Detailed information for compound 1571374

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 385.586 | Formula: C24H39N3O
  • H donors: 1 H acceptors: 1 LogP: 7.15 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCc1ccc(cc1)C(=O)N1CCC[C@@H]1C(=N)N
  • InChi: 1S/C24H39N3O/c1-2-3-4-5-6-7-8-9-10-11-13-20-15-17-21(18-16-20)24(28)27-19-12-14-22(27)23(25)26/h15-18,22H,2-14,19H2,1H3,(H3,25,26)/t22-/m1/s1
  • InChiKey: DHYWGRWKWDDFMU-JOCHJYFZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans beta-lactamase 0.0036 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0166 0.0516
Entamoeba histolytica cysteine proteinase, putative 0.0172 0.2415 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0175 0.0175
Brugia malayi photoreceptor-specific nuclear receptor 0.0232 0.3492 0.3492
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0534 0.0534
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0045 0.0148 0.0148
Entamoeba histolytica cysteine proteinase, putative 0.0097 0.1078 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0166 0.0516
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0046 0.0166 0.0686
Trypanosoma cruzi major cysteine proteinase, putative 0.0046 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0046 0.0166 0.0166
Brugia malayi nuclear hormone receptor 0.011 0.1305 0.1305
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0232 0.3492 0.3492
Brugia malayi nuclear receptor NHR-67 0.011 0.1305 0.1305
Schistosoma mansoni retinoic acid receptor RXR 0.0232 0.3492 0.3492
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0175 0.0175
Toxoplasma gondii cathepsin CPL 0.0172 0.2415 0.753
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.2415 0.753
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0232 0.3492 0.3492
Trypanosoma cruzi Aph-1 protein, putative 0.0092 0.0998 0.0998
Entamoeba histolytica cysteine protease, putative 0.0097 0.1078 0.4054
Schistosoma mansoni calpain-7 (C02 family) 0.0066 0.0534 0.0534
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0166 0.0166
Schistosoma mansoni thyroid hormone receptor 0.0232 0.3492 0.3492
Echinococcus granulosus cathepsin l1 0.0172 0.2415 0.2415
Schistosoma mansoni nuclear hormone receptor 0.0232 0.3492 0.3492
Brugia malayi cathepsin L precursor 0.0046 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.011 0.1305 0.1305
Brugia malayi hypothetical protein 0.0123 0.1539 0.1539
Trypanosoma cruzi cruzipain precursor, putative 0.0051 0.0264 0.0264
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0066 0.0534 0.0534
Echinococcus granulosus cathepsin b 0.0598 1 1
Schistosoma mansoni zinc finger protein 0.011 0.1305 0.1305
Onchocerca volvulus 0.0172 0.2415 0.6915
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.2415 0.753
Echinococcus granulosus calpain A 0.0066 0.0534 0.0534
Mycobacterium leprae conserved hypothetical protein 0.0036 0 0.5
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0123 0.1539 0.1539
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0172 0.2415 0.753
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0166 0.0516
Brugia malayi Cathepsin L-like cysteine proteinase 0.0121 0.1503 0.1503
Leishmania major cysteine peptidase A (CPA) 0.0172 0.2415 0.753
Loa Loa (eye worm) fibroinase 0.0172 0.2415 0.2415
Leishmania major cathepsin L-like protease 0.0172 0.2415 0.753
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0046 0.0166 0.0686
Onchocerca volvulus Cathepsin F homolog 0.0172 0.2415 0.6915
Brugia malayi tailless protein 0.011 0.1305 0.1305
Plasmodium vivax unspecified product 0.0051 0.0264 0.1095
Brugia malayi cathepsin F-like cysteine proteinase 0.0051 0.0264 0.0264
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0166 0.0516
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0216 0.3207 0.3207
Schistosoma mansoni nuclear hormone receptor 0.011 0.1305 0.1305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.2415 0.753
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0172 0.2415 0.753
Brugia malayi calpain family protein 1 0.0176 0.2486 0.2486
Echinococcus multilocularis nuclear receptor nhr 48 0.011 0.1305 0.1305
Loa Loa (eye worm) calpain 5 0.0046 0.0179 0.0179
Echinococcus granulosus cysteine protease 0.0097 0.1078 0.1078
Loa Loa (eye worm) hypothetical protein 0.011 0.1305 0.1305
Plasmodium vivax serine-repeat antigen (SERA) 0.0046 0.0166 0.0686
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0046 0.0166 0.0686
Loa Loa (eye worm) hypothetical protein 0.011 0.1305 0.1305
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0172 0.2415 0.2415
