TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 319.36 | Formula: C18H17N5O
H donors: 0 H acceptors: 4 LogP: 3.57 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(n1)n1c(nc(c1c(n2)C)C)c1cccnc1C
InChi: 1S/C18H17N5O/c1-10-13(6-5-9-19-10)17-21-12(3)16-11(2)20-14-7-8-15(24-4)22-18(14)23(16)17/h5-9H,1-4H3
InChiKey: KKGNLHFXELBTHO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 10A	Starlite/ChEMBL	References
Homo sapiens	phosphodiesterase 2A, cGMP-stimulated	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	Get druggable targets OG5_135549	All targets in OG5_135549
Schistosoma japonicum	cGMP-dependent 3',5'-cyclic phosphodiesterase, putative	Get druggable targets OG5_135549	All targets in OG5_135549
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	Get druggable targets OG5_135363	All targets in OG5_135363
Schistosoma japonicum	cGMP-dependent 3',5'-cyclic phosphodiesterase, putative	Get druggable targets OG5_135549	All targets in OG5_135549
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135363	All targets in OG5_135363
Schistosoma japonicum	ko:K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC3.1.4.17], putative	Get druggable targets OG5_135549	All targets in OG5_135549
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	Get druggable targets OG5_135363	All targets in OG5_135363
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135549	All targets in OG5_135549
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	Get druggable targets OG5_135549	All targets in OG5_135549
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	Get druggable targets OG5_135363	All targets in OG5_135363
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135363	All targets in OG5_135363

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	cAMP-specific phosphodiesterase	phosphodiesterase 10A	789 aa	666 aa	30.2 %
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	phosphodiesterase 2A, cGMP-stimulated	934 aa	748 aa	27.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0057	0.0368	0.0342
Schistosoma mansoni	calpain C (C02 family)	0.0084	0.0696	0.067
Onchocerca volvulus		0.0047	0.0246	0.1636
Brugia malayi	Cathepsin L-like precursor	0.004	0.0157	0.013
Brugia malayi	TAR-binding protein	0.0066	0.0484	0.0458
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0484	0.0458
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.0368	0.1105
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0116	0.177
Trichomonas vaginalis	pyruvate kinase, putative	0.0034	0.0088	0.0197
Leishmania major	cathepsin L-like protease	0.0047	0.0246	0.0522
Onchocerca volvulus	Cathepsin L homolog	0.0047	0.0246	0.1636
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0122	0.1882
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0057	0.0368	0.1105
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0842	1	1
Brugia malayi	Animal haem peroxidase family protein	0.0105	0.0963	0.0938
Trypanosoma brucei	calpain-like protein, putative	0.0084	0.0696	0.2009
Onchocerca volvulus	Cathepsin F homolog	0.0047	0.0246	0.1636
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0246	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0963	0.0938
Echinococcus granulosus	tar DNA binding protein	0.0066	0.0484	0.0458
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0269	0.0242
Echinococcus granulosus	pyruvate kinase	0.0034	0.0088	0.0061
Onchocerca volvulus		0.0047	0.0246	0.1636
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0034	0.0088	0.0061
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0116	0.177
Toxoplasma gondii	hypothetical protein	0.0041	0.0174	0.0475
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0246	0.0709
Schistosoma mansoni	cathepsin F (C01 family)	0.0047	0.0246	0.0219
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0116	0.177
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0963	0.0938
Brugia malayi	hypothetical protein	0.0105	0.0963	0.0938
Leishmania major	kinesin, putative	0.0058	0.0387	0.0989
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0047	0.0246	0.0709
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0061	0.0416	0.0389
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0246	0.0709
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0057	0.0368	0.1105
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0313	0.3516	0.3498
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0116	0.0089
Trypanosoma brucei	calpain-like protein, putative	0.0084	0.0696	0.2009
Toxoplasma gondii	hypothetical protein	0.0041	0.0174	0.0475
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0246	0.0709
Echinococcus multilocularis	calpain 5	0.0084	0.0696	0.0696
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0484	0.0458
Trypanosoma brucei	antigen, putative	0.0084	0.0696	0.2009
Loa Loa (eye worm)	fibroinase	0.0047	0.0246	0.0219
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.0368	0.1105
Onchocerca volvulus	Pyruvate kinase homolog	0.0034	0.0088	0.0455
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.0368	0.1105
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0057	0.0368	0.1105
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0246	0.0709
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0047	0.0246	0.0219
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0238	0.2592	0.2592
