TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 469.517 | Formula: C21H23N7O4S
H donors: 0 H acceptors: 4 LogP: 2.52 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: N=C(c1ccc(cc1)N1CCN(CC1)c1nnc(s1)c1ccc(o1)[N+](=O)[O-])N1CCOCC1
InChi: 1S/C21H23N7O4S/c22-19(26-11-13-31-14-12-26)15-1-3-16(4-2-15)25-7-9-27(10-8-25)21-24-23-20(33-21)17-5-6-18(32-17)28(29)30/h1-6,22H,7-14H2
InChiKey: FAWYGDZVAXKFIK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0239	0.0239
Mycobacterium ulcerans	beta-lactamase	0.0036	0	0.5
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0065	0.0733	0.0733
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1076	0.1076
Onchocerca volvulus		0.0079	0.1076	0.6035
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0065	0.0733	0.2516
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1076	0.3697
Loa Loa (eye worm)	calpain	0.0065	0.0733	0.0733
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.1076	0.1076
Onchocerca volvulus	Cathepsin L homolog	0.0079	0.1076	0.6035
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1076	0.3697
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0281	0.0404
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1076	0.1076
Schistosoma mansoni	cathepsin F (C01 family)	0.0057	0.0534	0.0534
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0172	0.3399	0.3399
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0079	0.1076	0.1076
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.1076	0.1076
Echinococcus multilocularis	hypothetical protein	0.0065	0.0733	0.0733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0281	0.0964
Leishmania major	cathepsin L-like protease	0.0079	0.1076	0.3697
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0534	0.1833
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1076	0.3697
Onchocerca volvulus		0.0057	0.0534	0.2992
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0239	0.0239
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1076	0.1076
Brugia malayi	Papain family cysteine protease containing protein	0.0079	0.1076	0.1076
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.0281	0.0281
Brugia malayi	calpain 7	0.0065	0.0733	0.0733
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1076	0.3697
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1076	0.3697
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0	0.5
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1076	0.1076
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1076	0.1076
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0281	0.0964
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0065	0.0733	0.0733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1076	0.3697
Echinococcus granulosus	calpain A	0.0065	0.0733	0.0733
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0079	0.1076	0.1076
Loa Loa (eye worm)	ctsf protein	0.0079	0.1076	0.1076
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0281	0.0404
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0153	0.2912	1
Plasmodium vivax	vivapain-3	0.0047	0.0281	0.2606
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0065	0.0733	0.0733
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.1076	0.1076
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1076	0.3697
Echinococcus granulosus	cathepsin b	0.0438	1	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0065	0.0733	0.0733
Toxoplasma gondii	cathepsin B	0.0153	0.2912	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0079	0.1076	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1076	0.1076
Plasmodium vivax	calpain, putative	0.0065	0.0733	0.6805
Toxoplasma gondii	cathepsin CPL	0.0079	0.1076	0.3697
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0079	0.1076	1
Loa Loa (eye worm)	calpain family protein 1	0.0127	0.2269	0.2269
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0065	0.0733	0.0733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0079	0.1076	0.3697
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1076	0.3697
Entamoeba histolytica	cysteine proteinase, putative	0.0057	0.0534	0.3457
Leishmania major	cathepsin L-like protease	0.0079	0.1076	0.3697
Leishmania major	cathepsin L-like protease	0.0079	0.1076	0.3697
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0534	0.0534
Loa Loa (eye worm)	fibroinase	0.0079	0.1076	0.1076
Mycobacterium leprae	conserved hypothetical protein	0.0036	0	0.5
Echinococcus granulosus	cathepsin l1	0.0079	0.1076	0.1076
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1076	0.3697
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0153	0.2912	0.2912
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0239	0.0239
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.1076	0.1076
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1076	0.3697
Echinococcus multilocularis	calpain 5	0.0065	0.0733	0.0733
Onchocerca volvulus	Cathepsin F homolog	0.0079	0.1076	0.6035
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0239	0.0239
Onchocerca volvulus		0.0079	0.1076	0.6035
Schistosoma mansoni	calpain-7 (C02 family)	0.0065	0.0733	0.0733
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0065	0.0733	0.2516
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1076	0.3697
Loa Loa (eye worm)	hypothetical protein	0.0172	0.3399	0.3399