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0175 0.0175
Onchocerca volvulus 0.0172 0.2415 0.6915
Entamoeba histolytica cysteine proteinase, putative 0.0097 0.1078 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0097 0.1078 0.1078
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0175 0.0175
Plasmodium vivax unspecified product 0.0046 0.0166 0.0686
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0166 0.0516
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0045 0.0148 0.0148
Toxoplasma gondii cathepsin B 0.0216 0.3207 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.2415 0.753
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0232 0.3492 0.3492
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0046 0.0166 0.0686
Echinococcus multilocularis FTZ F1 alpha 0.0232 0.3492 0.3492
Echinococcus granulosus thyroid hormone receptor alpha 0.011 0.1305 0.1305
Entamoeba histolytica cysteine proteinase, putative 0.0172 0.2415 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.1503 0.1503
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0232 0.3492 0.3492
Brugia malayi cathepsin Z-like cysteine proteinase 0.0046 0.0166 0.0166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.2415 0.753
Entamoeba histolytica calpain large subunit domain III containing protein 0.0046 0.0179 0.006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0175 0.0175
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0232 0.3492 1
Plasmodium vivax unspecified product 0.0097 0.1078 0.4462
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0046 0.0166 0.0516
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0232 0.3492 0.3492
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0166 0.0516
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0598 1 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0046 0.0166 0.0166
Brugia malayi Nuclear hormone receptor-like 1 0.0123 0.1539 0.1539
Onchocerca volvulus 0.0172 0.2415 0.6915
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.011 0.1305 0.1305
Onchocerca volvulus 0.011 0.1304 0.3733
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0046 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0123 0.1539 0.1539
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0237 0.3576 0.3576
Brugia malayi ecdysteroid receptor 0.0232 0.3492 0.3492
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0176 0.2486 0.2486
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0232 0.3492 0.3492
Entamoeba histolytica cysteine protease, putative 0.0172 0.2415 1
Loa Loa (eye worm) hypothetical protein 0.011 0.1305 0.1305
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0172 0.2415 0.753
Onchocerca volvulus 0.0121 0.1503 0.4304
Echinococcus granulosus calpain A 0.0191 0.2762 0.2762
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0232 0.3492 0.3492
Plasmodium falciparum cysteine proteinase falcipain 3 0.0172 0.2415 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.2415 0.753
Echinococcus multilocularis gamma secretase subunit aph 1 0.0237 0.3576 0.3576
Loa Loa (eye worm) hypothetical protein 0.0123 0.1539 0.1539
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0598 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.2415 0.753
Loa Loa (eye worm) nuclear hormone receptor 0.011 0.1305 0.1305
Brugia malayi nuclear hormone receptor family member nhr-6 0.011 0.1305 0.1305
Schistosoma mansoni Mername-AA248 (C02 family) 0.0066 0.0534 0.0534
Schistosoma mansoni calpain-7 (C02 family) 0.0066 0.0534 0.0534
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0166 0.0516
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.2415 0.753
Plasmodium falciparum cysteine proteinase falcipain 1 0.0097 0.1078 0.4054
Onchocerca volvulus Cathepsin L homolog 0.0172 0.2415 0.6915
Schistosoma mansoni cathepsin F (C01 family) 0.0121 0.1503 0.1503
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0232 0.3492 0.3492
Brugia malayi calpain family protein 1 0.0176 0.2486 0.2486
Echinococcus multilocularis ecdysone induced protein 78C 0.0232 0.3492 0.3492
Echinococcus granulosus ecdysone induced protein 78C 0.0232 0.3492 0.3492
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0191 0.2753 0.2753
Echinococcus granulosus cathepsin L cysteine proteinase 0.0172 0.2415 0.2415
Mycobacterium ulcerans lipase LipD 0.0036 0 0.5
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0046 0.0166 0.0166
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0232 0.3492 0.3492
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0172 0.2415 0.753