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0057	0.0368	0.1105
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0157	0.0421
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0122	0.011
Toxoplasma gondii	GAF domain-containing protein	0.0041	0.0174	0.0475
Leishmania major	cathepsin L-like protease	0.0047	0.0246	0.0522
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0084	0.0696	0.067
Schistosoma mansoni	peptidylglycine monooxygenase	0.0123	0.1185	0.116
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.028	0.3112	0.3093
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0269	0.0269
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.028	0.3112	0.3093
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0246	0.0219
Schistosoma mansoni	pyruvate kinase	0.0034	0.0088	0.0061
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0116	0.177
Echinococcus multilocularis	cysteine protease	0.0047	0.0246	0.0246
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.028	0.3112	1
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0122	0.0122
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0269	0.0242
Onchocerca volvulus		0.0047	0.0246	0.1636
Onchocerca volvulus		0.0105	0.0963	0.7002
Schistosoma mansoni	cathepsin F (C01 family)	0.004	0.0157	0.013
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0238	0.2592	0.2571
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0963	0.0938
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0842	1	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0963	0.0938
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0246	0.0709
Echinococcus multilocularis	cathepsin L	0.0029	0.0027	0.0027
Trypanosoma brucei	GAF domain/TIP41-like family, putative	0.0046	0.0235	0.0486
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0222	0.239	0.2369
Trypanosoma cruzi	cruzipain precursor, putative	0.0047	0.0246	0.0219
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0266	0.024
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.0174	0.2194
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1647	0.1624
Echinococcus granulosus	microtubule associated protein 2	0.0706	0.8332	0.8327
Schistosoma mansoni	hypothetical protein	0.0173	0.1796	0.1774
Echinococcus granulosus	calpain A	0.0238	0.2597	0.2577
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0174	0.0475
Leishmania major	cathepsin L-like protease	0.0047	0.0246	0.0522
Trypanosoma cruzi	cysteine proteinase, putative	0.0036	0.0116	0.0089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0116	0.0287
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0246	0.0219
Leishmania major	cathepsin L-like protease	0.0047	0.0246	0.0522
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0246	0.0522
Echinococcus multilocularis	cathepsin L cysteine protease	0.0047	0.0246	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0163	0.1672	0.1649
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.007	0.0528	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.0368	0.1105
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0842	1	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0036	0.0116	0.0089
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0047	0.0246	0.4366
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0174	0.0475
Toxoplasma gondii	cathepsin CPL	0.0047	0.0246	0.0709
Brugia malayi	hypothetical protein	0.0238	0.2595	0.2575
Trypanosoma cruzi	GAF domain/TIP41-like family, putative	0.0046	0.0235	0.0208
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0047	0.0246	0.4366
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0246	0.0709
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.0368	0.1105
Toxoplasma gondii	hypothetical protein	0.0041	0.0174	0.0475
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0842	1	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0057	0.0368	0.1105
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0084	0.0696	0.067
Echinococcus multilocularis	cathepsin b	0.0842	1	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.0368	0.1105
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0313	0.3516	0.3498
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.0368	0.1105
Trypanosoma brucei	kinesin, putative	0.0058	0.0387	0.0989
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0123	0.1185	0.116
Echinococcus multilocularis	peroxidasin	0.0105	0.0963	0.0963
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0084	0.0696	0.2009
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.0368	0.1105
Echinococcus granulosus	peroxidasin	0.0105	0.0963	0.0938
Echinococcus multilocularis	calpain	0.0084	0.0696	0.0696
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0246	0.0709
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.007	0.0528	0.0502
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0963	0.0938
Toxoplasma gondii	cathepsin B	0.028	0.3112	1
Brugia malayi	Animal haem peroxidase family protein	0.0105	0.0963	0.0938
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0238	0.2592	0.2571
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0963	0.0938
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0246	0.4366
Plasmodium vivax	calpain, putative	0.0084	0.0696	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0057	0.0368	0.0342
