0.0413 0.0408
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1544 0.6215 1
Brugia malayi exodeoxyribonuclease III family protein 0.0095 0.0222 0.0315
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0141 0.0413 0.0622
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0412 0.1536 0.2437
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.0139 0.0119
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0412 0.1536 0.2437
Loa Loa (eye worm) hypothetical protein 0.0063 0.0091 0.01
Schistosoma mansoni hypothetical protein 0.0068 0.0114 0.011
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0107 0.0272 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0098 0.0052
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.033 0.0362
Echinococcus multilocularis carbonic anhydrase II 0.0236 0.0806 0.0788
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1401 0.5624 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0064 0.0098 0.0052
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0245 0.0351
Toxoplasma gondii exonuclease III APE 0.0095 0.0222 0.0348
Loa Loa (eye worm) hypothetical protein 0.0455 0.1713 0.1878
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0064 0.0098 0.0125
Brugia malayi hypothetical protein 0.0066 0.0103 0.0121
Leishmania major carbonic anhydrase-like protein 0.0236 0.0806 0.1392
Brugia malayi cytoplasmic intermediate filament protein 0.0073 0.0131 0.0167
Loa Loa (eye worm) hypothetical protein 0.0064 0.0098 0.0107
Schistosoma mansoni ap endonuclease 0.0095 0.0222 0.0218
Trypanosoma cruzi target of rapamycin kinase 3 0.0097 0.0234 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0234 0.0274
Echinococcus multilocularis carbonic anhydrase 0.0141 0.0413 0.0394
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0064 0.0098 0.0078
Leishmania major hypothetical protein, conserved 0.0102 0.0252 0.04
Echinococcus granulosus cytidine deaminase 0.0057 0.0066 0.0046
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0274 0.0963 0.1459
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0236 0.0806 0.0884
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0071 0.0125 0.0174
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0107 0.0272 0.0391
Loa Loa (eye worm) hypothetical protein 0.0135 0.0391 0.0429
Trichomonas vaginalis glycogen phosphorylase, putative 0.0111 0.0291 0.0366
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0064 0.0098 0.0093
Brugia malayi Bromodomain containing protein 0.0075 0.0142 0.0184
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0163 0.0504 0.0852
Schistosoma mansoni trans-prenyltransferase 0.0412 0.1536 0.1532
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0064 0.0098 0.0113
Onchocerca volvulus 0.0057 0.0068 0.0017
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0058 0.0039
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1401 0.5624 0.5615
Schistosoma mansoni hypothetical protein 0.024 0.0822 0.0818
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.0823 0.0902
Entamoeba histolytica hypothetical protein 0.0064 0.0098 0.011
Schistosoma mansoni hypothetical protein 0.0133 0.0381 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Schistosoma mansoni intermediate filament proteins 0.0135 0.0391 0.0387
Loa Loa (eye worm) hypothetical protein 0.0141 0.0413 0.0452
Loa Loa (eye worm) isocitrate dehydrogenase 0.0047 0.0028 0.003
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0274 0.0963 0.1671
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0097 0.0234 0.0369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0148 0.0134
Loa Loa (eye worm) polyprenyl synthetase 0.1401 0.5624 0.6165
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0064 0.0098 0.011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0028 0.0008
Loa Loa (eye worm) hypothetical protein 0.0065 0.0101 0.0111
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.1223 0.4889 0.4879
Giardia lamblia Hypothetical protein 0.0064 0.0098 0.0058
Echinococcus granulosus carbonic anhydrase 0.0141 0.0413 0.0394
Echinococcus granulosus Glycosyl transferase family 35 0.0111 0.0291 0.0272
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.2459 1 1
Schistosoma mansoni thyroid hormone receptor 0.0169 0.0531 0.0526
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0077 0.0152 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Echinococcus granulosus glycogen phosphorylase 0.0111 0.0291 0.0272
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0412 0.1536 0.2435
Mycobacterium leprae PROBABLE HYDROLASE 0.007 0.012 0.0371
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0077 0.0148 0.0195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.04 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1544 0.6215 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.0139 0.0194
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.0363 0.1331 0.1314
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0107 0.0272 0.0436
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0121 0.009
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0139 0.0198
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0281 0.0995 0.0977
Onchocerca volvulus 0.0163 0.0504 0.2663
Loa Loa (eye worm) phosphatidylinositol 3 0.0064 0.0098 0.0107
Schistosoma mansoni carbonic anhydrase-related 0.0141 0.0413 0.0408
Brugia malayi carbohydrate phosphorylase 0.0111 0.0291 0.0425
Brugia malayi Pre-SET motif family protein 0.0208 0.0693 0.1075
Trichomonas vaginalis ap endonuclease, putative 0.0095 0.0222 0.0255
Schistosoma mansoni thymidylate kinase 0.029 0.1031 0.1027
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.029 0.1031 0.1792
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.0361 0.0539
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0064 0.0098 0.0093
Schistosoma mansoni hypothetical protein 0.0862 0.3397 0.3394
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1544 0.6215 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0077 0.0148 0.0215
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0064 0.0098 0.0125
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0274 0.0963 0.1512
Onchocerca volvulus 0.0135 0.0391 0.1976
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0412 0.1536 0.8029
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1401 0.5624 0.9039
Brugia malayi Hemopexin family protein 0.0081 0.0167 0.0226
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0064 0.0098 0.0078
Entamoeba histolytica Thymidylate kinase, putative 0.029 0.1031 0.1618
Mycobacterium ulcerans hydrolase 0.007 0.012 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0234 0.0274
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0114 0.014

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 816 nM Inhibitory activity against HIV-1 reverse transcriptase enzyme ChEMBL. 10522695
IC50 (binding) = 816 nM Inhibitory activity against HIV-1 reverse transcriptase enzyme ChEMBL. 10522695
IC90 (functional) = 8.33 nM Activity against whole cell using anti-infectivity assay ChEMBL. 10522695
IC90 (functional) = 8.33 nM Activity against whole cell using anti-infectivity assay ChEMBL. 10522695

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.