TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 305.326 | Formula: C16H19NO5
H donors: 1 H acceptors: 2 LogP: 0.85 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C1OCC(=C1c1ccc(cc1)O)OCCN1CCOCC1
InChi: 1S/C16H19NO5/c18-13-3-1-12(2-4-13)15-14(11-22-16(15)19)21-10-7-17-5-8-20-9-6-17/h1-4,18H,5-11H2
InChiKey: FSXNDMGGSRHELP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase, putative	0.0331	0.4182	0.4168
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0803	0.0803
Echinococcus granulosus	cathepsin b	0.0766	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0181	0.2173	0.5169
Entamoeba histolytica	cysteine proteinase, putative	0.0331	0.4182	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0078	0.0803	0.1875
Plasmodium vivax	unspecified product	0.0181	0.2173	0.4921
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0803	0.1875
Echinococcus granulosus	cysteine protease	0.0181	0.2173	0.1991
Echinococcus multilocularis	cathepsin L cysteine protease	0.0331	0.4182	0.4047
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1124	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1504	0.1504
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.4182	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.4182	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.4182	1
Leishmania major	cathepsin L-like protease	0.0331	0.4182	1
Entamoeba histolytica	cysteine protease, putative	0.0181	0.2173	0.5169
Plasmodium vivax	serine-repeat antigen (SERA)	0.0078	0.0803	0.1458
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0078	0.0803	0.0781
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0227	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0227	0.0488
Trypanosoma cruzi	cysteine peptidase, putative	0.0181	0.2173	0.2154
Schistosoma mansoni	calpain C (C02 family)	0.0067	0.0651	0.0628
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0229	0.2812	0.6706
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0803	0.0803
Giardia lamblia	Cathepsin B precursor	0.0291	0.3648	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.4182	1
Entamoeba histolytica	cysteine protease, putative	0.0181	0.2173	0.5169
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.4182	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0193	0.2334	0.2316
Brugia malayi	Cathepsin L-like precursor	0.0331	0.4182	0.4168
Brugia malayi	beta-lactamase family protein	0.0035	0.0227	0.0203
Echinococcus granulosus	cathepsin L cysteine protease	0.0181	0.2173	0.1991
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0331	0.4182	1
Schistosoma mansoni	cathepsin C	0.0078	0.0803	0.0781
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0331	0.4182	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0803	0.1875
Loa Loa (eye worm)	hypothetical protein	0.0229	0.2812	0.2812
Brugia malayi	Papain family cysteine protease containing protein	0.0078	0.0803	0.0781
Plasmodium falciparum	serine repeat antigen 9	0.0078	0.0803	0.1875
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0078	0.0803	0.0803
Schistosoma mansoni	cathepsin F (C01 family)	0.0331	0.4182	0.4168
Loa Loa (eye worm)	hypothetical protein	0.0331	0.4182	0.4182
Giardia lamblia	Cathepsin B precursor	0.0291	0.3648	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0067	0.0651	0.0628
Leishmania major	cathepsin L-like protease	0.0331	0.4182	1
Echinococcus multilocularis	cathepsin b	0.0766	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0078	0.0803	0.0803
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0245	0.3027	0.3027
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0227	0.0203
Entamoeba histolytica	cysteine protease, putative	0.0078	0.0803	0.1875
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0227	0.0203
Entamoeba histolytica	cysteine proteinase, putative	0.0331	0.4182	1
Trypanosoma cruzi	cysteine protease, putative	0.0181	0.2173	0.2154
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0078	0.0803	0.1875
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0291	0.3648	0.8715
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0181	0.2173	0.2154
Brugia malayi	calpain family protein 1	0.0178	0.2131	0.2112
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0227	0.5
Trypanosoma cruzi	major cysteine proteinase, putative	0.0078	0.0803	0.0781
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0245	0.3027	0.2865
Brugia malayi	Cathepsin L-like precursor	0.0229	0.2812	0.2795
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0067	0.0651	0.1508
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0067	0.0651	0.0628
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0331	0.4182	1
Echinococcus granulosus	cathepsin L	0.0078	0.0803	0.059
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0193	0.2334	0.2316
Entamoeba histolytica	cysteine protease, putative	0.0181	0.2173	0.5169
Giardia lamblia	Cathepsin B precursor	0.0291	0.3648	1
Toxoplasma gondii	cathepsin CPC2	0.0078	0.0803	0.1875
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0067	0.0651	0.0628
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0078	0.0803	0.0781
Onchocerca volvulus	Cathepsin F homolog	0.0331	0.4182	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0078	0.0803	0.1458