Brugia malayi	calpain 7	0.0084	0.0696	0.067
Onchocerca volvulus		0.004	0.0157	0.0973
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0116	0.177
Loa Loa (eye worm)	hypothetical protein	0.004	0.0157	0.013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0246	0.0709
Onchocerca volvulus		0.0047	0.0246	0.1636
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1185	0.116
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0116	0.177
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0116	0.0287
Brugia malayi	Proteasome A-type and B-type family protein	0.007	0.0528	0.0502
Loa Loa (eye worm)	pyruvate kinase	0.0034	0.0088	0.0061
Brugia malayi	calpain family protein 1	0.0222	0.239	0.2369
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0269	0.0242
Loa Loa (eye worm)	calpain family protein 1	0.0163	0.1672	0.1649
Leishmania major	proteasome beta 5 subunit, putative	0.007	0.0528	0.1454
Loa Loa (eye worm)	ctsf protein	0.0047	0.0246	0.0219
Echinococcus multilocularis	survival motor neuron protein 1	0.0238	0.2595	0.2595
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0122	0.0094
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0084	0.0696	0.067
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0963	0.0938
Echinococcus multilocularis	peptidyl glycine alpha amidating monooxygenase	0.0232	0.2522	0.2522
Echinococcus multilocularis	microtubule associated protein 2	0.0706	0.8332	0.8332
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.0368	0.1105
Onchocerca volvulus	Cathepsin L homolog	0.0047	0.0246	0.1636
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0088	0.0088
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0047	0.0246	0.0219
Trypanosoma brucei	calpain-like protein, putative	0.0084	0.0696	0.2009
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.0368	0.1105
Echinococcus granulosus	cathepsin b	0.0842	1	1
Chlamydia trachomatis	pyruvate kinase	0.0034	0.0088	0.5
Loa Loa (eye worm)	animal heme peroxidase	0.0105	0.0963	0.0938
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0034	0.0088	0.0061
Plasmodium vivax	vivapain-2	0.0047	0.0246	0.3271
Trichomonas vaginalis	pyruvate kinase, putative	0.0034	0.0088	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0963	0.0938
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0122	0.0094
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0047	0.0246	0.0246
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.0122	0.0305
Echinococcus granulosus	calpain	0.0084	0.0696	0.067
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0116	0.177
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0484	0.0458
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0103	0.0934	0.2939
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0057	0.0368	0.1105
Brugia malayi	RNA binding protein	0.0066	0.0484	0.0458
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0084	0.0696	0.067
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0963	0.0938
Echinococcus granulosus	cysteine protease	0.0036	0.0116	0.0089
Entamoeba histolytica	cysteine proteinase 2	0.0036	0.0116	0.177
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0246	0.0709
Schistosoma mansoni	cathepsin F (C01 family)	0.0047	0.0246	0.0219
Schistosoma mansoni	calpain-7 (C02 family)	0.0084	0.0696	0.067
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0034	0.0088	0.0308
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0246	0.0522
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0084	0.0696	0.2009
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0036	0.0116	0.177
Plasmodium vivax	unspecified product	0.0036	0.0116	0.1326
Onchocerca volvulus		0.0047	0.0246	0.1636
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0246	0.0709
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0269	0.0242
Onchocerca volvulus	Chorion peroxidase homolog	0.0105	0.0963	0.7002
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.007	0.0528	0.0502
Trypanosoma brucei	calpain-like protein, putative	0.0084	0.0696	0.2009
Leishmania major	cathepsin L-like protease	0.0047	0.0246	0.0522
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0484	0.0458
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0116	0.177
Onchocerca volvulus		0.0105	0.0963	0.7002
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0246	0.0522
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0246	0.0219
Schistosoma mansoni	peroxidasin	0.0105	0.0963	0.0938
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0036	0.0116	0.0092
Giardia lamblia	Pyruvate kinase	0.0034	0.0088	0.0197
Trypanosoma cruzi	cysteine peptidase, putative	0.0036	0.0116	0.0089
Trypanosoma cruzi	cysteine proteinase, putative	0.0036	0.0116	0.0089
Plasmodium vivax	vivapain-2	0.0047	0.0246	0.3271
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0041	0.0174	0.1497
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0084	0.0696	0.2009
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0238	0.2592	0.2571
Plasmodium vivax	vivapain-3	0.0036	0.0116	0.1326
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0034	0.0088	0.021
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0057	0.0368	0.1105
Mycobacterium ulcerans	putative regulatory protein	0.0041	0.0174	0.1314
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.007	0.0528	0.6822
