Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0025 | 0.1155 | 0.2744 |
Onchocerca volvulus | 0.0041 | 0.2324 | 0.5 | |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0066 | 0.4211 | 0.5 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0025 | 0.1155 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.338 | 0.338 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0066 | 0.4211 | 1 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0066 | 0.4211 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.338 | 0.8028 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0025 | 0.1155 | 0.2744 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1155 | 0.1155 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0066 | 0.4211 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.338 | 0.8028 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0025 | 0.1155 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0025 | 0.1155 | 0.5 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0025 | 0.1155 | 0.5 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0066 | 0.4211 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1155 | 0.1155 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0066 | 0.4211 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.338 | 0.8028 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0066 | 0.4211 | 1 |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.0041 | 0.2324 | 0.2324 |
Brugia malayi | protein ZK524.3 | 0.0025 | 0.1155 | 0.1155 |
Brugia malayi | methionyl-tRNA synthetase | 0.0025 | 0.1155 | 0.1155 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1155 | 0.1155 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0066 | 0.4211 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.338 | 0.8028 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0066 | 0.4211 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.338 | 0.8028 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0066 | 0.4211 | 0.5 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0025 | 0.1155 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 0.4211 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0066 | 0.4211 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.338 | 0.8028 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.338 | 0.8028 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0025 | 0.1155 | 0.2744 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0025 | 0.1155 | 0.2744 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0066 | 0.4211 | 1 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0025 | 0.1155 | 0.2744 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0066 | 0.4211 | 0.4211 |
Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 0.4211 | 0.4211 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0066 | 0.4211 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.338 | 0.338 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0066 | 0.4211 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 5.794 uM | PubChem BioAssay. Luminescence-based biochemical high throughput dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 118.577 uM | PubChem BioAssay. Counterscreen Fluorescent Polarization-based biochemical high throughput orthogonal dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.