TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 389.833 | Formula: C19H20ClN3O4
H donors: 1 H acceptors: 3 LogP: 3.41 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)C1CCN(CC1)/C(=N\O)/c1cccnc1Oc1ccc(cc1)Cl
InChi: 1S/C19H20ClN3O4/c1-26-19(24)13-8-11-23(12-9-13)17(22-25)16-3-2-10-21-18(16)27-15-6-4-14(20)5-7-15/h2-7,10,13,25H,8-9,11-12H2,1H3/b22-17-
InChiKey: JLEFODNTZSBPAB-XLNRJJMWSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0084	0.0533	0.0562
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.01	0.0755	0.0856
Echinococcus granulosus	calpain 7 C02 family	0.01	0.0755	0.0795
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.01	0.0755	0.0477
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0068	0.0317	0.0334
Giardia lamblia	Cathepsin B precursor	0.0278	0.3154	1
Leishmania major	cathepsin L-like protease	0.0422	0.5097	1
Brugia malayi	Cathepsin L-like precursor	0.0274	0.3108	0.3275
Brugia malayi	Papain family cysteine protease containing protein	0.0152	0.1448	0.1526
Plasmodium vivax	vivapain-1	0.0152	0.1448	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0191	0.1976	0.2083
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0274	0.3108	0.3108
Onchocerca volvulus		0.0274	0.3108	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.0962	0.1014
Brugia malayi	cathepsin L precursor	0.0068	0.0317	0.0334
Entamoeba histolytica	cysteine protease, putative	0.0152	0.1448	0.4054
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.01	0.0755	0.0856
Schistosoma mansoni	calpain-7 (C02 family)	0.01	0.0755	0.0795
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0747	0.949	1
Onchocerca volvulus		0.0274	0.3108	1
Brugia malayi	Cathepsin L-like precursor	0.0274	0.3108	0.3275
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0317	0.0334
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0274	0.3108	0.9835
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0068	0.0317	0.0334
Entamoeba histolytica	cysteine proteinase 2	0.0152	0.1448	0.4054
Trypanosoma cruzi	cruzipain precursor, putative	0.0084	0.0533	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0317	0.0334
Entamoeba histolytica	cysteine protease, putative	0.0152	0.1448	0.4054
Schistosoma mansoni	Mername-AA248 (C02 family)	0.01	0.0755	0.0795
Schistosoma mansoni	cathepsin C	0.0068	0.0317	0.0334
Brugia malayi	Papain family cysteine protease containing protein	0.0068	0.0317	0.0334
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.01	0.0755	0.0477
Trypanosoma cruzi	major cysteine proteinase, putative	0.0215	0.2307	0.2169
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0317	0.0334
Entamoeba histolytica	cysteine protease, putative	0.0152	0.1448	0.4054
Schistosoma mansoni	cathepsin B (C01 family)	0.0068	0.0317	0.0334
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.01	0.0755	0.0477
Echinococcus multilocularis	cathepsin b	0.0747	0.949	0.949
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.01	0.0755	0.0477
Trypanosoma brucei	calpain-like protein, putative	0.01	0.0755	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0747	0.949	1
Brugia malayi	Papain family cysteine protease containing protein	0.0068	0.0317	0.0334
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0338	0.3966	0.3978
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0068	0.0317	0.0334
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0068	0.0317	0.0334
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0274	0.3108	0.9835
Trypanosoma cruzi	cysteine peptidase, putative	0.0152	0.1448	0.1233
Trypanosoma cruzi	cysteine peptidase, putative	0.0084	0.0533	0.0236
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0747	0.949	1
Onchocerca volvulus		0.0274	0.3108	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	0.3108	0.9835
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0278	0.315	0.3319
Leishmania major	cathepsin L-like protease	0.0274	0.3108	0.581
Echinococcus granulosus	cathepsin b	0.0747	0.949	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0274	0.3108	0.3275
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0278	0.3154	0.5908
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.5097	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	0.3108	0.9835
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0068	0.0317	0.0334
Entamoeba histolytica	calpain large subunit domain III containing protein	0.007	0.0348	0.011
Echinococcus multilocularis	calpain A	0.0278	0.315	0.315
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0084	0.0533	0.0562
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.5097	1
Brugia malayi	Cathepsin L-like precursor	0.0191	0.1976	0.2083