Schistosoma mansoni	calpain (C02 family)	0.0084	0.0696	0.067
Loa Loa (eye worm)	cysteine protease	0.0047	0.0246	0.0219
Echinococcus multilocularis	cathepsin b	0.0842	1	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0122	0.0094
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0122	0.0305
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0057	0.0368	0.0342
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0246	0.0522
Echinococcus granulosus	geminin	0.0173	0.1796	0.1774
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0088	0.0088
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.007	0.0528	0.1623
Echinococcus multilocularis	calpain family protein 1, d	0.0163	0.1672	0.1672
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0157	0.0421
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0246	0.0709
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0047	0.0246	0.0709
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0057	0.0368	0.1105
Loa Loa (eye worm)	hypothetical protein	0.0256	0.2817	0.2797
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0246	0.0709
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0036	0.0116	0.0092
Echinococcus granulosus	survival motor neuron protein 1	0.0238	0.2595	0.2575
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0963	0.0938
Echinococcus multilocularis	cathepsin L	0.0036	0.0116	0.0116
Echinococcus granulosus	calpain 7 C02 family	0.0084	0.0696	0.067
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0057	0.0368	0.1105
Brugia malayi	calpain family protein 1	0.0222	0.239	0.2369
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0246	0.0522
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.007	0.0528	0.1623
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0246	0.0709
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.1169	0.1145
Echinococcus multilocularis	calpain A	0.0238	0.2597	0.2597
Echinococcus granulosus	calpain A	0.0084	0.0696	0.067
Echinococcus granulosus	cathepsin L	0.0036	0.0116	0.0089
Loa Loa (eye worm)	hypothetical protein	0.004	0.0157	0.013
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0246	0.0709
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0246	0.0709
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0116	0.177
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0246	0.0522
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0046	0.0235	0.2418
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.007	0.0528	0.1454
Entamoeba histolytica	cysteine proteinase, putative	0.004	0.0157	0.2596
Echinococcus granulosus	cathepsin b	0.0842	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.028	0.3112	1
Trypanosoma cruzi	kinesin, putative	0.0058	0.0387	0.0361
Onchocerca volvulus	Pyruvate kinase homolog	0.0034	0.0088	0.0455
Onchocerca volvulus	Peroxidasin homolog	0.0105	0.0963	0.7002
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0057	0.0368	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0138	0.1364	0.134
Leishmania major	hypothetical protein, conserved	0.0046	0.0235	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0963	0.0938
Schistosoma mansoni	microtubule-associated protein tau	0.0706	0.8332	0.8327
Plasmodium vivax	vivapain-1	0.0036	0.0116	0.1326
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0232	0.2522	0.2502
Schistosoma mansoni	calpain-7 (C02 family)	0.0084	0.0696	0.067
Toxoplasma gondii	proteasome subunit beta type, putative	0.007	0.0528	0.1623
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0057	0.0368	0.1105
Brugia malayi	Inositol-1	0.0037	0.0122	0.0094
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0246	0.0219
Loa Loa (eye worm)	cathepsin B	0.028	0.3112	0.3093
Loa Loa (eye worm)	inositol-1	0.0037	0.0122	0.0094
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0313	0.3516	0.3516
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.0368	0.1105
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0084	0.0696	0.067
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0057	0.0368	0.1105
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0057	0.0368	0.0342
Brugia malayi	calpain 5	0.0058	0.0387	0.0361
Brugia malayi	Peroxidasin	0.0105	0.0963	0.0938
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0036	0.0116	0.0089
Brugia malayi	RNA recognition motif domain containing protein	0.0066	0.0484	0.0458
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0057	0.0368	0.0368
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0246	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0963	0.0938
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.0368	0.1105
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0484	0.0458
Trypanosoma brucei	cysteine peptidase C (CPC)	0.028	0.3112	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.0368	0.1105
Loa Loa (eye worm)	hypothetical protein	0.0297	0.3321	0.3303
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0084	0.0696	0.067
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0246	0.0219
Brugia malayi	Cathepsin L-like cysteine proteinase	0.004	0.0157	0.013
Brugia malayi	cathepsin L-like precursor	0.004	0.0157	0.013
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0122	0.0305
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0116	0.177