Onchocerca volvulus	Cathepsin L homolog	0.0079	0.1076	0.6035
Schistosoma mansoni	cathepsin F (C01 family)	0.0079	0.1076	0.1076
Brugia malayi	cathepsin L-like precursor	0.0057	0.0534	0.0534
Trypanosoma cruzi	cysteine protease, putative	0.0047	0.0281	0.0281
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0281	0.0404
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0438	1	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1076	0.3697
Leishmania major	kinesin, putative	0.0045	0.0247	0.0848
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0065	0.0733	0.0733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1076	0.3697
Echinococcus granulosus	calpain	0.0065	0.0733	0.0733
Mycobacterium ulcerans	lipase LipD	0.0036	0	0.5
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0065	0.0733	0.0733
Mycobacterium ulcerans	hypothetical protein	0.0036	0	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0438	1	1
Trypanosoma brucei	calpain-like protein, putative	0.0065	0.0733	0.2516
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0281	0.0404
Echinococcus multilocularis	cathepsin L cysteine protease	0.0079	0.1076	0.1076
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0281	0.0281
Onchocerca volvulus		0.0079	0.1076	0.6035
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0187	0.3765	0.3765
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0281	0.0281
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0281	0.0281
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0239	0.0239
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0281	0.0404
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0438	1	1
Echinococcus multilocularis	cathepsin b	0.0438	1	1
Leishmania major	cathepsin L-like protease	0.0079	0.1076	0.3697
Schistosoma mansoni	cathepsin F (C01 family)	0.0079	0.1076	0.1076
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1076	0.3697
Plasmodium vivax	vivapain-2	0.0079	0.1076	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1076	0.3697
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0187	0.3765	0.3765
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0534	0.0534
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0281	0.0281
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0239	0.0239
Plasmodium vivax	vivapain-1	0.0047	0.0281	0.2606
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0079	0.1076	0.1076
Trypanosoma cruzi	kinesin, putative	0.0045	0.0247	0.0247
Plasmodium vivax	vivapain-2	0.0079	0.1076	1
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.1076	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1076	0.3697
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0065	0.0733	0.2516
Loa Loa (eye worm)	cathepsin B	0.0153	0.2912	0.2912
Echinococcus multilocularis	calpain family protein 1, d	0.0127	0.2269	0.2269
Trypanosoma brucei	antigen, putative	0.0065	0.0733	0.2516
Onchocerca volvulus		0.0079	0.1076	0.6035
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1076	0.3697
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0281	0.0281
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0153	0.2912	1
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0065	0.0733	0.0733
Echinococcus granulosus	calpain 5	0.0065	0.0733	0.0733
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1076	0.3697
Echinococcus multilocularis	cathepsin b	0.0438	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1076	0.3697
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1076	0.3697
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.0281	0.0281
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1076	0.3697
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1076	0.3697
Brugia malayi	Cathepsin L-like precursor	0.0057	0.0534	0.0534
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1076	0.3697
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0065	0.0733	0.0733
Loa Loa (eye worm)	calpain family protein 1	0.0172	0.3399	0.3399
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1076	0.3697
Mycobacterium leprae	Probable lipase LipE	0.0036	0	0.5
Onchocerca volvulus		0.0107	0.1784	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0239	0.0239
Brugia malayi	calpain family protein 1	0.0172	0.3399	0.3399
Onchocerca volvulus		0.0079	0.1076	0.6035
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0281	0.0404
Schistosoma mansoni	calpain (C02 family)	0.0065	0.0733	0.0733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1076	0.3697
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0534	0.1833
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0187	0.3765	0.3765
Brugia malayi	calpain family protein 1	0.0172	0.3399	0.3399
Trypanosoma brucei	kinesin, putative	0.0045	0.0247	0.0848
Trypanosoma brucei	calpain-like protein, putative	0.0065	0.0733	0.2516
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0153	0.2912	0.2912
Plasmodium vivax	unspecified product	0.0047	0.0281	0.2606
Loa Loa (eye worm)	hypothetical protein	0.0438	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1076	0.3697
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.1076	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0281	0.0964
Echinococcus granulosus	cathepsin b	0.0438	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0281	0.0404
