Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma brucei | methionyl-tRNA synthetase, putative | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0503 | 0.0503 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0025 | 0.0503 | 0.5 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0066 | 0.3784 | 1 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0025 | 0.0503 | 0.133 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0066 | 0.3784 | 0.5 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0066 | 0.3784 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3289 | 0.3289 |
Brugia malayi | methionyl-tRNA synthetase | 0.0025 | 0.0503 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0503 | 0.0503 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0503 | 0.0503 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Onchocerca volvulus | 0.0041 | 0.1758 | 0.5 | |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3289 | 0.3289 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0025 | 0.0503 | 0.133 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0025 | 0.0503 | 0.133 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 0.3784 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0025 | 0.0503 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0066 | 0.3784 | 1 |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.0041 | 0.1758 | 0.1758 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1767 | 0.1767 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0025 | 0.0503 | 0.5 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0025 | 0.0503 | 0.133 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0066 | 0.3784 | 1 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0066 | 0.3784 | 0.5 |
Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 0.3784 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0066 | 0.3784 | 0.5 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0066 | 0.3784 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3289 | 0.3289 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0025 | 0.0503 | 0.5 |
Brugia malayi | protein ZK524.3 | 0.0025 | 0.0503 | 0.0503 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0025 | 0.0503 | 0.133 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0025 | 0.0503 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1767 | 0.4669 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0066 | 0.3784 | 0.5 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0066 | 0.3784 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1767 | 0.1767 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 4.901 uM | PubChem BioAssay. Luminescence-based biochemical high throughput dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 10.274 uM | PubChem BioAssay. Counterscreen Fluorescent Polarization-based biochemical high throughput orthogonal dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.7783 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.