Detailed information for compound 1572755

Basic information

Technical information
  • TDR Targets ID: 1572755
  • Name: N-[4-(2-diethylaminoethylcarbamoyl)phenyl]-2- morpholin-4-yl-5-piperidin-1-ylsulfonylbenzam ide
  • MW: 571.731 | Formula: C29H41N5O5S
  • H donors: 2 H acceptors: 4 LogP: 2.55 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCN(CCNC(=O)c1ccc(cc1)NC(=O)c1cc(ccc1N1CCOCC1)S(=O)(=O)N1CCCCC1)CC
  • InChi: 1S/C29H41N5O5S/c1-3-32(4-2)17-14-30-28(35)23-8-10-24(11-9-23)31-29(36)26-22-25(40(37,38)34-15-6-5-7-16-34)12-13-27(26)33-18-20-39-21-19-33/h8-13,22H,3-7,14-21H2,1-2H3,(H,30,35)(H,31,36)
  • InChiKey: LKFNQYUGYYZQAU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[4-(2-diethylaminoethylcarbamoyl)phenyl]-2-morpholino-5-(1-piperidylsulfonyl)benzamide
  • N-[4-[(2-diethylaminoethylamino)-oxomethyl]phenyl]-2-morpholino-5-(1-piperidylsulfonyl)benzamide
  • N-[4-(2-diethylaminoethylcarbamoyl)phenyl]-2-morpholino-5-piperidinosulfonyl-benzamide
  • N-[4-(2-diethylaminoethylcarbamoyl)phenyl]-2-morpholin-4-yl-5-piperidin-1-ylsulfonyl-benzamide
  • T5376158

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0043 0.0153 0.0443
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0043 0.0153 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0048
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0435 0.3465 1
Onchocerca volvulus 0.0049 0.0209 0.0511
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1736 0.374
Brugia malayi MH2 domain containing protein 0.0144 0.1011 0.1011
Trypanosoma cruzi protein farnesyltransferase, putative 0.0043 0.0153 0.0153
Trypanosoma cruzi C-14 sterol reductase, putative 0.01 0.0636 0.0636
Schistosoma mansoni vesicular acetylcholine transporter 0.0435 0.3465 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0048 0.1476
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0301 0.2336 0.2336
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0209 0.0511
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0115 0.0115
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0043 0.0153 0.0226
Echinococcus multilocularis lamin b receptor 0.01 0.0636 0.0929
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0043 0.0153 0.0153
Brugia malayi mbt repeat family protein 0.0049 0.0209 0.0209
Trypanosoma brucei Sterol methyltransferase, putative 0.0398 0.3155 0.3155
Echinococcus granulosus tm gpcr rhodopsin 0.0574 0.4642 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0266 0.0573
Brugia malayi PHD-finger family protein 0.0028 0.0033 0.0033
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.146 0.3145
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0183 0.0267
Leishmania major sterol 24-c-methyltransferase, putative 0.0398 0.3155 0.3155
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0106 0.0154
Trypanosoma cruzi lanosterol synthase, putative 0.0311 0.242 0.242
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0033 0.1036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0183 0.0527
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0043 0.0153 0.033
Echinococcus granulosus lysine specific demethylase 5A 0.0092 0.0567 0.1221
Plasmodium falciparum geranylgeranyltransferase, putative 0.0043 0.0153 1
Leishmania major sterol C-24 reductase, putative 0.0052 0.0231 0.0231
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0043 0.0153 0.0226
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0043 0.0153 0.0226
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0322 0.0322
Giardia lamblia Rab geranylgeranyltransferase 0.0043 0.0153 1
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0043 0.0153 1
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0322 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0209 0.0209
Schistosoma mansoni jumonji/arid domain-containing protein 0.0092 0.0567 0.1636
Loa Loa (eye worm) hypothetical protein 0.0052 0.0231 0.0231
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0435 0.3465 0.3465
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0183 0.0393
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0183 0.0393
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0043 0.0153 0.0443
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0322 0.0929
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0115 0.3575
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0266 0.0768
Brugia malayi hypothetical protein 0.023 0.1736 0.1736
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1209 1 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0266 0.0389
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0107 0.0156
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0209 0.0602
Loa Loa (eye worm) hypothetical protein 0.0618 0.501 0.501
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.0194 0.1432 0.1432
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0043 0.0153 0.0443
Plasmodium falciparum phd finger protein, putative 0.0028 0.0033 0.2174
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0043 0.0153 0.0224
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0322 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0115 0.5
Trypanosoma cruzi lanosterol synthase, putative 0.0311 0.242 0.242
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1011 0.1011
Loa Loa (eye worm) hypothetical protein 0.1209 1 1
Plasmodium vivax geranylgeranyltransferase, putative 0.0043 0.0153 1
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0043 0.0153 0.0226