Schistosoma mansoni nuclear receptor 0.011 0.1305 0.1305
Brugia malayi orphan nuclear receptor NR2E1 0.011 0.1305 0.1305
Echinococcus multilocularis Nuclear hormone receptor HR96 0.011 0.1305 0.1305
Echinococcus granulosus Nuclear hormone receptor HR96 0.011 0.1305 0.1305
Plasmodium vivax serine-repeat antigen (SERA) 0.0046 0.0166 0.0686
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0046 0.0166 0.0686
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0534 0.1666
Brugia malayi hypothetical protein 0.011 0.1305 0.1305
Brugia malayi nuclear hormone receptor 0.0232 0.3492 0.3492
Loa Loa (eye worm) hypothetical protein 0.0232 0.3492 0.3492
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0066 0.0534 0.0534
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0232 0.3492 0.3492
Schistosoma mansoni gamma-secretase subunit aph-1 0.0237 0.3576 0.3576
Loa Loa (eye worm) hypothetical protein 0.011 0.1305 0.1305
Brugia malayi nuclear receptor RXR 0.0123 0.1539 0.1539
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0598 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.2415 0.753
Echinococcus multilocularis calpain 5 0.0066 0.0534 0.0534
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.011 0.1305 0.3738
Loa Loa (eye worm) hypothetical protein 0.011 0.1305 0.1305
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0232 0.3492 0.3492
Echinococcus multilocularis hypothetical protein 0.0066 0.0534 0.0534
Echinococcus granulosus cathepsin L 0.0097 0.1078 0.1078
Plasmodium vivax calpain, putative 0.0066 0.0534 0.2213
Loa Loa (eye worm) hypothetical protein 0.011 0.1305 0.1305
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0046 0.0166 0.0686
Loa Loa (eye worm) hypothetical protein 0.0598 1 1
Echinococcus multilocularis calpain family protein 1, d 0.013 0.1659 0.1659
Trypanosoma cruzi major cysteine proteinase, putative 0.0046 0.0166 0.0166
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0097 0.1078 0.1078
Loa Loa (eye worm) steroid hormone receptor 0.0232 0.3492 0.3492
Loa Loa (eye worm) hypothetical protein 0.0121 0.1503 0.1503
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0232 0.3492 0.3492
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0232 0.3492 0.3492
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0172 0.2415 0.753
Plasmodium vivax vivapain-3 0.0097 0.1078 0.4462
Trypanosoma cruzi cysteine protease, putative 0.0097 0.1078 0.1078
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0534 0.0534
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0232 0.3492 0.3492
Toxoplasma gondii cathepsin CPC1 0.0046 0.0166 0.0516
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.1078 0.336
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0191 0.2753 0.2753
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0598 1 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.2486 0.2486
Brugia malayi cathepsin Z-like cysteine proteinase 0.0046 0.0166 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0232 0.3492 0.3492
Echinococcus multilocularis calpain 0.0066 0.0534 0.0534
Brugia malayi Nuclear hormone receptor E75 0.011 0.1305 0.1305
Trypanosoma brucei cysteine peptidase C (CPC) 0.0216 0.3207 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0116 0.0116
Brugia malayi Nuclear hormone receptor E75 0.011 0.1305 0.1305
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0066 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.0232 0.3492 0.3492
Entamoeba histolytica cysteine proteinase 1, putative 0.0097 0.1078 0.4054
Leishmania major kinesin, putative 0.0046 0.0179 0.0558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0166 0.0516
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.011 0.1305 0.1305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.2415 0.753
Entamoeba histolytica cysteine protease, putative 0.0097 0.1078 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0172 0.2415 0.753
Leishmania major cathepsin L-like protease 0.0172 0.2415 0.753
Echinococcus granulosus calpain 5 0.0066 0.0534 0.0534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.2415 0.753
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0046 0.0166 0.0516
Echinococcus granulosus gamma secretase subunit aph 1 0.0237 0.3576 0.3576
Loa Loa (eye worm) DR-78 0.011 0.1305 0.1305
Entamoeba histolytica cysteine protease, putative 0.0097 0.1078 0.4054
Brugia malayi Cathepsin L-like precursor 0.0172 0.2415 0.2415
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0123 0.1539 0.1539
Brugia malayi Cathepsin L-like precursor 0.0172 0.2415 0.2415
