Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1255 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1128 | 1 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1255 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0165 | 0.1128 | 1 |
Brugia malayi | hypothetical protein | 0.0147 | 0.0982 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1128 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0982 | 1 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1255 | 1 | 0.5 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0354 | 0.2662 | 0.5 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA | 0.0901 | 0.7119 | 0.5 |
Echinococcus granulosus | geminin | 0.0165 | 0.1128 | 1 |
Mycobacterium leprae | PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA | 0.0901 | 0.7119 | 1 |
Onchocerca volvulus | 0.0147 | 0.0982 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.