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0043 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0043 0.0153 0.0153
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.019 0.019
Brugia malayi mbt repeat family protein 0.0049 0.0209 0.0209
Schistosoma mansoni Lamin B receptor (ERG24) 0.01 0.0636 0.1835
Schistosoma mansoni hypothetical protein 0.0047 0.019 0.0548
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0033 0.0096
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0043 0.0153 0.0224
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0209 0.0305
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0033 0.1036
Schistosoma mansoni jumonji domain containing protein 0.0131 0.09 0.2597
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0183 0.0183
Echinococcus granulosus peregrin 0.0028 0.0033 0.0072
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0043 0.0153 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1011 0.1011
Brugia malayi Bromodomain containing protein 0.0028 0.0033 0.0033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0183 0.0527
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0115 0.0115
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0043 0.0153 0.0153
Schistosoma mansoni survival motor neuron protein 0.0047 0.019 0.0548
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0209 0.045
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.015 0.1061 0.2286
Trypanosoma cruzi sterol C-24 reductase, putative 0.0052 0.0231 0.0231
Schistosoma mansoni hypothetical protein 0.0302 0.2347 0.6773
Trypanosoma brucei lanosterol synthase 0.0311 0.242 0.242
Loa Loa (eye worm) hypothetical protein 0.023 0.1736 0.1736
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0209 0.045
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0398 0.3155 0.3155
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0043 0.0153 0.4765
Loa Loa (eye worm) hypothetical protein 0.0028 0.0033 0.0033
Brugia malayi Pre-SET motif family protein 0.0209 0.1562 0.1562
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0332 1
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0106 0.0227
Loa Loa (eye worm) hypothetical protein 0.0064 0.0333 0.0333
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0398 0.3155 0.3155
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0332 0.0959
Plasmodium vivax SET domain protein, putative 0.003 0.0048 0.3098
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0322 0.0694
Schistosoma mansoni hypothetical protein 0.0028 0.0033 0.0096
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.015 0.1061 0.155
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0127 0.0186
Leishmania major lanosterol synthase, putative 0.0269 0.2061 0.2061
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0107 0.023
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0043 0.0153 0.4765
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0332 0.0332
Trypanosoma cruzi Emopamil binding protein, putative 0.0301 0.2336 0.2336
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0033 0.0033
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0301 0.2336 0.2336
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0322 0.047
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0033 0.0049
Leishmania major farnesyltransferase beta subunit 0.0043 0.0153 0.0153
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0043 0.0153 0.0226
Leishmania major C-8 sterol isomerase-like protein 0.1209 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0048 0.0069
Onchocerca volvulus 0.0294 0.2276 0.6536
Loa Loa (eye worm) hypothetical protein 0.0056 0.0266 0.0266
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0153 0.0153
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0038 0.0082
Trichomonas vaginalis set domain proteins, putative 0.0238 0.1806 1
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0043 0.0153 0.4765
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0048 0.0102
Onchocerca volvulus 0.003 0.0048 0.0041
Onchocerca volvulus 0.0301 0.2336 0.671
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0043 0.0153 0.0153
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0043 0.0153 0.0224
Schistosoma mansoni inositol monophosphatase 0.0038 0.0115 0.0332
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0048 0.0069
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0322 0.2062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0183 0.0267
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0153 0.0153
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0043 0.0153 0.0153
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0115 0.0369
Trypanosoma cruzi Emopamil binding protein, putative 0.0301 0.2336 0.2336
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0115 0.0115
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0398 0.3155 0.3155
Brugia malayi Pre-SET motif family protein 0.003 0.0048 0.0048
Trypanosoma brucei C-14 sterol reductase, putative 0.01 0.0636 0.0636
Trypanosoma cruzi C-14 sterol reductase, putative 0.01 0.0636 0.0636
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0332 0.0716
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0322 0.0929
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0127 0.0274
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0266 0.0389
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0043 0.0153 0.0226