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0232 0.3492 0.3492
Loa Loa (eye worm) hypothetical protein 0.0232 0.3492 0.3492
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0066 0.0534 0.0534
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0066 0.0534 0.1666
Brugia malayi calpain 7 0.0066 0.0534 0.0534
Brugia malayi cathepsin L-like precursor 0.0121 0.1503 0.1503
Entamoeba histolytica cysteine protease, putative 0.0097 0.1078 0.4054
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0232 0.3492 0.3492
Loa Loa (eye worm) nuclear receptor nhr-7B 0.011 0.1305 0.1305
Schistosoma mansoni cathepsin S (C01 family) 0.0046 0.0166 0.0166
Brugia malayi hypothetical protein 0.0123 0.1539 0.1539
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0123 0.1539 0.1539
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0166 0.0516
Loa Loa (eye worm) calpain family protein 1 0.013 0.1659 0.1659
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0051 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.011 0.1305 0.1305
Schistosoma mansoni nuclear receptor 0.011 0.1305 0.1305
Toxoplasma gondii cathepsin CPC2 0.0046 0.0166 0.0516
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0166 0.0516
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0166 0.0166
Leishmania major cathepsin L-like protease 0.0172 0.2415 0.753
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0123 0.1539 0.1539
Leishmania major cathepsin L-like protease 0.0172 0.2415 0.753
Echinococcus multilocularis cathepsin L cysteine protease 0.0172 0.2415 0.2415
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0066 0.0534 0.0534
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.011 0.1305 0.1305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.1503 0.4687
Onchocerca volvulus Cathepsin L homolog 0.0046 0.0166 0.0474
Echinococcus multilocularis cathepsin L 0.0097 0.1078 0.1078
Entamoeba histolytica cysteine protease, putative 0.0097 0.1078 0.4054
Echinococcus multilocularis calpain 7 (C02 family) 0.0066 0.0534 0.0534
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0046 0.0166 0.0516
Trypanosoma cruzi kinesin, putative 0.0046 0.0179 0.0179
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.011 0.1305 0.3738
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0166 0.0516
Brugia malayi nuclear receptor NHR-88 0.011 0.1305 0.1305
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0232 0.3492 0.3492
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.011 0.1305 0.1305
Leishmania major cathepsin L-like protease 0.0172 0.2415 0.753
Loa Loa (eye worm) hypothetical protein 0.011 0.1305 0.1305
Echinococcus multilocularis cysteine protease 0.0172 0.2415 0.2415
Echinococcus granulosus FTZ F1 alpha 0.0232 0.3492 0.3492
Loa Loa (eye worm) hypothetical protein 0.0123 0.1539 0.1539
Echinococcus granulosus cathepsin b 0.0598 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0097 0.1078 0.1078
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0191 0.2753 0.2753
Schistosoma mansoni steroid hormone receptor ad4bp 0.0232 0.3492 0.3492
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0046 0.0166 0.0166
Loa Loa (eye worm) cathepsin B 0.0216 0.3207 0.3207
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0046 0.0166 0.0166
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0232 0.3492 0.3492
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0097 0.1078 0.336
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0172 0.2415 0.753
Brugia malayi conserved hypotetical protein 0.011 0.1305 0.1305
Echinococcus multilocularis cathepsin L cysteine protease 0.0172 0.2415 0.2415
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0066 0.0534 0.0534
Onchocerca volvulus 0.0172 0.2415 0.6915
Loa Loa (eye worm) hypothetical protein 0.0232 0.3492 0.3492
Leishmania major cathepsin L-like protease 0.0172 0.2415 0.753
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0264 0.0264
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0172 0.2415 0.2415
Echinococcus granulosus Nuclear hormone receptor HR96 0.011 0.1305 0.1305
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0172 0.2415 0.753
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0216 0.3207 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0232 0.3492 0.3492
Brugia malayi Cathepsin L-like precursor 0.0172 0.2415 0.2415
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0046 0.0166 0.0686
Onchocerca volvulus 0.0232 0.3492 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0046 0.0166 0.0166
Onchocerca volvulus 0.011 0.1305 0.3738