Schistosoma mansoni	cathepsin F (C01 family)	0.0274	0.3108	0.3275
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.5097	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.01	0.0755	0.0477
Echinococcus multilocularis	cathepsin b	0.0747	0.949	0.949
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	0.3108	0.9835
Leishmania major	cathepsin L-like protease	0.0274	0.3108	0.581
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0278	0.315	0.3319
Trypanosoma cruzi	cruzipain precursor, putative	0.0422	0.5097	0.5211
Trypanosoma brucei	calpain-like protein, putative	0.01	0.0755	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0317	0.0334
Brugia malayi	Papain family cysteine protease containing protein	0.0068	0.0317	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0266	0.2988	0.3148
Echinococcus granulosus	calpain A	0.0278	0.315	0.3319
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0533	0.0562
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0152	0.1448	0.2317
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	0.3108	0.9835
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0278	0.3154	1
Echinococcus granulosus	cathepsin l1	0.0191	0.1976	0.2083
Entamoeba histolytica	cysteine proteinase, putative	0.0274	0.3108	1
Entamoeba histolytica	cysteine protease, putative	0.0152	0.1448	0.4054
Loa Loa (eye worm)	cathepsin B	0.0278	0.3154	0.3324
Brugia malayi	Cathepsin L-like precursor	0.0274	0.3108	0.3275
Brugia malayi	Cathepsin L-like precursor	0.0274	0.3108	0.3275
Trypanosoma brucei	antigen, putative	0.01	0.0755	0.0856
Brugia malayi	Cathepsin L-like precursor	0.0191	0.1976	0.2083
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0068	0.0317	0.0334
Brugia malayi	cathepsin F-like cysteine proteinase	0.0068	0.0317	0.0334
Trypanosoma cruzi	cysteine protease, putative	0.0152	0.1448	0.1233
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.5097	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	0.3108	0.9835
Onchocerca volvulus	Cathepsin L homolog	0.0274	0.3108	1
Brugia malayi	MH2 domain containing protein	0.0116	0.0962	0.1014
Plasmodium vivax	calpain, putative	0.01	0.0755	0.1568
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	0.3108	0.9835
Toxoplasma gondii	cathepsin CPL	0.0274	0.3108	0.9835
Loa Loa (eye worm)	calpain	0.01	0.0755	0.0795
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0152	0.1448	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0152	0.1448	0.4054
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0274	0.3108	0.3108
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0317	0.0334
Brugia malayi	cathepsin L-like precursor	0.0191	0.1976	0.2083
Brugia malayi	cathepsin B-like cysteine proteinase	0.0747	0.949	1
Echinococcus multilocularis	calpain	0.01	0.0755	0.0755
Leishmania major	cathepsin L-like protease	0.0422	0.5097	1
Schistosoma mansoni	calpain C (C02 family)	0.01	0.0755	0.0795
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0068	0.0317	0.0334
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0274	0.3108	0.9835
Entamoeba histolytica	cysteine protease, putative	0.0152	0.1448	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0274	0.3108	0.9835
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.01	0.0755	0.0477
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.5097	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.01	0.0755	0.0856
Trypanosoma cruzi	cysteine proteinase, putative	0.0152	0.1448	0.1233
Loa Loa (eye worm)	calpain family protein 1	0.0266	0.2988	0.3148
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0747	0.949	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0317	0.0334
Entamoeba histolytica	cysteine proteinase, putative	0.0152	0.1448	0.4054
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0278	0.315	0.3319
Echinococcus granulosus	cysteine protease	0.0152	0.1448	0.1526
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0274	0.3108	0.3275
Trypanosoma cruzi	kinesin, putative	0.007	0.0348	0.0034
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0068	0.0317	0.0334
Echinococcus multilocularis	cysteine protease	0.0274	0.3108	0.3108
Brugia malayi	cathepsin L-like cysteine proteinase	0.0068	0.0317	0.0334
Trypanosoma cruzi	kinesin, putative	0.007	0.0348	0.0034
Plasmodium vivax	vivapain-2	0.0274	0.3108	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0152	0.1448	0.2317
Onchocerca volvulus		0.0191	0.1976	0.5946
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0274	0.3108	0.9835
Loa Loa (eye worm)	hypothetical protein	0.0235	0.2581	0.272
Schistosoma mansoni	cathepsin S (C01 family)	0.0068	0.0317	0.0334
Plasmodium vivax	vivapain-2	0.0274	0.3108	1