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0036	0.0116	0.0089
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0161	0.1647	0.1624
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0246	0.0219
Loa Loa (eye worm)	RNA binding protein	0.0066	0.0484	0.0458
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0122	0.0094
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0084	0.0696	0.067
Loa Loa (eye worm)	hypothetical protein	0.0232	0.2522	0.2502
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0034	0.0088	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0174	0.0475
Loa Loa (eye worm)	calpain	0.0084	0.0696	0.067
Echinococcus granulosus	cathepsin l1	0.004	0.0157	0.013
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0246	0.0522
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0058	0.0387	0.7186
Echinococcus granulosus	peptidyl glycine alpha amidating monooxygenase	0.0232	0.2522	0.2502
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0057	0.0368	0.1105
Schistosoma mansoni	hypothetical protein	0.0173	0.1796	0.1774
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0084	0.0696	0.067
Onchocerca volvulus		0.0105	0.0963	0.7002
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0161	0.1647	0.1624
Trypanosoma cruzi	kinesin, putative	0.0058	0.0387	0.0361
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.007	0.0528	1
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0116	0.177
Echinococcus granulosus	pyruvate kinase	0.0034	0.0088	0.0061
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0084	0.0696	0.2009
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0084	0.0696	0.067
Entamoeba histolytica	cysteine proteinase 1, putative	0.0036	0.0116	0.177
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0057	0.0368	0.1105
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0246	0.0219
Echinococcus multilocularis	proteasome (prosome, macropain)	0.007	0.0528	0.0528
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0246	0.4366
Plasmodium vivax	pyruvate kinase, putative	0.0034	0.0088	0.091
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0116	0.177
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0246	0.0219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0246	0.0709
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.007	0.0528	0.0502
Leishmania major	cysteine peptidase A (CPA)	0.0047	0.0246	0.0522
Brugia malayi	Animal haem peroxidase family protein	0.0105	0.0963	0.0938
Leishmania major	cathepsin L-like protease	0.0047	0.0246	0.0522
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0246	0.0709
Loa Loa (eye worm)	pyruvate kinase	0.0034	0.0088	0.0061
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0246	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0963	0.0938
Onchocerca volvulus		0.0047	0.0246	0.1636
Echinococcus multilocularis	geminin	0.0173	0.1796	0.1796
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0246	0.4366
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.004	0.0157	0.013
Leishmania major	cathepsin L-like protease	0.0047	0.0246	0.0522
Onchocerca volvulus		0.0049	0.0266	0.1788
Echinococcus multilocularis	hypothetical protein	0.0084	0.0696	0.0696
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0057	0.0368	0.1105
Echinococcus multilocularis	calpain 7 (C02 family)	0.0084	0.0696	0.0696
Mycobacterium ulcerans	putative regulatory protein	0.0041	0.0174	0.1314
Loa Loa (eye worm)	hypothetical protein	0.004	0.0157	0.013
Trypanosoma cruzi	cysteine protease, putative	0.0036	0.0116	0.0089
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0122	0.0094
Onchocerca volvulus	Peroxidasin homolog	0.0105	0.0963	0.7002
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.0484	0.0458
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0037	0.0122	0.0513
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0842	1	1
Schistosoma mansoni	hypothetical protein	0.0049	0.0266	0.024
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0.0122	0.5
Schistosoma mansoni	pyruvate kinase	0.0034	0.0088	0.0061
Onchocerca volvulus		0.0047	0.0246	0.1636
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0047	0.0246	0.0219
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0269	0.0242
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0116	0.177
Brugia malayi	Animal haem peroxidase family protein	0.0105	0.0963	0.0938
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0174	0.2191
Plasmodium falciparum	GAF domain-related protein, putative	0.0041	0.0174	0.2924
Mycobacterium ulcerans	proteasome PrcB	0.007	0.0528	0.6754
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0047	0.0246	0.0219
Leishmania major	cathepsin L-like protease	0.0047	0.0246	0.0522
Schistosoma mansoni	peroxidasin	0.0105	0.0963	0.0938
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0246	0.0219
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0047	0.0246	0.0246
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0246	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0963	0.0938
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0266	0.024
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0116	0.177
Onchocerca volvulus	Peroxidase homolog	0.0105	0.0963	0.7002
Giardia lamblia	Cathepsin B precursor	0.028	0.3112	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0062	0.043	0.1304