Trypanosoma cruzi cysteine peptidase, putative 0.0172 0.2415 0.2415
Onchocerca volvulus 0.0172 0.2415 0.6915
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0232 0.3492 0.3492
Giardia lamblia Cathepsin B precursor 0.0216 0.3207 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0172 0.2415 0.2415
Loa Loa (eye worm) nuclear receptor NHR-67 0.011 0.1305 0.1305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0166 0.0516
Loa Loa (eye worm) hypothetical protein 0.011 0.1305 0.1305
Schistosoma mansoni RAR-like nuclear receptor 0.0232 0.3492 0.3492
Trypanosoma brucei Aph-1 protein, putative 0.0092 0.0998 0.3112
Entamoeba histolytica cysteine proteinase, putative 0.0097 0.1078 0.4054
Echinococcus multilocularis cysteine protease 0.0172 0.2415 0.2415
Mycobacterium leprae Probable lipase LipE 0.0036 0 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0232 0.3492 0.3492
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0232 0.3492 0.3492
Plasmodium vivax vivapain-2 0.0172 0.2415 1
Brugia malayi Cathepsin L-like precursor 0.0121 0.1503 0.1503
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0175 0.0175
Brugia malayi cathepsin F-like cysteine proteinase 0.0046 0.0166 0.0166
Entamoeba histolytica cysteine protease, putative 0.0097 0.1078 0.4054
Brugia malayi Cathepsin L-like precursor 0.0051 0.0264 0.0264
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0123 0.1539 0.1539
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0534 0.1666
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0172 0.2415 0.753
Loa Loa (eye worm) hypothetical protein 0.0232 0.3492 0.3492
Loa Loa (eye worm) ctsf protein 0.0172 0.2415 0.2415
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.2415 0.753
Trypanosoma cruzi cysteine peptidase, putative 0.0172 0.2415 0.2415
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0232 0.3492 0.3492
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0534 0.1666
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0232 0.3492 0.3492
Brugia malayi Nuclear hormone receptor-like 1 0.0232 0.3492 0.3492
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0175 0.0175
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0166 0.0166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.2415 0.753
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0046 0.0166 0.0516
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0232 0.3492 0.3492
Loa Loa (eye worm) calpain family protein 1 0.0176 0.2486 0.2486
Loa Loa (eye worm) hypothetical protein 0.0046 0.0166 0.0166
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0046 0.0166 0.0166
Onchocerca volvulus Protein ultraspiracle homolog 0.0232 0.3492 1
Loa Loa (eye worm) hypothetical protein 0.011 0.1304 0.1304
Echinococcus multilocularis Nuclear hormone receptor HR96 0.011 0.1305 0.1305
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0166 0.0516
Echinococcus multilocularis cathepsin b 0.0598 1 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0 0.5
Leishmania major cathepsin L-like protease 0.0172 0.2415 0.753
Loa Loa (eye worm) hypothetical protein 0.0123 0.1539 0.1539
Brugia malayi Cathepsin L-like precursor 0.0121 0.1503 0.1503
Plasmodium vivax vivapain-1 0.0097 0.1078 0.4462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.2415 0.753
Trypanosoma cruzi cysteine proteinase, putative 0.0097 0.1078 0.1078
Echinococcus granulosus cathepsin l1 0.0121 0.1503 0.1503
Trypanosoma cruzi cysteine peptidase, putative 0.0172 0.2415 0.2415
Brugia malayi steroid hormone receptor 0.0232 0.3492 0.3492
Brugia malayi nuclear hormone receptor family member odr-7 0.011 0.1305 0.1305
Entamoeba histolytica cysteine protease, putative 0.0097 0.1078 0.4054
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.011 0.1305 0.1305
Loa Loa (eye worm) hypothetical protein 0.0051 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0046 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.011 0.1305 0.1305
Echinococcus multilocularis Tolloid protein 1 0.0045 0.0148 0.0148
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0598 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0175 0.0175
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0534 0.1666
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.2415 0.753
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0166 0.0166
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0232 0.3492 0.3492
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0 0.5
Schistosoma mansoni calpain C (C02 family) 0.0066 0.0534 0.0534
Trypanosoma brucei kinesin, putative 0.0046 0.0179 0.0558