Schistosoma mansoni	calpain-7 (C02 family)	0.0065	0.0733	0.0733
Onchocerca volvulus		0.0079	0.1076	0.6035
Giardia lamblia	Cathepsin B precursor	0.0153	0.2912	0.5
Entamoeba histolytica	cysteine protease, putative	0.0079	0.1076	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0047	0.0281	0.0281
Trypanosoma brucei	calpain-like protein, putative	0.0065	0.0733	0.2516
Trypanosoma cruzi	cruzipain precursor, putative	0.0079	0.1076	0.1076
Echinococcus multilocularis	calpain 7 (C02 family)	0.0065	0.0733	0.0733
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0281	0.0404
Trypanosoma brucei	calpain-like protein, putative	0.0065	0.0733	0.2516
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0065	0.0733	0.0733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1076	0.3697
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0239	0.0239
Echinococcus multilocularis	cysteine protease	0.0079	0.1076	0.1076
Entamoeba histolytica	cysteine proteinase 2	0.0047	0.0281	0.0404
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1076	0.3697
Leishmania major	cysteine peptidase A (CPA)	0.0079	0.1076	0.3697
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0227	0.4755	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1076	0.3697
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0079	0.1076	0.1076
Loa Loa (eye worm)	hypothetical protein	0.0127	0.2269	0.2269
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0281	0.0404
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0438	1	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0281	0.0404
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0079	0.1076	1
Loa Loa (eye worm)	cysteine protease	0.0079	0.1076	0.1076
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0065	0.0733	0.2516
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0534	0.0534
Leishmania major	cathepsin L-like protease	0.0079	0.1076	0.3697
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0239	0.0239
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0438	1	1
Giardia lamblia	Cathepsin B precursor	0.0153	0.2912	0.5
Echinococcus granulosus	cathepsin l1	0.0057	0.0534	0.0534
Entamoeba histolytica	cysteine proteinase 1, putative	0.0047	0.0281	0.0404
Schistosoma mansoni	calpain C (C02 family)	0.0065	0.0733	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1784	0.1784
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1076	0.3697
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1076	0.1076
Trypanosoma cruzi	kinesin, putative	0.0045	0.0247	0.0247
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0079	0.1076	0.1076
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0153	0.2912	1
Leishmania major	cathepsin L-like protease	0.0079	0.1076	0.3697
Brugia malayi	Cathepsin L-like precursor	0.0057	0.0534	0.0534
Echinococcus multilocularis	cathepsin L cysteine protease	0.0079	0.1076	0.1076
Brugia malayi	calpain 5	0.0045	0.0247	0.0247
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1076	0.3697
Loa Loa (eye worm)	calpain 5	0.0045	0.0247	0.0247
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0057	0.0534	0.0534
Echinococcus granulosus	cysteine protease	0.0047	0.0281	0.0281
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0187	0.3765	0.3765
Echinococcus multilocularis	calpain	0.0065	0.0733	0.0733
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0281	0.0404
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0281	0.0404
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0281	0.0404
Echinococcus granulosus	cathepsin L	0.0047	0.0281	0.0281
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0281	0.0404
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0281	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0153	0.2913	0.2913
Echinococcus multilocularis	cathepsin L	0.0047	0.0281	0.0281
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1076	0.3697
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1076	0.3697
Echinococcus granulosus	calpain A	0.0187	0.3777	0.3777
Onchocerca volvulus		0.0079	0.1076	0.6035
Echinococcus multilocularis	calpain A	0.0187	0.3777	0.3777
Echinococcus multilocularis	cysteine protease	0.0079	0.1076	0.1076
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0065	0.0733	0.0733
Echinococcus granulosus	cathepsin L cysteine protease	0.0047	0.0281	0.0281
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0079	0.1076	0.1076
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0065	0.0733	0.2516
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.0534	0.0534
Echinococcus granulosus	calpain 7 C02 family	0.0065	0.0733	0.0733
Giardia lamblia	Cathepsin B precursor	0.0153	0.2912	0.5
Leishmania major	cathepsin L-like protease	0.0079	0.1076	0.3697
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0079	0.1076	0.3697
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0281	0.0404
Leishmania major	cathepsin L-like protease	0.0079	0.1076	0.3697
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1076	0.3697
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0281	0.0964
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0281	0.0404
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0281	0.0281

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1789689

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1571370