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0078	0.0803	0.1458
Leishmania major	cathepsin L-like protease	0.0331	0.4182	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0181	0.2173	0.5169
Loa Loa (eye worm)	AStacin protease	0.0028	0.0132	0.0132
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0354	0.0332
Trypanosoma cruzi	cysteine proteinase, putative	0.0181	0.2173	0.2154
Plasmodium vivax	vivapain-2	0.0331	0.4182	1
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0067	0.0651	0.1508
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0227	0.5
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0227	0.5
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0078	0.0803	0.0781
Loa Loa (eye worm)	hypothetical protein	0.0766	1	1
Brugia malayi	Cathepsin L-like precursor	0.0229	0.2812	0.2795
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0181	0.2173	0.5169
Plasmodium falciparum	serine repeat antigen 8	0.0078	0.0803	0.1875
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0354	0.0131
Plasmodium vivax	unspecified product	0.0102	0.1124	0.2268
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0331	0.4182	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0067	0.0651	0.0628
Plasmodium vivax	calpain, putative	0.0067	0.0651	0.1072
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0227	0.0227
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0331	0.4182	0.4182
Entamoeba histolytica	cysteine proteinase 2	0.0181	0.2173	0.5169
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0331	0.4182	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0078	0.0803	0.1458
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0078	0.0803	0.1875
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0181	0.2173	0.5169
Brugia malayi	beta-lactamase	0.0035	0.0227	0.0203
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0078	0.0803	0.1458
Entamoeba histolytica	cysteine proteinase, putative	0.0229	0.2812	0.6706
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0803	0.1875
Plasmodium falciparum	serine repeat antigen 3	0.0078	0.0803	0.1875
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0227	0.5
Brugia malayi	cathepsin L-like cysteine proteinase	0.0078	0.0803	0.0781
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0181	0.2173	0.5169
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0078	0.0803	0.0803
Plasmodium falciparum	serine repeat antigen 4	0.0078	0.0803	0.1875
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0078	0.0803	0.0781
Plasmodium vivax	vivapain-1	0.0181	0.2173	0.4921
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0803	0.1875
Leishmania major	cathepsin L-like protease	0.0331	0.4182	1
Plasmodium falciparum	serine repeat antigen 6	0.0078	0.0803	0.1875
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0229	0.2812	0.6706
Onchocerca volvulus		0.0331	0.4182	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0766	1	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0078	0.0803	0.1875
Loa Loa (eye worm)	calpain	0.0067	0.0651	0.0651
Brugia malayi	calpain 7	0.0067	0.0651	0.0628
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0354	0.0332
Plasmodium falciparum	serine repeat antigen 5	0.0078	0.0803	0.1875
Loa Loa (eye worm)	calpain family protein 1	0.0178	0.2131	0.2131
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0078	0.0803	0.0781
Trypanosoma brucei	calpain-like protein, putative	0.0067	0.0651	0.1508
Onchocerca volvulus		0.0111	0.1234	0.2548
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.4182	1
Onchocerca volvulus		0.0331	0.4182	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0078	0.0803	0.0781
Echinococcus multilocularis	calpain 7 (C02 family)	0.0067	0.0651	0.0434
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0181	0.2173	0.2154
Echinococcus granulosus	calpain A	0.0193	0.2341	0.2163
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0181	0.2173	0.2154
Echinococcus granulosus	gamma secretase subunit aph 1	0.0245	0.3027	0.2865
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0354	0.0131
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.4182	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.4182	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0067	0.0651	0.0628
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0078	0.0803	0.1458
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0803	0.1875
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0803	0.0803
Trypanosoma cruzi	Aph-1 protein, putative	0.0095	0.1029	0.1008
Echinococcus granulosus	Tolloid protein 1	0.0045	0.0358	0.0134
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0227	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0227	0.0227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0803	0.1875
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0331	0.4182	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.4182	1
Entamoeba histolytica	cysteine protease, putative	0.0078	0.0803	0.1875
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0181	0.2173	0.2154
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0067	0.0651	0.0628
Echinococcus multilocularis	cysteine protease	0.0331	0.4182	0.4047
Onchocerca volvulus		0.0078	0.0803	0.1458
Brugia malayi	Cathepsin L-like precursor	0.0331	0.4182	0.4168
