Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ceramide glucosyltransferase | 0.0232 | 0.6856 | 0.656 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.7624 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0311 | 1 | 1 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0232 | 0.6856 | 0.656 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.7624 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.7624 | 1 |
Trypanosoma cruzi | lysosomal alpha-mannosidase precursor, putative | 0.0082 | 0.0861 | 0.5 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0203 | 0.5672 | 0.5264 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0203 | 0.5672 | 0.5264 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0311 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.7624 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0061 | 0 | 0.5 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0232 | 0.6856 | 0.679 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0203 | 0.5672 | 0.5264 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0252 | 0.7624 | 0.2443 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0232 | 0.6856 | 0.4612 |
Echinococcus granulosus | bile acid beta glucosidase | 0.0203 | 0.5672 | 0.5264 |
Echinococcus multilocularis | beta galactosidase | 0.016 | 0.3963 | 0.3394 |
Trypanosoma cruzi | lysosomal alpha-mannosidase precursor, putative | 0.0082 | 0.0861 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.3037 | 0.289 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.452 | 0.1027 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0232 | 0.6856 | 0.656 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.854 | 0.8509 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.7624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.3963 | 0.3836 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0252 | 0.7624 | 0.7574 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0061 | 0 | 0.5 |
Trypanosoma brucei | lysosomal alpha-mannosidase precursor, putative | 0.0082 | 0.0861 | 1 |
Onchocerca volvulus | 0.0311 | 1 | 1 | |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0203 | 0.5672 | 0.5264 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0311 | 1 | 1 |
Schistosoma mansoni | beta-galactosidase | 0.016 | 0.3963 | 0.3394 |
Schistosoma mansoni | alpha-glucosidase | 0.0311 | 1 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0105 | 0.1776 | 0.5 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0232 | 0.6856 | 0.656 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.7624 | 1 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0203 | 0.5672 | 0.5264 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0311 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0311 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.452 | 0.1027 |
Echinococcus granulosus | beta galactosidase | 0.016 | 0.3963 | 0.3394 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | uM | Inhibitory concentration of the compound against Xanthine oxidase; Not active at 50 ug/mL concentration | ChEMBL. | 12873513 |
IC50 (binding) | NA 0 uM | Inhibitory concentration of the compound against Xanthine oxidase; Not active at 50 ug/mL concentration | ChEMBL. | 12873513 |
IC50 (binding) | = 77.76 uM | Inhibition of yeast Alpha-glucosidase | ChEMBL. | 12873513 |
SC50 (binding) | = 11.53 uM | Free radical scavenging assessed as DPPH colour reduction | ChEMBL. | 12873513 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.