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0264 0.0264
Onchocerca volvulus Cathepsin L homolog 0.0172 0.2415 0.6915
Entamoeba histolytica cysteine proteinase, putative 0.0121 0.1503 0.5946
Trypanosoma brucei calpain-like protein, putative 0.0066 0.0534 0.1666
Loa Loa (eye worm) hypothetical protein 0.011 0.1305 0.1305
Schistosoma mansoni cathepsin F (C01 family) 0.0172 0.2415 0.2415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.1078 0.336
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0097 0.1078 0.1078
Trypanosoma brucei calpain-like protein, putative 0.0066 0.0534 0.1666
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0121 0.1503 0.1503
Giardia lamblia Cathepsin B precursor 0.0216 0.3207 1
Brugia malayi nuclear receptor RXR 0.011 0.1305 0.1305
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0097 0.1078 0.336
Echinococcus granulosus cathepsin L cysteine protease 0.0097 0.1078 0.1078
Echinococcus granulosus nuclear receptor nhr 48 0.011 0.1305 0.1305
Brugia malayi Steroid receptor seven-up type 2 0.0232 0.3492 0.3492
Schistosoma mansoni nuclear receptor nhr-48 0.011 0.1305 0.1305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.2415 0.753
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0534 0.0534
Echinococcus granulosus calpain 7 C02 family 0.0066 0.0534 0.0534
Schistosoma mansoni coup transcription factor 0.0232 0.3492 0.3492
Echinococcus granulosus cathepsin L 0.0046 0.0166 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.2415 0.753
Trypanosoma cruzi cysteine proteinase, putative 0.0097 0.1078 0.1078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.2415 0.753
Toxoplasma gondii preprocathepsin c precursor, putative 0.0046 0.0166 0.0516
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0046 0.0166 0.0686
Loa Loa (eye worm) cysteine protease 0.0172 0.2415 0.2415
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0172 0.2415 0.2415
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0166 0.0166
Brugia malayi Cathepsin L-like precursor 0.0172 0.2415 0.2415
Brugia malayi calpain 5 0.0046 0.0179 0.0179
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0172 0.2415 0.753
Schistosoma mansoni thyroid hormone receptor 0.0232 0.3492 0.3492
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0232 0.3492 0.3492
Loa Loa (eye worm) hypothetical protein 0.0123 0.1539 0.1539
Echinococcus multilocularis thyroid hormone receptor alpha 0.0232 0.3492 0.3492
Loa Loa (eye worm) hypothetical protein 0.0046 0.0166 0.0166
Onchocerca volvulus 0.0172 0.2415 0.6915
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0232 0.3492 0.3492
Echinococcus multilocularis calpain A 0.0191 0.2762 0.2762
Onchocerca volvulus 0.011 0.1305 0.3738
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0097 0.1078 0.1078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0166 0.0516
Mycobacterium ulcerans hypothetical protein 0.0036 0 0.5
Entamoeba histolytica cysteine protease, putative 0.0097 0.1078 0.4054
Loa Loa (eye worm) hypothetical protein 0.0232 0.3492 0.3492
Schistosoma mansoni nuclear hormone receptor 0.011 0.1305 0.1305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.2415 0.753
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.011 0.1305 0.1305
Entamoeba histolytica cysteine proteinase, putative 0.0097 0.1078 0.4054
Echinococcus multilocularis cathepsin L 0.0046 0.0166 0.0166
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.011 0.1305 0.1305
Entamoeba histolytica cysteine protease, putative 0.0097 0.1078 0.4054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0175 0.0175
Schistosoma mansoni cathepsin C 0.0046 0.0166 0.0166
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0166 0.0166
Schistosoma mansoni cathepsin s 0.0051 0.0264 0.0264
Schistosoma mansoni calpain (C02 family) 0.0066 0.0534 0.0534
Trypanosoma brucei calpain-like protein, putative 0.0066 0.0534 0.1666
Trypanosoma cruzi cysteine peptidase, putative 0.0097 0.1078 0.1078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.2415 0.753
Echinococcus granulosus Tolloid protein 1 0.0045 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0121 0.1503 0.1503
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0232 0.3492 0.3492
Loa Loa (eye worm) hypothetical protein 0.0232 0.3492 0.3492
Leishmania major cathepsin L-like protease 0.0172 0.2415 0.753
Brugia malayi Cathepsin L-like precursor 0.0172 0.2415 0.2415
Giardia lamblia Cathepsin B precursor 0.0216 0.3207 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0232 0.3492 0.3492
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0172 0.2415 1