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0078	0.0803	0.1875
Plasmodium falciparum	serine repeat antigen 2	0.0078	0.0803	0.1875
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0331	0.4182	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0227	0.0203
Trichomonas vaginalis	esterase, putative	0.0035	0.0227	0.0488
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.4182	1
Entamoeba histolytica	cysteine protease, putative	0.0078	0.0803	0.1875
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0078	0.0803	0.1875
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0047	0.0381	0.086
Trypanosoma cruzi	cysteine peptidase, putative	0.0331	0.4182	0.4168
Echinococcus multilocularis	calpain	0.0067	0.0651	0.0434
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.4182	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0766	1	1
Loa Loa (eye worm)	cathepsin B	0.0291	0.3648	0.3648
Trypanosoma cruzi	kinesin, putative	0.0047	0.0381	0.0358
Plasmodium vivax	unspecified product	0.0078	0.0803	0.1458
Toxoplasma gondii	cathepsin CPL	0.0331	0.4182	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.4182	1
Onchocerca volvulus		0.0331	0.4182	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0354	0.0332
Brugia malayi	Cathepsin L-like precursor	0.0331	0.4182	0.4168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0078	0.0803	0.1875
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0331	0.4182	1
Entamoeba histolytica	cysteine protease, putative	0.0181	0.2173	0.5169
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0078	0.0803	0.1875
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0078	0.0803	0.0781
Brugia malayi	cathepsin F-like cysteine proteinase	0.0078	0.0803	0.0781
Entamoeba histolytica	cysteine protease, putative	0.0078	0.0803	0.1875
Brugia malayi	fibroinase precursor	0.0078	0.0803	0.0781
Brugia malayi	calpain 5	0.0047	0.0381	0.0358
Trypanosoma cruzi	cysteine peptidase, putative	0.0331	0.4182	0.4168
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0067	0.0651	0.0628
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0354	0.0131
Brugia malayi	Papain family cysteine protease containing protein	0.0078	0.0803	0.0781
Trypanosoma cruzi	Aph-1 protein, putative	0.0095	0.1029	0.1008
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0766	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0078	0.0803	0.1458
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0766	1	1
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0045	0.0358	0.0358
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0102	0.1124	0.1103
Brugia malayi	Papain family cysteine protease containing protein	0.0078	0.0803	0.0781
Leishmania major	cathepsin L-like protease	0.0331	0.4182	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0227	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0333	0.0333
Entamoeba histolytica	protein kinase, putative	0.0047	0.0381	0.086
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0078	0.0803	0.1875
Echinococcus granulosus	cathepsin l1	0.0229	0.2812	0.2645
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0078	0.0803	0.1875
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0229	0.2812	0.2795
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0067	0.0651	0.0628
Echinococcus granulosus	calpain 5	0.0067	0.0651	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0227	0.0227
Plasmodium falciparum	serine repeat antigen 7	0.0078	0.0803	0.1875
Schistosoma mansoni	calpain-7 (C02 family)	0.0067	0.0651	0.0628
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0078	0.0803	0.1458
Leishmania major	hypothetical protein, conserved	0.0035	0.0227	0.0488
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0078	0.0803	0.1875
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0766	1	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0227	0.0488
Entamoeba histolytica	cysteine proteinase, putative	0.0181	0.2173	0.5169
Entamoeba histolytica	cysteine protease, putative	0.0181	0.2173	0.5169
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0354	0.0354
Echinococcus multilocularis	Tolloid protein 1	0.0045	0.0358	0.0134
Leishmania major	cathepsin L-like protease	0.0331	0.4182	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.4182	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0078	0.0803	0.1875
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0078	0.0803	0.1458
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0067	0.0651	0.0628
Entamoeba histolytica	cysteine protease, putative	0.0078	0.0803	0.1875
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0078	0.0803	0.0781
Onchocerca volvulus		0.0331	0.4182	1
Brugia malayi	cathepsin L precursor	0.0078	0.0803	0.0781
Echinococcus multilocularis	cathepsin L cysteine protease	0.0331	0.4182	0.4047
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0178	0.2131	0.2112
Toxoplasma gondii	cathepsin B	0.0291	0.3648	0.8715
Trypanosoma brucei	kinesin, putative	0.0047	0.0381	0.086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.4182	1
Plasmodium vivax	vivapain-2	0.0331	0.4182	1
Echinococcus multilocularis	calpain 5	0.0067	0.0651	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1234	0.1234
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0067	0.0651	0.0628