Entamoeba histolytica	cysteine protease, putative	0.0152	0.1448	0.4054
Schistosoma mansoni	cathepsin s	0.0084	0.0533	0.0562
Leishmania major	cathepsin L-like protease	0.0274	0.3108	0.581
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0152	0.1448	0.1526
Loa Loa (eye worm)	hypothetical protein	0.0191	0.1976	0.2083
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	0.3108	0.9835
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0274	0.3108	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0152	0.1448	0.1526
Schistosoma mansoni	calpain (C02 family)	0.01	0.0755	0.0795
Entamoeba histolytica	cysteine proteinase, putative	0.0191	0.1976	0.5946
Schistosoma mansoni	calpain-7 (C02 family)	0.01	0.0755	0.0795
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.5097	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.01	0.0755	0.0856
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.01	0.0755	0.0856
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.0962	0.1014
Echinococcus multilocularis	cathepsin L cysteine protease	0.0274	0.3108	0.3108
Onchocerca volvulus		0.0274	0.3108	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0278	0.3154	0.3093
Trypanosoma cruzi	cysteine peptidase, putative	0.0422	0.5097	0.5211
Brugia malayi	calpain family protein 1	0.0266	0.2988	0.3148
Entamoeba histolytica	cysteine proteinase, putative	0.0152	0.1448	0.4054
Trypanosoma brucei	calpain-like protein, putative	0.01	0.0755	0.0856
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.5097	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	0.3108	0.9835
Trypanosoma brucei	calpain-like protein, putative	0.01	0.0755	0.0856
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0274	0.3108	0.3275
Echinococcus multilocularis	calpain 5	0.01	0.0755	0.0755
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0068	0.0317	0.0334
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0152	0.1448	0.1526
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0747	0.949	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.5097	1
Entamoeba histolytica	cysteine protease, putative	0.0152	0.1448	0.4054
Giardia lamblia	Cathepsin B precursor	0.0278	0.3154	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0274	0.3108	0.9835
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0274	0.3108	1
Giardia lamblia	Cathepsin B precursor	0.0278	0.3154	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0274	0.3108	0.9835
Echinococcus multilocularis	calpain family protein 1, d	0.0196	0.2042	0.2042
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	0.3108	0.9835
Brugia malayi	calpain 7	0.01	0.0755	0.0795
Echinococcus granulosus	cathepsin l1	0.0274	0.3108	0.3275
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	0.3108	0.9835
Echinococcus multilocularis	cathepsin L	0.0068	0.0317	0.0317
Trypanosoma cruzi	cysteine proteinase, putative	0.0152	0.1448	0.1233
Onchocerca volvulus		0.0274	0.3108	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0274	0.3108	0.3275
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0152	0.1448	0.3987
Plasmodium vivax	vivapain-3	0.0152	0.1448	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0196	0.2042	0.2152
Schistosoma mansoni	cathepsin F (C01 family)	0.0191	0.1976	0.2083
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.01	0.0755	0.0477
Echinococcus multilocularis	cathepsin L	0.0152	0.1448	0.1448
Brugia malayi	calpain family protein 1	0.0266	0.2988	0.3148
Echinococcus multilocularis	calpain 7 (C02 family)	0.01	0.0755	0.0755
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	0.3108	0.9835
Loa Loa (eye worm)	cysteine protease	0.0274	0.3108	0.3275
Loa Loa (eye worm)	hypothetical protein	0.0165	0.1635	0.1723
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0068	0.0317	0.0334
Entamoeba histolytica	cysteine proteinase, putative	0.0152	0.1448	0.4054
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0278	0.315	0.315
Onchocerca volvulus	Cathepsin F homolog	0.0274	0.3108	1
Brugia malayi	Papain family cysteine protease containing protein	0.0152	0.1448	0.1526
Loa Loa (eye worm)	hypothetical protein	0.0191	0.1976	0.2083
Toxoplasma gondii	cathepsin B	0.0278	0.3154	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0274	0.3108	0.9835
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.01	0.0755	0.0477
Plasmodium vivax	unspecified product	0.0152	0.1448	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0422	0.5097	0.5211
Echinococcus granulosus	calpain	0.01	0.0755	0.0795
Trypanosoma cruzi	cysteine peptidase, putative	0.0422	0.5097	0.5211
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0191	0.1976	0.5848