Brugia malayi ecdysone receptor 0.011 0.1305 0.1305
Trypanosoma brucei calpain-like protein, putative 0.0066 0.0534 0.1666
Loa Loa (eye worm) hypothetical protein 0.0046 0.0166 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.2415 0.753
Entamoeba histolytica protein kinase, putative 0.0046 0.0179 0.006
Trypanosoma brucei antigen, putative 0.0066 0.0534 0.1666
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0172 0.2415 0.753
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0232 0.3492 0.3492
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.2415 0.753
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0046 0.0166 0.0686
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.349 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.011 0.1305 0.1305
Entamoeba histolytica cysteine protease, putative 0.0097 0.1078 0.4054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0232 0.3492 0.3492
Loa Loa (eye worm) hypothetical protein 0.0051 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.013 0.1659 0.1659
Trypanosoma cruzi cruzipain precursor, putative 0.0172 0.2415 0.2415
Onchocerca volvulus 0.0172 0.2415 0.6915
Brugia malayi gamma-secretase subunit aph-1 0.0237 0.3576 0.3576
Onchocerca volvulus 0.0046 0.0166 0.0474
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0232 0.3492 0.3492
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0191 0.2753 0.2753
Trypanosoma cruzi Aph-1 protein, putative 0.0092 0.0998 0.0998
Trypanosoma cruzi kinesin, putative 0.0046 0.0179 0.0179
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0232 0.3492 0.3492
Trypanosoma cruzi cysteine peptidase, putative 0.0172 0.2415 0.2415
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0216 0.3207 0.3207
Brugia malayi Papain family cysteine protease containing protein 0.0172 0.2415 0.2415
Entamoeba histolytica cysteine protease, putative 0.0097 0.1078 0.4054
Brugia malayi Cathepsin L-like precursor 0.0172 0.2415 0.2415
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0166 0.0166
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0232 0.3492 0.3492
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0172 0.2415 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0166 0.0516
Loa Loa (eye worm) hypothetical protein 0.0046 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0156 0.213 0.213
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.2415 0.753
Brugia malayi Nuclear hormone receptor-like 1 0.0123 0.1539 0.1539
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0172 0.2415 0.2415
Loa Loa (eye worm) hypothetical protein 0.0232 0.3492 0.3492
Loa Loa (eye worm) hypothetical protein 0.0051 0.0264 0.0264
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0166 0.0166
Entamoeba histolytica cysteine protease, putative 0.0097 0.1078 0.4054
Loa Loa (eye worm) hypothetical protein 0.0172 0.2415 0.2415
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0046 0.0166 0.0166
Loa Loa (eye worm) calpain 0.0066 0.0534 0.0534
Entamoeba histolytica cysteine protease, putative 0.0097 0.1078 0.4054
Brugia malayi nuclear receptor NHR-88 0.0232 0.3492 0.3492
Onchocerca volvulus Bile acid receptor homolog 0.0232 0.3492 1
Entamoeba histolytica cysteine proteinase 2 0.0097 0.1078 0.4054
Brugia malayi hypothetical protein 0.011 0.1305 0.1305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.2415 0.753
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.1503 0.4687
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0232 0.3492 0.3492
Schistosoma mansoni cathepsin F (C01 family) 0.0172 0.2415 0.2415
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0046 0.0166 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0216 0.3207 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0232 0.3492 0.3492
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0097 0.1078 0.1078
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0046 0.0166 0.0686
Schistosoma mansoni cathepsin B (C01 family) 0.0046 0.0166 0.0166
Brugia malayi fibroinase precursor 0.0046 0.0166 0.0166
Plasmodium vivax vivapain-2 0.0172 0.2415 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0232 0.3492 0.3492
Echinococcus multilocularis cathepsin b 0.0598 1 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0534 0.0534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.2415 0.753
Echinococcus granulosus calpain 0.0066 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.011 0.1305 0.1305

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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