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0803	0.1875
Entamoeba histolytica	cysteine proteinase, putative	0.0181	0.2173	0.5169
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0331	0.4182	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.4182	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0078	0.0803	0.1458
Trypanosoma cruzi	major cysteine proteinase, putative	0.0078	0.0803	0.0781
Echinococcus granulosus	cathepsin b	0.0766	1	1
Echinococcus multilocularis	cathepsin L	0.0078	0.0803	0.059
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0803	0.0803
Loa Loa (eye worm)	hypothetical protein	0.0178	0.2131	0.2131
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0291	0.3648	0.3632
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0078	0.0803	0.0781
Toxoplasma gondii	cathepsin CPC1	0.0078	0.0803	0.1875
Leishmania major	kinesin, putative	0.0047	0.0381	0.086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.4182	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0078	0.0803	0.1875
Brugia malayi	calpain family protein 1	0.0178	0.2131	0.2112
Onchocerca volvulus		0.0229	0.2812	0.6537
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0331	0.4182	1
Echinococcus granulosus	cathepsin l1	0.0331	0.4182	0.4047
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0803	0.0803
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0227	0.0227
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0193	0.2334	0.2156
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0354	0.0131
Loa Loa (eye worm)	fibroinase	0.0331	0.4182	0.4182
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0291	0.3648	0.8715
Brugia malayi	Cathepsin L-like precursor	0.0102	0.1124	0.1103
Entamoeba histolytica	cysteine protease, putative	0.0181	0.2173	0.5169
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0331	0.4182	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0067	0.0651	0.1508
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0229	0.2812	0.2795
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0331	0.4182	1
Onchocerca volvulus	Cathepsin L homolog	0.0331	0.4182	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0181	0.2173	0.5169
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.0803	0.1875
Echinococcus multilocularis	hypothetical protein	0.0067	0.0651	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0227	0.0227
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0291	0.3648	0.3632
Plasmodium vivax	vivapain-3	0.0181	0.2173	0.4921
Leishmania major	cysteine peptidase A (CPA)	0.0331	0.4182	1
Echinococcus granulosus	calpain 7 C02 family	0.0067	0.0651	0.0434
Onchocerca volvulus		0.0331	0.4182	1
Onchocerca volvulus		0.0331	0.4182	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.4182	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.4182	1
Entamoeba histolytica	cysteine protease, putative	0.0078	0.0803	0.1875
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0078	0.0803	0.1458
Echinococcus multilocularis	cathepsin L	0.0181	0.2173	0.1991
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0245	0.3027	0.3011
Entamoeba histolytica	cysteine protease, putative	0.0331	0.4182	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0331	0.4182	0.4168
Entamoeba histolytica	cysteine protease, putative	0.0181	0.2173	0.5169
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0227	0.0227
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.4182	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0227	0.0203
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0291	0.3648	0.8715
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0078	0.0803	0.0781
Entamoeba histolytica	cysteine protease, putative	0.0181	0.2173	0.5169
Brugia malayi	Cathepsin L-like precursor	0.0331	0.4182	0.4168
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0078	0.0803	0.1875
Loa Loa (eye worm)	hypothetical protein	0.0229	0.2812	0.2812
Echinococcus multilocularis	cysteine protease	0.0331	0.4182	0.4047
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0331	0.4182	0.4182
Schistosoma mansoni	calpain (C02 family)	0.0067	0.0651	0.0628
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0227	0.0488
Brugia malayi	gamma-secretase subunit aph-1	0.0245	0.3027	0.3011
Echinococcus granulosus	calpain	0.0067	0.0651	0.0434
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0067	0.0651	0.1508
Loa Loa (eye worm)	cysteine protease	0.0331	0.4182	0.4182
Onchocerca volvulus		0.0331	0.4182	1
Trypanosoma brucei	calpain-like protein, putative	0.0067	0.0651	0.1508
Entamoeba histolytica	cysteine proteinase, putative	0.0181	0.2173	0.5169
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0078	0.0803	0.1875
Loa Loa (eye worm)	ctsf protein	0.0331	0.4182	0.4182
Echinococcus multilocularis	cathepsin b	0.0766	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0227	0.0227
Entamoeba histolytica	cysteine protease, putative	0.0181	0.2173	0.5169
Trypanosoma cruzi	kinesin, putative	0.0047	0.0381	0.0358
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0078	0.0803	0.1458
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1124	0.1124
Loa Loa (eye worm)	calpain 5	0.0047	0.0381	0.0381