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0533	0.0562
Entamoeba histolytica	cysteine protease, putative	0.0152	0.1448	0.4054
Echinococcus granulosus	calpain 5	0.01	0.0755	0.0795
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0747	0.949	1
Echinococcus granulosus	cathepsin L	0.0068	0.0317	0.0334
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0068	0.0317	0.0334
Schistosoma mansoni	cathepsin F (C01 family)	0.0274	0.3108	0.3275
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	0.3108	0.9835
Entamoeba histolytica	cysteine protease, putative	0.0152	0.1448	0.4054
Plasmodium vivax	unspecified product	0.0084	0.0533	0.0774
Echinococcus multilocularis	hypothetical protein	0.01	0.0755	0.0755
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0278	0.3154	0.5908
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.5097	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0274	0.3108	0.3042
Entamoeba histolytica	cysteine protease, putative	0.0152	0.1448	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.5097	1
Echinococcus multilocularis	cysteine protease	0.0274	0.3108	0.3108
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0068	0.0317	0.0334
Brugia malayi	cathepsin F-like cysteine proteinase	0.0084	0.0533	0.0562
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0274	0.3108	0.9835
Onchocerca volvulus		0.0274	0.3108	1
Entamoeba histolytica	cysteine protease, putative	0.0152	0.1448	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0152	0.1448	0.1526
Echinococcus granulosus	cathepsin b	0.0747	0.949	1
Entamoeba histolytica	protein kinase, putative	0.007	0.0348	0.011
Brugia malayi	fibroinase precursor	0.0068	0.0317	0.0334
Loa Loa (eye worm)	calpain 5	0.007	0.0348	0.0367
Brugia malayi	Cathepsin L-like precursor	0.0084	0.0533	0.0562
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0191	0.1976	0.2083
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.01	0.0755	0.0477
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0266	0.2988	0.3148
Loa Loa (eye worm)	hypothetical protein	0.0274	0.3108	0.3275
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0152	0.1448	0.3987
Brugia malayi	Cathepsin L-like precursor	0.0274	0.3108	0.3275
Entamoeba histolytica	cysteine protease, putative	0.0274	0.3108	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0152	0.1448	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0422	0.5097	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0274	0.3108	0.9835
Brugia malayi	Papain family cysteine protease containing protein	0.0274	0.3108	0.3275
Onchocerca volvulus		0.0165	0.1635	0.4723
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0068	0.0317	0.0334
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0278	0.3154	0.3324
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0274	0.3108	0.9835
Loa Loa (eye worm)	fibroinase	0.0274	0.3108	0.3275
Leishmania major	cysteine peptidase A (CPA)	0.0274	0.3108	0.581
Entamoeba histolytica	cysteine protease, putative	0.0152	0.1448	0.4054
Onchocerca volvulus	Cathepsin L homolog	0.0274	0.3108	1
Leishmania major	cathepsin L-like protease	0.0274	0.3108	0.581
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0533	0.0562
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0152	0.1448	0.1233
Onchocerca volvulus		0.0274	0.3108	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0274	0.3108	0.3108
Loa Loa (eye worm)	calpain family protein 1	0.0196	0.2042	0.2152
Loa Loa (eye worm)	ctsf protein	0.0274	0.3108	0.3275
Echinococcus granulosus	cathepsin L	0.0152	0.1448	0.1526
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.01	0.0755	0.0477
Brugia malayi	Cathepsin L-like precursor	0.0274	0.3108	0.3275
Leishmania major	cathepsin L-like protease	0.0422	0.5097	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0191	0.1976	0.5848
Echinococcus granulosus	calpain A	0.01	0.0755	0.0795
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	0.3108	0.9835
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	0.3108	0.9835
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0274	0.3108	1
Entamoeba histolytica	cysteine proteinase, putative	0.0152	0.1448	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0068	0.0317	0.0334
Entamoeba histolytica	cysteine proteinase, putative	0.0274	0.3108	1
Brugia malayi	calpain 5	0.007	0.0348	0.0367
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0068	0.0317	0.0334
Leishmania major	cathepsin L-like protease	0.0274	0.3108	0.581

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 4 %	DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1861119

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1576603