Trypanosoma cruzi sterol C-24 reductase, putative 0.0052 0.0231 0.0231
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0208 0.1547 0.1547
Giardia lamblia Prenyltransferase 0.0043 0.0153 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0115 0.0115
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0043 0.0153 0.0153
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0209 0.0602
Onchocerca volvulus 0.0238 0.1806 0.5167
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0043 0.0153 0.033
Trypanosoma brucei C-8 sterol isomerase, putative 0.1209 1 1
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0172 0.1248 1
Leishmania major geranylgeranyltransferase, putative 0.0043 0.0153 0.0153
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0398 0.3155 0.3155
Echinococcus multilocularis vesicular acetylcholine transporter 0.0435 0.3465 0.5061
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0398 0.3155 0.3155
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0043 0.0153 0.2067
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0332 0.0485
Loa Loa (eye worm) hypothetical protein 0.0043 0.0153 0.0153
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0266 0.0573
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0043 0.0153 0.0443
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0301 0.2336 0.2336
Echinococcus multilocularis lysine specific demethylase 5A 0.0092 0.0567 0.0828
Echinococcus multilocularis peregrin 0.0028 0.0033 0.0049
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0043 0.0153 0.2067
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0332 0.0332
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0209 0.0209
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0288 0.0288
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0574 0.4642 0.6781
Leishmania major hypothetical protein, conserved 0.0301 0.2336 0.2336
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0043 0.0153 0.0226
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0043 0.0153 0.0226
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0043 0.0153 1
Brugia malayi jmjC domain containing protein 0.015 0.1061 0.1061
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0033 0.2174
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0209 0.0602
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0043 0.0153 0.0226
Loa Loa (eye worm) inositol-1 0.0038 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0194 0.1432 0.1432
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1736 0.2536
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0183 0.0527
Brugia malayi vesicular acetylcholine transporter unc-17 0.0435 0.3465 0.3465
Schistosoma mansoni hypothetical protein 0.0037 0.0107 0.0308
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0048 0.0137
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0033 0.0072
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0081 0.5
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0115 0.0168
Brugia malayi jmjC domain containing protein 0.0092 0.0567 0.0567
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0322 1
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0107 0.0308
Brugia malayi hypothetical protein 0.0294 0.2276 0.2276
Loa Loa (eye worm) hypothetical protein 0.0294 0.2276 0.2276
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0332 0.0332
Trypanosoma brucei Emopamil binding protein, putative 0.0301 0.2336 0.2336
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0332 0.0332
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0322 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0183 0.0183
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0266 0.0266
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0209 0.0305
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.146 0.2132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0048 0.0137
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0332 0.0332
Loa Loa (eye worm) MBCTL1 0.0056 0.0266 0.0266
Leishmania major sterol 24-c-methyltransferase, putative 0.0398 0.3155 0.3155
Leishmania major C-14 sterol reductase, putative 0.01 0.0636 0.0636
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0115 0.0248
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0332 0.0332
Echinococcus granulosus lamin b receptor 0.01 0.0636 0.137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0048 0.0137
Schistosoma mansoni inositol monophosphatase 0.0038 0.0115 0.0332
Schistosoma mansoni jumonji/arid domain-containing protein 0.0092 0.0567 0.1636
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0835 0.6845 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0092 0.0567 0.0567
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0043 0.0153 0.0153
Onchocerca volvulus 0.0047 0.019 0.0457
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0048 0.0137
Echinococcus granulosus vesicular acetylcholine transporter 0.0435 0.3465 0.7464
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0043 0.0153 0.0153
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0043 0.0153 0.2067
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.1562 0.1562
Brugia malayi hypothetical protein 0.0037 0.0107 0.0107
Brugia malayi Inositol-1 0.0038 0.0115 0.0115
Trypanosoma cruzi protein farnesyltransferase, putative 0.0043 0.0153 0.0153

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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