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.4182	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0102	0.1124	0.1103
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0331	0.4182	0.4047
Trypanosoma brucei	calpain-like protein, putative	0.0067	0.0651	0.1508
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0331	0.4182	0.4047
Toxoplasma gondii	ABC1 family protein	0.0035	0.0227	0.0488
Trypanosoma brucei	Aph-1 protein, putative	0.0095	0.1029	0.2419
Entamoeba histolytica	cysteine protease, putative	0.0181	0.2173	0.5169
Schistosoma mansoni	cathepsin F (C01 family)	0.0229	0.2812	0.2795
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0331	0.4182	1
Brugia malayi	Cathepsin L-like precursor	0.0331	0.4182	0.4168
Leishmania major	cathepsin L-like protease	0.0331	0.4182	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.4182	1
Loa Loa (eye worm)	calpain family protein 1	0.0131	0.1504	0.1504
Trypanosoma cruzi	cysteine peptidase, putative	0.0102	0.1124	0.1103
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0102	0.1124	0.1124
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0078	0.0803	0.1875
Trypanosoma cruzi	cysteine peptidase, putative	0.0331	0.4182	0.4168
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0193	0.2334	0.2156
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0227	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1124	0.1124
Trypanosoma brucei	calpain-like protein, putative	0.0067	0.0651	0.1508
Brugia malayi	Papain family cysteine protease containing protein	0.0181	0.2173	0.2154
Loa Loa (eye worm)	hypothetical protein	0.002	0.0024	0.0024
Entamoeba histolytica	hypothetical protein	0.0078	0.0803	0.1875
Echinococcus multilocularis	calpain A	0.0193	0.2341	0.2163
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.4182	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0078	0.0803	0.1875
Schistosoma mansoni	cathepsin F (C01 family)	0.0331	0.4182	0.4168
Brugia malayi	Papain family cysteine protease containing protein	0.0181	0.2173	0.2154
Schistosoma mansoni	cathepsin s	0.0102	0.1124	0.1103
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0331	0.4182	0.4047
Loa Loa (eye worm)	calpain D	0.002	0.0024	0.0024
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0227	0.0488
Brugia malayi	beta-lactamase family protein	0.0035	0.0227	0.0203
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0227	0.0488
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0045	0.0358	0.0335
Brugia malayi	Papain family cysteine protease containing protein	0.0331	0.4182	0.4168
Echinococcus granulosus	cathepsin L	0.0181	0.2173	0.1991
Mycobacterium ulcerans	lipase LipD	0.0035	0.0227	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0181	0.2173	0.5169
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.4182	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0078	0.0803	0.0781
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.4182	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0078	0.0803	0.1458
Loa Loa (eye worm)	hypothetical protein	0.0158	0.1861	0.1861
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0354	0.0332
Trypanosoma cruzi	cysteine proteinase, putative	0.0181	0.2173	0.2154
Leishmania major	cathepsin L-like protease	0.0331	0.4182	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0331	0.4182	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0803	0.0803
Brugia malayi	cathepsin L-like precursor	0.0229	0.2812	0.2795
Schistosoma mansoni	calpain-7 (C02 family)	0.0067	0.0651	0.0628
Entamoeba histolytica	cysteine protease, putative	0.0181	0.2173	0.5169
Brugia malayi	cathepsin F-like cysteine proteinase	0.0102	0.1124	0.1103
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0226	0.2773	1
Loa Loa (eye worm)	hypothetical protein	0.0229	0.2812	0.2812
Echinococcus multilocularis	calpain family protein 1, d	0.0131	0.1504	0.1307
Entamoeba histolytica	cysteine protease, putative	0.0181	0.2173	0.5169
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.4182	1
Onchocerca volvulus	Cathepsin L homolog	0.0331	0.4182	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0078	0.0803	0.0781
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0078	0.0803	0.0781
Entamoeba histolytica	cysteine protease, putative	0.0181	0.2173	0.5169
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0067	0.0651	0.0628
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0078	0.0803	0.0781
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0227	0.5
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0067	0.0651	0.1508
Plasmodium falciparum	serine repeat antigen 1	0.0078	0.0803	0.1875
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0331	0.4182	0.4047
Brugia malayi	Cathepsin L-like precursor	0.0331	0.4182	0.4168
Trypanosoma brucei	antigen, putative	0.0067	0.0651	0.1508
Echinococcus granulosus	calpain A	0.0067	0.0651	0.0434

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC50 (functional)	= 1.1 ug ml-1	Antibacterial activity against Candida albicans ATCC 10231 after 48 hrs by MTT colorimetric method	ChEMBL.	21669535
MIC50 (functional)	> 50 ug ml-1	Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT colorimetric method	ChEMBL.	21669535

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1796325

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1576602