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0034	0.0088	0.0061
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0116	0.177
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0036	0.0116	0.0089
Schistosoma mansoni	peptidyl-glycine monooxygenase	0.0232	0.2522	0.2502
Giardia lamblia	Cathepsin B precursor	0.028	0.3112	1
Trypanosoma cruzi	GAF domain/TIP41-like family, putative	0.0046	0.0235	0.0208
Loa Loa (eye worm)	calpain family protein 1	0.0222	0.239	0.2369
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.007	0.0528	0.0502
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0057	0.0368	0.0927
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0246	0.0709
Loa Loa (eye worm)	calpain 5	0.0058	0.0387	0.0361
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.0246	0.0709
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein	0.0063	0.0438	0.0412
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0057	0.0368	0.0927
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0269	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0842	1	1
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0116	0.177
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0246	0.0709
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0246	0.0522
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0116	0.0089
Brugia malayi	MH2 domain containing protein	0.0122	0.1169	0.1145
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0269	0.0242
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0246	0.0709
Onchocerca volvulus		0.0138	0.1364	1
Loa Loa (eye worm)	pyruvate kinase	0.0034	0.0088	0.0061
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0047	0.0246	0.4366
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0087	0.0739	1
Loa Loa (eye worm)	animal heme peroxidase	0.0105	0.0963	0.0938
Loa Loa (eye worm)	hypothetical protein	0.0196	0.2081	0.2059
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0084	0.0696	0.2009
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0062	0.043	0.1304
Echinococcus multilocularis	cathepsin L cysteine protease	0.0047	0.0246	0.0246
Brugia malayi	Blistered cuticle protein 3	0.0105	0.0963	0.0938
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.0934	0.2939
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.0484	0.0458
Entamoeba histolytica	protein kinase, putative	0.0058	0.0387	0.7186
Giardia lamblia	Cathepsin B precursor	0.028	0.3112	1
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0174	0.0475
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0084	0.0696	0.067
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0057	0.0368	0.1105
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0122	0.0305
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0246	0.0709
Onchocerca volvulus	Pyruvate kinase homolog	0.0034	0.0088	0.0455
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0116	0.177
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0269	0.0269
Plasmodium vivax	proteasome subunit beta type-5, putative	0.007	0.0528	0.7491
Brugia malayi	Animal haem peroxidase family protein	0.0105	0.0963	0.0938
Loa Loa (eye worm)	animal heme peroxidase	0.0105	0.0963	0.0938
Echinococcus granulosus	cathepsin l1	0.0047	0.0246	0.0219
Echinococcus granulosus	calpain 5	0.0084	0.0696	0.067
Echinococcus multilocularis	tar DNA binding protein	0.0066	0.0484	0.0484
Loa Loa (eye worm)	animal heme peroxidase	0.0105	0.0963	0.0938
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0103	0.0934	0.2939
Brugia malayi	Cathepsin L-like precursor	0.004	0.0157	0.013
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0087	0.0739	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0084	0.0696	0.067
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0246	0.0522
Echinococcus multilocularis	cysteine protease	0.0047	0.0246	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0222	0.239	0.2369
Plasmodium falciparum	pyruvate kinase	0.0034	0.0088	0.1215
Onchocerca volvulus	Dual oxidase homolog	0.0105	0.0963	0.7002
Toxoplasma gondii	pyruvate kinase PyK1	0.0034	0.0088	0.0197
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.1169	0.1145
Loa Loa (eye worm)	blistered cuticle protein 3	0.0105	0.0963	0.0938
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0246	0.0219
Schistosoma mansoni	dopamine-beta-monooxygenase	0.0123	0.1185	0.116
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0088	0.0061
Echinococcus granulosus	cathepsin L cysteine protease	0.0036	0.0116	0.0089
Echinococcus granulosus	proteasome prosome macropain	0.007	0.0528	0.0502
Loa Loa (eye worm)	hypothetical protein	0.0238	0.2595	0.2575
Onchocerca volvulus	Peroxidase homolog	0.0105	0.0963	0.7002
Plasmodium falciparum	proteasome subunit beta type-5	0.007	0.0528	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0246	0.0219
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0103	0.0934	0.2939
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0122	0.011

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.2 nM	Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay	ChEMBL.	21988093
IC50 (binding)	= 17 nM	Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assay	ChEMBL.	21988093

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1916090

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1576028